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Search results 1 to 96 out of 96 for Socs5

0.142s

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Hits by Pathway

Hits by Category

Hits by Strain

Type Details Score
Gene
9655 | SOCS5
Type: gene
Organism: human
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Gene
549598 | socs5
Type: gene
Organism: frog, western clawed
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Gene
500616 | Socs5
Type: gene
Organism: rat
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Gene
474581 | SOCS5
Type: gene
Organism: dog, domestic
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Gene
459209 | SOCS5
Type: gene
Organism: chimpanzee
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Gene
514773 | SOCS5
Type: gene
Organism: cattle
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Gene
428570 | SOCS5
Type: gene
Organism: chicken
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Gene
714998 | SOCS5
Type: gene
Organism: macaque, rhesus
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Protein Domain
IPR028420 | SOCS5
Type: Family
Description: Suppressor of cytokine signalling (SOCS) proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS5 inhibits the IL4 signaling pathway, which promotes the Th (helper T) 2 cell development []. SOCS5 and SOCS4 regulate epidermal growth factor receptor signaling [].
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Protein Coding Gene
MGI:2385459 | Socs5
Type: protein_coding_gene
Organism: mouse, laboratory
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Publication
12242343 | J:113957
First Author: Seki Y
Year: 2002
Journal: Proc Natl Acad Sci U S A
Title: Expression of the suppressor of cytokine signaling-5 (SOCS5) negatively regulates IL-4-dependent STAT6 activation and Th2 differentiation.
Volume: 99
Issue: 20
Pages: 13003-8
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Publication
15199163 | J:91591
First Author: Brender C
Year: 2004
Journal: Mol Cell Biol
Title: SOCS5 is expressed in primary B and T lymphoid cells but is dispensable for lymphocyte production and function.
Volume: 24
Issue: 13
Pages: 6094-103
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Protein
Q3UXZ1
Organism: Mus musculus/domesticus
Length: 203  
Fragment?: true
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Publication
15590694 | -
First Author: Kario E
Year: 2005
Journal: J Biol Chem
Title: Suppressors of cytokine signaling 4 and 5 regulate epidermal growth factor receptor signaling.
Volume: 280
Issue: 8
Pages: 7038-48
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Protein
O54928
Organism: Mus musculus/domesticus
Length: 536  
Fragment?: false
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Protein
Q6A021
Organism: Mus musculus/domesticus
Length: 198  
Fragment?: true
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Publication
17142765 | J:140666
First Author: Watanabe H
Year: 2006
Journal: J Immunol
Title: Overexpression of suppressor of cytokine signaling-5 in T cells augments innate immunity during septic peritonitis.
Volume: 177
Issue: 12
Pages: 8650-7
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Publication
28195529 | J:241209
   
First Author: Kedzierski L
Year: 2017
Journal: Elife
Title: Suppressor of cytokine signaling (SOCS)5 ameliorates influenza infection via inhibition of EGFR signaling.
Volume: 6
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Protein Coding Gene
MGP_CAROLIEiJ_G0021943 | -
Type: protein_coding_gene
Organism: Mus caroli
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Protein Coding Gene
MGP_129S1SvImJ_G0024099 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AJ_G0024058 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AKRJ_G0024027 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_BALBcJ_G0024059 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C3HHeJ_G0023824 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI_C57BL6J_2385459 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C57BL6NJ_G0024504 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CASTEiJ_G0023303 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CBAJ_G0023798 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_DBA2J_G0023926 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_FVBNJ_G0023892 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_LPJ_G0024010 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NODShiLtJ_G0023920 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NZOHlLtJ_G0024549 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PWKPhJ_G0023048 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_WSBEiJ_G0023369 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PahariEiJ_G0020933 | -
Type: protein_coding_gene
Organism: Mus pahari
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Protein Coding Gene
MGP_SPRETEiJ_G0022859 | -
Type: protein_coding_gene
Organism: Mus spretus
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Publication
12101419 | J:78100
First Author: Callus BA
Year: 2002
Journal: Oncogene
Title: SOCS36E, a novel Drosophila SOCS protein, suppresses JAK/STAT and EGF-R signalling in the imaginal wing disc.
Volume: 21
Issue: 31
Pages: 4812-21
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Publication
12593841 | J:82402
First Author: Boengler K
Year: 2003
Journal: Biochem Biophys Res Commun
Title: The ankyrin repeat containing SOCS box protein 5: a novel protein associated with arteriogenesis.
Volume: 302
Issue: 1
Pages: 17-22
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Publication
11837794 | J:146726
First Author: Cooney RN
Year: 2002
Journal: Shock
Title: Suppressors of cytokine signaling (SOCS): inhibitors of the JAK/STAT pathway.
Volume: 17
Issue: 2
Pages: 83-90
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GXD Expression
GXD Expression
   
