Type |
Details |
Score |
Gene |
Type: |
gene |
Organism: |
human |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
cattle |
|
•
•
•
•
•
|
Gene |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
chimpanzee |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
dog, domestic |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
chicken |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
zebrafish |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
macaque, rhesus |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Family |
Description: |
Sclerostin (SOST) is a negative regulator of bone growth that acts through inhibition of Wnt signalling and bone formation []. Mutations in the SOST gene have been linked to several bone diseases, such as sclerosteosis 1 (SOST1)3 [], van Buchem disease (VBCH) []and craniodiaphyseal dysplasia autosomal dominant (CDD) []. |
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•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:7530032 |
Assay Type: |
RNA in situ |
Annotation Date: |
2023-09-25 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1736422 |
Pattern: |
Not Specified |
Stage: |
TS22 |
Assay Id: |
MGI:7530042 |
Age: |
embryonic day 14.5 |
Image: |
4a Sost E14.5 |
|
Specimen Label: |
4a Sost E14.5 |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:7530032 |
Assay Type: |
RNA in situ |
Annotation Date: |
2023-09-25 |
Strength: |
Strong |
Sex: |
Not Specified |
Emaps: |
EMAPS:1736423 |
Pattern: |
Regionally restricted |
Stage: |
TS23 |
Assay Id: |
MGI:7530042 |
Age: |
embryonic day 15.5 |
Image: |
4a Sost E15.5 |
Note: |
Notable increased in expression by E15.5 following palatal fusion. |
Specimen Label: |
4a Sost E15.5 |
Detected: |
true |
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:7530032 |
Assay Type: |
RNA in situ |
Annotation Date: |
2023-09-25 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1736423 |
Pattern: |
Regionally restricted |
Stage: |
TS23 |
Assay Id: |
MGI:7530042 |
Age: |
embryonic day 15.5 |
Image: |
4b Sost E15.5 |
|
Specimen Label: |
4b Sost E15.5 |
Detected: |
true |
Specimen Num: |
3 |
|
•
•
•
•
•
|
Publication |
First Author: |
Semënov M |
Year: |
2005 |
Journal: |
J Biol Chem |
Title: |
SOST is a ligand for LRP5/LRP6 and a Wnt signaling inhibitor. |
Volume: |
280 |
Issue: |
29 |
Pages: |
26770-5 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kim SJ |
Year: |
2011 |
Journal: |
Hum Genet |
Title: |
Identification of signal peptide domain SOST mutations in autosomal dominant craniodiaphyseal dysplasia. |
Volume: |
129 |
Issue: |
5 |
Pages: |
497-502 |
|
•
•
•
•
•
|
Publication |
First Author: |
Balemans W |
Year: |
2002 |
Journal: |
J Med Genet |
Title: |
Identification of a 52 kb deletion downstream of the SOST gene in patients with van Buchem disease. |
Volume: |
39 |
Issue: |
2 |
Pages: |
91-7 |
|
•
•
•
•
•
|
Publication |
First Author: |
Collette NM |
Year: |
2012 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Targeted deletion of Sost distal enhancer increases bone formation and bone mass. |
Volume: |
109 |
Issue: |
35 |
Pages: |
14092-7 |
|
•
•
•
•
•
|
Publication |
First Author: |
Tu X |
Year: |
2012 |
Journal: |
Bone |
Title: |
Sost downregulation and local Wnt signaling are required for the osteogenic response to mechanical loading. |
Volume: |
50 |
Issue: |
1 |
Pages: |
209-17 |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
211
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Publication |
First Author: |
Balemans W |
Year: |
2001 |
Journal: |
Hum Mol Genet |
Title: |
Increased bone density in sclerosteosis is due to the deficiency of a novel secreted protein (SOST). |
Volume: |
10 |
Issue: |
5 |
Pages: |
537-43 |
|
•
•
•
•
•
|
Publication |
First Author: |
Collette NM |
Year: |
2010 |
Journal: |
Dev Biol |
Title: |
Genetic evidence that SOST inhibits WNT signaling in the limb. |
Volume: |
342 |
Issue: |
2 |
Pages: |
169-79 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kramer I |
Year: |
