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Search results 1 to 100 out of 556 for Socs3

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Type Details Score
Gene
Type: gene
Organism: human
Gene
Type: gene
Organism: frog, western clawed
Gene
Type: gene
Organism: rat
Gene
Type: gene
Organism: dog, domestic
Gene
Type: gene
Organism: chimpanzee
Gene
Type: gene
Organism: cattle
Gene
Type: gene
Organism: chicken
Gene
Type: gene
Organism: macaque, rhesus
Protein Domain
Type: Family
Description: Cytokine signaling mediated by the JAK-STAT pathway plays essential roles in differentiation, maturation, proliferation and apoptosis of a various types of cells. Suppressor of cytokine signaling (SOCS) proteins are negative feedback regulators of the JAK-STAT signaling pathway. SOCS1 and SOCS3 are potent inhibitors of JAKs and can play pivotal roles in inflammation, as well as in the development and progression of cancers []. All SOCS share a central SH2 domain and a C-terminal SOCS box, but only SOCS1 and SOCS3 possess a kinase inhibitory region immediately upstream of the central SH2 [].SOCS3 interacts with gp130, a common cytokine receptor for interleukin (IL)-6, leukemia inhibitory factor (LIF) and other members of the IL-6 family of cytokines. SOCS3 has been reported also to interact with the leptin receptor, erythropoietin receptor, insulin receptor, IL-12beta receptor and granulocyte-colony stimulating factor receptor [].
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Gene
Type: gene
Organism: human
Publication
First Author: Boyle K
Year: 2008
Journal: J Reprod Immunol
Title: The role of SOCS3 in modulating leukaemia inhibitory factor signalling during murine placental development.
Volume: 77
Issue: 1
Pages: 1-6
Publication
First Author: Hill GR
Year: 2010
Journal: Blood
Title: SOCS3 regulates graft-versus-host disease.
Volume: 116
Issue: 2
Pages: 287-96
Publication
First Author: Feng ZP
Year: 2012
Journal: Proteins
Title: The N-terminal domains of SOCS proteins: a conserved region in the disordered N-termini of SOCS4 and 5.
Volume: 80
Issue: 3
Pages: 946-57
Publication
First Author: Inagaki-Ohara K
Year: 2013
Journal: JAKSTAT
Title: SOCS, inflammation, and cancer.
Volume: 2
Issue: 3
Pages: e24053
Protein
Organism: Mus musculus/domesticus
Length: 225  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 225  
Fragment?: false
Publication
First Author: Croker BA
Year: 2003
Journal: Nat Immunol
Title: SOCS3 negatively regulates IL-6 signaling in vivo.
Volume: 4
Issue: 6
Pages: 540-5
Publication
First Author: Stahl A
Year: 2012
Journal: Blood
Title: SOCS3 is an endogenous inhibitor of pathologic angiogenesis.
Volume: 120
Issue: 14
Pages: 2925-9
Publication
First Author: Le Provost F
Year: 2005
Journal: Biochem Biophys Res Commun
Title: SOCS3 promotes apoptosis of mammary differentiated cells.
Volume: 338
Issue: 4
Pages: 1696-701
Publication
First Author: Smith PD
Year: 2009
Journal: Neuron
Title: SOCS3 deletion promotes optic nerve regeneration in vivo.
Volume: 64
Issue: 5
Pages: 617-23
Publication
First Author: Qin H
Year: 2012
Journal: J Immunol
Title: SOCS3 deficiency promotes M1 macrophage polarization and inflammation.
Volume: 189
Issue: 7
Pages: 3439-48
Publication
First Author: Emery B
Year: 2006
Journal: Mol Cell Neurosci
Title: SOCS3 negatively regulates LIF signaling in neural precursor cells.
Volume: 31
Issue: 4
Pages: 739-47
Publication
First Author: Berger H
Year: 2013
Journal: Cancer Res
Title: SOCS3 transactivation by PPARγ prevents IL-17-driven cancer growth.
