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Search results 1 to 100 out of 1635 for Sparc

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Type Details Score
Protein Domain
Type: Family
Description: SPARC (also known as BM-40 or osteonectin) is a matricellular protein essential for embryo development in invertebrates and highly expressed in bone []. It participates in normal tissue remodeling as it regulates the deposition of extracellular matrix, as well as in neoplastic transformation []. It is involved in extracellular matrix (ECM) assembly and fibrosis through binding both fibrillar collagen and basal lamina collagen IV []. It regulates the activity of matrix metalloproteinases (MMPs), as well as the growth factor signaling mediated by cell surface receptors including vascular endothelial growth factor (VEGF) receptor, basic fibroblast growth factor (bFGF), and transforming growth factor (TGF) beta1. Overexpression of SPARC has been linked to cancers []. SPARC is also a bone-associated protein that has a major role in bone development and mineralisation. It is involved in the initiation and progression of vascular calcification and upregulated by adiponectin []. Furthermore, SPARC may be one of the molecules that govern the uptake and delivery of proteins from blood to the cerebrospinal fluid (CSF) during brain development [].SPARC contains an N-terminal acidic 52-residue segment followed by a follistatin-like (FS) domain, and an alpha-helical EC domain with 2 unusual calcium-binding EF-hands and the collagen-binding site []. Platelet-derived growth factor (PDGF) interacts with its EC domain, but in a calcium-independent manner, whereas collagen binding is calcium-dependent [, , ].
Gene
Type: gene
Organism: Homo sapiens
Gene
Type: gene
Organism: Drosophila melanogaster
Gene
Type: gene
Organism: Rattus norvegicus
Gene
Type: gene
Organism: Danio rerio
Protein
Organism: Mus musculus
Length: 172  
Fragment?: true
Protein
Organism: Mus musculus
Length: 302  
Fragment?: false
Protein
Organism: Mus musculus
Length: 332  
Fragment?: false
Protein
Organism: Mus musculus
Length: 301  
Fragment?: false
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Publication
First Author: Kapinas K
Year: 2012
Journal: Matrix Biol
Title: Bone matrix osteonectin limits prostate cancer cell growth and survival.
Volume: 31
Issue: 5
Pages: 299-307
Publication
First Author: Hohenester E
Year: 2008
Journal: Proc Natl Acad Sci U S A
Title: Structural basis of sequence-specific collagen recognition by SPARC.
Volume: 105
Issue: 47
Pages: 18273-7
Publication
First Author: Hohenester E
Year: 1997
Journal: EMBO J
Title: Crystal structure of a pair of follistatin-like and EF-hand calcium-binding domains in BM-40.
Volume: 16
Issue: 13
Pages: 3778-86
Publication
First Author: Botti G
Year: 2014
Journal: Virchows Arch
Title: SPARC/osteonectin is involved in metastatic process to the lung during melanoma progression.
Volume: 465
Issue: 3
Pages: 331-8
Publication
First Author: Niknam S
Year: 2015
Journal: Int J Mol Cell Med
Title: The effect of adiponectin on osteonectin gene expression by oxidized low density lipoprotein-treated vascular smooth muscle cells.
Volume: 4
Issue: 1
Pages: 60-6
Publication
First Author: Liddelow SA
Year: 2011
Journal: Eur J Neurosci
Title: SPARC/osteonectin, an endogenous mechanism for targeting albumin to the blood-cerebrospinal fluid interface during brain development.
Volume: 34
Issue: 7
Pages: 1062-73
Publication
First Author: Maurer P
Year: 1995
Journal: J Mol Biol
Title: The C-terminal portion of BM-40 (SPARC/osteonectin) is an autonomously folding and crystallisable domain that binds calcium and collagen IV.
Volume: 253
Issue: 2
Pages: 347-57
Publication
First Author: Kelm RJ Jr
Year: 1990
Journal: Blood
Title: Human platelet osteonectin: release, surface expression, and partial characterization.
Volume: 75
Issue: 5
Pages: 1105-13
Protein
Organism: Mus musculus
Length: 302  
Fragment?: false
Publication
First Author: Mason IJ
Year: 1986
Journal: EMBO J
Title: Evidence from molecular cloning that SPARC, a major product of mouse embryo parietal endoderm, is related to an endothelial cell 'culture shock' glycoprotein of Mr 43,000.
Volume: 5
Issue: 7
Pages: 1465-72
Publication
First Author: McVey JH
Year: 1988
Journal: J Biol Chem
Title: Characterization of the mouse SPARC/osteonectin gene. Intron/exon organization and an unusual promoter region.
