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Search results 1 to 100 out of 465 for Socs1

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Type Details Score
Gene
8651 | SOCS1
Type: gene
Organism: human
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Gene
518795 | SOCS1
Type: gene
Organism: cattle
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Gene
416630 | SOCS1
Type: gene
Organism: chicken
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Gene
711180 | SOCS1
Type: gene
Organism: macaque, rhesus
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Gene
496789 | socs1
Type: gene
Organism: frog, western clawed
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Gene
252971 | Socs1
Type: gene
Organism: rat
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Gene
490006 | SOCS1
Type: gene
Organism: dog, domestic
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Gene
737070 | SOCS1
Type: gene
Organism: chimpanzee
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Protein Domain
IPR028411 | SOCS1
Type: Family
Description: Cytokine signaling mediated by the JAK-STAT pathway plays essential roles in differentiation, maturation, proliferation and apoptosis of a various types of cells. Suppressor of cytokine signaling (SOCS) proteins are negative feedback regulators of the JAK-STAT signaling pathway. SOCS1 and SOCS3 are potent inhibitors of JAKs and can play pivotal roles in inflammation, as well as in the development and progression of cancers []. All SOCS share a central SH2 domain and a C-terminal SOCS box, but only SOCS1 and SOCS3 possess a kinase inhibitory region immediately upstream of the central SH2 [].SOCS1 plays a key role in the negative regulation of interferon-gamma signaling and in T cell differentiation [, , ].
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Protein Coding Gene
MGI:1354910 | Socs1
Type: protein_coding_gene
Organism: mouse, laboratory
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Publication
21893603 | -
First Author: Takahashi R
Year: 2011
Journal: J Exp Med
Title: SOCS1 is essential for regulatory T cell functions by preventing loss of Foxp3 expression as well as IFN-{gamma} and IL-17A production.
Volume: 208
Issue: 10
Pages: 2055-67
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Publication
15983045 | J:101166
First Author: Jamieson E
Year: 2005
Journal: J Biol Chem
Title: Socs1 deficiency enhances hepatic insulin signaling.
Volume: 280
Issue: 36
Pages: 31516-21
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Publication
10490100 | J:57475
First Author: Marine JC
Year: 1999
Journal: Cell
Title: SOCS1 deficiency causes a lymphocyte-dependent perinatal lethality.
Volume: 98
Issue: 5
Pages: 609-16
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Publication
22634176 | J:192426
First Author: Wu T
Year: 2012
Journal: Bone
Title: miR-155 modulates TNF-α-inhibited osteogenic differentiation by targeting SOCS1 expression.
Volume: 51
Issue: 3
Pages: 498-505
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Publication
20005840 | J:155447
First Author: Calabrese V
Year: 2009
Journal: Mol Cell
Title: SOCS1 links cytokine signaling to p53 and senescence.
Volume: 36
Issue: 5
Pages: 754-67
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Publication
15197228 | J:91651
First Author: Yoshida T
Year: 2004
Journal: J Exp Med
Title: SOCS1 is a suppressor of liver fibrosis and hepatitis-induced carcinogenesis.
Volume: 199
Issue: 12
Pages: 1701-7
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Publication
12645661 | -
First Author: Larsen L
Year: 2002
Journal: APMIS
Title: Suppressors of cytokine signalling: SOCS.
Volume: 110
Issue: 12
Pages: 833-44
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Publication
22423360 | -
First Author: Feng ZP
Year: 2012
Journal: Proteins
Title: The N-terminal domains of SOCS proteins: a conserved region in the disordered N-termini of SOCS4 and 5.
Volume: 80
Issue: 3
Pages: 946-57
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Publication
24069550 | -
First Author: Inagaki-Ohara K
Year: 2013
Journal: JAKSTAT
Title: SOCS, inflammation, and cancer.
Volume: 2
Issue: 3
Pages: e24053
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Publication
22771905 | J:188544
First Author: Zhang J
Year: 2012
Journal: FEBS Lett
Title: Interferon-β-induced miR-155 inhibits osteoclast differentiation by targeting SOCS1 and MITF.
