|  Help  |  About  |  Contact Us

Search our database by keyword

Examples

  • Search this entire website. Enter identifiers, names or keywords for genes, diseases, strains, ontology terms, etc. (e.g. Pax6, Parkinson, ataxia)
  • Use OR to search for either of two terms (e.g. OR mus) or quotation marks to search for phrases (e.g. "dna binding").
  • Boolean search syntax is supported: e.g. Balb* for partial matches or mus AND NOT embryo to exclude a term

Search results 1 to 100 out of 2018 for Sparc

<< First    < Previous  |  Next >    Last >>
0.045s

Categories

Hits by Pathway

Hits by Category

Hits by Strain

Type Details Score
Protein Domain
IPR037641 | SPARC
Type: Family
Description: SPARC (also known as BM-40 or osteonectin) is a matricellular protein essential for embryo development in invertebrates and highly expressed in bone []. It participates in normal tissue remodeling as it regulates the deposition of extracellular matrix, as well as in neoplastic transformation []. It is involved in extracellular matrix (ECM) assembly and fibrosis through binding both fibrillar collagen and basal lamina collagen IV []. It regulates the activity of matrix metalloproteinases (MMPs), as well as the growth factor signaling mediated by cell surface receptors including vascular endothelial growth factor (VEGF) receptor, basic fibroblast growth factor (bFGF), and transforming growth factor (TGF) beta1. Overexpression of SPARC has been linked to cancers []. SPARC is also a bone-associated protein that has a major role in bone development and mineralisation. It is involved in the initiation and progression of vascular calcification and upregulated by adiponectin []. Furthermore, SPARC may be one of the molecules that govern the uptake and delivery of proteins from blood to the cerebrospinal fluid (CSF) during brain development [].SPARC contains an N-terminal acidic 52-residue segment followed by a follistatin-like (FS) domain, and an α-helical EC domain with 2 unusual calcium-binding EF-hands and the collagen-binding site []. Platelet-derived growth factor (PDGF) interacts with its EC domain, but in a calcium-independent manner, whereas collagen binding is calcium-dependent [, , ].
•
•
•
•
•
Gene
121107687 | LOC121107687
Type: gene
Organism: chicken
•
•
•
•
•
Gene
6678 | SPARC
Type: gene
Organism: human
•
•
•
•
•
Gene
394973 | sparc
Type: gene
Organism: frog, western clawed
•
•
•
•
•
Gene
282077 | SPARC
Type: gene
Organism: cattle
•
•
•
•
•
Gene
key_86691 | SPARC
Type: gene
Organism: horse
•
•
•
•
•
Protein
Q5NCU3
Organism: Mus musculus/domesticus
Length: 172  
Fragment?: true
•
•
•
•
•
Protein
P07214
Organism: Mus musculus/domesticus
Length: 302  
Fragment?: false
•
•
•
•
•
Protein
Q3TXI6
Organism: Mus musculus/domesticus
Length: 302  
Fragment?: false
•
•
•
•
•
Protein
Q5NCU5
Organism: Mus musculus/domesticus
Length: 302  
Fragment?: false
•
•
•
•
•
Protein
Q5NCU4
Organism: Mus musculus/domesticus
Length: 301  
Fragment?: false
•
•
•
•
•
Protein
A0A1L1SSH9
Organism: Mus musculus/domesticus
Length: 332  
Fragment?: false
•
•
•
•
•
Gene
24791 | Sparc
Type: gene
Organism: rat
•
•
•
•
•
Gene
471709 | SPARC
Type: gene
Organism: chimpanzee
•
•
•
•
•
Gene
100855736 | SPARC
Type: gene
Organism: dog, domestic
•
•
•
•
•
Gene
386571 | SPARC
Type: gene
Organism: chicken
•
•
•
•
•
Gene
321357 | sparc
Type: gene
Organism: zebrafish
•
•
•
•
•
Gene
712388 | SPARC
Type: gene
Organism: macaque, rhesus
•
•
•
•
•
Protein Coding Gene
MGI:98373 | Sparc
Type: protein_coding_gene
Organism: mouse, laboratory
•
•
•
•
•
Publication
22525512 | J:188301
First Author: Kapinas K
Year: 2012
Journal: Matrix Biol
Title: Bone matrix osteonectin limits prostate cancer cell growth and survival.
Volume: 31
Issue: 5
Pages: 299-307
•
•
•
•
•
Publication
9233787 | -
First Author: Hohenester E
Year: 1997
Journal: EMBO J
Title: Crystal structure of a pair of follistatin-like and EF-hand calcium-binding domains in BM-40.
Volume: 16
Issue: 13
Pages: 3778-86
•
•
•
•
•
Publication
19011090 | -