2010 |
Journal: |
J Bone Miner Res |
Title: |
Parathyroid hormone (PTH)-induced bone gain is blunted in SOST overexpressing and deficient mice. |
Volume: |
25 |
Issue: |
2 |
Pages: |
178-89 |
|
•
•
•
•
•
|
Publication |
First Author: |
van Bezooijen RL |
Year: |
2007 |
Journal: |
Dev Dyn |
Title: |
SOST expression is restricted to the great arteries during embryonic and neonatal cardiovascular development. |
Volume: |
236 |
Issue: |
2 |
Pages: |
606-12 |
|
•
•
•
•
•
|
Publication |
First Author: |
Brunkow ME |
Year: |
2001 |
Journal: |
Am J Hum Genet |
Title: |
Bone dysplasia sclerosteosis results from loss of the SOST gene product, a novel cystine knot-containing protein. |
Volume: |
68 |
Issue: |
3 |
Pages: |
577-89 |
|
•
•
•
•
•
|
Publication |
First Author: |
Li J |
Year: |
2019 |
Journal: |
Biomed Res Int |
Title: |
SOST Deficiency Aggravates Osteoarthritis in Mice by Promoting Sclerosis of Subchondral Bone. |
Volume: |
2019 |
|
Pages: |
7623562 |
|
•
•
•
•
•
|
Publication |
First Author: |
Collette NM |
Year: |
2013 |
Journal: |
Dev Biol |
Title: |
Sost and its paralog Sostdc1 coordinate digit number in a Gli3-dependent manner. |
Volume: |
383 |
Issue: |
1 |
Pages: |
90-105 |
|
•
•
•
•
•
|
Publication |
First Author: |
Ren Y |
Year: |
2015 |
Journal: |
FASEB J |
Title: |
Removal of SOST or blocking its product sclerostin rescues defects in the periodontitis mouse model. |
Volume: |
29 |
Issue: |
7 |
Pages: |
2702-11 |
|
•
•
•
•
•
|
Publication |
First Author: |
Yang H |
Year: |
2020 |
Journal: |
Sci Rep |
Title: |
Cortical bone adaptation to a moderate level of mechanical loading in male Sost deficient mice. |
Volume: |
10 |
Issue: |
1 |
Pages: |
22299 |
|
•
•
•
•
•
|
Publication |
First Author: |
Chang MK |
Year: |
2014 |
Journal: |
J Bone Miner Res |
Title: |
Reversing LRP5-dependent osteoporosis and SOST deficiency-induced sclerosing bone disorders by altering WNT signaling activity. |
Volume: |
29 |
Issue: |
1 |
Pages: |
29-42 |
|
•
•
•
•
•
|
Publication |
First Author: |
Pflanz D |
Year: |
2017 |
Journal: |
Sci Rep |
Title: |
Sost deficiency led to a greater cortical bone formation response to mechanical loading and altered gene expression. |
Volume: |
7 |
Issue: |
1 |
Pages: |
9435 |
|
•
•
•
•
•
|
Publication |
First Author: |
Yee CS |
Year: |
2018 |
Journal: |
J Bone Miner Res |
Title: |
Conditional Deletion of Sost in MSC-Derived Lineages Identifies Specific Cell-Type Contributions to Bone Mass and B-Cell Development. |
Volume: |
33 |
Issue: |
10 |
Pages: |
1748-1759 |
|
•
•
•
•
•
|
Publication |
First Author: |
Bonnet N |
Year: |
2009 |
Journal: |
J Biol Chem |
Title: |
The matricellular protein periostin is required for sost inhibition and the anabolic response to mechanical loading and physical activity. |
Volume: |
284 |
Issue: |
51 |
Pages: |
35939-50 |
|
•
•
•
•
•
|
Publication |
First Author: |
Cohen-Kfir E |
Year: |
2011 |
Journal: |
Endocrinology |
Title: |
Sirt1 is a regulator of bone mass and a repressor of Sost encoding for sclerostin, a bone formation inhibitor. |
Volume: |
152 |
Issue: |
12 |
Pages: |
4514-24 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kamiya N |
Year: |
2010 |
Journal: |
J Bone Miner Res |
Title: |
Wnt inhibitors Dkk1 and Sost are downstream targets of BMP signaling through the type IA receptor (BMPRIA) in osteoblasts. |
Volume: |
25 |
Issue: |
2 |
Pages: |
200-10 |
|
•
•
•
•
•
|
Publication |
First Author: |
Delgado-Calle J |
Year: |
2017 |
Journal: |
Leukemia |
Title: |
Genetic deletion of Sost or pharmacological inhibition of sclerostin prevent multiple myeloma-induced bone disease without affecting tumor growth. |
Volume: |
31 |
Issue: |
12 |
Pages: |
2686-2694 |
|
•
•
•
•
•
|
Publication |
First Author: |
Moriishi T |
Year: |
2012 |
Journal: |
PLoS One |
Title: |
Osteocyte network; a negative regulatory system for bone mass augmented by the induction of Rankl in osteoblasts and Sost in osteocytes at unloading. |
Volume: |
7 |
Issue: |
6 |
Pages: |