Volume: 586
Issue: 19
Pages: 3255-62
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Publication
11553846 | -
First Author: Krebs DL
Year: 2001
Journal: Stem Cells
Title: SOCS proteins: negative regulators of cytokine signaling.
Volume: 19
Issue: 5
Pages: 378-87
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Publication
28679957 | J:291467
 
First Author: Piñeros Alvarez AR
Year: 2017
Journal: JCI Insight
Title: SOCS1 is a negative regulator of metabolic reprogramming during sepsis.
Volume: 2
Issue: 13
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Protein
O35716
Organism: Mus musculus/domesticus
Length: 212  
Fragment?: false
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Publication
27183599 | J:329103
First Author: Qayum AA
Year: 2016
Journal: J Immunol
Title: IL-10-Induced miR-155 Targets SOCS1 To Enhance IgE-Mediated Mast Cell Function.
Volume: 196
Issue: 11
Pages: 4457-67
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Publication
24778118 | J:331328
First Author: Rao R
Year: 2014
Journal: Infect Immun
Title: Staphylococcal enterotoxin B-induced microRNA-155 targets SOCS1 to promote acute inflammatory lung injury.
Volume: 82
Issue: 7
Pages: 2971-9
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Publication
27583437 | J:250853
First Author: Ushiki T
Year: 2016
Journal: PLoS One
Title: Rapid Inflammation in Mice Lacking Both SOCS1 and SOCS3 in Hematopoietic Cells.
Volume: 11
Issue: 9
Pages: e0162111
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Publication
21304519 | J:220939
 
First Author: Chinen T
Year: 2011
Journal: Nat Commun
Title: Prostaglandin E2 and SOCS1 have a role in intestinal immune tolerance.
Volume: 2
Pages: 190
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Publication
21393632 | J:169668
First Author: Hashimoto M
Year: 2011
Journal: Int Immunol
Title: SOCS1 regulates type I/type II NKT cell balance by regulating IFNgamma signaling.
Volume: 23
Issue: 3
Pages: 165-76
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Publication
19469017 | J:150670
First Author: Hashimoto M
Year: 2009
Journal: Cancer Sci
Title: Silencing of SOCS1 in macrophages suppresses tumor development by enhancing antitumor inflammation.
Volume: 100
Issue: 4
Pages: 730-6
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Publication
33724556 | J:310460
First Author: Karki P
Year: 2021
Journal: FASEB J
Title: Microtubule-dependent mechanism of anti-inflammatory effect of SOCS1 in endothelial dysfunction and lung injury.
Volume: 35
Issue: 4
Pages: e21388
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Publication
28753604 | J:245164
First Author: Demirel Ö
Year: 2017
Journal: PLoS One
Title: SOCS1 function in BCR-ABL mediated myeloproliferative disease is dependent on the cytokine environment.
Volume: 12
Issue: 7
Pages: e0180401
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Publication
28900038 | J:246805
First Author: Blumer T
Year: 2017
Journal: J Biol Chem
Title: SOCS1 is an inducible negative regulator of interferon λ (IFN-λ)-induced gene expression in vivo.
Volume: 292
Issue: 43
Pages: 17928-17938
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Publication
23443260 | J:198836
First Author: Rodriguez GM
Year: 2013
Journal: J Invest Dermatol
Title: SOCS1 prevents potentially skin-reactive cytotoxic T lymphocytes from gaining the ability to cause inflammatory lesions.
Volume: 133
Issue: 8
Pages: 2013-22
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Publication
36765862 | J:333332
 
First Author: Khan MGM
Year: 2023
Journal: Cancers (Basel)
Title: SOCS1 Deficiency Promotes Hepatocellular Carcinoma via SOCS3-Dependent CDKN1A Induction and NRF2 Activation.
Volume: 15
Issue: 3
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Publication
11445538 | J:70408
First Author: Lindeman GJ
Year: 2001
Journal: Genes Dev
Title: SOCS1 deficiency results in accelerated mammary gland development and rescues lactation in prolactin receptor-deficient mice.
Volume: 15
Issue: 13
Pages: 1631-6
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Publication
33220174 | J:300512
First Author: Du J
Year: 2020
Journal: Dev Cell
Title: N6-Adenosine Methylation of Socs1 mRNA Is Required to Sustain the Negative Feedback Control of Macrophage Activation.
