|  Help  |  About  |  Contact Us

Search our database by keyword

Examples

  • Search this entire website. Enter identifiers, names or keywords for genes, diseases, strains, ontology terms, etc. (e.g. Pax6, Parkinson, ataxia)
  • Use OR to search for either of two terms (e.g. OR mus) or quotation marks to search for phrases (e.g. "dna binding").
  • Boolean search syntax is supported: e.g. Balb* for partial matches or mus AND NOT embryo to exclude a term

Search results 1 to 100 out of 286 for Sp3

<< First    < Previous  |  Next >    Last >>
0.039s
Type Details Score
Gene
Type: gene
Organism: human
Gene
Type: gene
Organism: cattle
Gene
Type: gene
Organism: macaque, rhesus
Gene
Type: gene
Organism: chicken
Gene
Type: gene
Organism: frog, western clawed
Protein
Organism: Mus musculus/domesticus
Length: 688  
Fragment?: true
Gene
Type: gene
Organism: rat
Gene
Type: gene
Organism: dog, domestic
Gene
Type: gene
Organism: chimpanzee
Protein Domain
Type: Family
Description: Sp3 (specificity protein 3) belongs to the Sp family of transcription that control expression of a large number of genes implicated in different processes, including cell-cycle-regulated, hormone-induced and housekeeping genes. The functional complexity of Sp3 may be increased by the presence of at least two shorter Sp3 isoforms inaddition to the full-length protein []. Sp3 has the ability to both activate and repress transcription; this dual nature of Sp3 is regulated by SUMOylation []. Sp3 can interact with and recruit a large number of proteins including the transcription initiation complex, histone modifying enzymes and chromatin remodeling complexes, which suggests it is an important transcription factor in chromatin remodeling and the regulation of gene expression [].
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Publication
First Author: Kennett SB
Year: 1997
Journal: Nucleic Acids Res
Title: Sp3 encodes multiple proteins that differ in their capacity to stimulate or repress transcription.
Volume: 25
Issue: 15
Pages: 3110-7
Publication
First Author: Li L
Year: 2010
Journal: Ann Anat
Title: The role of Sp1 and Sp3 in normal and cancer cell biology.
Volume: 192
Issue: 5
Pages: 275-83
Protein
Organism: Mus musculus/domesticus
Length: 783  
Fragment?: false
Publication
First Author: Hagen G
Year: 1995
Journal: J Biol Chem
Title: Functional analyses of the transcription factor Sp4 reveal properties distinct from Sp1 and Sp3.
Volume: 270
Issue: 42
Pages: 24989-94
Gene
Type: gene
Organism: human
GXD Expression      
Probe: MGI:2662368
Assay Type: Western blot
Annotation Date: 2003-06-10
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:2662385
Age: postnatal adult
Specimen Label: lane 5, Sp3 -/-
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:2662368
Assay Type: Western blot
Annotation Date: 2003-06-10
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:2662385
Age: postnatal adult
Specimen Label: land 6, Sp3 +/-
Detected: true
Specimen Num: 2
Publication
First Author: Li M
Year: 2003
Journal: Biol Reprod
Title: Sp1 and Sp3 Are important regulators of AP-2gamma gene transcription.
Volume: 69
Issue: 4
Pages: 1220-30
Publication
First Author: van Loo PF
Year: 2007
Journal: Mol Cell Biol
Title: Transcription factor Sp3 knockout mice display serious cardiac malformations.
Volume: 27
Issue: 24
Pages: 8571-82
Publication
First Author: Bouwman P
Year: 2000
Journal: EMBO J
Title: Transcription factor Sp3 is essential for post-natal survival and late tooth development.
Volume: 19
Issue: 4
Pages: 655-61
Publication
First Author: Yamakawa H
Year: 2017
Journal: Cell Rep
Title: The Transcription Factor Sp3 Cooperates with HDAC2 to Regulate Synaptic Function and Plasticity in Neurons.
Volume: 20
Issue: 6
Pages: 1319-1334
Publication
First Author: Zelko IN
Year: 2004
Journal: Free Radic Biol Med
Title: Sp1 and Sp3 transcription factors mediate trichostatin A-induced and basal expression of extracellular superoxide dismutase.
