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Search results 1 to 100 out of 486 for Sost

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Type Details Score
Gene
50964 | SOST
Type: gene
Organism: human
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Gene
740261 | SOST
Type: gene
Organism: chimpanzee
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Gene
490948 | SOST
Type: gene
Organism: dog, domestic
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Gene
429784 | SOST
Type: gene
Organism: chicken
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Gene
100000500 | sost
Type: gene
Organism: zebrafish
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Gene
713617 | SOST
Type: gene
Organism: macaque, rhesus
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Gene
282880 | SOST
Type: gene
Organism: cattle
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Gene
80722 | Sost
Type: gene
Organism: rat
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Protein Coding Gene
MGI:1921749 | Sost
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Domain
IPR015665 | SOST
Type: Family
Description: Sclerostin (SOST) is a negative regulator of bone growth that acts through inhibition of Wnt signalling and bone formation []. Mutations in the SOST gene have been linked to several bone diseases, such as sclerosteosis 1 (SOST1)3 [], van Buchem disease (VBCH) []and craniodiaphyseal dysplasia autosomal dominant (CDD) [].
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GXD Expression
GXD Expression
Probe: MGI:7530032
Assay Type: RNA in situ
Annotation Date: 2023-09-25
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1736423
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:7530042
Age: embryonic day 15.5
Image: 4a Sost E15.5
Note: Notable increased in expression by E15.5 following palatal fusion.
Specimen Label: 4a Sost E15.5
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
 
Probe: MGI:7530032
Assay Type: RNA in situ
Annotation Date: 2023-09-25
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1736422
Pattern: Not Specified
Stage: TS22
Assay Id: MGI:7530042
Age: embryonic day 14.5
Image: 4a Sost E14.5
Specimen Label: 4a Sost E14.5
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
 
Probe: MGI:7530032
Assay Type: RNA in situ
Annotation Date: 2023-09-25
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1736423
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:7530042
Age: embryonic day 15.5
Image: 4b Sost E15.5
Specimen Label: 4b Sost E15.5
Detected: true
Specimen Num: 3
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Publication
15908424 | J:164786
First Author: Semënov M
Year: 2005
Journal: J Biol Chem
Title: SOST is a ligand for LRP5/LRP6 and a Wnt signaling inhibitor.
Volume: 280
Issue: 29
Pages: 26770-5
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Publication
21221996 | -
First Author: Kim SJ
Year: 2011
Journal: Hum Genet
Title: Identification of signal peptide domain SOST mutations in autosomal dominant craniodiaphyseal dysplasia.
Volume: 129
Issue: 5
Pages: 497-502
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Publication
11836356 | -
First Author: Balemans W
Year: 2002
Journal: J Med Genet
Title: Identification of a 52 kb deletion downstream of the SOST gene in patients with van Buchem disease.
Volume: 39
Issue: 2
Pages: 91-7
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Publication
22886088 | J:188586
First Author: Collette NM
Year: 2012
Journal: Proc Natl Acad Sci U S A
Title: Targeted deletion of Sost distal enhancer increases bone formation and bone mass.
Volume: 109
Issue: 35
Pages: 14092-7
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Publication
22075208 | J:180217
First Author: Tu X
Year: 2012
Journal: Bone
Title: Sost downregulation and local Wnt signaling are required for the osteogenic response to mechanical loading.
Volume: 50
Issue: 1
Pages: 209-17
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Publication
20359476 | J:161416
First Author: Collette NM
Year: 2010
Journal: Dev Biol
Title: Genetic evidence that SOST inhibits WNT signaling in the limb.
Volume: 342
Issue: 2
Pages: 169-79
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Protein
Q99P68
Organism: Mus musculus/domesticus
Length: 211  
Fragment?: false
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Publication
11181578 | -
First Author: Balemans W
Year: 2001
Journal: Hum Mol Genet
Title: Increased bone density in sclerosteosis is due to the deficiency of a novel secreted protein (SOST).
Volume: 10
Issue: 5
Pages: 537-43
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Publication
19594304 | J:179873
First Author: Kramer I
Year: 2010
Journal: J Bone Miner Res
Title: Parathyroid hormone (PTH)-induced bone gain is blunted in SOST overexpressing and deficient mice.
Volume: 25
Issue: 2
Pages: 178-89
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Publication
17195180 | J:117264
First Author: van Bezooijen RL
Year: 2007
Journal: Dev Dyn
Title: SOST expression is restricted to the great arteries during embryonic and neonatal cardiovascular development.
Volume: 236
Issue: 2
Pages: 606-12
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Publication
11179006 | J:67858
First Author: Brunkow ME
Year: 2001
Journal: Am J Hum Genet
Title: Bone dysplasia sclerosteosis results from loss of the SOST gene product, a novel cystine knot-containing protein.
Volume: 68
Issue: 3
Pages: 577-89
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Publication
31828128 | J:291639
 