Volume: 55
Issue: 6
Pages: 737-753.e7
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Publication
28550203 | J:250655
First Author: Takahashi R
Year: 2017
Journal: J Immunol
Title: SOCS1 Is a Key Molecule That Prevents Regulatory T Cell Plasticity under Inflammatory Conditions.
Volume: 199
Issue: 1
Pages: 149-158
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Publication
29150567 | J:253405
First Author: Alice AF
Year: 2018
Journal: J Immunol
Title: Amplifying IFN-γ Signaling in Dendritic Cells by CD11c-Specific Loss of SOCS1 Increases Innate Immunity to Infection while Decreasing Adaptive Immunity.
Volume: 200
Issue: 1
Pages: 177-185
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Publication
18606672 | J:137465
First Author: Yu CR
Year: 2008
Journal: J Immunol
Title: SOCS1 regulates CCR7 expression and migration of CD4+ T cells into peripheral tissues.
Volume: 181
Issue: 2
Pages: 1190-8
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Publication
21206089 | J:171834
First Author: Serezani CH
Year: 2011
Journal: J Clin Invest
Title: Leukotriene B4 amplifies NF-κB activation in mouse macrophages by reducing SOCS1 inhibition of MyD88 expression.
Volume: 121
Issue: 2
Pages: 671-82
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Publication
19144316 | J:143720
First Author: Lu LF
Year: 2009
Journal: Immunity
Title: Foxp3-dependent microRNA155 confers competitive fitness to regulatory T cells by targeting SOCS1 protein.
Volume: 30
Issue: 1
Pages: 80-91
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Publication
37860002 | J:341621
 
First Author: Kandhi R
Year: 2023
Journal: Front Immunol
Title: Hepatic stellate cell-intrinsic role of SOCS1 in controlling hepatic fibrogenic response and the pro-inflammatory macrophage compartment during liver fibrosis.
Volume: 14
Pages: 1259246
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Publication
10490099 | J:57474
First Author: Alexander WS
Year: 1999
Journal: Cell
Title: SOCS1 is a critical inhibitor of interferon gamma signaling and prevents the potentially fatal neonatal actions of this cytokine.
Volume: 98
Issue: 5
Pages: 597-608
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Publication
21646388 | J:186745
First Author: Sachithanandan N
Year: 2011
Journal: Diabetes
Title: Macrophage deletion of SOCS1 increases sensitivity to LPS and palmitic acid and results in systemic inflammation and hepatic insulin resistance.
Volume: 60
Issue: 8
Pages: 2023-31
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Publication
16357940 | J:105256
First Author: Evel-Kabler K
Year: 2006
Journal: J Clin Invest
Title: SOCS1 restricts dendritic cells' ability to break self tolerance and induce antitumor immunity by regulating IL-12 production and signaling.
Volume: 116
Issue: 1
Pages: 90-100
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Publication
32900697 | J:308014
 
First Author: Opazo-Ríos L
Year: 2020
Journal: BMJ Open Diabetes Res Care
Title: Anti-inflammatory, antioxidant and renoprotective effects of SOCS1 mimetic peptide in the BTBR ob/ob mouse model of type 2 diabetes.
Volume: 8
Issue: 1
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Publication
21778271 | J:181394
First Author: Yu CR
Year: 2011
Journal: Invest Ophthalmol Vis Sci
Title: Suppressor of cytokine signaling-1 (SOCS1) inhibits lymphocyte recruitment into the retina and protects SOCS1 transgenic rats and mice from ocular inflammation.
Volume: 52
Issue: 9
Pages: 6978-86
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Publication
31653894 | J:285664
First Author: Sutherland APR
Year: 2019
Journal: Sci Rep
Title: IL-21 regulates SOCS1 expression in autoreactive CD8+ T cells but is not required for acquisition of CTL activity in the islets of non-obese diabetic mice.
Volume: 9
Issue: 1
Pages: 15302
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Publication
19734231 | J:152785
First Author: Starr R
Year: 2009
Journal: J Immunol
Title: SOCS-1 binding to tyrosine 441 of IFN-gamma receptor subunit 1 contributes to the attenuation of IFN-gamma signaling in vivo.