Volume: 37
Issue: 8
Pages: 1256-71
Publication
First Author: Peñuelas-Urquides K
Year: 2016
Journal: Biochem J
Title: Transcription factors YY1, Sp1 and Sp3 modulate dystrophin Dp71 gene expression in hepatic cells.
Volume: 473
Issue: 13
Pages: 1967-76
Publication
First Author: Carver BJ
Year: 2013
Journal: J Biol Chem
Title: Interactions between NF-κB and SP3 connect inflammatory signaling with reduced FGF-10 expression.
Volume: 288
Issue: 21
Pages: 15318-25
Publication  
First Author: McCoy AM
Year: 2023
Journal: Development
Title: Sp3 is essential for normal lung morphogenesis and cell cycle progression during mouse embryonic development.
Volume: 150
Issue: 5
Publication
First Author: Li H
Year: 2004
Journal: Biochim Biophys Acta
Title: Murine glypican-4 gene structure and expression; Sp1 and Sp3 play a major role in glypican-4 expression in 3T3-F442A cells.
Volume: 1679
Issue: 2
Pages: 141-55
GXD Expression    
Probe: MGI:6184061
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689421
Pattern: Not Specified
Stage: TS21
Assay Id: MGI:6191374
Age: embryonic day 13.5
Specimen Label: Table S2 - E13.5 - Sp3
Detected: true
Specimen Num: 2
GXD Expression    
Probe: MGI:6184061
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689424
Pattern: Not Specified
Stage: TS24
Assay Id: MGI:6191374
Age: embryonic day 15.5
Specimen Label: Table S2 - E15.5 - Sp3
Detected: true
Specimen Num: 3
GXD Expression    
Probe: MGI:6184061
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6191374
Age: postnatal day 4
Specimen Label: Table S2 - P4 - Sp3
Detected: true
Specimen Num: 5
GXD Expression    
Probe: MGI:6184061
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6191374
Age: postnatal day 14
Specimen Label: Table S2 - P14 - Sp3
Detected: true
Specimen Num: 6
GXD Expression    
Probe: MGI:6184061
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689419
Pattern: Not Specified
Stage: TS19
Assay Id: MGI:6191374
Age: embryonic day 11.5
Specimen Label: Table S2 - E11.5 - Sp3
Detected: true
Specimen Num: 1
GXD Expression    
Probe: MGI:6184061
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689426
Pattern: Not Specified
Stage: TS26
Assay Id: MGI:6191374
Age: embryonic day 18.5
Specimen Label: Table S2 - E18.5 - Sp3
Detected: true
Specimen Num: 4
GXD Expression    
Probe: MGI:6184061
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6191374
Age: postnatal day 28
Specimen Label: Table S2 - P28 - Sp3
Detected: true
Specimen Num: 7
Publication
First Author: Ma W
Year: 2008
Journal: Biol Reprod
Title: Expression patterns of SP1 and SP3 during mouse spermatogenesis: SP1 down-regulation correlates with two successive promoter changes and translationally compromised transcripts.
Volume: 79
Issue: 2
Pages: 289-300
Publication
First Author: Thakur BK
Year: 2016
Journal: Nucleic Acids Res
Title: Physiological TLR5 expression in the intestine is regulated by differential DNA binding of Sp1/Sp3 through simultaneous Sp1 dephosphorylation and Sp3 phosphorylation by two different PKC isoforms.
Volume: 44
Issue: 12
Pages: 5658-72
Publication
First Author: Kim CS
Year: 2006
Journal: Nucleic Acids Res
Title: Evidence of the neuron-restrictive silencer factor (NRSF) interaction with Sp3 and its synergic repression to the mu opioid receptor (MOR) gene.
Volume: 34
Issue: 22
Pages: 6392-403
Publication
First Author: Pichel JG
Year: 2003
Journal: Mech Dev
Title: Developmental cooperation of leukemia inhibitory factor and insulin-like growth factor I in mice is tissue-specific and essential for lung maturation involving the transcription factors Sp3 and TTF-1.
