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Search results 1 to 100 out of 531 for Sphk1

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0.041s
Type Details Score
Gene
Type: gene
Organism: human
Gene
Type: gene
Organism: chimpanzee
Gene
Type: gene
Organism: dog, domestic
Gene
Type: gene
Organism: cattle
Gene
Type: gene
Organism: chicken
Gene
Type: gene
Organism: zebrafish
Gene
Type: gene
Organism: macaque, rhesus
Gene
Type: gene
Organism: frog, western clawed
Gene
Type: gene
Organism: rat
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Publication        
First Author: Genoway
Year: 2017
Title: Generation of Sphk1 and Sphk2
Publication
First Author: Puneet P
Year: 2010
Journal: Science
Title: SphK1 regulates proinflammatory responses associated with endotoxin and polymicrobial sepsis.
Volume: 328
Issue: 5983
Pages: 1290-4
Publication
First Author: Mohammed S
Year: 2020
Journal: FASEB J
Title: Regulatory role of SphK1 in TLR7/9-dependent type I interferon response and autoimmunity.
Volume: 34
Issue: 3
Pages: 4329-4347
Publication
First Author: Avni D
Year: 2021
Journal: FASEB J
Title: Deletion or inhibition of SphK1 mitigates fulminant hepatic failure by suppressing TNFα-dependent inflammation and apoptosis.
Volume: 35
Issue: 3
Pages: e21415
Gene
Type: gene
Organism: human
Publication
First Author: Lee JY
Year: 2018
Journal: Nat Commun
Title: Neuronal SphK1 acetylates COX2 and contributes to pathogenesis in a model of Alzheimer's Disease.
Volume: 9
Issue: 1
Pages: 1479
Publication
First Author: Maceyka M
Year: 2005
Journal: J Biol Chem
Title: SphK1 and SphK2, sphingosine kinase isoenzymes with opposing functions in sphingolipid metabolism.
Volume: 280
Issue: 44
Pages: 37118-29
Publication  
First Author: Hafizi R
Year: 2022
Journal: Int J Mol Sci
Title: Sphk1 and Sphk2 Differentially Regulate Erythropoietin Synthesis in Mouse Renal Interstitial Fibroblast-like Cells.
Volume: 23
Issue: 11
Publication
First Author: Park SB
Year: 2020
Journal: Dig Dis Sci
Title: Intestinal Epithelial Deletion of Sphk1 Prevents Colitis-Associated Cancer Development by Inhibition of Epithelial STAT3 Activation.
Volume: 65
Issue: 8
Pages: 2284-2293
Publication
First Author: Geng T
Year: 2015
Journal: J Lipid Res
Title: SphK1 mediates hepatic inflammation in a mouse model of NASH induced by high saturated fat feeding and initiates proinflammatory signaling in hepatocytes.
Volume: 56
Issue: 12
Pages: 2359-71
Publication
First Author: Shen H
Year: 2014
Journal: Nat Cell Biol
Title: Coupling between endocytosis and sphingosine kinase 1 recruitment.
Volume: 16
Issue: 7
Pages: 652-62
Publication
First Author: Young MM
Year: 2016
Journal: Cell Rep
Title: Sphingosine Kinase 1 Cooperates with Autophagy to Maintain Endocytic Membrane Trafficking.
Volume: 17
Issue: 6
Pages: 1532-1545
Publication
First Author: Zhang Y
Year: 2014
Journal: J Clin Invest
Title: Elevated sphingosine-1-phosphate promotes sickling and sickle cell disease progression.
Volume: 124
Issue: 6
Pages: 2750-61
Publication
First Author: Bao Y
Year: 2016
Journal: Oncotarget
Title: Tumor suppressor PRSS8 targets Sphk1/S1P/Stat3/Akt signaling in colorectal cancer.
Volume: 7
Issue: 18
Pages: 26780-92
Publication
First Author: Xie J
Year: 2020
Journal: Sci Rep
Title: K27Q/K29Q mutations in sphingosine kinase 1 attenuate high-fat diet induced obesity and altered glucose homeostasis in mice.