Volume: 183
Issue: 7
Pages: 4537-44
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Publication
15924143 | J:99147
First Author: Catlett IM
Year: 2005
Journal: Nat Immunol
Title: Suppressor of cytokine signaling 1 is required for the differentiation of CD4+ T cells.
Volume: 6
Issue: 7
Pages: 715-21
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Publication
12433365 | J:125159
First Author: Kinjyo I
Year: 2002
Journal: Immunity
Title: SOCS1/JAB is a negative regulator of LPS-induced macrophage activation.
Volume: 17
Issue: 5
Pages: 583-91
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Publication
20934424 | J:165520
First Author: Stevenson NJ
Year: 2010
Journal: FEBS Lett
Title: Suppressor of cytokine signalling (SOCS) 1 and 3 enhance cell adhesion and inhibit migration towards the chemokine eotaxin/CCL11.
Volume: 584
Issue: 21
Pages: 4469-74
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Publication
11522790 | J:159012
First Author: Hanada T
Year: 2001
Journal: J Biol Chem
Title: A mutant form of JAB/SOCS1 augments the cytokine-induced JAK/STAT pathway by accelerating degradation of wild-type JAB/CIS family proteins through the SOCS-box.
Volume: 276
Issue: 44
Pages: 40746-54
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Publication
12911518 | J:103879
First Author: Bullen DV
Year: 2003
Journal: Parasite Immunol
Title: The lack of suppressor of cytokine signalling-1 (SOCS1) protects mice from the development of cerebral malaria caused by Plasmodium berghei ANKA.
Volume: 25
Issue: 3
Pages: 113-8
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Publication
15778397 | J:97964
First Author: Hanada T
Year: 2005
Journal: J Immunol
Title: Induction of hyper Th1 cell-type immune responses by dendritic cells lacking the suppressor of cytokine signaling-1 gene.
Volume: 174
Issue: 7
Pages: 4325-32
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Publication
12917417 | J:86132
First Author: Ilangumaran S
Year: 2003
Journal: J Biol Chem
Title: Suppressor of cytokine signaling 1 regulates an endogenous inhibitor of a mast cell protease.
Volume: 278
Issue: 43
Pages: 41871-80
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Publication
16120757 | J:129148
First Author: Inagaki-Ohara K
Year: 2006
Journal: Gut
Title: Suppressor of cytokine signalling 1 in lymphocytes regulates the development of intestinal inflammation in mice.
Volume: 55
Issue: 2
Pages: 212-9
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Publication
21788442 | J:179143
First Author: Collins EL
Year: 2011
Journal: J Immunol
Title: Inhibition of SOCS1-/- lethal autoinflammatory disease correlated to enhanced peripheral Foxp3+ regulatory T cell homeostasis.
Volume: 187
Issue: 5
Pages: 2666-76
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Publication
31637892 | J:287887
First Author: Zhang P
Year: 2019
Journal: Yonsei Med J
Title: Inhibition of miRNA-222-3p Relieves Staphylococcal Enterotoxin B-Induced Liver Inflammatory Injury by Upregulating Suppressors of Cytokine Signaling 1.
Volume: 60
Issue: 11
Pages: 1093-1102
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Publication
21764457 | J:177208
First Author: Fujimoto A
Year: 2011
Journal: Mol Immunol
Title: Involvement of suppressor of cytokine signaling-1 in globular adiponectin-induced granulocyte colony-stimulating factor in RAW 264 cell.
Volume: 48
Issue: 15-16
Pages: 2052-8
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Publication
11576226 | J:71691
First Author: Bullen DV
Year: 2001
Journal: Immunology
Title: Neutralization of interferon-gamma in neonatal SOCS1-/- mice prevents fatty degeneration of the liver but not subsequent fatal inflammatory disease.
Volume: 104
Issue: 1
Pages: 92-8
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Publication
23831231 | J:205316
 
First Author: Choi HI
Year: 2013
Journal: Free Radic Biol Med
Title: Peroxiredoxin V selectively regulates IL-6 production by modulating the Jak2-Stat5 pathway.