First Author: Hohenester E
Year: 2008
Journal: Proc Natl Acad Sci U S A
Title: Structural basis of sequence-specific collagen recognition by SPARC.
Volume: 105
Issue: 47
Pages: 18273-7
•
•
•
•
•
Publication
24993904 | -
First Author: Botti G
Year: 2014
Journal: Virchows Arch
Title: SPARC/osteonectin is involved in metastatic process to the lung during melanoma progression.
Volume: 465
Issue: 3
Pages: 331-8
•
•
•
•
•
Publication
25815284 | -
First Author: Niknam S
Year: 2015
Journal: Int J Mol Cell Med
Title: The effect of adiponectin on osteonectin gene expression by oxidized low density lipoprotein-treated vascular smooth muscle cells.
Volume: 4
Issue: 1
Pages: 60-6
•
•
•
•
•
Publication
21899600 | -
First Author: Liddelow SA
Year: 2011
Journal: Eur J Neurosci
Title: SPARC/osteonectin, an endogenous mechanism for targeting albumin to the blood-cerebrospinal fluid interface during brain development.
Volume: 34
Issue: 7
Pages: 1062-73
•
•
•
•
•
Publication
7563094 | -
First Author: Maurer P
Year: 1995
Journal: J Mol Biol
Title: The C-terminal portion of BM-40 (SPARC/osteonectin) is an autonomously folding and crystallisable domain that binds calcium and collagen IV.
Volume: 253
Issue: 2
Pages: 347-57
•
•
•
•
•
Publication
2306517 | -
First Author: Kelm RJ Jr
Year: 1990
Journal: Blood
Title: Human platelet osteonectin: release, surface expression, and partial characterization.
Volume: 75
Issue: 5
Pages: 1105-13
•
•
•
•
•
GXD Expression
GXD Expression
Probe: MGI:7311967
Assay Type: RNA in situ
Annotation Date: 2023-09-25
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1736422
Pattern: Not Specified
Stage: TS22
Assay Id: MGI:7530041
Age: embryonic day 14.5
Image: 4b Sparc E14.5
Note: Expression in mature functional osteoblasts. Expression throughout developing palatal mesenchyme.
Specimen Label: 4b Sparc E14.5
Detected: true
Specimen Num: 3
•
•
•
•
•
GXD Expression
GXD Expression
Probe: MGI:7311967
Assay Type: RNA in situ
Annotation Date: 2023-09-25
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1736422
Pattern: Not Specified
Stage: TS22
Assay Id: MGI:7530041
Age: embryonic day 14.5
Image: 4a Sparc E14.5
Note: Expression in mature functional osteoblasts. Expression throughout developing palatal mesenchyme.
Specimen Label: 4a Sparc E14.5
Detected: true
Specimen Num: 1
•
•
•
•
•
GXD Expression
GXD Expression
Probe: MGI:7311967
Assay Type: RNA in situ
Annotation Date: 2023-09-25
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1736423
Pattern: Not Specified
Stage: TS23
Assay Id: MGI:7530041
Age: embryonic day 15.5
Image: 4a Sparc E15.5
Note: Expression in mature functional osteoblasts. Expression throughout developing palatal mesenchyme.
Specimen Label: 4a Sparc E15.5
Detected: true
Specimen Num: 2
•
•
•
•
•
GXD Expression
GXD Expression
Probe: MGI:7311967
Assay Type: RNA in situ
Annotation Date: 2023-09-25
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1736423
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:7530041
Age: embryonic day 15.5
Image: 4b Sparc E15.5
Note: Expression in mature functional osteoblasts. Expression throughout developing palatal mesenchyme. Diffuse expression in central ossification centers.
Specimen Label: 4b Sparc E15.5
Detected: true
Specimen Num: 4
•
•
•
•
•
Publication
3755680 | J:8388
First Author: Mason IJ
Year: 1986
Journal: EMBO J
Title: Evidence from molecular cloning that SPARC, a major product of mouse embryo parietal endoderm, is related to an endothelial cell 'culture shock' glycoprotein of Mr 43,000.
Volume: 5
Issue: 7
Pages: 1465-72
•
•
•
•
•
Publication
9501084 | -
First Author: Sasaki T
Year: 1998
Journal: EMBO J
Title: Crystal structure and mapping by site-directed mutagenesis of the collagen-binding epitope of an activated form of BM-40/SPARC/osteonectin.
Volume: 17
Issue: 6
Pages: 1625-34
•
•
•
•
•
Publication
3165375 | J:9287
First Author: McVey JH
Year: 1988
Journal: J Biol Chem
Title: Characterization of the mouse SPARC/osteonectin gene. Intron/exon organization and an unusual promoter region.