Volume: 10
Issue: 1
Pages: 20038
Publication
First Author: Allende ML
Year: 2004
Journal: J Biol Chem
Title: Mice deficient in sphingosine kinase 1 are rendered lymphopenic by FTY720.
Volume: 279
Issue: 50
Pages: 52487-92
Publication
First Author: Lima S
Year: 2017
Journal: J Biol Chem
Title: Sphingosine and Sphingosine Kinase 1 Involvement in Endocytic Membrane Trafficking.
Volume: 292
Issue: 8
Pages: 3074-3088
Publication
First Author: Baker DA
Year: 2010
Journal: J Immunol
Title: Genetic sphingosine kinase 1 deficiency significantly decreases synovial inflammation and joint erosions in murine TNF-alpha-induced arthritis.
Volume: 185
Issue: 4
Pages: 2570-9
Publication
First Author: Shimizu Y
Year: 2018
Journal: Carcinogenesis
Title: Genetic deletion of sphingosine kinase 1 suppresses mouse breast tumor development in an HER2 transgenic model.
Volume: 39
Issue: 1
Pages: 47-55
Publication  
First Author: Schwiebs A
Year: 2016
Journal: Front Pharmacol
Title: Activation-Induced Cell Death of Dendritic Cells Is Dependent on Sphingosine Kinase 1.
Volume: 7
Pages: 94
Publication
First Author: Bachmaier K
Year: 2012
Journal: PLoS One
Title: Sphingosine kinase 1 mediation of expression of the anaphylatoxin receptor C5L2 dampens the inflammatory response to endotoxin.
Volume: 7
Issue: 2
Pages: e30742
Publication
First Author: Zhang X
Year: 2019
Journal: Am J Nephrol
Title: Knockout of Sphingosine Kinase 1 Attenuates Renal Fibrosis in Unilateral Ureteral Obstruction Model.
Volume: 50
Issue: 3
Pages: 196-203
Publication
First Author: Furuya H
Year: 2017
Journal: J Transl Med
Title: Sphingosine kinase 1 expression enhances colon tumor growth.
Volume: 15
Issue: 1
Pages: 120
Publication
First Author: Qi Y
Year: 2013
Journal: FASEB J
Title: Loss of sphingosine kinase 1 predisposes to the onset of diabetes via promoting pancreatic β-cell death in diet-induced obese mice.
Volume: 27
Issue: 10
Pages: 4294-304
Publication
First Author: Rojas-Canales D
Year: 2017
Journal: Diabetes
Title: Local Sphingosine Kinase 1 Activity Improves Islet Transplantation.
Volume: 66
Issue: 5
Pages: 1301-1311
Publication  
First Author: Siedlinski M
Year: 2017
Journal: Sci Rep
Title: Vascular transcriptome profiling identifies Sphingosine kinase 1 as a modulator of angiotensin II-induced vascular dysfunction.
Volume: 7
Pages: 44131
Publication
First Author: Le Scolan E
Year: 2005
Journal: Blood
Title: Overexpression of sphingosine kinase 1 is an oncogenic event in erythroleukemic progression.
Volume: 106
Issue: 5
Pages: 1808-16
Publication
First Author: Yang J
Year: 2005
Journal: J Immunol
Title: Sphingosine kinase 1 is a negative regulator of CD4+ Th1 cells.
Volume: 175
Issue: 10
Pages: 6580-8
Publication
First Author: Poitevin S
Year: 2014
Journal: Cardiovasc Res
Title: Sphingosine kinase 1 expressed by endothelial colony-forming cells has a critical role in their revascularization activity.
Volume: 103
Issue: 1
Pages: 121-30
Publication
First Author: Ju T
Year: 2016
Journal: Biochem Biophys Res Commun
Title: Targeting colorectal cancer cells by a novel sphingosine kinase 1 inhibitor PF-543.