Volume: 263
Issue: 23
Pages: 11111-6
Publication
First Author: Engel J
Year: 1987
Journal: Biochemistry
Title: Calcium binding domains and calcium-induced conformational transition of SPARC/BM-40/osteonectin, an extracellular glycoprotein expressed in mineralized and nonmineralized tissues.
Volume: 26
Issue: 22
Pages: 6958-65
Publication
First Author: Sasaki T
Year: 1998
Journal: EMBO J
Title: Crystal structure and mapping by site-directed mutagenesis of the collagen-binding epitope of an activated form of BM-40/SPARC/osteonectin.
Volume: 17
Issue: 6
Pages: 1625-34
Gene
Type: gene
Organism: Homo sapiens
UniProt Feature
Begin: 18
Description: SPARC
Type: chain
End: 302
Protein
Organism: Mus musculus
Length: 302  
Fragment?: false
Publication
First Author: Campolongo M
Year: 2012
Journal: Genes Brain Behav
Title: Hippocampal SPARC regulates depression-related behavior.
Volume: 11
Issue: 8
Pages: 966-76
Publication
First Author: Norose K
Year: 1998
Journal: Invest Ophthalmol Vis Sci
Title: SPARC deficiency leads to early-onset cataractogenesis.
Volume: 39
Issue: 13
Pages: 2674-80
Publication
First Author: Luo Z
Year: 2012
Journal: Exp Hematol
Title: SPARC promotes the development of erythroid progenitors.
Volume: 40
Issue: 10
Pages: 828-36
Publication
First Author: Albrecht D
Year: 2012
Journal: Mol Cell Neurosci
Title: SPARC prevents maturation of cholinergic presynaptic terminals.
Volume: 49
Issue: 3
Pages: 364-74
Publication
First Author: Sansom OJ
Year: 2007
Journal: Gut
Title: Deficiency of SPARC suppresses intestinal tumorigenesis in APCMin/+ mice.
Volume: 56
Issue: 10
Pages: 1410-4
Publication
First Author: Greiling TM
Year: 2009
Journal: Exp Eye Res
Title: Absence of SPARC leads to impaired lens circulation.
Volume: 89
Issue: 3
Pages: 416-25
Publication
First Author: Sangaletti S
Year: 2011
Journal: Am J Pathol
Title: SPARC oppositely regulates inflammation and fibrosis in bleomycin-induced lung damage.
Volume: 179
Issue: 6
Pages: 3000-10
Publication
First Author: Stary M
Year: 2005
Journal: Exp Cell Res
Title: Parietal endoderm secreted SPARC promotes early cardiomyogenesis in vitro.
Volume: 310
Issue: 2
Pages: 331-43
Publication
First Author: Sangaletti S
Year: 2008
Journal: Cancer Res
Title: Macrophage-derived SPARC bridges tumor cell-extracellular matrix interactions toward metastasis.
Volume: 68
Issue: 21
Pages: 9050-9
Publication
First Author: Kelly KA
Year: 2007
Journal: J Leukoc Biol
Title: SPARC is a VCAM-1 counter-ligand that mediates leukocyte transmigration.
Volume: 81
Issue: 3
Pages: 748-56
Publication  
First Author: Shubham K
Year: 2012
Journal: Mol Vis
Title: Pax6 interacts with SPARC and TGF-β in murine eyes.
Volume: 18
Pages: 951-6
Publication
First Author: Sussman AN
Year: 2009
Journal: Am J Pathol
Title: SPARC accelerates disease progression in experimental crescentic glomerulonephritis.
Volume: 174
Issue: 5
Pages: 1827-36
Publication
First Author: Said N
Year: 2013
Journal: J Clin Invest
Title: Loss of SPARC in bladder cancer enhances carcinogenesis and progression.
Volume: 123
Issue: 2
Pages: 751-66
Publication
First Author: Rivera LB
Year: 2011
Journal: J Cell Biol
Title: SPARC promotes pericyte recruitment via inhibition of endoglin-dependent TGF-β1 activity.
Volume: 193
Issue: 7
Pages: 1305-19
Publication
First Author: Lloyd-Burton SM
Year: 2013
Journal: J Neurosci
Title: SPARC regulates microgliosis and functional recovery following cortical ischemia.
Volume: 33
Issue: 10
Pages: 4468-81
Publication
First Author: Song H
Year: 2010
Journal: Biochem Biophys Res Commun
Title: SPARC interacts with AMPK and regulates GLUT4 expression.
