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Search results 1 to 100 out of 368 for Sphk2

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Type Details Score
Gene
56848 | SPHK2
Type: gene
Organism: human
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Gene
468943 | SPHK2
Type: gene
Organism: chimpanzee
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Gene
533103 | SPHK2
Type: gene
Organism: cattle
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Gene
100150090 | sphk2
Type: gene
Organism: zebrafish
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Gene
718088 | SPHK2
Type: gene
Organism: macaque, rhesus
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Gene
100494664 | sphk2
Type: gene
Organism: frog, western clawed
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Gene
308589 | Sphk2
Type: gene
Organism: rat
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Gene
484401 | SPHK2
Type: gene
Organism: dog, domestic
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Protein Coding Gene
MGI:1861380 | Sphk2
Type: protein_coding_gene
Organism: mouse, laboratory
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Publication
32546724 | J:293399
First Author: Zhang YH
Year: 2020
Journal: Oncogene
Title: SphK2 confers 5-fluorouracil resistance to colorectal cancer via upregulating H3K56ac-mediated DPD expression.
Volume: 39
Issue: 29
Pages: 5214-5227
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Publication
35682566 | J:327558
 
First Author: Hafizi R
Year: 2022
Journal: Int J Mol Sci
Title: Sphk1 and Sphk2 Differentially Regulate Erythropoietin Synthesis in Mouse Renal Interstitial Fibroblast-like Cells.
Volume: 23
Issue: 11
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Publication
35260749 | J:322541
First Author: Martín-Hernández D
Year: 2022
Journal: Sci Rep
Title: Sphk2 deletion is involved in structural abnormalities and Th17 response but does not aggravate colon inflammation induced by sub-chronic stress.
Volume: 12
Issue: 1
Pages: 4073
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Publication
- | J:248572
       
First Author: Genoway
Year: 2017
Title: Generation of Sphk1 and Sphk2
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Publication
31842752 | J:283003
First Author: Ebenezer DL
Year: 2019
Journal: BMC Genomics
Title: Genetic deletion of Sphk2 confers protection against Pseudomonas aeruginosa mediated differential expression of genes related to virulent infection and inflammation in mouse lung.
Volume: 20
Issue: 1
Pages: 984
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Publication
28807595 | J:248835
First Author: Schwalm S
Year: 2017
Journal: Am J Pathol
Title: Sphingosine Kinase-2 Deficiency Ameliorates Kidney Fibrosis by Up-Regulating Smad7 in a Mouse Model of Unilateral Ureteral Obstruction.
Volume: 187
Issue: 11
Pages: 2413-2429
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Publication
24859201 | J:213200
First Author: Hait NC
Year: 2014
Journal: Nat Neurosci
Title: Active, phosphorylated fingolimod inhibits histone deacetylases and facilitates fear extinction memory.
Volume: 17
Issue: 7
Pages: 971-80
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Publication
32917816 | J:296267
First Author: Aji G
Year: 2020
Journal: Proc Natl Acad Sci U S A
Title: Regulation of hepatic insulin signaling and glucose homeostasis by sphingosine kinase 2.
Volume: 117
Issue: 39
Pages: 24434-24442
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Publication
31123291 | J:279887
First Author: Qi H
Year: 2019
Journal: Sci Rep
Title: Sphingosine Kinase 2 Phosphorylation of FTY720 is Unnecessary for Prevention of Light-Induced Retinal Damage.
Volume: 9
Issue: 1
Pages: 7771
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Publication
16093248 | J:102911
First Author: Kharel Y
Year: 2005
Journal: J Biol Chem
Title: Sphingosine kinase 2 is required for modulation of lymphocyte traffic by FTY720.
Volume: 280
Issue: 44
Pages: 36865-72
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Publication
30593892 | J:270483
First Author: Ravichandran S
Year: 2019
Journal: Biochim Biophys Acta Mol Basis Dis
Title: Sphk2-/- mice are protected from obesity and insulin resistance.
Volume: 1865
Issue: 3
Pages: 570-576
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Publication
29518138 | J:258749
First Author: Ghosh M
Year: 2018
Journal: PLoS One
Title: Cell-intrinsic sphingosine kinase 2 promotes macrophage polarization and renal inflammation in response to unilateral ureteral obstruction.
Volume: 13
Issue: 3
Pages: e0194053
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Publication
34474613 | J:341293
First Author: Jiménez-Altayó F
Year: 2022
Journal: J Cereb Blood Flow Metab
Title: Arachnoid membrane as a source of sphingosine-1-phosphate that regulates mouse middle cerebral artery tone.
Volume: 42
Issue: 1
Pages: 162-174
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Publication
36541910 | J:333513
First Author: Weigel C
Year: 2023
Journal: Cancer Res
Title: Sphingosine Kinase 2 in Stromal Fibroblasts Creates a Hospitable Tumor Microenvironment in Breast Cancer.
Volume: 83
Issue: 4
Pages: 553-567
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Publication
31003959 | J:295717
First Author: Kwong EK
Year: 2019
Journal: Dig Liver Dis
Title: The role of sphingosine kinase 2 in alcoholic liver disease.
Volume: 51
Issue: 8
Pages: 1154-1163
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Publication
21872577 | J:177531
First Author: Pfeilschifter W
Year: 2011
Journal: Biochem Biophys Res Commun
Title: Activation of sphingosine kinase 2 is an endogenous protective mechanism in cerebral ischemia.
Volume: 413
Issue: 2
Pages: 212-7
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Publication
28625547 | J:249705
 