Volume: 470
Issue: 3
Pages: 728-734
Publication
First Author: Kowalski GM
Year: 2015
Journal: Biochim Biophys Acta
Title: Overexpression of sphingosine kinase 1 in liver reduces triglyceride content in mice fed a low but not high-fat diet.
Volume: 1851
Issue: 2
Pages: 210-9
Publication
First Author: Sysol JR
Year: 2018
Journal: Am J Physiol Lung Cell Mol Physiol
Title: Micro-RNA-1 is decreased by hypoxia and contributes to the development of pulmonary vascular remodeling via regulation of sphingosine kinase 1.
Volume: 314
Issue: 3
Pages: L461-L472
Publication  
First Author: Cheresh P
Year: 2020
Journal: Int J Mol Sci
Title: The Sphingosine Kinase 1 Inhibitor, PF543, Mitigates Pulmonary Fibrosis by Reducing Lung Epithelial Cell mtDNA Damage and Recruitment of Fibrogenic Monocytes.
Volume: 21
Issue: 16
Publication
First Author: Alvarez SE
Year: 2010
Journal: Nature
Title: Sphingosine-1-phosphate is a missing cofactor for the E3 ubiquitin ligase TRAF2.
Volume: 465
Issue: 7301
Pages: 1084-8
Publication
First Author: Yu J
Year: 2020
Journal: Transgenic Res
Title: Generation of mice with hepatocyte-specific conditional deletion of sphingosine kinase 1.
Volume: 29
Issue: 4
Pages: 419-428
Publication
First Author: Venkataraman K
Year: 2006
Journal: Biochem J
Title: Extracellular export of sphingosine kinase-1a contributes to the vascular S1P gradient.
Volume: 397
Issue: 3
Pages: 461-71
Publication
First Author: Kim EY
Year: 2014
Journal: FASEB J
Title: Role of sphingosine kinase 1 and sphingosine-1-phosphate in CD40 signaling and IgE class switching.
Volume: 28
Issue: 10
Pages: 4347-58
Publication
First Author: Morishige JI
Year: 2023
Journal: J Lipid Res
Title: Sphingosine kinase 1 is involved in triglyceride breakdown by maintaining lysosomal integrity in brown adipocytes.
Volume: 64
Issue: 11
Pages: 100450
Publication
First Author: Furuya H
Year: 2017
Journal: Carcinogenesis
Title: Sphingosine Kinase 1 expression in peritoneal macrophages is required for colon carcinogenesis.
Volume: 38
Issue: 12
Pages: 1218-1227
Publication
First Author: Lai WQ
Year: 2008
Journal: J Immunol
Title: The role of sphingosine kinase in a murine model of allergic asthma.
Volume: 180
Issue: 6
Pages: 4323-9
Publication
First Author: Nayak D
Year: 2010
Journal: Neuroscience
Title: Sphingosine kinase 1 regulates the expression of proinflammatory cytokines and nitric oxide in activated microglia.
Volume: 166
Issue: 1
Pages: 132-44
Publication  
First Author: Zheng S
Year: 2015
Journal: Exp Neurol
Title: Sphingosine kinase 1 mediates neuroinflammation following cerebral ischemia.
Volume: 272
Pages: 160-9
Publication
First Author: Funaki M
Year: 2017
Journal: Sci Rep
Title: Peretinoin, an acyclic retinoid, inhibits hepatocarcinogenesis by suppressing sphingosine kinase 1 expression in vitro and in vivo.
Volume: 7
Issue: 1
Pages: 16978
Publication
First Author: Di A
Year: 2010
Journal: J Biol Chem
Title: A novel function of sphingosine kinase 1 suppression of JNK activity in preventing inflammation and injury.
Volume: 285
Issue: 21
Pages: 15848-57
Publication  
First Author: Montefusco D
Year: 2022
Journal: Mol Metab
Title: Sphingosine kinase 1 mediates sexual dimorphism in fibrosis in a mouse model of NASH.