First Author: Li J
Year: 2019
Journal: Biomed Res Int
Title: SOST Deficiency Aggravates Osteoarthritis in Mice by Promoting Sclerosis of Subchondral Bone.
Volume: 2019
Pages: 7623562
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Publication
23994639 | J:203431
First Author: Collette NM
Year: 2013
Journal: Dev Biol
Title: Sost and its paralog Sostdc1 coordinate digit number in a Gli3-dependent manner.
Volume: 383
Issue: 1
Pages: 90-105
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Publication
25757567 | J:225475
First Author: Ren Y
Year: 2015
Journal: FASEB J
Title: Removal of SOST or blocking its product sclerostin rescues defects in the periodontitis mouse model.
Volume: 29
Issue: 7
Pages: 2702-11
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Publication
33339872 | J:304419
First Author: Yang H
Year: 2020
Journal: Sci Rep
Title: Cortical bone adaptation to a moderate level of mechanical loading in male Sost deficient mice.
Volume: 10
Issue: 1
Pages: 22299
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Publication
23901037 | J:233245
First Author: Chang MK
Year: 2014
Journal: J Bone Miner Res
Title: Reversing LRP5-dependent osteoporosis and SOST deficiency-induced sclerosing bone disorders by altering WNT signaling activity.
Volume: 29
Issue: 1
Pages: 29-42
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Publication
28842678 | J:255362
First Author: Pflanz D
Year: 2017
Journal: Sci Rep
Title: Sost deficiency led to a greater cortical bone formation response to mechanical loading and altered gene expression.
Volume: 7
Issue: 1
Pages: 9435
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Publication
29750826 | J:303064
First Author: Yee CS
Year: 2018
Journal: J Bone Miner Res
Title: Conditional Deletion of Sost in MSC-Derived Lineages Identifies Specific Cell-Type Contributions to Bone Mass and B-Cell Development.
Volume: 33
Issue: 10
Pages: 1748-1759
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Publication
19837663 | J:158206
First Author: Bonnet N
Year: 2009
Journal: J Biol Chem
Title: The matricellular protein periostin is required for sost inhibition and the anabolic response to mechanical loading and physical activity.
Volume: 284
Issue: 51
Pages: 35939-50
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Publication
21952235 | J:179103
First Author: Cohen-Kfir E
Year: 2011
Journal: Endocrinology
Title: Sirt1 is a regulator of bone mass and a repressor of Sost encoding for sclerostin, a bone formation inhibitor.
Volume: 152
Issue: 12
Pages: 4514-24
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Publication
19874086 | J:179863
First Author: Kamiya N
Year: 2010
Journal: J Bone Miner Res
Title: Wnt inhibitors Dkk1 and Sost are downstream targets of BMP signaling through the type IA receptor (BMPRIA) in osteoblasts.
Volume: 25
Issue: 2
Pages: 200-10
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Publication
28529307 | J:252430
First Author: Delgado-Calle J
Year: 2017
Journal: Leukemia
Title: Genetic deletion of Sost or pharmacological inhibition of sclerostin prevent multiple myeloma-induced bone disease without affecting tumor growth.
Volume: 31
Issue: 12
Pages: 2686-2694
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Publication
22768243 | J:274059
First Author: Moriishi T
Year: 2012
Journal: PLoS One
Title: Osteocyte network; a negative regulatory system for bone mass augmented by the induction of Rankl in osteoblasts and Sost in osteocytes at unloading.
Volume: 7
Issue: 6
Pages: e40143
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Publication
21945937 | J:178480
First Author: Kamiya N
Year: 2011
Journal: Biochem Biophys Res Commun
Title: Loss-of-function of ACVR1 in osteoblasts increases bone mass and activates canonical Wnt signaling through suppression of Wnt inhibitors SOST and DKK1.
Volume: 414
Issue: 2
Pages: 326-30
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Publication
25445453 | J:218597
 