e40143 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kamiya N |
Year: |
2011 |
Journal: |
Biochem Biophys Res Commun |
Title: |
Loss-of-function of ACVR1 in osteoblasts increases bone mass and activates canonical Wnt signaling through suppression of Wnt inhibitors SOST and DKK1. |
Volume: |
414 |
Issue: |
2 |
Pages: |
326-30 |
|
•
•
•
•
•
|
Publication |
First Author: |
Morse A |
Year: |
2015 |
Journal: |
Bone |
Title: |
Endochondral fracture healing with external fixation in the Sost knockout mouse results in earlier fibrocartilage callus removal and increased bone volume fraction and strength. |
Volume: |
71 |
|
Pages: |
155-63 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kamiya N |
Year: |
2016 |
Journal: |
Bone |
Title: |
Targeted disruption of BMP signaling through type IA receptor (BMPR1A) in osteocyte suppresses SOST and RANKL, leading to dramatic increase in bone mass, bone mineral density and mechanical strength. |
Volume: |
91 |
|
Pages: |
53-63 |
|
•
•
•
•
•
|
Publication |
First Author: |
Robling AG |
Year: |
2016 |
Journal: |
Bone |
Title: |
Sost, independent of the non-coding enhancer ECR5, is required for bone mechanoadaptation. |
Volume: |
92 |
|
Pages: |
180-188 |
|
•
•
•
•
•
|
Publication |
First Author: |
Mosey H |
Year: |
2017 |
Journal: |
Front Mater |
Title: |
Sost Deficiency does not Alter Bone's Lacunar or Vascular Porosity in Mice. |
Volume: |
4 |
|
Pages: |
27 |
|
•
•
•
•
•
|
Publication |
First Author: |
Koide M |
Year: |
2022 |
Journal: |
Bone |
Title: |
Evidence for the major contribution of remodeling-based bone formation in sclerostin-deficient mice. |
Volume: |
160 |
|
Pages: |
116401 |
|
•
•
•
•
•
|
Allele |
Name: |
transgene insertion A, Gabriela G Loots |
Allele Type: |
Transgenic |
Attribute String: |
Humanized sequence, Inserted expressed sequence |
|
•
•
•
•
•
|
Publication |
First Author: |
Koide M |
Year: |
2020 |
Journal: |
Sci Rep |
Title: |
Sclerostin expression in trabecular bone is downregulated by osteoclasts. |
Volume: |
10 |
Issue: |
1 |
Pages: |
13751 |
|
•
•
•
•
•
|
Publication |
First Author: |
O'Donohue AK |
Year: |
2023 |
Journal: |
Bone |
Title: |
Targeted postnatal knockout of Sclerostin using a bone-targeted adeno-associated viral vector increases bone anabolism and decreases canalicular density. |
Volume: |
167 |
|
Pages: |
116636 |
|
•
•
•
•
•
|
Publication |
First Author: |
Krishna SM |
Year: |
2017 |
Journal: |
Arterioscler Thromb Vasc Biol |
Title: |
Wnt Signaling Pathway Inhibitor Sclerostin Inhibits Angiotensin II-Induced Aortic Aneurysm and Atherosclerosis. |
Volume: |
37 |
Issue: |
3 |
Pages: |
553-566 |
|
•
•
•
•
•
|
Publication |
First Author: |
Chang JC |
Year: |
2018 |
Journal: |
J Bone Miner Res |
Title: |
SOST/Sclerostin Improves Posttraumatic Osteoarthritis and Inhibits MMP2/3 Expression After Injury. |
Volume: |
33 |
Issue: |
6 |
Pages: |
1105-1113 |
|
•
•
•
•
•
|
Publication |
First Author: |
Loots GG |
Year: |
2005 |
Journal: |
Genome Res |
Title: |
Genomic deletion of a long-range bone enhancer misregulates sclerostin in Van Buchem disease. |
Volume: |
15 |
Issue: |
7 |
Pages: |
928-35 |
|
•
•
•
•
•
|
Publication |
First Author: |
Niziolek PJ |
Year: |
2015 |
Journal: |
J Bone Miner Res |
Title: |
High Bone Mass-Causing Mutant LRP5 Receptors Are Resistant to Endogenous Inhibitors In Vivo. |
Volume: |
30 |
Issue: |
10 |
Pages: |
1822-30 |
|
•
•
•
•
•
|
Publication |
First Author: |
Naka T |
Year: |
2011 |
Journal: |
J Endod |
Title: |
Spatiotemporal expression of sclerostin in odontoblasts during embryonic mouse tooth morphogenesis. |
Volume: |
37 |
Issue: |
3 |
Pages: |
340-5 |
|
•
•
•
•
•
|
Publication |
First Author: |
Shu R |
Year: |
2017 |
Journal: |
PLoS One |
Title: |
Sclerostin Promotes Bone Remodeling in the Process of Tooth Movement. |
Volume: |
12 |
Issue: |
1 |
Pages: |
e0167312 |
|
•
•
•
•
•
|
Publication |
First Author: |
Ryan ZC |
Year: |
2013 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Sclerostin alters serum vitamin D metabolite and fibroblast growth factor 23 concentrations and the urinary excretion of calcium. |