Volume: 62
Pages: 101523
Publication
First Author: Tao R
Year: 2007
Journal: Cardiovasc Res
Title: Deletion of the sphingosine kinase-1 gene influences cell fate during hypoxia and glucose deprivation in adult mouse cardiomyocytes.
Volume: 74
Issue: 1
Pages: 56-63
Publication
First Author: Jin ZQ
Year: 2008
Journal: Cardiovasc Res
Title: Ischaemic postconditioning protects isolated mouse hearts against ischaemia/reperfusion injury via sphingosine kinase isoform-1 activation.
Volume: 79
Issue: 1
Pages: 134-40
Publication
First Author: Jin ZQ
Year: 2007
Journal: Cardiovasc Res
Title: A sphingosine kinase 1 mutation sensitizes the myocardium to ischemia/reperfusion injury.
Volume: 76
Issue: 1
Pages: 41-50
Publication
First Author: Jiang ZJ
Year: 2019
Journal: J Neurochem
Title: Extracellular and intracellular sphingosine-1-phosphate distinctly regulates exocytosis in chromaffin cells.
Volume: 149
Issue: 6
Pages: 729-746
Publication
First Author: Olivera A
Year: 2007
Journal: Immunity
Title: The sphingosine kinase-sphingosine-1-phosphate axis is a determinant of mast cell function and anaphylaxis.
Volume: 26
Issue: 3
Pages: 287-97
Publication  
First Author: Vettorazzi S
Year: 2015
Journal: Nat Commun
Title: Glucocorticoids limit acute lung inflammation in concert with inflammatory stimuli by induction of SphK1.
Volume: 6
Pages: 7796
Publication    
First Author: Etemadi N
Year: 2015
Journal: Elife
Title: TRAF2 regulates TNF and NF-κB signalling to suppress apoptosis and skin inflammation independently of Sphingosine kinase 1.
Volume: 4
Publication
First Author: Liu H
Year: 2000
Journal: J Biol Chem
Title: Molecular cloning and functional characterization of a novel mammalian sphingosine kinase type 2 isoform.
Volume: 275
Issue: 26
Pages: 19513-20
Publication
First Author: Grin'kina NM
Year: 2012
Journal: PLoS One
Title: Sphingosine kinase 1 deficiency exacerbates LPS-induced neuroinflammation.
Volume: 7
Issue: 5
Pages: e36475
Publication
First Author: Kharel Y
Year: 2012
Journal: Biochem J
Title: Sphingosine kinase type 2 inhibition elevates circulating sphingosine 1-phosphate.
Volume: 447
Issue: 1
Pages: 149-57
Publication
First Author: Jo SK
Year: 2009
Journal: Kidney Int
Title: Divergent roles of sphingosine kinases in kidney ischemia-reperfusion injury.
Volume: 75
Issue: 2
Pages: 167-75
Publication
First Author: Natoli TA
Year: 2012
Journal: Hum Mol Genet
Title: Loss of GM3 synthase gene, but not sphingosine kinase 1, is protective against murine nephronophthisis-related polycystic kidney disease.
Volume: 21
Issue: 15
Pages: 3397-407
Publication
First Author: Tauseef M
Year: 2008
Journal: Circ Res
Title: Activation of sphingosine kinase-1 reverses the increase in lung vascular permeability through sphingosine-1-phosphate receptor signaling in endothelial cells.
Volume: 103
Issue: 10
Pages: 1164-72
Publication  
First Author: Blot FGC
Year: 2021
Journal: Proc Natl Acad Sci U S A
Title: Sphingolipid metabolism governs Purkinje cell patterned degeneration in Atxn1[82Q]/+ mice.
Volume: 118
Issue: 36
Publication
First Author: Takuwa N
Year: 2010
Journal: Cardiovasc Res
Title: S1P3-mediated cardiac fibrosis in sphingosine kinase 1 transgenic mice involves reactive oxygen species.