Volume: 65
Pages: 270-9
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Publication
27050510 | J:234950
First Author: Zhao D
Year: 2016
Journal: Cell Rep
Title: H3K4me3 Demethylase Kdm5a Is Required for NK Cell Activation by Associating with p50 to Suppress SOCS1.
Volume: 15
Issue: 2
Pages: 288-99
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Publication
24966052 | J:215477
First Author: Galic S
Year: 2014
Journal: Biochem J
Title: Suppressor of cytokine signalling (SOCS) proteins as guardians of inflammatory responses critical for regulating insulin sensitivity.
Volume: 461
Issue: 2
Pages: 177-88
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Publication
16091384 | J:100705
First Author: Tsukada J
Year: 2005
Journal: Int Immunol
Title: The role of suppressor of cytokine signaling 1 as a negative regulator for aberrant expansion of CD8alpha+ dendritic cell subset.
Volume: 17
Issue: 9
Pages: 1167-78
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Publication
18322180 | J:132905
First Author: Tanaka K
Year: 2008
Journal: J Immunol
Title: Loss of suppressor of cytokine signaling 1 in helper T cells leads to defective Th17 differentiation by enhancing antagonistic effects of IFN-gamma on STAT3 and Smads.
Volume: 180
Issue: 6
Pages: 3746-56
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Publication
30097285 | J:298059
 
First Author: Mafanda EK
Year: 2019
Journal: Cytokine
Title: Essential role of suppressor of cytokine signaling 1 (SOCS1) in hepatocytes and macrophages in the regulation of liver fibrosis.
Volume: 124
Pages: 154501
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Publication
15899915 | J:118492
First Author: Chong MM
Year: 2005
Journal: Blood
Title: Suppressor of cytokine signaling-1 in T cells and macrophages is critical for preventing lethal inflammation.
Volume: 106
Issue: 5
Pages: 1668-75
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Publication
20406299 | J:166409
First Author: Woodward EA
Year: 2010
Journal: Immunology
Title: The anti-inflammatory effects of interleukin-4 are not mediated by suppressor of cytokine signalling-1 (SOCS1).
Volume: 131
Issue: 1
Pages: 118-27
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Publication
12928391 | J:85085
First Author: Ilangumaran S
Year: 2003
Journal: J Immunol
Title: Suppressor of cytokine signaling 1 regulates IL-15 receptor signaling in CD8+CD44high memory T lymphocytes.
Volume: 171
Issue: 5
Pages: 2435-45
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Publication
18524780 | J:139060
First Author: Haffner MC
Year: 2008
Journal: J Biol Chem
Title: Interaction and functional interference of glucocorticoid receptor and SOCS1.
Volume: 283
Issue: 32
Pages: 22089-96
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Publication
16687505 | J:144406
First Author: Balabanov R
Year: 2006
Journal: J Neurosci
Title: Suppressor of cytokine signaling 1 expression protects oligodendrocytes from the deleterious effects of interferon-gamma.
Volume: 26
Issue: 19
Pages: 5143-52
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Publication
21258009 | J:170508
First Author: Saba I
Year: 2011
Journal: Blood
Title: IL-7R-dependent survival and differentiation of early T-lineage progenitors is regulated by the BTB/POZ domain transcription factor Miz-1.
Volume: 117
Issue: 12
Pages: 3370-81
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Publication
16311601 | J:112593
First Author: Fenner JE
Year: 2006
Journal: Nat Immunol
Title: Suppressor of cytokine signaling 1 regulates the immune response to infection by a unique inhibition of type I interferon activity.
Volume: 7
Issue: 1
Pages: 33-9
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Publication
22792286 | J:225096
First Author: Uto-Konomi A
Year: 2012
Journal: PLoS One
Title: Dysregulation of suppressor of cytokine signaling 3 in keratinocytes causes skin inflammation mediated by interleukin-20 receptor-related cytokines.
Volume: 7
Issue: 7
Pages: e40343
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Publication
20937844 | J:165640
First Author: Wang P
Year: 2010
Journal: J Immunol
Title: Inducible microRNA-155 feedback promotes type I IFN signaling in antiviral innate immunity by targeting suppressor of cytokine signaling 1.