First Author: Lei M
Year: 2017
Journal: Behav Brain Res
Title: Contextual fear conditioning is enhanced in mice lacking functional sphingosine kinase 2.
Volume: 333
Pages: 9-16
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Publication
34399014 | J:323971
First Author: Song H
Year: 2021
Journal: Glia
Title: Sphingosine kinase 2 is essential for remyelination following cuprizone intoxication.
Volume: 69
Issue: 12
Pages: 2863-2881
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Publication
31128248 | J:276976
First Author: Weigert A
Year: 2019
Journal: Biochim Biophys Acta Mol Cell Biol Lipids
Title: Sphingosine kinase 2 is a negative regulator of inflammatory macrophage activation.
Volume: 1864
Issue: 9
Pages: 1235-1246
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Publication
29392309 | J:256964
First Author: Eresch J
Year: 2018
Journal: Invest Ophthalmol Vis Sci
Title: Sphingosine Kinase 2 Modulates Retinal Neovascularization in the Mouse Model of Oxygen-Induced Retinopathy.
Volume: 59
Issue: 2
Pages: 653-661
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Publication
32065229 | J:289156
First Author: Kharel Y
Year: 2020
Journal: Biochem J
Title: Mechanism of sphingosine 1-phosphate clearance from blood.
Volume: 477
Issue: 5
Pages: 925-935
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Publication
30840833 | J:292022
First Author: Mohammed S
Year: 2019
Journal: FASEB J
Title: Examination of the role of sphingosine kinase 2 in a murine model of systemic lupus erythematosus.
Volume: 33
Issue: 6
Pages: 7061-7071
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Publication
16223773 | J:129314
First Author: Zemann B
Year: 2006
Journal: Blood
Title: Sphingosine kinase type 2 is essential for lymphopenia induced by the immunomodulatory drug FTY720.
Volume: 107
Issue: 4
Pages: 1454-8
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Publication
17346996 | J:120074
First Author: Olivera A
Year: 2007
Journal: Immunity
Title: The sphingosine kinase-sphingosine-1-phosphate axis is a determinant of mast cell function and anaphylaxis.
Volume: 26
Issue: 3
Pages: 287-97
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Publication
17947634 | J:153014
First Author: Samy ET
Year: 2007
Journal: J Immunol
Title: Cutting edge: Modulation of intestinal autoimmunity and IL-2 signaling by sphingosine kinase 2 independent of sphingosine 1-phosphate.
Volume: 179
Issue: 9
Pages: 5644-8
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Publication
16118219 | J:273514
First Author: Maceyka M
Year: 2005
Journal: J Biol Chem
Title: SphK1 and SphK2, sphingosine kinase isoenzymes with opposing functions in sphingolipid metabolism.
Volume: 280
Issue: 44
Pages: 37118-29
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Publication
10751414 | J:62994
First Author: Liu H
Year: 2000
Journal: J Biol Chem
Title: Molecular cloning and functional characterization of a novel mammalian sphingosine kinase type 2 isoform.
Volume: 275
Issue: 26
Pages: 19513-20
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Publication
32897877 | J:299980
First Author: Studstill CJ
Year: 2020
Journal: J Clin Invest
Title: Sphingosine kinase 2 restricts T cell immunopathology but permits viral persistence.
Volume: 130
Issue: 12
Pages: 6523-6538
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Publication
22747486 | J:191026
First Author: Kharel Y
Year: 2012
Journal: Biochem J
Title: Sphingosine kinase type 2 inhibition elevates circulating sphingosine 1-phosphate.
Volume: 447
Issue: 1
Pages: 149-57
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Publication
23359503 | J:193463
First Author: Dillahunt SE
Year: 2013
Journal: J Immunol
Title: Usage of sphingosine kinase isoforms in mast cells is species and/or cell type determined.
Volume: 190
Issue: 5
Pages: 2058-67
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Publication
28082452 | J:259018
First Author: Meissner A
Year: 2017
Journal: Cardiovasc Res
Title: Sphingosine-1-phosphate signalling-a key player in the pathogenesis of Angiotensin II-induced hypertension.
Volume: 113
Issue: 2
Pages: 123-133
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Publication
30251698 | J:270611
First Author: Zhu X
Year: 2018
Journal: Biochim Biophys Acta Mol Basis Dis
Title: Sphingosine kinase 2 cooperating with Fyn promotes kidney fibroblast activation and fibrosis via STAT3 and AKT.
Volume: 1864
Issue: 11
Pages: 3824-3836
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Publication
26129975 | J:249239
First Author: Urtz N
Year: 2015
Journal: Circ Res
Title: Sphingosine 1-Phosphate Produced by Sphingosine Kinase 2 Intrinsically Controls Platelet Aggregation In Vitro and In Vivo.
Volume: 117
Issue: 4
Pages: 376-87
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Publication
18971925 | J:145617
First Author: Jo SK
Year: 2009
Journal: Kidney Int
Title: Divergent roles of sphingosine kinases in kidney ischemia-reperfusion injury.
Volume: 75
Issue: 2
Pages: 167-75
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Publication
17292973 | J:141742
First Author: Zemann B
Year: 2007
Journal: Immunol Lett
Title: Normal neutrophil functions in sphingosine kinase type 1 and 2 knockout mice.
Volume: 109
Issue: 1
Pages: 56-63
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Publication
32521763 | J:298973
 