Volume: 396
Issue: 4
Pages: 961-6
Publication
First Author: Nie J
Year: 2009
Journal: J Biol Chem
Title: SPARC inhibits adipogenesis by its enhancement of beta-catenin signaling.
Volume: 284
Issue: 2
Pages: 1279-90
Publication
First Author: McCurdy SM
Year: 2011
Journal: Am J Physiol Heart Circ Physiol
Title: SPARC mediates early extracellular matrix remodeling following myocardial infarction.
Volume: 301
Issue: 2
Pages: H497-505
Publication
First Author: Harris BS
Year: 2011
Journal: Am J Physiol Heart Circ Physiol
Title: SPARC regulates collagen interaction with cardiac fibroblast cell surfaces.
Volume: 301
Issue: 3
Pages: H841-7
Gene
Type: gene
Organism: Homo sapiens
Gene
Type: gene
Organism: Homo sapiens
Publication
First Author: Jørgensen LH
Year: 2017
Journal: Am J Pathol
Title: SPARC Interacts with Actin in Skeletal Muscle in Vitro and in Vivo.
Volume: 187
Issue: 2
Pages: 457-474
Publication
First Author: Tseng C
Year: 2016
Journal: Stem Cells
Title: Proteolytic Isoforms of SPARC Induce Adipose Stromal Cell Mobilization in Obesity.
Volume: 34
Issue: 1
Pages: 174-90
Publication
First Author: Mason IJ
Year: 1986
Journal: EMBO J
Title: Developmental and transformation-sensitive expression of the Sparc gene on mouse chromosome 11.
Volume: 5
Issue: 8
Pages: 1831-7
Publication
First Author: Said N
Year: 2009
Journal: Oncogene
Title: The role of SPARC in the TRAMP model of prostate carcinogenesis and progression.
Volume: 28
Issue: 39
Pages: 3487-98
Publication
First Author: Huang DY
Year: 2008
Journal: J Pathol
Title: Transcription factor SOX-5 enhances nasopharyngeal carcinoma progression by down-regulating SPARC gene expression.
Volume: 214
Issue: 4
Pages: 445-55
Publication
First Author: Holland PW
Year: 1987
Journal: J Cell Biol
Title: In vivo expression of mRNA for the Ca++-binding protein SPARC (osteonectin) revealed by in situ hybridization.
Volume: 105
Issue: 1
Pages: 473-82
Publication  
First Author: Tichet M
Year: 2015
Journal: Nat Commun
Title: Tumour-derived SPARC drives vascular permeability and extravasation through endothelial VCAM1 signalling to promote metastasis.
Volume: 6
Pages: 6993
Publication
First Author: Mazzolini G
Year: 2018
Journal: Sci Rep
Title: SPARC expression is associated with hepatic injury in rodents and humans with non-alcoholic fatty liver disease.
Volume: 8
Issue: 1
Pages: 725
Publication
First Author: Schellings MW
Year: 2009
Journal: J Exp Med
Title: Absence of SPARC results in increased cardiac rupture and dysfunction after acute myocardial infarction.
Volume: 206
Issue: 1
Pages: 113-23
Publication
First Author: Luo Z
Year: 2014
Journal: J Leukoc Biol
Title: SPARC deficiency affects bone marrow stromal function, resulting in impaired B lymphopoiesis.
Volume: 96
Issue: 1
Pages: 73-82
Publication  
First Author: Rienks M
Year: 2018
Journal: Matrix Biol
Title: SPARC preserves endothelial glycocalyx integrity, and protects against adverse cardiac inflammation and injury during viral myocarditis.
Volume: 74
Pages: 21-34
Publication
First Author: Wong SY
Year: 2008
Journal: Clin Exp Metastasis
Title: Analyses of the role of endogenous SPARC in mouse models of prostate and breast cancer.
Volume: 25
Issue: 2
Pages: 109-18
Publication
First Author: Rentz TJ
Year: 2007
Journal: J Biol Chem
Title: SPARC regulates processing of procollagen I and collagen fibrillogenesis in dermal fibroblasts.
Volume: 282
Issue: 30
Pages: 22062-71
Publication
First Author: Gruber HE
Year: 2005
Journal: J Histochem Cytochem
Title: Targeted deletion of the SPARC gene accelerates disc degeneration in the aging mouse.
Volume: 53
Issue: 9
Pages: 1131-8
Publication
First Author: Brekken RA
Year: 2003
Journal: J Clin Invest
Title: Enhanced growth of tumors in SPARC null mice is associated with changes in the ECM.
Volume: 111
Issue: 4
Pages: 487-95
Publication
First Author: Yan Q
Year: 2005
Journal: Invest Ophthalmol Vis Sci
Title: Absence of SPARC in murine lens epithelium leads to increased deposition of laminin-1 in lens capsule.