Volume: |
110 |
Issue: |
15 |
Pages: |
6199-204 |
|
•
•
•
•
•
|
Publication |
First Author: |
Cain CJ |
Year: |
2012 |
Journal: |
J Bone Miner Res |
Title: |
Absence of sclerostin adversely affects B-cell survival. |
Volume: |
27 |
Issue: |
7 |
Pages: |
1451-61 |
|
•
•
•
•
•
|
Publication |
First Author: |
Sato AY |
Year: |
2016 |
Journal: |
J Bone Miner Res |
Title: |
Protection From Glucocorticoid-Induced Osteoporosis by Anti-Catabolic Signaling in the Absence of Sost/Sclerostin. |
Volume: |
31 |
Issue: |
10 |
Pages: |
1791-1802 |
|
•
•
•
•
•
|
Publication |
First Author: |
Zhang D |
Year: |
2016 |
Journal: |
Biochem Biophys Res Commun |
Title: |
The systemic effects of sclerostin overexpression using ΦC31 integrase in mice. |
Volume: |
472 |
Issue: |
3 |
Pages: |
471-6 |
|
•
•
•
•
•
|
Publication |
First Author: |
Stegen S |
Year: |
2018 |
Journal: |
Nat Commun |
Title: |
Osteocytic oxygen sensing controls bone mass through epigenetic regulation of sclerostin. |
Volume: |
9 |
Issue: |
1 |
Pages: |
2557 |
|
•
•
•
•
•
|
Publication |
First Author: |
Li X |
Year: |
2008 |
Journal: |
J Bone Miner Res |
Title: |
Targeted deletion of the sclerostin gene in mice results in increased bone formation and bone strength. |
Volume: |
23 |
Issue: |
6 |
Pages: |
860-9 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kim SP |
Year: |
2021 |
Journal: |
FASEB J |
Title: |
Bone-derived sclerostin and Wnt/β-catenin signaling regulate PDGFRα+ adipoprogenitor cell differentiation. |
Volume: |
35 |
Issue: |
11 |
Pages: |
e21957 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kim SP |
Year: |
2023 |
Journal: |
iScience |
Title: |
Peroxisome proliferator activated receptor-γ in osteoblasts controls bone formation and fat mass by regulating sclerostin expression. |
Volume: |
26 |
Issue: |
7 |
Pages: |
106999 |
|
•
•
•
•
•
|
Publication |
First Author: |
Atkins GJ |
Year: |
2011 |
Journal: |
J Bone Miner Res |
Title: |
Sclerostin is a locally acting regulator of late-osteoblast/preosteocyte differentiation and regulates mineralization through a MEPE-ASARM-dependent mechanism. |
Volume: |
26 |
Issue: |
7 |
Pages: |
1425-36 |
|
•
•
•
•
•
|
Publication |
First Author: |
Joll JE 2nd |
Year: |
2022 |
Journal: |
Am J Physiol Heart Circ Physiol |
Title: |
Sclerostin ablation prevents aortic valve stenosis in mice. |
Volume: |
323 |
Issue: |
5 |
Pages: |
H1037-H1047 |
|
•
•
•
•
•
|
Publication |
First Author: |
Wein MN |
Year: |
2016 |
Journal: |
Nat Commun |
Title: |
SIKs control osteocyte responses to parathyroid hormone. |
Volume: |
7 |
|
Pages: |
13176 |
|
•
•
•
•
•
|
Publication |
First Author: |
McGee-Lawrence ME |
Year: |
2013 |
Journal: |
Biochem Biophys Res Commun |
Title: |
Sclerostin deficient mice rapidly heal bone defects by activating β-catenin and increasing intramembranous ossification. |
Volume: |
441 |
Issue: |
4 |
Pages: |
886-90 |
|
•
•
•
•
•
|
Publication |
First Author: |
Amri N |
Year: |
2016 |
Journal: |
Am J Pathol |
Title: |
Distorted Patterns of Dentinogenesis and Eruption in Msx2 Null Mutants: Involvement of Sost/Sclerostin. |
Volume: |
186 |
Issue: |
10 |
Pages: |
2577-87 |
|
•
•
•
•
•
|
Publication |
First Author: |
Marulanda J |
Year: |
2023 |
Journal: |
Sci Rep |
Title: |
Effect of sclerostin inactivation in a mouse model of severe dominant osteogenesis imperfecta. |
Volume: |
13 |
Issue: |
1 |
Pages: |
5010 |
|
•
•
•
•
•
|
Publication |
First Author: |
Grimston SK |
Year: |
2017 |
Journal: |
PLoS One |
Title: |
Heterozygous deletion of both sclerostin (Sost) and connexin43 (Gja1) genes in mice is not sufficient to impair cortical bone modeling. |
Volume: |
12 |
Issue: |
11 |
Pages: |
e0187980 |
|
•
•
•
•
•
|
Publication |
First Author: |
Chen J |
Year: |
2014 |
Journal: |
Osteoarthritis Cartilage |
Title: |
Estrogen via estrogen receptor beta partially inhibits mandibular condylar cartilage growth. |
Volume: |
22 |
Issue: |
11 |
Pages: |
1861-8 |