Volume: 120
Issue: 3
Pages: 349-61
Publication
First Author: Wang G
Year: 2003
Journal: J Biol Chem
Title: Transcriptional regulation of mouse delta-opioid receptor gene by CpG methylation: involvement of Sp3 and a methyl-CpG-binding protein, MBD2, in transcriptional repression of mouse delta-opioid receptor gene in Neuro2A cells.
Volume: 278
Issue: 42
Pages: 40550-6
Publication
First Author: Giatzakis C
Year: 2004
Journal: Endocrinology
Title: Differential utilization of the promoter of peripheral-type benzodiazepine receptor by steroidogenic versus nonsteroidogenic cell lines and the role of Sp1 and Sp3 in the regulation of basal activity.
Volume: 145
Issue: 3
Pages: 1113-23
Publication
First Author: Yajima S
Year: 1998
Journal: DNA Cell Biol
Title: Sp family transcription factors regulate expression of rat D2 dopamine receptor gene.
Volume: 17
Issue: 5
Pages: 471-9
Publication
First Author: Van Loo PF
Year: 2003
Journal: Blood
Title: Impaired hematopoiesis in mice lacking the transcription factor Sp3.
Volume: 102
Issue: 3
Pages: 858-66
Publication
First Author: Lu H
Year: 2023
Journal: Nat Commun
Title: Endothelial Sp1/Sp3 are essential to the effect of captopril on blood pressure in male mice.
Volume: 14
Issue: 1
Pages: 5891
Publication
First Author: Ma L
Year: 2004
Journal: J Biol Chem
Title: Transcriptional regulation of the mouse gene encoding the alpha-4 subunit of the GABAA receptor.
Volume: 279
Issue: 39
Pages: 40451-61
Publication
First Author: Stielow B
Year: 2010
Journal: PLoS Genet
Title: Epigenetic silencing of spermatocyte-specific and neuronal genes by SUMO modification of the transcription factor Sp3.
Volume: 6
Issue: 11
Pages: e1001203
Publication
First Author: Meinders M
Year: 2015
Journal: Blood
Title: Sp1/Sp3 transcription factors regulate hallmarks of megakaryocyte maturation and platelet formation and function.
Volume: 125
Issue: 12
Pages: 1957-67
Publication
First Author: Krüger I
Year: 2007
Journal: Dev Dyn
Title: Sp1/Sp3 compound heterozygous mice are not viable: impaired erythropoiesis and severe placental defects.
Volume: 236
Issue: 8
Pages: 2235-44
Publication
First Author: Ferguson M
Year: 2003
Journal: Nucleic Acids Res
Title: Histone deacetylase inhibition is associated with transcriptional repression of the Hmga2 gene.
Volume: 31
Issue: 12
Pages: 3123-33
Publication
First Author: Rojvirat P
Year: 2011
Journal: Biochim Biophys Acta
Title: Functional characterization of the proximal promoter of the murine pyruvate carboxylase gene in hepatocytes: role of multiple gc boxes.
Volume: 1809
Issue: 10
Pages: 541-8
Publication
First Author: Göllner H
Year: 2001
Journal: Mech Dev
Title: Impaired ossification in mice lacking the transcription factor Sp3.
Volume: 106
Issue: 1-2
Pages: 77-83
Gene
Type: gene
Organism: macaque, rhesus
Publication
First Author: Yao D
Year: 2007
Journal: J Biol Chem
Title: High glucose increases angiopoietin-2 transcription in microvascular endothelial cells through methylglyoxal modification of mSin3A.
Volume: 282
Issue: 42
Pages: 31038-45
Publication
First Author: Armstrong L
Year: 2004
Journal: Mech Dev
Title: A role for nucleoprotein Zap3 in the reduction of telomerase activity during embryonic stem cell differentiation.
Volume: 121
Issue: 12
Pages: 1509-22
Publication
First Author: Ingram RM
Year: 2011
Journal: Exp Hematol
Title: Differential regulation of sense and antisense promoter activity at the Csf1R locus in B cells by the transcription factor PAX5.