Volume: 46
Issue: 12
Pages: 4652-60
Publication
First Author: Francki A
Year: 1999
Journal: J Biol Chem
Title: SPARC regulates the expression of collagen type I and transforming growth factor-beta1 in mesangial cells.
Volume: 274
Issue: 45
Pages: 32145-52
Publication  
First Author: Basu A
Year: 2001
Journal: BMC Cell Biol
Title: Impaired wound healing in mice deficient in a matricellular protein SPARC (osteonectin, BM-40).
Volume: 2
Pages: 15
Publication
First Author: Ehninger A
Year: 2014
Journal: Blood
Title: Loss of SPARC protects hematopoietic stem cells from chemotherapy toxicity by accelerating their return to quiescence.
Volume: 123
Issue: 26
Pages: 4054-63
Publication
First Author: Seet LF
Year: 2010
Journal: PLoS One
Title: SPARC deficiency results in improved surgical survival in a novel mouse model of glaucoma filtration surgery.
Volume: 5
Issue: 2
Pages: e9415
Publication
First Author: Nomura S
Year: 1988
Journal: J Cell Biol
Title: Developmental expression of 2ar (osteopontin) and SPARC (osteonectin) RNA as revealed by in situ hybridization.
Volume: 106
Issue: 2
Pages: 441-50
Publication
First Author: Kupprion C
Year: 1998
Journal: J Biol Chem
Title: SPARC (BM-40, osteonectin) inhibits the mitogenic effect of vascular endothelial growth factor on microvascular endothelial cells.
Volume: 273
Issue: 45
Pages: 29635-40
Publication
First Author: Mendis DB
Year: 1994
Journal: Brain Res Mol Brain Res
Title: Expression of the gene encoding the extracellular matrix glycoprotein SPARC in the developing and adult mouse brain.
Volume: 24
Issue: 1-4
Pages: 11-9
Publication
First Author: Wilson MJ
Year: 2006
Journal: Mol Reprod Dev
Title: The matricellular protein SPARC is internalized in Sertoli, Leydig, and germ cells during testis differentiation.
Volume: 73
Issue: 5
Pages: 531-9
Publication
First Author: Vincent AJ
Year: 2008
Journal: Dev Dyn
Title: SPARC is expressed by macroglia and microglia in the developing and mature nervous system.
Volume: 237
Issue: 5
Pages: 1449-62
Publication
First Author: Lankat-Buttgereit B
Year: 1988
Journal: FEBS Lett
Title: Cloning and complete amino acid sequences of human and murine basement membrane protein BM-40 (SPARC, osteonectin).
Volume: 236
Issue: 2
Pages: 352-6
Publication
First Author: Mann K
Year: 1987
Journal: FEBS Lett
Title: Solubilization of protein BM-40 from a basement membrane tumor with chelating agents and evidence for its identity with osteonectin and SPARC.
Volume: 218
Issue: 1
Pages: 167-72
Gene
Type: gene
Organism: Homo sapiens
Gene
Type: gene
Organism: Homo sapiens
Gene
Type: gene
Organism: Homo sapiens
Publication
First Author: Arnold SA
Year: 2010
Journal: Dis Model Mech
Title: Lack of host SPARC enhances vascular function and tumor spread in an orthotopic murine model of pancreatic carcinoma.
Volume: 3
Issue: 1-2
Pages: 57-72
Publication  
First Author: Mansergh FC
Year: 2004
Journal: Mol Vis
Title: Gene expression changes during cataract progression in Sparc null mice: differential regulation of mouse globins in the lens.
Volume: 10
Pages: 490-511
Publication
First Author: Mansergh FC
Year: 2007
Journal: Physiol Genomics
Title: Osteopenia in Sparc (osteonectin)-deficient mice: characterization of phenotypic determinants of femoral strength and changes in gene expression.
Volume: 32
Issue: 1
Pages: 64-73
Publication
First Author: Yan Q
Year: 2003
Journal: J Histochem Cytochem
Title: Expression of the matricellular protein SPARC in murine lens: SPARC is necessary for the structural integrity of the capsular basement membrane.
Volume: 51
Issue: 4
Pages: 503-11
Publication
First Author: Atorrasagasti C
Year: 2013
Journal: PLoS One
Title: Lack of the matricellular protein SPARC (secreted protein, acidic and rich in cysteine) attenuates liver fibrogenesis in mice.