First Author: Morse A
Year: 2015
Journal: Bone
Title: Endochondral fracture healing with external fixation in the Sost knockout mouse results in earlier fibrocartilage callus removal and increased bone volume fraction and strength.
Volume: 71
Pages: 155-63
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Publication
27402532 | J:235500
 
First Author: Kamiya N
Year: 2016
Journal: Bone
Title: Targeted disruption of BMP signaling through type IA receptor (BMPR1A) in osteocyte suppresses SOST and RANKL, leading to dramatic increase in bone mass, bone mineral density and mechanical strength.
Volume: 91
Pages: 53-63
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Publication
27601226 | J:255350
 
First Author: Robling AG
Year: 2016
Journal: Bone
Title: Sost, independent of the non-coding enhancer ECR5, is required for bone mechanoadaptation.
Volume: 92
Pages: 180-188
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Publication
29349060 | J:256700
 
First Author: Mosey H
Year: 2017
Journal: Front Mater
Title: Sost Deficiency does not Alter Bone's Lacunar or Vascular Porosity in Mice.
Volume: 4
Pages: 27
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Publication
35381389 | J:323403
 
First Author: Koide M
Year: 2022
Journal: Bone
Title: Evidence for the major contribution of remodeling-based bone formation in sclerostin-deficient mice.
Volume: 160
Pages: 116401
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Publication
32792620 | J:294900
First Author: Koide M
Year: 2020
Journal: Sci Rep
Title: Sclerostin expression in trabecular bone is downregulated by osteoclasts.
Volume: 10
Issue: 1
Pages: 13751
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Allele
Tg(RP11-209M4)AGglo | MGI:5304449
Name: transgene insertion A, Gabriela G Loots
Allele Type: Transgenic
Attribute String: Humanized sequence, Inserted expressed sequence
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Publication
36462771 | J:332799
 
