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Search results 1 to 22 out of 22 for Spg20

0.019s

Type

Details

Score

Gene

418902 | SPG20

Type:	gene
Organism:	chicken

•

Publication

21559443 | J:172449

First Author:	Joshi DC
Year:	2011
Journal:	PLoS One
Title:	SPG20 protein spartin associates with cardiolipin via its plant-related senescence domain and regulates mitochondrial Ca2+ homeostasis.
Volume:	6
Issue:	4
Pages:	e19290

•

Protein

Q8R1X6

Organism:	Mus musculus/domesticus
Length:	671
Fragment?:	false

•

Protein

Q8R1X6-2

Organism:	Mus musculus/domesticus
Length:	614
Fragment?:	false

•

Publication

12134148 | -

First Author:	Patel H
Year:	2002
Journal:	Nat Genet
Title:	SPG20 is mutated in Troyer syndrome, an hereditary spastic paraplegia.
Volume:	31
Issue:	4
Pages:	347-8

•

Protein Coding Gene

MGI:2139806 | Spart

Type:	protein_coding_gene
Organism:	mouse, laboratory

•

Publication

20719964 | -

First Author:	Renvoisé B
Year:	2010
Journal:	Mol Biol Cell
Title:	SPG20 protein spartin is recruited to midbodies by ESCRT-III protein Ist1 and participates in cytokinesis.
Volume:	21
Issue:	19
Pages:	3293-303

•

DO Term

DOID:0050886 | Troyer syndrome

•

Gene

23111 | SPART

Type:	gene
Organism:	human

•

Allele

Spart<tm1.1Xen> | MGI:5430946

Name:	spartin; targeted mutation 1.1, Taconic Biosciences
Allele Type:	Targeted
Attribute String:	Null/knockout

•

Genotype

Symbol:	Spart/Spart
Background:	involves: C57BL/6J
Zygosity:	hm
Has Mutant Allele:	true

•

Publication

22619377 | J:185987

First Author:	Renvoisé B
Year:	2012
Journal:	Hum Mol Genet
Title:	Spg20-/- mice reveal multimodal functions for Troyer syndrome protein spartin in lipid droplet maintenance, cytokinesis and BMP signaling.
Volume:	21
Issue:	16
Pages:	3604-18

•

Publication

15823537 | -

First Author:	Roll-Mecak A
Year:	2005
Journal:	Curr Biol
Title:	The Drosophila homologue of the hereditary spastic paraplegia protein, spastin, severs and disassembles microtubules.
Volume:	15
Issue:	7
Pages:	650-5

•

Publication

8075396 | -

First Author:	Kiyosue T
Year:	1994
Journal:	Plant Mol Biol
Title:	Cloning of cDNAs for genes that are early-responsive to dehydration stress (ERDs) in Arabidopsis thaliana L.: identification of three ERDs as HSP cognate genes.
Volume:	25
Issue:	5
Pages:	791-8

•

Protein Domain

IPR045036 | Spartin-like

Type:

Family

Description:

This entry includes senescence/dehydration-associated proteins from plants and Spartin from animals. This group of proteins share the C-terminal AAA ATPase domain [].Besides its C-terminal AAA ATPase domain, Spartin contains an N-terminal MIT (contained within microtubule-interacting and transport molecules) domain and a -P-P-x-Y- motif. Spastin monomers assemble into hexameric, ring-shaped ATPases that sever microtubules along their lengths [, ]. In flies, Spartin has been shown to regulates both synaptic development and neuronal survival by controlling microtubule stability via the BMP-dFMRP-Futsch pathway []. In humans, Spartin (also known as SPG20) has been linked to Troyer syndrome, characterised by spastic dysarthria, cognitive impairment, short stature, and distal muscle wasting in addition to lower extremity spastic weakness []. SPG20 has been shown to be recruited to the midbodyand participates in cytokinesis [].In plants, this group of proteins have been linked to senescence and dehydration [, ]. Different from their animal homologues, they don't have the MIT domain. In Hemerocallis, petals have a genetically based program that leads to senescence and cell death approximately 24 hours after the, flower opens, and it is believed that senescence proteins produced around that time have a role in this program [].

•

Protein

D3Z1M5

Organism:	Mus musculus/domesticus
Length:	92
Fragment?:	true

•

Protein

D3Z2D6

Organism:	Mus musculus/domesticus
Length:	116
Fragment?:	true

•

Publication

10412903 | -

First Author:	Panavas T
Year:	1999
Journal:	Plant Mol Biol
Title:	Identification of senescence-associated genes from daylily petals.
Volume:	40
Issue:	2
Pages:	237-48

•

Publication

18202664 | -

First Author:	Roll-Mecak A
Year:	2008
Journal:	Nature
Title:	Structural basis of microtubule severing by the hereditary spastic paraplegia protein spastin.
Volume:	451
Issue:	7176
Pages:	363-7

•

Publication

23439121 | -

First Author:	Nahm M
Year:	2013
Journal:	Neuron
Title:	Spartin regulates synaptic growth and neuronal survival by inhibiting BMP-mediated microtubule stabilization.
Volume:	77
Issue:	4
Pages:	680-95

•

Protein

D3Z3F8

Organism:	Mus musculus/domesticus
Length:	582
Fragment?:	false

•

Protein

Q3TVW1

Organism:	Mus musculus/domesticus
Length:	671
Fragment?:	false

•

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