Volume: 73
Issue: 12
Pages: 3578-90
Publication
First Author: Jorgensen SB
Year: 2013
Journal: Diabetes
Title: Deletion of skeletal muscle SOCS3 prevents insulin resistance in obesity.
Volume: 62
Issue: 1
Pages: 56-64
Publication  
First Author: Martino N
Year: 2021
Journal: JCI Insight
Title: Endothelial SOCS3 maintains homeostasis and promotes survival in endotoxemic mice.
Volume: 6
Issue: 14
Publication
First Author: Narayana Y
Year: 2009
Journal: Mol Immunol
Title: SOCS3 expression induced by PIM2 requires PKC and PI3K signaling.
Volume: 46
Issue: 15
Pages: 2947-54
Publication
First Author: San Martin S
Year: 2013
Journal: Eur J Histochem
Title: Stat3 and Socs3 expression patterns during murine placenta development.
Volume: 57
Issue: 2
Pages: e19
Publication  
First Author: Ohno-Urabe S
Year: 2018
Journal: J Am Heart Assoc
Title: Role of Macrophage Socs3 in the Pathogenesis of Aortic Dissection.
Volume: 7
Issue: 2
Publication
First Author: Marine JC
Year: 1999
Journal: Cell
Title: SOCS3 is essential in the regulation of fetal liver erythropoiesis.
Volume: 98
Issue: 5
Pages: 617-27
Publication
First Author: Nadrah K
Year: 2015
Journal: PLoS One
Title: Immature B Cell Egress from Bone Marrow Is SOCS3 Independent.
Volume: 10
Issue: 8
Pages: e0136061
Publication
First Author: Ozawa Y
Year: 2007
Journal: Dev Biol
Title: SOCS3 is required to temporally fine-tune photoreceptor cell differentiation.
Volume: 303
Issue: 2
Pages: 591-600
Publication
First Author: Le Y
Year: 2007
Journal: Immunity
Title: SOCS3 protein developmentally regulates the chemokine receptor CXCR4-FAK signaling pathway during B lymphopoiesis.
Volume: 27
Issue: 5
Pages: 811-23
Publication
First Author: Korovina I
Year: 2020
Journal: J Innate Immun
Title: Myeloid SOCS3 Deficiency Regulates Angiogenesis via Enhanced Apoptotic Endothelial Cell Engulfment.
Volume: 12
Issue: 3
Pages: 248-256
Publication
First Author: Bajpai A
Year: 2017
Journal: Sci Rep
Title: Insights into gene expression profiles induced by Socs3 depletion in keratinocytes.
Volume: 7
Issue: 1
Pages: 15830
Publication
First Author: Ogata H
Year: 2006
Journal: Gastroenterology
Title: Deletion of the SOCS3 gene in liver parenchymal cells promotes hepatitis-induced hepatocarcinogenesis.
Volume: 131
Issue: 1
Pages: 179-93
Publication
First Author: Torisu T
Year: 2007
Journal: Genes Cells
Title: The dual function of hepatic SOCS3 in insulin resistance in vivo.
Volume: 12
Issue: 2
Pages: 143-54
Publication  
First Author: Ramos-Lobo AM
Year: 2017
Journal: Neuroscience
Title: SOCS3 ablation in SF1 cells causes modest metabolic effects during pregnancy and lactation.
Volume: 365
Pages: 114-124
Publication
First Author: Pedroso JAB
Year: 2017
Journal: J Endocrinol
Title: SOCS3 expression in SF1 cells regulates adrenal differentiation and exercise performance.
Volume: 235
Issue: 3
Pages: 207-222
Publication
First Author: Palanivel R
Year: 2012
Journal: Diabetologia
Title: Reduced Socs3 expression in adipose tissue protects female mice against obesity-induced insulin resistance.
Volume: 55
Issue: 11
Pages: 3083-93
Publication
First Author: Kiu H
Year: 2009
Journal: Growth Factors
Title: Regulation of multiple cytokine signalling pathways by SOCS3 is independent of SOCS2.