First Author: O'Donohue AK
Year: 2023
Journal: Bone
Title: Targeted postnatal knockout of Sclerostin using a bone-targeted adeno-associated viral vector increases bone anabolism and decreases canalicular density.
Volume: 167
Pages: 116636
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Publication
28062506 | J:301931
First Author: Krishna SM
Year: 2017
Journal: Arterioscler Thromb Vasc Biol
Title: Wnt Signaling Pathway Inhibitor Sclerostin Inhibits Angiotensin II-Induced Aortic Aneurysm and Atherosclerosis.
Volume: 37
Issue: 3
Pages: 553-566
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Publication
29377313 | J:267286
First Author: Chang JC
Year: 2018
Journal: J Bone Miner Res
Title: SOST/Sclerostin Improves Posttraumatic Osteoarthritis and Inhibits MMP2/3 Expression After Injury.
Volume: 33
Issue: 6
Pages: 1105-1113
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Publication
15965026 | J:99965
First Author: Loots GG
Year: 2005
Journal: Genome Res
Title: Genomic deletion of a long-range bone enhancer misregulates sclerostin in Van Buchem disease.
Volume: 15
Issue: 7
Pages: 928-35
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Publication
25808845 | J:278576
First Author: Niziolek PJ
Year: 2015
Journal: J Bone Miner Res
Title: High Bone Mass-Causing Mutant LRP5 Receptors Are Resistant to Endogenous Inhibitors In Vivo.
Volume: 30
Issue: 10
Pages: 1822-30
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Publication
21329818 | J:170473
First Author: Naka T
Year: 2011
Journal: J Endod
Title: Spatiotemporal expression of sclerostin in odontoblasts during embryonic mouse tooth morphogenesis.
Volume: 37
Issue: 3
Pages: 340-5
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Publication
27163932 | J:334021
First Author: Sato AY
Year: 2016
Journal: J Bone Miner Res
Title: Protection From Glucocorticoid-Induced Osteoporosis by Anti-Catabolic Signaling in the Absence of Sost/Sclerostin.
Volume: 31
Issue: 10
Pages: 1791-1802
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Publication
23530237 | J:196184
First Author: Ryan ZC
Year: 2013
Journal: Proc Natl Acad Sci U S A
Title: Sclerostin alters serum vitamin D metabolite and fibroblast growth factor 23 concentrations and the urinary excretion of calcium.
Volume: 110
Issue: 15
Pages: 6199-204
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Publication
22434688 | J:232017
First Author: Cain CJ
Year: 2012
Journal: J Bone Miner Res
Title: Absence of sclerostin adversely affects B-cell survival.
Volume: 27
Issue: 7
Pages: 1451-61
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Publication
28081119 | J:246838
First Author: Shu R
Year: 2017
Journal: PLoS One
Title: Sclerostin Promotes Bone Remodeling in the Process of Tooth Movement.
Volume: 12
Issue: 1
Pages: e0167312
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Publication
26845353 | J:234028
First Author: Zhang D
Year: 2016
Journal: Biochem Biophys Res Commun
Title: The systemic effects of sclerostin overexpression using ΦC31 integrase in mice.
Volume: 472
Issue: 3
Pages: 471-6
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Publication
29967369 | J:266095
First Author: Stegen S
Year: 2018
Journal: Nat Commun
Title: Osteocytic oxygen sensing controls bone mass through epigenetic regulation of sclerostin.
Volume: 9
Issue: 1
Pages: 2557
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Publication
18269310 | J:150166
First Author: Li X
Year: 2008
Journal: J Bone Miner Res
Title: Targeted deletion of the sclerostin gene in mice results in increased bone formation and bone strength.
Volume: 23
Issue: 6
Pages: 860-9
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Publication
34606641 | J:317715
First Author: Kim SP
Year: 2021
Journal: FASEB J
Title: Bone-derived sclerostin and Wnt/β-catenin signaling regulate PDGFRα+ adipoprogenitor cell differentiation.
Volume: 35
Issue: 11
Pages: e21957
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Publication
21312267 | J:233115
First Author: Atkins GJ
Year: 2011
Journal: J Bone Miner Res
Title: Sclerostin is a locally acting regulator of late-osteoblast/preosteocyte differentiation and regulates mineralization through a MEPE-ASARM-dependent mechanism.
Volume: 26
Issue: 7
Pages: 1425-36
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Publication
36240434 | J:334618
First Author: Joll JE 2nd
Year: 2022
Journal: Am J Physiol Heart Circ Physiol
Title: Sclerostin ablation prevents aortic valve stenosis in mice.
Volume: 323
Issue: 5
Pages: H1037-H1047
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Publication
24211207 | J:211503
First Author: McGee-Lawrence ME
Year: 2013
Journal: Biochem Biophys Res Commun
Title: Sclerostin deficient mice rapidly heal bone defects by activating β-catenin and increasing intramembranous ossification.
Volume: 441
Issue: 4
Pages: 886-90
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Publication
27759007 | J:240495
 