Probe: MGI:6430234
Assay Type: RT-PCR
Annotation Date: 2020-05-28
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1716827
Stage: TS27
Assay Id: MGI:6430411
Age: postnatal day 0
Image: S1
Specimen Label: P0
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
   
Probe: MGI:6430234
Assay Type: RT-PCR
Annotation Date: 2020-05-28
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1716828
Stage: TS28
Assay Id: MGI:6430411
Age: postnatal day 7
Image: S1
Specimen Label: P7
Detected: true
Specimen Num: 4
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GXD Expression
GXD Expression
   
Probe: MGI:6430234
Assay Type: RT-PCR
Annotation Date: 2020-05-28
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1716821
Stage: TS21
Assay Id: MGI:6430411
Age: embryonic day 13.5
Image: S1
Specimen Label: E13
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
   
Probe: MGI:6430234
Assay Type: RT-PCR
Annotation Date: 2020-05-28
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1716824
Stage: TS24
Assay Id: MGI:6430411
Age: embryonic day 16.5
Image: S1
Specimen Label: E16
Detected: true
Specimen Num: 2
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Publication
28196914 | J:258541
First Author: Hazra B
Year: 2017
Journal: Sci Signal
Title: The host microRNA miR-301a blocks the IRF1-mediated neuronal innate immune response to Japanese encephalitis virus infection.
Volume: 10
Issue: 466
Pages: eaaf5185
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Publication
24255059 | J:223623
First Author: Loyer X
Year: 2014
Journal: Circ Res
Title: Inhibition of microRNA-92a prevents endothelial dysfunction and atherosclerosis in mice.
Volume: 114
Issue: 3
Pages: 434-43
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Publication
17611223 | J:124116
First Author: Khaled WT
Year: 2007
Journal: Development
Title: The IL-4/IL-13/Stat6 signalling pathway promotes luminal mammary epithelial cell development.
Volume: 134
Issue: 15
Pages: 2739-50
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Publication
15695332 | J:96642
First Author: Nicholson SE
Year: 2005
Journal: Proc Natl Acad Sci U S A
Title: Suppressor of cytokine signaling (SOCS)-5 is a potential negative regulator of epidermal growth factor signaling.
Volume: 102
Issue: 7
Pages: 2328-33
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Publication
9419338 | J:51029
First Author: Hilton DJ
Year: 1998
Journal: Proc Natl Acad Sci U S A
Title: Twenty proteins containing a C-terminal SOCS box form five structural classes.
Volume: 95
Issue: 1
Pages: 114-9
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Publication
29361558 | J:257927
 
First Author: Fairchild CL
Year: 2018
Journal: Development
Title: RBX2 maintains final retinal cell position in a DAB1-dependent and -independent fashion.
Volume: 145
Issue: 3
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Publication
24210661 | J:205551
First Author: Simó S
Year: 2013
Journal: Dev Cell
Title: Rbx2 regulates neuronal migration through different cullin 5-RING ligase adaptors.
Volume: 27
Issue: 4
Pages: 399-411
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Publication
- | J:342601
       
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniPathway vocabulary mapping
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Publication
- | J:157064
     
First Author: University of California, Davis
Year: 2010
Journal: MGI Direct Data Submission
Title: Alleles produced for the KOMP project by the University of California, Davis
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Publication
- | J:157065
     
First Author: Helmholtz Zentrum Muenchen GmbH
Year: 2010
Journal: MGI Direct Data Submission
Title: Alleles produced for the EUCOMM and EUCOMMTools projects by the Helmholtz Zentrum Muenchen GmbH (Hmgu)
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Publication
- | J:72247
       
First Author: DDB, FB, MGI, GOA, ZFIN curators
Year: 2001
Title: Gene Ontology annotation through association of InterPro records with GO terms
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Publication
- | J:85000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Title: MGI Sequence Curation Reference
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Publication
- | J:78475
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Chromosome assignment of mouse genes using the Mouse Genome Sequencing Consortium (MGSC) assembly and the ENSEMBL Database
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Publication
16141072 | J:99680
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
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Publication
11217851 | J:65060
First Author: Kawai J
Year: 2001
Journal: Nature
Title: Functional annotation of a full-length mouse cDNA collection.
Volume: 409
Issue: 6821
Pages: 685-90
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Publication
- | J:23000
       
First Author: MGD Nomenclature Committee
Year: 1995
Title: Nomenclature Committee Use
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Publication
- | J:342587
       
First Author: AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators
Year: 2011
Title: Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
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Publication
- | J:342605
       
First Author: GOA curators
Year: 2016
Title: Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
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Publication
- | J:68900
     