Volume: 185
Issue: 10
Pages: 6226-33
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Publication
19620279 | J:152602
First Author: Diao Y
Year: 2009
Journal: Mol Cell Biol
Title: SOCS1, SOCS3, and PIAS1 promote myogenic differentiation by inhibiting the leukemia inhibitory factor-induced JAK1/STAT1/STAT3 pathway.
Volume: 29
Issue: 18
Pages: 5084-93
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Publication
20519645 | J:161432
First Author: Ramanathan S
Year: 2010
Journal: J Immunol
Title: Regulation of cytokine-driven functional differentiation of CD8 T cells by suppressor of cytokine signaling 1 controls autoimmunity and preserves their proliferative capacity toward foreign antigens.
Volume: 185
Issue: 1
Pages: 357-66
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Publication
19299500 | J:164975
First Author: Fukuyama S
Year: 2009
Journal: Am J Respir Crit Care Med
Title: Pulmonary suppressor of cytokine signaling-1 induced by IL-13 regulates allergic asthma phenotype.
Volume: 179
Issue: 11
Pages: 992-8
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Publication
17404264 | J:145200
First Author: Zimmerer JM
Year: 2007
Journal: J Immunol
Title: IFN-alpha-induced signal transduction, gene expression, and antitumor activity of immune effector cells are negatively regulated by suppressor of cytokine signaling proteins.
Volume: 178
Issue: 8
Pages: 4832-45
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Publication
12907450 | J:86680
First Author: Ilangumaran S
Year: 2003
Journal: Blood
Title: Suppressor of cytokine signaling 1 attenuates IL-15 receptor signaling in CD8+ thymocytes.
Volume: 102
Issue: 12
Pages: 4115-22
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Publication
19617348 | J:156365
First Author: Srivastava V
Year: 2009
Journal: J Biol Chem
Title: Toll-like receptor 2 and DC-SIGNR1 differentially regulate suppressors of cytokine signaling 1 in dendritic cells during Mycobacterium tuberculosis infection.
Volume: 284
Issue: 38
Pages: 25532-41
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Publication
12682261 | J:125437
First Author: Bullen DV
Year: 2003
Journal: J Immunol
Title: Persistence of lesions in suppressor of cytokine signaling-1-deficient mice infected with Leishmania major.
Volume: 170
Issue: 8
Pages: 4267-72
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Publication
18321577 | J:134472
First Author: Croom HA
Year: 2008
Journal: Mol Immunol
Title: Perturbed thymopoiesis in vitro in the absence of suppressor of cytokine signalling 1 and 3.
Volume: 45
Issue: 10
Pages: 2888-96
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Publication
26725321 | J:227978
First Author: Yeganeh M
Year: 2016
Journal: Oncogene
Title: Suppressor of cytokine signaling 1-dependent regulation of the expression and oncogenic functions of p21(CIP1/WAF1) in the liver.
Volume: 35
Issue: 32
Pages: 4200-11
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Publication
15728516 | J:97719
First Author: Ohishi M
Year: 2005
Journal: J Immunol
Title: Suppressors of cytokine signaling-1 and -3 regulate osteoclastogenesis in the presence of inflammatory cytokines.
Volume: 174
Issue: 5
Pages: 3024-31
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Publication
28182772 | J:246665
First Author: Alston CI
Year: 2017
Journal: PLoS One
Title: Murine cytomegalovirus infection of mouse macrophages stimulates early expression of suppressor of cytokine signaling (SOCS)1 and SOCS3.
Volume: 12
Issue: 2
Pages: e0171812
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Publication
21622562 | J:175389
First Author: Carow B
Year: 2011
Journal: J Biol Chem
Title: Silencing suppressor of cytokine signaling-1 (SOCS1) in macrophages improves Mycobacterium tuberculosis control in an interferon-gamma (IFN-gamma)-dependent manner.
Volume: 286
Issue: 30
Pages: 26873-87
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Publication
15491990 | J:95152
First Author: Gingras S
Year: 2004
Journal: J Biol Chem
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