Volume: 8
Issue: 2
Pages: e54962
Publication
First Author: Bassuk JA
Year: 1999
Journal: Exp Eye Res
Title: Disruption of the Sparc locus in mice alters the differentiation of lenticular epithelial cells and leads to cataract formation.
Volume: 68
Issue: 3
Pages: 321-31
Publication
First Author: Barker TH
Year: 2005
Journal: Am J Pathol
Title: Matricellular homologs in the foreign body response: hevin suppresses inflammation, but hevin and SPARC together diminish angiogenesis.
Volume: 166
Issue: 3
Pages: 923-33
Publication
First Author: Tripodo C
Year: 2012
Journal: Blood
Title: Stromal SPARC contributes to the detrimental fibrotic changes associated with myeloproliferation whereas its deficiency favors myeloid cell expansion.
Volume: 120
Issue: 17
Pages: 3541-54
Publication
First Author: Iruela-Arispe ML
Year: 1996
Journal: Dev Dyn
Title: Type I collagen-deficient Mov-13 mice do not retain SPARC in the extracellular matrix: implications for fibroblast function.
Volume: 207
Issue: 2
Pages: 171-83
Publication
First Author: Rosset EM
Year: 2017
Journal: PLoS One
Title: SPARC and the N-propeptide of collagen I influence fibroblast proliferation and collagen assembly in the periodontal ligament.
Volume: 12
Issue: 2
Pages: e0173209
Publication
First Author: Siva K
Year: 2012
Journal: Leukemia
Title: SPARC is dispensable for murine hematopoiesis, despite its suspected pathophysiological role in 5q-myelodysplastic syndrome.
Volume: 26
Issue: 11
Pages: 2416-9
Publication
First Author: McKinnon PJ
Year: 1996
Journal: Genome Res
Title: The exon structure of the mouse Sc1 gene is very similar to the mouse Sparc gene.
Volume: 6
Issue: 11
Pages: 1077-83
Publication
First Author: Bradshaw AD
Year: 2010
Journal: Am J Physiol Heart Circ Physiol
Title: Age-dependent alterations in fibrillar collagen content and myocardial diastolic function: role of SPARC in post-synthetic procollagen processing.
Volume: 298
Issue: 2
Pages: H614-22
Publication
First Author: Lehmann S
Year: 2007
Journal: Leukemia
Title: Common deleted genes in the 5q- syndrome: thrombocytopenia and reduced erythroid colony formation in SPARC null mice.
Volume: 21
Issue: 9
Pages: 1931-6
Publication
First Author: Lloyd-Burton S
Year: 2012
Journal: J Comp Neurol
Title: SPARC-like 1 (SC1) is a diversely expressed and developmentally regulated matricellular protein that does not compensate for the absence of SPARC in the CNS.
Volume: 520
Issue: 12
Pages: 2575-90
Publication
First Author: Weaver MS
Year: 2008
Journal: J Biol Chem
Title: The copper binding domain of SPARC mediates cell survival in vitro via interaction with integrin beta1 and activation of integrin-linked kinase.
Volume: 283
Issue: 33
Pages: 22826-37
Gene
Type: gene
Organism: Rattus norvegicus
Publication
First Author: Barlow JL
Year: 2010
Journal: Nat Med
Title: A p53-dependent mechanism underlies macrocytic anemia in a mouse model of human 5q- syndrome.
Volume: 16
Issue: 1
Pages: 59-66
Publication
First Author: Cheng SV
Year: 1987
Journal: DNA
Title: Chromosomal localization of the mouse homolog of the Huntington's disease linked G8 (D4S10) marker.
Volume: 6
Issue: 5
Pages: 401-7
Publication
First Author: Sangaletti S
Year: 2005
Journal: J Cell Sci
Title: Accelerated dendritic-cell migration and T-cell priming in SPARC-deficient mice.
Volume: 118
Issue: Pt 16
Pages: 3685-94
Publication
First Author: Jones EV
Year: 2011
Journal: J Neurosci
Title: Astrocytes control glutamate receptor levels at developing synapses through SPARC-beta-integrin interactions.
Volume: 31
Issue: 11
Pages: 4154-65
Publication
First Author: Rotta G
Year: 2008
Journal: J Exp Med
Title: Contrasting roles of SPARC-related granuloma in bacterial containment and in the induction of anti-Salmonella typhimurium immunity.
Volume: 205
Issue: 3
Pages: 657-67
Publication
First Author: Nozaki M
Year: 2006
Journal: J Clin Invest
Title: Loss of SPARC-mediated VEGFR-1 suppression after injury reveals a novel antiangiogenic activity of VEGF-A.
Volume: 116
Issue: 2
Pages: 422-9