Volume: 263
Issue: 23
Pages: 11111-6
•
•
•
•
•
Publication
3427055 | J:240593
First Author: Engel J
Year: 1987
Journal: Biochemistry
Title: Calcium binding domains and calcium-induced conformational transition of SPARC/BM-40/osteonectin, an extracellular glycoprotein expressed in mineralized and nonmineralized tissues.
Volume: 26
Issue: 22
Pages: 6958-65
•
•
•
•
•
Gene
8404 | SPARCL1
Type: gene
Organism: human
•
•
•
•
•
Publication
22950524 | J:203247
First Author: Campolongo M
Year: 2012
Journal: Genes Brain Behav
Title: Hippocampal SPARC regulates depression-related behavior.
Volume: 11
Issue: 8
Pages: 966-76
•
•
•
•
•
Publication
9856777 | J:52120
First Author: Norose K
Year: 1998
Journal: Invest Ophthalmol Vis Sci
Title: SPARC deficiency leads to early-onset cataractogenesis.
Volume: 39
Issue: 13
Pages: 2674-80
•
•
•
•
•
UniProt Feature
UniProt Feature
Begin: 18
Description: SPARC
Type: chain
End: 302
•
•
•
•
•
UniProt Feature
UniProt Feature
Begin: 18
Description: SPARC
Type: chain
End: 302
•
•
•
•
•
UniProt Feature
UniProt Feature
Begin: 18
Description: SPARC
Type: chain
End: 301
•
•
•
•
•
UniProt Feature
UniProt Feature
Begin: 18
Description: SPARC
Type: chain
End: 172
•
•
•
•
•
UniProt Feature
UniProt Feature
Begin: 18
Description: SPARC
Type: chain
End: 302
•
•
•
•
•
UniProt Feature
UniProt Feature
Begin: 48
Description: SPARC
Type: chain
End: 332
•
•
•
•
•
Publication
22306863 | J:196751
First Author: Albrecht D
Year: 2012
Journal: Mol Cell Neurosci
Title: SPARC prevents maturation of cholinergic presynaptic terminals.
Volume: 49
Issue: 3
Pages: 364-74
•
•
•
•
•
Publication
22687753 | J:203600
First Author: Luo Z
Year: 2012
Journal: Exp Hematol
Title: SPARC promotes the development of erythroid progenitors.
Volume: 40
Issue: 10
Pages: 828-36
•
•
•
•
•
Publication
17299058 | J:139856
First Author: Sansom OJ
Year: 2007
Journal: Gut
Title: Deficiency of SPARC suppresses intestinal tumorigenesis in APCMin/+ mice.
Volume: 56
Issue: 10
Pages: 1410-4
•
•
•
•
•
Publication
22001347 | J:180066
First Author: Sangaletti S
Year: 2011
Journal: Am J Pathol
Title: SPARC oppositely regulates inflammation and fibrosis in bleomycin-induced lung damage.
Volume: 179
Issue: 6
Pages: 3000-10
•
•
•
•
•
Publication
16165126 | J:102813
First Author: Stary M
Year: 2005
Journal: Exp Cell Res
Title: Parietal endoderm secreted SPARC promotes early cardiomyogenesis in vitro.
Volume: 310
Issue: 2
Pages: 331-43
•
•
•
•
•
Publication
18974151 | J:140635
First Author: Sangaletti S
Year: 2008
Journal: Cancer Res
Title: Macrophage-derived SPARC bridges tumor cell-extracellular matrix interactions toward metastasis.
Volume: 68
Issue: 21
Pages: 9050-9
•
•
•
•
•
Publication
19401199 | J:151198
First Author: Greiling TM
Year: 2009
Journal: Exp Eye Res
Title: Absence of SPARC leads to impaired lens circulation.
Volume: 89
Issue: 3
Pages: 416-25
•
•
•
•
•
Publication
17178915 | J:118613
First Author: Kelly KA
Year: 2007
Journal: J Leukoc Biol
Title: SPARC is a VCAM-1 counter-ligand that mediates leukocyte transmigration.
Volume: 81
Issue: 3
Pages: 748-56
•
•
•
•
•
Publication
23321672 | J:194491
First Author: Said N
Year: 2013
Journal: J Clin Invest
Title: Loss of SPARC in bladder cancer enhances carcinogenesis and progression.
Volume: 123
Issue: 2
Pages: 751-66
•
•
•
•
•
Publication
19342370 | J:147976
First Author: Sussman AN
Year: 2009
Journal: Am J Pathol
Title: SPARC accelerates disease progression in experimental crescentic glomerulonephritis.
Volume: 174
Issue: 5
Pages: 1827-36
•
•
•
•
•
Publication
30933983 | J:273634
First Author: Deckx S
Year: 2019
Journal: PLoS One
Title: Extracellular SPARC increases cardiomyocyte contraction during health and disease.
Volume: 14
Issue: 4
Pages: e0209534
•
•
•
•
•
Publication
21708981 | J:174202
First Author: Rivera LB
Year: 2011
Journal: J Cell Biol
Title: SPARC promotes pericyte recruitment via inhibition of endoglin-dependent TGF-β1 activity.
Volume: 193
Issue: 7
Pages: 1305-19
•
•
•
•
•
Publication
22539874 | J:191618
 