Volume: 39
Issue: 7
Pages: 730-40.e1-2
Publication
First Author: Wegener A
Year: 2017
Journal: J Neurochem
Title: Sp2 is the only glutamine-rich specificity protein with minor impact on development and differentiation in myelinating glia.
Volume: 140
Issue: 2
Pages: 245-256
Publication
First Author: Hwang CK
Year: 2010
Journal: Mol Pharmacol
Title: Up-regulation of the mu-opioid receptor gene is mediated through chromatin remodeling and transcriptional factors in differentiated neuronal cells.
Volume: 78
Issue: 1
Pages: 58-68
Publication
First Author: Okumura K
Year: 2004
Journal: Biochem Biophys Res Commun
Title: c-Jun and Sp1 family are critical for retinoic acid induction of the lamin A/C retinoic acid-responsive element.
Volume: 320
Issue: 2
Pages: 487-92
Publication
First Author: Clem BF
Year: 2006
Journal: Mol Endocrinol
Title: Association of the mSin3A-histone deacetylase 1/2 corepressor complex with the mouse steroidogenic acute regulatory protein gene.
Volume: 20
Issue: 1
Pages: 100-13
Publication
First Author: Zhu L
Year: 2009
Journal: Gene
Title: Regulation of the mouse CTP: phosphoethanolamine cytidylyltransferase gene Pcyt2 during myogenesis.
Volume: 447
Issue: 1
Pages: 51-9
Publication
First Author: Gao P
Year: 2020
Journal: Genes Dev
Title: Transcriptional regulatory network controlling the ontogeny of hematopoietic stem cells.
Volume: 34
Issue: 13-14
Pages: 950-964
Publication
First Author: Bu Y
Year: 2007
Journal: J Biol Chem
Title: v-Src-mediated down-regulation of SSeCKS metastasis suppressor gene promoter by the recruitment of HDAC1 into a USF1-Sp1-Sp3 complex.
Volume: 282
Issue: 37
Pages: 26725-39
Publication
First Author: Perera EM
Year: 2010
Journal: Gene
Title: Structural and functional characterization of the mouse tescalcin promoter.
Volume: 464
Issue: 1-2
Pages: 50-62
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus caroli
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus pahari
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus spretus
GXD Expression      
Probe: MGI:2662368
Assay Type: Western blot
Annotation Date: 2003-06-10
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:2662385
Age: postnatal adult
Specimen Label: lane 7, +/+
Detected: true
Specimen Num: 3
GXD Expression    
Probe: MGI:2675589
Assay Type: Western blot
Annotation Date: 2003-10-03
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1610524
Stage: TS24
Assay Id: MGI:2675609
Age: embryonic day 16.5
Image: 5
Specimen Label: F
Detected: true
Specimen Num: 5
GXD Expression      
Probe: MGI:3816113
Assay Type: RT-PCR
Annotation Date: 2008-11-20
Strength: Present
Sex: Female
Emaps: EMAPS:3102528
Stage: TS28
Assay Id: MGI:3816917
Age: postnatal
Specimen Label: Metaphase II
Detected: true
Specimen Num: 1
GXD Expression      
Probe: MGI:3816113
Assay Type: RT-PCR
Annotation Date: 2008-11-20
Strength: Present
Sex: Not Specified
Emaps: EMAPS:360422
Stage: TS02
Assay Id: MGI:3816917
Age: embryonic day 1.5
Specimen Label: 2-cell embryo
Detected: true
Specimen Num: 2
GXD Expression      
Probe: MGI:3816113
Assay Type: RT-PCR
Annotation Date: 2008-11-20
Strength: Present
Sex: Not Specified
Emaps: EMAPS:360433
Stage: TS03
Assay Id: MGI:3816917
Age: embryonic day 2.0
Specimen Label: 4-cell embryo
Detected: true
Specimen Num: 3
GXD Expression      
Probe: MGI:3816113
Assay Type: RT-PCR
Annotation Date: 2008-11-20
Strength: Present
Sex: Not Specified
Emaps: EMAPS:360443
Stage: TS03
Assay Id: MGI:3816917