Volume: 85
Issue: 3
Pages: 484-93
Publication
First Author: Wilkerson JL
Year: 2019
Journal: Mol Neurobiol
Title: Sphingosine Kinase-1 Is Essential for Maintaining External/Outer Limiting Membrane and Associated Adherens Junctions in the Aging Retina.
Volume: 56
Issue: 10
Pages: 7188-7207
Publication
First Author: Huang LS
Year: 2013
Journal: FASEB J
Title: Targeting sphingosine kinase 1 attenuates bleomycin-induced pulmonary fibrosis.
Volume: 27
Issue: 4
Pages: 1749-60
Publication
First Author: Dillahunt SE
Year: 2013
Journal: J Immunol
Title: Usage of sphingosine kinase isoforms in mast cells is species and/or cell type determined.
Volume: 190
Issue: 5
Pages: 2058-67
Publication
First Author: Kawamori T
Year: 2009
Journal: FASEB J
Title: Role for sphingosine kinase 1 in colon carcinogenesis.
Volume: 23
Issue: 2
Pages: 405-14
Publication
First Author: Tauseef M
Year: 2016
Journal: FASEB J
Title: Transient receptor potential channel 1 maintains adherens junction plasticity by suppressing sphingosine kinase 1 expression to induce endothelial hyperpermeability.
Volume: 30
Issue: 1
Pages: 102-10
Publication
First Author: Albinet V
Year: 2014
Journal: Oncogene
Title: Dual role of sphingosine kinase-1 in promoting the differentiation of dermal fibroblasts and the dissemination of melanoma cells.
Volume: 33
Issue: 26
Pages: 3364-73
Publication  
First Author: Couttas TA
Year: 2020
Journal: Metabolites
Title: A Novel Function of Sphingosine Kinase 2 in the Metabolism of Sphinga-4,14-Diene Lipids.
Volume: 10
Issue: 6
Publication
First Author: Harijith A
Year: 2016
Journal: Am J Physiol Lung Cell Mol Physiol
Title: Hyperoxia-induced p47phox activation and ROS generation is mediated through S1P transporter Spns2, and S1P/S1P1&2 signaling axis in lung endothelium.
Volume: 311
Issue: 2
Pages: L337-51
Publication
First Author: Qi Y
Year: 2015
Journal: J Biol Chem
Title: Sphingosine Kinase 1 Protects Hepatocytes from Lipotoxicity via Down-regulation of IRE1α Protein Expression.
Volume: 290
Issue: 38
Pages: 23282-90
Publication
First Author: Lai WQ
Year: 2009
Journal: J Immunol
Title: Distinct roles of sphingosine kinase 1 and 2 in murine collagen-induced arthritis.
Volume: 183
Issue: 3
Pages: 2097-103
Publication
First Author: Mizutani N
Year: 2013
Journal: Biochim Biophys Acta
Title: Sphingosine kinase 1 expression is downregulated during differentiation of Friend cells due to decreased c-MYB.
Volume: 1833
Issue: 5
Pages: 1006-16
Publication  
First Author: Nussbaum C
Year: 2015
Journal: Nat Commun
Title: Sphingosine-1-phosphate receptor 3 promotes leukocyte rolling by mobilizing endothelial P-selectin.
Volume: 6
Pages: 6416
Publication
First Author: Xiong Y
Year: 2013
Journal: J Biol Chem
Title: Sphingosine kinases are not required for inflammatory responses in macrophages.
Volume: 288
Issue: 45
Pages: 32563-73
Publication
First Author: Chen J
Year: 2014
Journal: Am J Respir Crit Care Med
Title: The sphingosine kinase 1/sphingosine-1-phosphate pathway in pulmonary arterial hypertension.
Volume: 190
Issue: 9
Pages: 1032-43
Publication
First Author: Zhang W
Year: 2014
Journal: J Biol Chem
Title: Adipocyte lipolysis-stimulated interleukin-6 production requires sphingosine kinase 1 activity.
Volume: 289
Issue: 46
Pages: 32178-85
Publication
First Author: Urtz N
Year: 2004
Journal: Mol Cell Biol
Title: Early activation of sphingosine kinase in mast cells and recruitment to FcepsilonRI are mediated by its interaction with Lyn kinase.