First Author: Couttas TA
Year: 2020
Journal: Metabolites
Title: A Novel Function of Sphingosine Kinase 2 in the Metabolism of Sphinga-4,14-Diene Lipids.
Volume: 10
Issue: 6
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Publication
19596980 | J:151588
First Author: Lai WQ
Year: 2009
Journal: J Immunol
Title: Distinct roles of sphingosine kinase 1 and 2 in murine collagen-induced arthritis.
Volume: 183
Issue: 3
Pages: 2097-103
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Publication
20959514 | J:273588
First Author: Strub GM
Year: 2011
Journal: FASEB J
Title: Sphingosine-1-phosphate produced by sphingosine kinase 2 in mitochondria interacts with prohibitin 2 to regulate complex IV assembly and respiration.
Volume: 25
Issue: 2
Pages: 600-12
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Publication
20026661 | J:156826
First Author: Pham TH
Year: 2010
Journal: J Exp Med
Title: Lymphatic endothelial cell sphingosine kinase activity is required for lymphocyte egress and lymphatic patterning.
Volume: 207
Issue: 1
Pages: 17-27
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Publication
24081141 | J:204993
First Author: Xiong Y
Year: 2013
Journal: J Biol Chem
Title: Sphingosine kinases are not required for inflammatory responses in macrophages.
Volume: 288
Issue: 45
Pages: 32563-73
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Publication
25637806 | J:221807
 
First Author: Sivasubramanian M
Year: 2015
Journal: Neuroscience
Title: Sphingosine kinase 2 and sphingosine-1-phosphate promotes mitochondrial function in dopaminergic neurons of mouse model of Parkinson's disease and in MPP+ -treated MN9D cells in vitro.
Volume: 290
Pages: 636-48
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Publication
26283908 | J:290048
 
First Author: Canlas J
Year: 2015
Journal: Front Mol Neurosci
Title: Sphingosine kinase 2-deficiency mediated changes in spinal pain processing.
Volume: 8
Pages: 29
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Publication
33640975 | J:316862
 