Age: embryonic day 2.5
Specimen Label: 8-cell embryo
Detected: true
Specimen Num: 4
GXD Expression      
Probe: MGI:3816113
Assay Type: RT-PCR
Annotation Date: 2008-11-20
Strength: Present
Sex: Not Specified
Emaps: EMAPS:360453
Stage: TS03
Assay Id: MGI:3816917
Age: embryonic day 3.0
Specimen Label: Morula
Detected: true
Specimen Num: 5
GXD Expression      
Probe: MGI:3816113
Assay Type: RT-PCR
Annotation Date: 2008-11-20
Strength: Present
Sex: Not Specified
Emaps: EMAPS:360464
Stage: TS04
Assay Id: MGI:3816917
Age: embryonic day 3.5
Specimen Label: E3.5 blastocyst
Detected: true
Specimen Num: 6
GXD Expression      
Probe: MGI:3816113
Assay Type: RT-PCR
Annotation Date: 2008-11-20
Strength: Present
Sex: Not Specified
Emaps: EMAPS:360465
Stage: TS05
Assay Id: MGI:3816917
Age: embryonic day 4.5
Specimen Label: E4.5 blastocyst
Detected: true
Specimen Num: 7
GXD Expression      
Probe: MGI:3816113
Assay Type: RT-PCR
Annotation Date: 2008-11-20
Strength: Present
Sex: Not Specified
Emaps: EMAPS:160415
Stage: TS05
Assay Id: MGI:3816917
Age: embryonic day 4.5
Specimen Label: E4.5 inner cell mass
Detected: true
Specimen Num: 8
GXD Expression      
Probe: MGI:6491302
Assay Type: Western blot
Annotation Date: 2021-01-13
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1610528
Stage: TS28
Assay Id: MGI:6491533
Age: postnatal adult
Specimen Label: WT
Detected: true
Specimen Num: 1
GXD Expression      
Probe: MGI:6491302
Assay Type: Western blot
Annotation Date: 2021-01-13
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1610528
Stage: TS28
Assay Id: MGI:6491533
Age: postnatal adult
Specimen Label: WT
Detected: true
Specimen Num: 2
GXD Expression      
Probe: MGI:6491302
Assay Type: Western blot
Annotation Date: 2021-01-13
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1610528
Stage: TS28
Assay Id: MGI:6491533
Age: postnatal adult
Specimen Label: KO
Detected: true
Specimen Num: 3
GXD Expression      
Probe: MGI:6491302
Assay Type: Western blot
Annotation Date: 2021-01-13
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1610528
Stage: TS28
Assay Id: MGI:6491533
Age: postnatal adult
Specimen Label: KO
Detected: true
Specimen Num: 4
GXD Expression    
Probe: MGI:7433200
Assay Type: RT-PCR
Annotation Date: 2023-02-13
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1790624
Stage: TS24
Assay Id: MGI:7433220
Age: embryonic day 16.5
Image: 4
Specimen Label: +/+
Detected: true
Specimen Num: 1
GXD Expression    
Probe: MGI:7433200
Assay Type: RT-PCR
Annotation Date: 2023-02-13
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1790624
Stage: TS24
Assay Id: MGI:7433220
Age: embryonic day 16.5
Image: 4
Specimen Label: -/-
Detected: true
Specimen Num: 2
GXD Expression      
Probe: MGI:7468960
Assay Type: Northern blot
Annotation Date: 2023-05-05
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1610526
Stage: TS26
Assay Id: MGI:7469667
Age: embryonic day 18.5
Specimen Label: 7
Detected: true
Specimen Num: 1
GXD Expression      
Probe: MGI:7468960
Assay Type: Northern blot
Annotation Date: 2023-05-05
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1610526
Stage: TS26
Assay Id: MGI:7469667
Age: embryonic day 18.5
Specimen Label: 8
Detected: true
Specimen Num: 2
GXD Expression      
Probe: MGI:7468960
Assay Type: Northern blot
Annotation Date: 2023-05-05
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1610526
Stage: TS26
Assay Id: MGI:7469667
Age: embryonic day 18.5
Specimen Label: 9
Detected: true
Specimen Num: 3