Volume: 27
Issue: 6
Pages: 384-93
Publication  
First Author: Liu S
Year: 2019
Journal: Front Immunol
Title: Influenza Virus-Induced Robust Expression of SOCS3 Contributes to Excessive Production of IL-6.
Volume: 10
Pages: 1843
Publication
First Author: Croker BA
Year: 2004
Journal: Immunity
Title: SOCS3 is a critical physiological negative regulator of G-CSF signaling and emergency granulopoiesis.
Volume: 20
Issue: 2
Pages: 153-65
Publication
First Author: Ushiki T
Year: 2016
Journal: PLoS One
Title: Rapid Inflammation in Mice Lacking Both SOCS1 and SOCS3 in Hematopoietic Cells.
Volume: 11
Issue: 9
Pages: e0162111
Publication
First Author: Yasukawa H
Year: 2003
Journal: Nat Immunol
Title: IL-6 induces an anti-inflammatory response in the absence of SOCS3 in macrophages.
Volume: 4
Issue: 6
Pages: 551-6
Publication
First Author: Geoffroy CG
Year: 2022
Journal: iScience
Title: Targeting PTEN but not SOCS3 resists an age-dependent decline in promoting axon sprouting.
Volume: 25
Issue: 11
Pages: 105383
Publication  
First Author: Li L
Year: 2020
Journal: Mol Immunol
Title: SOCS3-deficient lung epithelial cells uptaking neutrophil-derived SOCS3 worsens lung influenza infection.
Volume: 125
Pages: 51-62
Publication
First Author: Jones SA
Year: 2011
Journal: J Immunol
Title: SOCS3 deletion in B cells alters cytokine responses and germinal center output.
Volume: 187
Issue: 12
Pages: 6318-26
Publication  
First Author: Liu S
Year: 2021
Journal: Front Cell Dev Biol
Title: SOCS3 Negatively Regulates Cardiac Hypertrophy via Targeting GRP78-Mediated ER Stress During Pressure Overload.
Volume: 9
Pages: 629932
Publication
First Author: Gu X
Year: 2024
Journal: FASEB J
Title: MiR-9 promotes G-MDSC recruitment and tumor proliferation by targeting SOCS3 in breast cancer.
Volume: 38
Issue: 1
Pages: e23388
Publication
First Author: Pillemer BB
Year: 2007
Journal: Eur J Immunol
Title: Deficient SOCS3 expression in CD4+CD25+FoxP3+ regulatory T cells and SOCS3-mediated suppression of Treg function.
Volume: 37
Issue: 8
Pages: 2082-9
Publication
First Author: Miao T
Year: 2008
Journal: Mol Cell Neurosci
Title: SOCS3 suppresses AP-1 transcriptional activity in neuroblastoma cells through inhibition of c-Jun N-terminal kinase.
Volume: 37
Issue: 2
Pages: 367-75
Publication    
First Author: Walker EC
Year: 2020
Journal: Elife
Title: Cortical bone maturation in mice requires SOCS3 suppression of gp130/STAT3 signalling in osteocytes.
Volume: 9
Publication
First Author: Liu X
Year: 2008
Journal: Mol Immunol
Title: SOCS3 promotes TLR4 response in macrophages by feedback inhibiting TGF-beta1/Smad3 signaling.
Volume: 45
Issue: 5
Pages: 1405-13
Publication
First Author: Chen Z
Year: 2006
Journal: Proc Natl Acad Sci U S A
Title: Selective regulatory function of Socs3 in the formation of IL-17-secreting T cells.
Volume: 103
Issue: 21
Pages: 8137-42
Publication
First Author: Wiejak J
Year: 2014
Journal: FEBS Lett
Title: The role of c-Jun in controlling the EPAC1-dependent induction of the SOCS3 gene in HUVECs.