|
•
•
•
•
•
|
Publication |
First Author: |
Chang MK |
Year: |
2014 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Disruption of Lrp4 function by genetic deletion or pharmacological blockade increases bone mass and serum sclerostin levels. |
Volume: |
111 |
Issue: |
48 |
Pages: |
E5187-95 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kedlaya R |
Year: |
2013 |
Journal: |
Sci Transl Med |
Title: |
Sclerostin inhibition reverses skeletal fragility in an Lrp5-deficient mouse model of OPPG syndrome. |
Volume: |
5 |
Issue: |
211 |
Pages: |
211ra158 |
|
•
•
•
•
•
|
Publication |
First Author: |
Winkler DG |
Year: |
2003 |
Journal: |
EMBO J |
Title: |
Osteocyte control of bone formation via sclerostin, a novel BMP antagonist. |
Volume: |
22 |
Issue: |
23 |
Pages: |
6267-76 |
|
•
•
•
•
•
|
Publication |
First Author: |
Lin C |
Year: |
2009 |
Journal: |
J Bone Miner Res |
Title: |
Sclerostin mediates bone response to mechanical unloading through antagonizing Wnt/beta-catenin signaling. |
Volume: |
24 |
Issue: |
10 |
Pages: |
1651-61 |
|
•
•
•
•
•
|
Publication |
First Author: |
Ellies DL |
Year: |
2014 |
Journal: |
PLoS One |
Title: |
Wise regulates bone deposition through genetic interactions with Lrp5. |
Volume: |
9 |
Issue: |
5 |
Pages: |
e96257 |
|
•
•
•
•
•
|
Publication |
First Author: |
Bonnet N |
Year: |
2012 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Regulation of beta catenin signaling and parathyroid hormone anabolic effects in bone by the matricellular protein periostin. |
Volume: |
109 |
Issue: |
37 |
Pages: |
15048-53 |
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Publication |
First Author: |
Brommage R |
Year: |
2021 |
Journal: |
Bone |
Title: |
MicroCT analyses of mouse femoral neck architecture. |
Volume: |
145 |
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Pages: |
115040 |
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Publication |
First Author: |
Wein MN |
Year: |
2015 |
Journal: |
J Bone Miner Res |
Title: |
HDAC5 controls MEF2C-driven sclerostin expression in osteocytes. |
Volume: |
30 |
Issue: |
3 |
Pages: |
400-11 |
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Publication |
First Author: |
Zhao G |
Year: |
2018 |
Journal: |
J Bone Miner Res |
Title: |
CYR61/CCN1 Regulates Sclerostin Levels and Bone Maintenance. |
Volume: |
33 |
Issue: |
6 |
Pages: |
1076-1089 |
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Publication |
First Author: |
Morfin C |
Year: |
2024 |
Journal: |
Bone |
Title: |
Mef2c regulates bone mass through Sost-dependent and -independent mechanisms. |
Volume: |
179 |
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Pages: |
116976 |
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Publication |
First Author: |
Witcher PC |
Year: |
2018 |
Journal: |
JCI Insight |
Title: |
Sclerostin neutralization unleashes the osteoanabolic effects of Dkk1 inhibition. |
Volume: |
3 |
Issue: |
11 |
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Publication |
First Author: |
Niziolek PJ |
Year: |
2011 |
Journal: |
Bone |
Title: |
High-bone-mass-producing mutations in the Wnt signaling pathway result in distinct skeletal phenotypes. |
Volume: |
49 |
Issue: |
5 |
Pages: |
1010-9 |
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Publication |
First Author: |
Gao X |
Year: |
2019 |
Journal: |
Hum Mol Genet |
Title: |
Systemic investigation of bone and muscle abnormalities in dystrophin/utrophin double knockout mice during postnatal development and the mechanisms. |
Volume: |
28 |
Issue: |
10 |
Pages: |
1738-1751 |
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Publication |
First Author: |
Ohyama Y |
Year: |
2004 |
Journal: |
Endocrinology |
Title: |
Spaciotemporal association and bone morphogenetic protein regulation of sclerostin and osterix expression during embryonic osteogenesis. |
Volume: |
145 |
Issue: |
10 |
Pages: |
4685-92 |
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Publication |
First Author: |
Choi HY |
Year: |
2009 |