First Author: Shubham K
Year: 2012
Journal: Mol Vis
Title: Pax6 interacts with SPARC and TGF-β in murine eyes.
Volume: 18
Pages: 951-6
•
•
•
•
•
Publication
23467362 | J:196279
First Author: Lloyd-Burton SM
Year: 2013
Journal: J Neurosci
Title: SPARC regulates microgliosis and functional recovery following cortical ischemia.
Volume: 33
Issue: 10
Pages: 4468-81
•
•
•
•
•
Publication
20460104 | J:162435
First Author: Song H
Year: 2010
Journal: Biochem Biophys Res Commun
Title: SPARC interacts with AMPK and regulates GLUT4 expression.
Volume: 396
Issue: 4
Pages: 961-6
•
•
•
•
•
Publication
18990699 | J:145572
First Author: Nie J
Year: 2009
Journal: J Biol Chem
Title: SPARC inhibits adipogenesis by its enhancement of beta-catenin signaling.
Volume: 284
Issue: 2
Pages: 1279-90
•
•
•
•
•
Publication
21666116 | J:176928
First Author: Harris BS
Year: 2011
Journal: Am J Physiol Heart Circ Physiol
Title: SPARC regulates collagen interaction with cardiac fibroblast cell surfaces.
Volume: 301
Issue: 3
Pages: H841-7
•
•
•
•
•
Publication
21602472 | J:173342
First Author: McCurdy SM
Year: 2011
Journal: Am J Physiol Heart Circ Physiol
Title: SPARC mediates early extracellular matrix remodeling following myocardial infarction.
Volume: 301
Issue: 2
Pages: H497-505
•
•
•
•
•
Publication
27908613 | J:240042
First Author: Jørgensen LH
Year: 2017
Journal: Am J Pathol
Title: SPARC Interacts with Actin in Skeletal Muscle in Vitro and in Vivo.
Volume: 187
Issue: 2
Pages: 457-474
•
•
•
•
•
Publication
26381424 | J:232948
First Author: Tseng C
Year: 2016
Journal: Stem Cells
Title: Proteolytic Isoforms of SPARC Induce Adipose Stromal Cell Mobilization in Obesity.
Volume: 34
Issue: 1
Pages: 174-90
•
•
•
•
•
Publication
3758028 | J:8425
First Author: Mason IJ
Year: 1986
Journal: EMBO J
Title: Developmental and transformation-sensitive expression of the Sparc gene on mouse chromosome 11.
Volume: 5
Issue: 8
Pages: 1831-7
•
•
•
•
•
Publication
19597474 | J:153913
First Author: Said N
Year: 2009
Journal: Oncogene
Title: The role of SPARC in the TRAMP model of prostate carcinogenesis and progression.
Volume: 28
Issue: 39
Pages: 3487-98
•
•
•
•
•
Publication
37781916 | J:341432
 