First Author: Wein MN
Year: 2016
Journal: Nat Commun
Title: SIKs control osteocyte responses to parathyroid hormone.
Volume: 7
Pages: 13176
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Publication
24225945 | J:213541
First Author: Kedlaya R
Year: 2013
Journal: Sci Transl Med
Title: Sclerostin inhibition reverses skeletal fragility in an Lrp5-deficient mouse model of OPPG syndrome.
Volume: 5
Issue: 211
Pages: 211ra158
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Publication
29149200 | J:251980
First Author: Grimston SK
Year: 2017
Journal: PLoS One
Title: Heterozygous deletion of both sclerostin (Sost) and connexin43 (Gja1) genes in mice is not sufficient to impair cortical bone modeling.
Volume: 12
Issue: 11
Pages: e0187980
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Publication
36973504 | J:334824
First Author: Marulanda J
Year: 2023
Journal: Sci Rep
Title: Effect of sclerostin inactivation in a mouse model of severe dominant osteogenesis imperfecta.
Volume: 13
Issue: 1
Pages: 5010
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Publication
25404300 | J:216649
First Author: Chang MK
Year: 2014
Journal: Proc Natl Acad Sci U S A
Title: Disruption of Lrp4 function by genetic deletion or pharmacological blockade increases bone mass and serum sclerostin levels.
Volume: 111
Issue: 48
Pages: E5187-95
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Publication
25046534 | J:315997
First Author: Chen J
Year: 2014
Journal: Osteoarthritis Cartilage
Title: Estrogen via estrogen receptor beta partially inhibits mandibular condylar cartilage growth.
Volume: 22
Issue: 11
Pages: 1861-8
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Publication
27524798 | J:235599
First Author: Amri N
Year: 2016
Journal: Am J Pathol
Title: Distorted Patterns of Dentinogenesis and Eruption in Msx2 Null Mutants: Involvement of Sost/Sclerostin.
Volume: 186
Issue: 10
Pages: 2577-87
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Publication
14633986 | J:86838
First Author: Winkler DG
Year: 2003
Journal: EMBO J
Title: Osteocyte control of bone formation via sclerostin, a novel BMP antagonist.
Volume: 22
Issue: 23
Pages: 6267-76
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Publication
19419300 | J:168665
First Author: Lin C
Year: 2009
Journal: J Bone Miner Res
Title: Sclerostin mediates bone response to mechanical unloading through antagonizing Wnt/beta-catenin signaling.
Volume: 24
Issue: 10
Pages: 1651-61
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Publication
31437568 | J:305177
 
First Author: Brommage R
Year: 2021
Journal: Bone
Title: MicroCT analyses of mouse femoral neck architecture.
Volume: 145
Pages: 115040
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Publication
22927401 | J:190032
First Author: Bonnet N
Year: 2012
Journal: Proc Natl Acad Sci U S A
Title: Regulation of beta catenin signaling and parathyroid hormone anabolic effects in bone by the matricellular protein periostin.
Volume: 109
Issue: 37
Pages: 15048-53
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Publication
24789067 | J:216098
First Author: Ellies DL
Year: 2014
Journal: PLoS One
Title: Wise regulates bone deposition through genetic interactions with Lrp5.
Volume: 9
Issue: 5
Pages: e96257
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Publication
25271055 | J:315347
First Author: Wein MN
Year: 2015
Journal: J Bone Miner Res
Title: HDAC5 controls MEF2C-driven sclerostin expression in osteocytes.
Volume: 30
Issue: 3
Pages: 400-11
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Publication
21855668 | J:178741
First Author: Niziolek PJ
Year: 2011
Journal: Bone
Title: High-bone-mass-producing mutations in the Wnt signaling pathway result in distinct skeletal phenotypes.
Volume: 49
Issue: 5
Pages: 1010-9
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Publication
29351359 | J:280194
First Author: Zhao G
Year: 2018
Journal: J Bone Miner Res
Title: CYR61/CCN1 Regulates Sclerostin Levels and Bone Maintenance.
Volume: 33
Issue: 6
Pages: 1076-1089
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Publication
29875318 | J:291000
 