Volume: 24
Issue: 19
Pages: 8765-77
Publication  
First Author: Chen J
Year: 2022
Journal: Int J Mol Sci
Title: Sphingosine Kinase 1 Deficiency in Smooth Muscle Cells Protects against Hypoxia-Mediated Pulmonary Hypertension via YAP1 Signaling.
Volume: 23
Issue: 23
Publication  
First Author: Thuy AV
Year: 2022
Journal: Int J Mol Sci
Title: The Impact of Sphingosine Kinases on Inflammation-Induced Cytokine Release and Vascular Endothelial Barrier Integrity.
Volume: 23
Issue: 21
Publication  
First Author: Walker JM
Year: 2021
Journal: Endocrinology
Title: An Unanticipated Role for Sphingosine Kinase-2 in Bone and in the Anabolic Effect of Parathyroid Hormone.
Volume: 162
Issue: 5
Publication  
First Author: Canlas J
Year: 2015
Journal: Front Mol Neurosci
Title: Sphingosine kinase 2-deficiency mediated changes in spinal pain processing.
Volume: 8
Pages: 29
Publication
First Author: Wadgaonkar R
Year: 2009
Journal: Am J Physiol Lung Cell Mol Physiol
Title: Differential regulation of sphingosine kinases 1 and 2 in lung injury.
Volume: 296
Issue: 4
Pages: L603-13
Publication
First Author: Chakraborty P
Year: 2019
Journal: Cell Rep
Title: Pro-Survival Lipid Sphingosine-1-Phosphate Metabolically Programs T Cells to Limit Anti-tumor Activity.
Volume: 28
Issue: 7
Pages: 1879-1893.e7
Publication
First Author: Panayotis N
Year: 2018
Journal: Cell Rep
Title: Importin α5 Regulates Anxiety through MeCP2 and Sphingosine Kinase 1.
Volume: 25
Issue: 11
Pages: 3169-3179.e7
Publication
First Author: Sun K
Year: 2015
Journal: Blood
Title: Elevated adenosine signaling via adenosine A2B receptor induces normal and sickle erythrocyte sphingosine kinase 1 activity.
Volume: 125
Issue: 10
Pages: 1643-52
Publication
First Author: Ishimaru K
Year: 2019
Journal: Sci Rep
Title: Sphingosine kinase-2 prevents macrophage cholesterol accumulation and atherosclerosis by stimulating autophagic lipid degradation.
Volume: 9
Issue: 1
Pages: 18329
Publication
First Author: Chen J
Year: 2016
Journal: Biochim Biophys Acta
Title: Deletion of sphingosine kinase 1 ameliorates hepatic steatosis in diet-induced obese mice: Role of PPARγ.
Volume: 1861
Issue: 2
Pages: 138-147
Publication
First Author: Olivera A
Year: 2006
Journal: J Biol Chem
Title: IgE-dependent activation of sphingosine kinases 1 and 2 and secretion of sphingosine 1-phosphate requires Fyn kinase and contributes to mast cell responses.
Volume: 281
Issue: 5
Pages: 2515-25
Publication
First Author: Lan T
Year: 2018
Journal: Hepatology
Title: Sphingosine kinase 1 promotes liver fibrosis by preventing miR-19b-3p-mediated inhibition of CCR2.
Volume: 68
Issue: 3
Pages: 1070-1086
Publication      
First Author: Nguyen TQ
Year: 2020
Journal: J Biol Chem
Title: Erythrocytes efficiently utilize exogenous sphingosines for S1P synthesis and export via Mfsd2b.
Publication
First Author: Harijith A
Year: 2013
Journal: Am J Pathol
Title: Sphingosine kinase 1 deficiency confers protection against hyperoxia-induced bronchopulmonary dysplasia in a murine model: role of S1P signaling and Nox proteins.
Volume: 183
Issue: 4
Pages: 1169-82