First Author: Ryu S
Year: 2023
Journal: J Clin Invest
Title: Reduction of SPARC protects mice against NLRP3 inflammasome activation and obesity.
Volume: 133
Issue: 19
•
•
•
•
•
Publication
31281314 | J:298373
 
First Author: Sangaletti S
Year: 2019
Journal: Front Immunol
Title: SPARC Is a New Myeloid-Derived Suppressor Cell Marker Licensing Suppressive Activities.
Volume: 10
Pages: 1369
•
•
•
•
•
Publication
18085523 | J:131812
First Author: Huang DY
Year: 2008
Journal: J Pathol
Title: Transcription factor SOX-5 enhances nasopharyngeal carcinoma progression by down-regulating SPARC gene expression.
Volume: 214
Issue: 4
Pages: 445-55
•
•
•
•
•
Publication
35963236 | J:328359
First Author: Ryu S
Year: 2022
Journal: Immunity
Title: The matricellular protein SPARC induces inflammatory interferon-response in macrophages during aging.
Volume: 55
Issue: 9
Pages: 1609-1626.e7
•
•
•
•
•
Publication
33067534 | J:299003
First Author: Hu L
Year: 2020
Journal: Sci Rep
Title: SPARC promotes insulin secretion through down-regulation of RGS4 protein in pancreatic β cells.
Volume: 10
Issue: 1
Pages: 17581
•
•
•
•
•
Publication
2440898 | J:19171
First Author: Holland PW
Year: 1987
Journal: J Cell Biol
Title: In vivo expression of mRNA for the Ca++-binding protein SPARC (osteonectin) revealed by in situ hybridization.
Volume: 105
Issue: 1
Pages: 473-82
•
•
•
•
•
Publication
25925867 | J:222775
 
First Author: Tichet M
Year: 2015
Journal: Nat Commun
Title: Tumour-derived SPARC drives vascular permeability and extravasation through endothelial VCAM1 signalling to promote metastasis.
Volume: 6
Pages: 6993
•
•
•
•
•
GXD Expression
GXD Expression
   
Probe: MGI:6184086
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689419
Pattern: Not Specified
Stage: TS19
Assay Id: MGI:6191376
Age: embryonic day 11.5
Specimen Label: Table S2 - E11.5 - Sparc
Detected: true
Specimen Num: 1
•
•
•
•
•
GXD Expression
GXD Expression
   