First Author: Witcher PC
Year: 2018
Journal: JCI Insight
Title: Sclerostin neutralization unleashes the osteoanabolic effects of Dkk1 inhibition.
Volume: 3
Issue: 11
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Publication
30689868 | J:293767
First Author: Gao X
Year: 2019
Journal: Hum Mol Genet
Title: Systemic investigation of bone and muscle abnormalities in dystrophin/utrophin double knockout mice during postnatal development and the mechanisms.
Volume: 28
Issue: 10
Pages: 1738-1751
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Publication
15217980 | J:92630
First Author: Ohyama Y
Year: 2004
Journal: Endocrinology
Title: Spaciotemporal association and bone morphogenetic protein regulation of sclerostin and osterix expression during embryonic osteogenesis.
Volume: 145
Issue: 10
Pages: 4685-92
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Publication
19936252 | J:155399
First Author: Choi HY
Year: 2009
Journal: PLoS One
Title: Lrp4, a novel receptor for Dickkopf 1 and sclerostin, is expressed by osteoblasts and regulates bone growth and turnover in vivo.
Volume: 4
Issue: 11
Pages: e7930
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Publication
20816666 | J:165583
First Author: Yang F
Year: 2010
Journal: Biochem Biophys Res Commun
Title: Sclerostin is a direct target of osteoblast-specific transcription factor osterix.
Volume: 400
Issue: 4
Pages: 684-8
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Publication
27188231 | J:240210
 
First Author: Jadhav G
Year: 2016
Journal: Sci Rep
Title: Morc3 mutant mice exhibit reduced cortical area and thickness, accompanied by altered haematopoietic stem cells niche and bone cell differentiation.
Volume: 6
Pages: 25964
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Publication
31480885 | J:320741
First Author: Vesela B
Year: 2019
Journal: Organogenesis
Title: Specification of Sprouty2 functions in osteogenesis in in vivo context.
Volume: 15
Issue: 4
Pages: 111-119
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Publication
17002572 | J:128100
First Author: Ellies DL
Year: 2006
Journal: J Bone Miner Res
Title: Bone density ligand, Sclerostin, directly interacts with LRP5 but not LRP5G171V to modulate Wnt activity.
Volume: 21
Issue: 11
Pages: 1738-49
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Publication
18927151 | J:143588
First Author: Kamiya N
Year: 2008
Journal: Development
Title: BMP signaling negatively regulates bone mass through sclerostin by inhibiting the canonical Wnt pathway.
Volume: 135
Issue: 22
Pages: 3801-11
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Protein Coding Gene
MGP_CAROLIEiJ_G0017231 | -
Type: protein_coding_gene
Organism: Mus caroli
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Protein Coding Gene
MGP_129S1SvImJ_G0019214 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AJ_G0019182 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AKRJ_G0019151 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_BALBcJ_G0019156 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C3HHeJ_G0018965 | -
Type: protein_coding_gene
Organism: mouse, laboratory
•
•
•
•
•
Protein Coding Gene
MGI_C57BL6J_1921749 | -
Type: protein_coding_gene
Organism: mouse, laboratory
•
•
•
•
•
Protein Coding Gene
MGP_C57BL6NJ_G0019605 | -
Type: protein_coding_gene
Organism: mouse, laboratory
•
•
•
•
•
Protein Coding Gene
MGP_CASTEiJ_G0018519 | -
Type: protein_coding_gene
Organism: mouse, laboratory
•
•
•
•
•
Protein Coding Gene
MGP_CBAJ_G0018934 | -
Type: protein_coding_gene
Organism: mouse, laboratory
•
•
•
•
•
Protein Coding Gene
MGP_DBA2J_G0019046 | -
Type: protein_coding_gene
Organism: mouse, laboratory
•
•
•
•
•
Protein Coding Gene
MGP_FVBNJ_G0019036 | -
Type: protein_coding_gene
Organism: mouse, laboratory
•
•
•
•
•
Protein Coding Gene
MGP_LPJ_G0019115 | -
Type: protein_coding_gene
Organism: mouse, laboratory
•
•
•
•
•
Protein Coding Gene
MGP_NODShiLtJ_G0019067 | -
Type: protein_coding_gene
Organism: mouse, laboratory
•
•
•
•
•
Protein Coding Gene
MGP_NZOHlLtJ_G0019643 | -
Type: protein_coding_gene
Organism: mouse, laboratory
•
•
•
•
•




MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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