Journal: |
PLoS One |
Title: |
Lrp4, a novel receptor for Dickkopf 1 and sclerostin, is expressed by osteoblasts and regulates bone growth and turnover in vivo. |
Volume: |
4 |
Issue: |
11 |
Pages: |
e7930 |
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Publication |
First Author: |
Raju R |
Year: |
2023 |
Journal: |
Front Physiol |
Title: |
Profiles of Wnt pathway gene expression during tooth morphogenesis. |
Volume: |
14 |
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Pages: |
1316635 |
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Publication |
First Author: |
Yang F |
Year: |
2010 |
Journal: |
Biochem Biophys Res Commun |
Title: |
Sclerostin is a direct target of osteoblast-specific transcription factor osterix. |
Volume: |
400 |
Issue: |
4 |
Pages: |
684-8 |
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Publication |
First Author: |
Jadhav G |
Year: |
2016 |
Journal: |
Sci Rep |
Title: |
Morc3 mutant mice exhibit reduced cortical area and thickness, accompanied by altered haematopoietic stem cells niche and bone cell differentiation. |
Volume: |
6 |
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Pages: |
25964 |
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Publication |
First Author: |
Vesela B |
Year: |
2019 |
Journal: |
Organogenesis |
Title: |
Specification of Sprouty2 functions in osteogenesis in in vivo context. |
Volume: |
15 |
Issue: |
4 |
Pages: |
111-119 |
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Publication |
First Author: |
Ellies DL |
Year: |
2006 |
Journal: |
J Bone Miner Res |
Title: |
Bone density ligand, Sclerostin, directly interacts with LRP5 but not LRP5G171V to modulate Wnt activity. |
Volume: |
21 |
Issue: |
11 |
Pages: |
1738-49 |
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Publication |
First Author: |
Kamiya N |
Year: |
2008 |
Journal: |
Development |
Title: |
BMP signaling negatively regulates bone mass through sclerostin by inhibiting the canonical Wnt pathway. |
Volume: |
135 |
Issue: |
22 |
Pages: |
3801-11 |
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Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
Mus caroli |
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Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
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Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
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•
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Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
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•
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Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
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•
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Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
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•
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Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
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•
•
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Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
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•
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•
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Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
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•
•
•
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Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
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•
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Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
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•
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•
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Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
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