First Author: The Jackson Laboratory Mouse Radiation Hybrid Database
Year: 2004
Journal: Database Release
Title: Mouse T31 Radiation Hybrid Data Load
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Publication
12466851 | J:80000
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
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Publication
- | J:164563
       
First Author: The Gene Ontology Consortium
Year: 2010
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs
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Publication
- | J:75000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
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Publication
- | J:157972
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
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Publication
- | J:57747
     
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
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Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
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Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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Publication
16210657 | J:119104
First Author: Ozaki A
Year: 2005
Journal: J Immunol
Title: The control of allergic conjunctivitis by suppressor of cytokine signaling (SOCS)3 and SOCS5 in a murine model.
Volume: 175
Issue: 8
Pages: 5489-97
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Protein Domain
IPR037343 | SOCS5_SOCS
Type: Domain
Description: This entry represents the SOCS box domain of SOCS5.Suppressor of cytokine signalling (SOCS) proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS5 inhibits the IL4 signaling pathway, which promotes the Th (helper T) 2 cell development []. SOCS5 and SOCS4 regulate epidermal growth factor receptor signaling [].The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions [, ].
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Protein Domain
IPR028416 | SOCS4
Type: Family
Description: SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS4 (Suppressor of cytokine signalling 4) is the substrate-recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins []. SOCS4 and SOCS5 regulate epidermal growth factor receptor signaling [].
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Protein Domain
IPR035864 | SOCS4_SH2
Type: Domain
Description: SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS4 (Suppressor of cytokine signalling 4) is the substrate-recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins []. SOCS4 and SOCS5 regulate epidermal growth factor receptor signaling [].This entry represents the SH3 domain of SOCS4.
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Publication
17997974 | -
First Author: Bullock AN
Year: 2007
Journal: Structure
Title: Structure of the SOCS4-ElonginB/C complex reveals a distinct SOCS box interface and the molecular basis for SOCS-dependent EGFR degradation.
Volume: 15
Issue: 11
Pages: 1493-504
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Protein
Q8C1K3
Organism: Mus musculus/domesticus
Length: 377  
Fragment?: false
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Protein
A0A2I3BQ19
Organism: Mus musculus/domesticus
Length: 129  
Fragment?: true
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Protein
Q6PG92
Organism: Mus musculus/domesticus
Length: 243  
Fragment?: true
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Protein Domain
IPR037342 | SOCS4_SOCS
Type: Domain
Description: This entry represents the SOCS box domain of SOCS4.SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS4 (Suppressor of cytokine signalling 4) is the substrate-recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins []. SOCS4 and SOCS5 regulate epidermal growth factor receptor signaling [].The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions [, ].
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Publication
15661890 | J:96417
First Author: Huang Z
Year: 2005
Journal: J Immunol
Title: IFN-gamma suppresses STAT6 phosphorylation by inhibiting its recruitment to the IL-4 receptor.
Volume: 174
Issue: 3
Pages: 1332-7
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Publication
24619648 | J:259192
First Author: Jiang S
Year: 2014
Journal: Sci Signal
Title: MeCP2 reinforces STAT3 signaling and the generation of effector CD4+ T cells by promoting miR-124-mediated suppression of SOCS5.
Volume: 7
Issue: 316
Pages: ra25
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Publication
31751468 | J:286650
First Author: Cao Y
Year: 2020
Journal: Hum Mol Genet
Title: Dynamic effects of Fto in regulating the proliferation and differentiation of adult neural stem cells of mice.
Volume: 29
Issue: 5
Pages: 727-735
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Publication
28182772 | J:246665
First Author: Alston CI
Year: 2017
Journal: PLoS One
Title: Murine cytomegalovirus infection of mouse macrophages stimulates early expression of suppressor of cytokine signaling (SOCS)1 and SOCS3.
Volume: 12
Issue: 2
Pages: e0171812
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Publication
9869640 | -
First Author: Kamura T
Year: 1998
Journal: Genes Dev
Title: The Elongin BC complex interacts with the conserved SOCS-box motif present in members of the SOCS, ras, WD-40 repeat, and ankyrin repeat families.
Volume: 12
Issue: 24
Pages: 3872-81
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Protein
Q91ZA6
Organism: Mus musculus/domesticus
Length: 436  
Fragment?: false
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Publication
16675548 | -
First Author: Bullock AN
Year: 2006
Journal: Proc Natl Acad Sci U S A
Title: Crystal structure of the SOCS2-elongin C-elongin B complex defines a prototypical SOCS box ubiquitin ligase.
Volume: 103
Issue: 20
Pages: 7637-42
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Protein
Q8C1J7
Organism: Mus musculus/domesticus
Length: 104  
Fragment?: true
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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