Probe: MGI:6184086
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689421
Pattern: Not Specified
Stage: TS21
Assay Id: MGI:6191376
Age: embryonic day 13.5
Specimen Label: Table S2 - E13.5 - Sparc
Detected: true
Specimen Num: 2
•
•
•
•
•
GXD Expression
GXD Expression
   
Probe: MGI:6184086
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689424
Pattern: Not Specified
Stage: TS24
Assay Id: MGI:6191376
Age: embryonic day 15.5
Specimen Label: Table S2 - E15.5 - Sparc
Detected: true
Specimen Num: 3
•
•
•
•
•
GXD Expression
GXD Expression
   
Probe: MGI:6184086
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689426
Pattern: Not Specified
Stage: TS26
Assay Id: MGI:6191376
Age: embryonic day 18.5
Specimen Label: Table S2 - E18.5 - Sparc
Detected: true
Specimen Num: 4
•
•
•
•
•
GXD Expression
GXD Expression
   
Probe: MGI:6184086
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6191376
Age: postnatal day 4
Specimen Label: Table S2 - P4 - Sparc
Detected: true
Specimen Num: 5
•
•
•
•
•
GXD Expression
GXD Expression
   
Probe: MGI:6184086
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6191376
Age: postnatal day 14
Specimen Label: Table S2 - P14 - Sparc
Detected: true
Specimen Num: 6
•
•
•
•
•
GXD Expression
GXD Expression
   
Probe: MGI:6184086
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6191376
Age: postnatal day 28
Specimen Label: Table S2 - P28 - Sparc
Detected: true
Specimen Num: 7
•
•
•
•
•
Publication
18058030 | J:133592
First Author: Wong SY
Year: 2008
Journal: Clin Exp Metastasis
Title: Analyses of the role of endogenous SPARC in mouse models of prostate and breast cancer.
Volume: 25
Issue: 2
Pages: 109-18
•
•
•
•
•
Publication
11532190 | J:102567
 
First Author: Basu A
Year: 2001
Journal: BMC Cell Biol
Title: Impaired wound healing in mice deficient in a matricellular protein SPARC (osteonectin, BM-40).
Volume: 2
Pages: 15
•
•
•
•
•
Publication
24783223 | J:318673
 
First Author: de Castro Brás LE
Year: 2014
Journal: Biomed Res Int
Title: Age and SPARC change the extracellular matrix composition of the left ventricle.
Volume: 2014
Pages: 810562
•
•
•
•
•
Publication
16303962 | J:103786
First Author: Yan Q
Year: 2005
Journal: Invest Ophthalmol Vis Sci
Title: Absence of SPARC in murine lens epithelium leads to increased deposition of laminin-1 in lens capsule.
Volume: 46
Issue: 12
Pages: 4652-60
•
•
•
•
•
Publication
24833352 | J:213736
First Author: Ehninger A
Year: 2014
Journal: Blood
Title: Loss of SPARC protects hematopoietic stem cells from chemotherapy toxicity by accelerating their return to quiescence.
Volume: 123
Issue: 26
Pages: 4054-63
•
•
•
•
•
Publication
17522057 | J:124607
First Author: Rentz TJ
Year: 2007
Journal: J Biol Chem
Title: SPARC regulates processing of procollagen I and collagen fibrillogenesis in dermal fibroblasts.
Volume: 282
Issue: 30
Pages: 22062-71
•
•
•
•
•
Publication
33306449 | J:300047
First Author: Riley HJ
Year: 2021
Journal: Am J Physiol Heart Circ Physiol
Title: SPARC production by bone marrow-derived cells contributes to myocardial fibrosis in pressure overload.
Volume: 320
Issue: 2
Pages: H604-H612
•
•
•
•
•
Publication
24598056 | J:212014
First Author: Luo Z
Year: 2014
Journal: J Leukoc Biol
Title: SPARC deficiency affects bone marrow stromal function, resulting in impaired B lymphopoiesis.
Volume: 96
Issue: 1
Pages: 73-82
•
•
•
•
•
Publication
10542250 | J:115124
First Author: Francki A
Year: 1999
Journal: J Biol Chem
Title: SPARC regulates the expression of collagen type I and transforming growth factor-beta1 in mesangial cells.
Volume: 274
Issue: 45
Pages: 32145-52
•
•
•
•
•
Publication
15879573 | J:101698
First Author: Gruber HE
Year: 2005
Journal: J Histochem Cytochem
Title: Targeted deletion of the SPARC gene accelerates disc degeneration in the aging mouse.
Volume: 53
Issue: 9
Pages: 1131-8
•
•
•
•
•
Publication
38070276 | J:343771
 