Volume: 588
Issue: 9
Pages: 1556-61
Publication
First Author: Croker BA
Year: 2008
Journal: Exp Hematol
Title: Socs3 maintains the specificity of biological responses to cytokine signals during granulocyte and macrophage differentiation.
Volume: 36
Issue: 7
Pages: 786-98
Publication    
First Author: Yan Z
Year: 2019
Journal: JCI Insight
Title: Deficiency of Socs3 leads to brain-targeted EAE via enhanced neutrophil activation and ROS production.
Volume: 5
Publication
First Author: Liu S
Year: 2018
Journal: Cell Physiol Biochem
Title: Cardiac Ablation of SOCS3 Aggravates DOCA-Salt-Induced Hypertrophic Remodeling by Activation of Gp130-Dependent Signaling in Mice.
Volume: 47
Issue: 1
Pages: 140-150
Publication
First Author: Nakaya M
Year: 2009
Journal: J Immunol
Title: SOCS3 in T and NKT cells negatively regulates cytokine production and ameliorates ConA-induced hepatitis.
Volume: 183
Issue: 11
Pages: 7047-53
Publication
First Author: Nohara S
Year: 2021
Journal: PLoS One
Title: SOCS3 deficiency in cardiomyocytes elevates sensitivity of ischemic preconditioning that synergistically ameliorates myocardial ischemia reperfusion injury.
Volume: 16
Issue: 7
Pages: e0254712
Publication
First Author: Zhu BM
Year: 2008
Journal: J Invest Dermatol
Title: SOCS3 negatively regulates the gp130-STAT3 pathway in mouse skin wound healing.
Volume: 128
Issue: 7
Pages: 1821-9
Publication
First Author: Kim E
Year: 2017
Journal: J Exp Med
Title: Rb family proteins enforce the homeostasis of quiescent hematopoietic stem cells by repressing Socs3 expression.
Volume: 214
Issue: 7
Pages: 1901-1912
Publication
First Author: Cho K
Year: 2021
Journal: iScience
Title: Altered microbiota by a high-fat diet accelerates lethal myeloid hematopoiesis associated with systemic SOCS3 deficiency.
Volume: 24
Issue: 10
Pages: 103117
Publication
First Author: Mori H
Year: 2007
Journal: Biochem Biophys Res Commun
Title: Suppression of SOCS3 expression in the pancreatic beta-cell leads to resistance to type 1 diabetes.
Volume: 359
Issue: 4
Pages: 952-8
Publication
First Author: Mise-Omata S
Year: 2023
Journal: Cell Rep
Title: SOCS3 deletion in effector T cells confers an anti-tumorigenic role of IL-6 to the pro-tumorigenic cytokine.
Volume: 42
Issue: 8
Pages: 112940
Publication  
First Author: Li S
Year: 2015
Journal: Neurobiol Dis
Title: Injured adult retinal axons with Pten and Socs3 co-deletion reform active synapses with suprachiasmatic neurons.
Volume: 73
Pages: 366-76
Publication
First Author: McFarland BC
Year: 2016
Journal: Oncotarget
Title: Loss of SOCS3 in myeloid cells prolongs survival in a syngeneic model of glioma.
Volume: 7
Issue: 15
Pages: 20621-35
Publication
First Author: Sun W
Year: 2018
Journal: Exp Cell Res
Title: MBD2-mediated Th17 differentiation in severe asthma is associated with impaired SOCS3 expression.
Volume: 371
Issue: 1
Pages: 196-204
Publication  
First Author: Hao Y
Year: 2023
Journal: Brain Res
Title: Inhibition of SOCS3 signaling in the nucleus tractus solitarii and retrotrapezoid nucleus alleviates hypoventilation in diet-induced obese male mice.
Volume: 1822
Pages: 148608
Publication
First Author: Kershaw NJ
Year: 2013
Journal: Nat Struct Mol Biol
Title: SOCS3 binds specific receptor-JAK complexes to control cytokine signaling by direct kinase inhibition.