First Author: Arai M
Year: 2024
Journal: Biochem Biophys Res Commun
Title: Effect of Sparc knockout on the extracellular matrix of mouse periodontal ligament cells.
Volume: 692
Pages: 149364
•
•
•
•
•
Publication
12588887 | J:81896
First Author: Brekken RA
Year: 2003
Journal: J Clin Invest
Title: Enhanced growth of tumors in SPARC null mice is associated with changes in the ECM.
Volume: 111
Issue: 4
Pages: 487-95
•
•
•
•
•
Publication
29335425 | J:264496
First Author: Mazzolini G
Year: 2018
Journal: Sci Rep
Title: SPARC expression is associated with hepatic injury in rodents and humans with non-alcoholic fatty liver disease.
Volume: 8
Issue: 1
Pages: 725
•
•
•
•
•
Publication
19103879 | J:144036
First Author: Schellings MW
Year: 2009
Journal: J Exp Med
Title: Absence of SPARC results in increased cardiac rupture and dysfunction after acute myocardial infarction.
Volume: 206
Issue: 1
Pages: 113-23
•
•
•
•
•
Publication
29730504 | J:271090
 
First Author: Rienks M
Year: 2018
Journal: Matrix Biol
Title: SPARC preserves endothelial glycocalyx integrity, and protects against adverse cardiac inflammation and injury during viral myocarditis.
Volume: 74
Pages: 21-34
•
•
•
•
•
Publication
3410046 | -
First Author: Lankat-Buttgereit B
Year: 1988
Journal: FEBS Lett
Title: Cloning and complete amino acid sequences of human and murine basement membrane protein BM-40 (SPARC, osteonectin).
Volume: 236
Issue: 2
Pages: 352-6
•
•
•
•
•
Publication
3109947 | -
First Author: Mann K
Year: 1987
Journal: FEBS Lett
Title: Solubilization of protein BM-40 from a basement membrane tumor with chelating agents and evidence for its identity with osteonectin and SPARC.
Volume: 218
Issue: 1
Pages: 167-72
•
•
•
•
•
Publication
34185677 | J:309416
First Author: Enriquez C
Year: 2021
Journal: Cancer Res
Title: Castration-Induced Downregulation of SPARC in Stromal Cells Drives Neuroendocrine Differentiation of Prostate Cancer.
Volume: 81
Issue: 16
Pages: 4257-4274
•
•
•
•
•
Publication
20195533 | J:157899
First Author: Seet LF
Year: 2010
Journal: PLoS One
Title: SPARC deficiency results in improved surgical survival in a novel mouse model of glaucoma filtration surgery.
Volume: 5
Issue: 2
Pages: e9415
•
•
•
•
•
Publication
33493647 | J:303858
 
First Author: Brayman VL
Year: 2021
Journal: Neurosci Lett
Title: Roles of the synaptic molecules Hevin and SPARC in mouse neuromuscular junction development and repair.
Volume: 746
Pages: 135663
•
•
•
•
•




MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

Copyright © 2017 by The Jackson Laboratory. All Rights Reserved

© 2002 - 2017 Department of Genetics, University of Cambridge, Downing Street,
Cambridge CB2 3EH, United Kingdom