Volume: 20
Issue: 4
Pages: 469-76
Publication  
First Author: Speth JM
Year: 2019
Journal: JCI Insight
Title: Alveolar macrophage secretion of vesicular SOCS3 represents a platform for lung cancer therapeutics.
Volume: 4
Issue: 20
Publication
First Author: Zampieri TT
Year: 2015
Journal: Mol Metab
Title: SOCS3 deficiency in leptin receptor-expressing cells mitigates the development of pregnancy-induced metabolic changes.
Volume: 4
Issue: 3
Pages: 237-45
Publication
First Author: Inagaki-Ohara K
Year: 2014
Journal: Oncogene
Title: Enhancement of leptin receptor signaling by SOCS3 deficiency induces development of gastric tumors in mice.
Volume: 33
Issue: 1
Pages: 74-84
Publication
First Author: Cho DC
Year: 2017
Journal: Nat Commun
Title: Bone corticalization requires local SOCS3 activity and is promoted by androgen action via interleukin-6.
Volume: 8
Issue: 1
Pages: 806
Publication
First Author: Mori H
Year: 2004
Journal: Nat Med
Title: Socs3 deficiency in the brain elevates leptin sensitivity and confers resistance to diet-induced obesity.
Volume: 10
Issue: 7
Pages: 739-43
Publication
First Author: Hiwatashi K
Year: 2011
Journal: Cancer Lett
Title: Suppression of SOCS3 in macrophages prevents cancer metastasis by modifying macrophage phase and MCP2/CCL8 induction.
Volume: 308
Issue: 2
Pages: 172-80
Publication
First Author: Sun Y
Year: 2015
Journal: Sci Signal
Title: SOCS3 in retinal neurons and glial cells suppresses VEGF signaling to prevent pathological neovascular growth.
Volume: 8
Issue: 395
Pages: ra94
Publication  
First Author: Hackett AR
Year: 2016
Journal: Neurobiol Dis
Title: STAT3 and SOCS3 regulate NG2 cell proliferation and differentiation after contusive spinal cord injury.
Volume: 89
Pages: 10-22
Publication
First Author: Pedroso JA
Year: 2016
Journal: Endocrinology
Title: Changes in Leptin Signaling by SOCS3 Modulate Fasting-Induced Hyperphagia and Weight Regain in Mice.
Volume: 157
Issue: 10
Pages: 3901-3914
Publication
First Author: Zhang R
Year: 2008
Journal: Endocrinology
Title: Selective inactivation of Socs3 in SF1 neurons improves glucose homeostasis without affecting body weight.
Volume: 149
Issue: 11
Pages: 5654-61
Publication
First Author: Lu Y
Year: 2006
Journal: J Biol Chem
Title: Loss of SOCS3 gene expression converts STAT3 function from anti-apoptotic to pro-apoptotic.
Volume: 281
Issue: 48
Pages: 36683-90
Publication
First Author: Wang Z
Year: 2019
Journal: Am J Physiol Regul Integr Comp Physiol
Title: Role of SOCS3 in POMC neurons in metabolic and cardiovascular regulation.
Volume: 316
Issue: 4
Pages: R338-R351
Publication
First Author: Wang T
Year: 2024
Journal: Mol Ther
Title: SOCS3 regulates pathological retinal angiogenesis through modulating SPP1 expression in microglia and macrophages.
Volume: 32
Issue: 5
Pages: 1425-1444
Publication
First Author: Meguro K
Year: 2016
Journal: J Invest Dermatol
Title: SOCS3 Expressed in M2 Macrophages Attenuates Contact Hypersensitivity by Suppressing MMP-12 Production.
Volume: 136
Issue: 3
Pages: 649-57
Publication
First Author: Kimura A
Year: 2004
Journal: J Biol Chem
Title: SOCS3 is a physiological negative regulator for granulopoiesis and granulocyte colony-stimulating factor receptor signaling.
Volume: 279
Issue: 8
Pages: 6905-10
Publication
First Author: Matarazzo V
Year: 2012
Journal: J Neurosci
Title: Inactivation of Socs3 in the hypothalamus enhances the hindbrain response to endogenous satiety signals via oxytocin signaling.
Volume: 32
Issue: 48
Pages: 17097-107
Publication
First Author: Nagata T
Year: 2015
Journal: PLoS One
Title: Cardiac-Specific SOCS3 Deletion Prevents In Vivo Myocardial Ischemia Reperfusion Injury through Sustained Activation of Cardioprotective Signaling Molecules.
Volume: 10
Issue: 5
Pages: e0127942
Publication
First Author: Fischer P
Year: 2004
Journal: Biochem J
Title: The role of the inhibitors of interleukin-6 signal transduction SHP2 and SOCS3 for desensitization of interleukin-6 signalling.
Volume: 378
Issue: Pt 2
Pages: 449-60
Publication
First Author: Luckey MA
Year: 2020
Journal: Eur J Immunol
Title: SOCS3 is a suppressor of γc cytokine signaling and constrains generation of murine Foxp3+ regulatory T cells.
Volume: 50
Issue: 7
Pages: 986-999
Publication
First Author: Yan C
Year: 2013
Journal: FASEB J
Title: Myeloid depletion of SOCS3 enhances LPS-induced acute lung injury through CCAAT/enhancer binding protein δ pathway.
Volume: 27
Issue: 8
Pages: 2967-76
Publication
First Author: Du X
Year: 2021
Journal: Mol Neurodegener
Title: Deletion of Socs3 in LysM+ cells and Cx3cr1 resulted in age-dependent development of retinal microgliopathy.
Volume: 16
Issue: 1
Pages: 9
Publication
First Author: Pedroso JA
Year: 2014
Journal: Mol Metab
Title: Inactivation of SOCS3 in leptin receptor-expressing cells protects mice from diet-induced insulin resistance but does not prevent obesity.
Volume: 3
Issue: 6
Pages: 608-18
Publication
First Author: Taleb S
Year: 2009
Journal: J Exp Med
Title: Loss of SOCS3 expression in T cells reveals a regulatory role for interleukin-17 in atherosclerosis.
Volume: 206
Issue: 10
Pages: 2067-77
Publication
First Author: Wang M
Year: 2007
Journal: Am J Physiol Heart Circ Physiol
Title: Deficiency of TNFR1 protects myocardium through SOCS3 and IL-6 but not p38 MAPK or IL-1beta.
Volume: 292
Issue: 4
Pages: H1694-9
Publication
First Author: Yajima T
Year: 2011
Journal: Circulation
Title: Absence of SOCS3 in the cardiomyocyte increases mortality in a gp130-dependent manner accompanied by contractile dysfunction and ventricular arrhythmias.
Volume: 124
Issue: 24
Pages: 2690-701
Publication
First Author: Bucher F
Year: 2016
Journal: Invest Ophthalmol Vis Sci
Title: CNTF Attenuates Vasoproliferative Changes Through Upregulation of SOCS3 in a Mouse-Model of Oxygen-Induced Retinopathy.
Volume: 57
Issue: 10
Pages: 4017-26
Publication
First Author: Satoh T
Year: 2012
Journal: Eur J Immunol
Title: The development of IL-17/IFN-γ-double producing CTLs from Tc17 cells is driven by epigenetic suppression of Socs3 gene promoter.
Volume: 42
Issue: 9
Pages: 2329-42
Publication
First Author: Li Y
Year: 2016
Journal: Am J Physiol Heart Circ Physiol
Title: Context-dependent effects of SOCS3 in angiotensin II-induced vascular dysfunction and hypertension in mice: mechanisms and role of bone marrow-derived cells.
Volume: 311
Issue: 1
Pages: H146-56
Publication
First Author: Son HJ
Year: 2017
Journal: J Immunol
Title: Oncostatin M Suppresses Activation of IL-17/Th17 via SOCS3 Regulation in CD4+ T Cells.
Volume: 198
Issue: 4
Pages: 1484-1491