First Author: Walker JM
Year: 2021
Journal: Endocrinology
Title: An Unanticipated Role for Sphingosine Kinase-2 in Bone and in the Anabolic Effect of Parathyroid Hormone.
Volume: 162
Issue: 5
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Publication
19168577 | J:149705
First Author: Wadgaonkar R
Year: 2009
Journal: Am J Physiol Lung Cell Mol Physiol
Title: Differential regulation of sphingosine kinases 1 and 2 in lung injury.
Volume: 296
Issue: 4
Pages: L603-13
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Publication
23775711 | J:201763
First Author: Zhang L
Year: 2013
Journal: Blood
Title: Sphingosine kinase 2 (Sphk2) regulates platelet biogenesis by providing intracellular sphingosine 1-phosphate (S1P).
Volume: 122
Issue: 5
Pages: 791-802
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Publication
23043544 | J:191001
First Author: Wacker BK
Year: 2012
Journal: J Neurochem
Title: Hypoxic preconditioning induces stroke tolerance in mice via a cascading HIF, sphingosine kinase, and CCL2 signaling pathway.
Volume: 123
Issue: 6
Pages: 954-62
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Publication
31797978 | J:297801
First Author: Ishimaru K
Year: 2019
Journal: Sci Rep
Title: Sphingosine kinase-2 prevents macrophage cholesterol accumulation and atherosclerosis by stimulating autophagic lipid degradation.
Volume: 9
Issue: 1
Pages: 18329
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Publication
27799486 | J:292972
First Author: Bajwa A
Year: 2017
Journal: J Am Soc Nephrol
Title: Sphingosine Kinase 2 Deficiency Attenuates Kidney Fibrosis via IFN-γ.
Volume: 28
Issue: 4
Pages: 1145-1161
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Publication
16316995 | J:148067
First Author: Olivera A
Year: 2006
Journal: J Biol Chem
Title: IgE-dependent activation of sphingosine kinases 1 and 2 and secretion of sphingosine 1-phosphate requires Fyn kinase and contributes to mast cell responses.
Volume: 281
Issue: 5
Pages: 2515-25
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Publication
34015468 | J:321734
 
First Author: Imeri F
Year: 2021
Journal: Matrix Biol
Title: Loss of sphingosine kinase 2 enhances Wilm's tumor suppressor gene 1 and nephrin expression in podocytes and protects from streptozotocin-induced podocytopathy and albuminuria in mice.
Volume: 98
Pages: 32-48
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Publication
20407207 | J:161468
First Author: Olivera A
Year: 2010
Journal: J Clin Invest
Title: Sphingosine kinase 1 and sphingosine-1-phosphate receptor 2 are vital to recovery from anaphylactic shock in mice.
Volume: 120
Issue: 5
Pages: 1429-40
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Publication
30655318 | J:272408
First Author: Vaidya M
Year: 2019
Journal: J Lipid Res
Title: Regulation of ABCA1-mediated cholesterol efflux by sphingosine-1-phosphate signaling in macrophages.
Volume: 60
Issue: 3
Pages: 506-515
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Publication
22096531 | J:180974
First Author: Meng H
Year: 2011
Journal: PLoS One
Title: Loss of sphingosine kinase 1/S1P signaling impairs cell growth and survival of neurons and progenitor cells in the developing sensory ganglia.
Volume: 6
Issue: 11
Pages: e27150
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Protein Coding Gene
MGP_CAROLIEiJ_G0029739 | -
Type: protein_coding_gene
Organism: Mus caroli
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Protein Coding Gene
MGP_129S1SvImJ_G0032242 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AJ_G0032221 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AKRJ_G0032157 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_BALBcJ_G0032233 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C3HHeJ_G0031948 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI_C57BL6J_1861380 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C57BL6NJ_G0032725 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CASTEiJ_G0031277 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CBAJ_G0031913 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_DBA2J_G0032071 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_FVBNJ_G0032022 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_LPJ_G0032149 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NODShiLtJ_G0032059 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NZOHlLtJ_G0032741 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PWKPhJ_G0030999 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_WSBEiJ_G0031394 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PahariEiJ_G0012964 | -
Type: protein_coding_gene
Organism: Mus pahari
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Protein Coding Gene
MGP_SPRETEiJ_G0030837 | -
Type: protein_coding_gene
Organism: Mus spretus
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Publication
26808312 | J:279745
 
First Author: Imeri F
Year: 2016
Journal: Neuropharmacology
Title: Sphingosine kinase 2 deficient mice exhibit reduced experimental autoimmune encephalomyelitis: Resistance to FTY720 but not ST-968 treatments.
Volume: 105
Pages: 341-350
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Publication
30452878 | J:288002
First Author: Song Z
Year: 2019
Journal: FASEB J
Title: Sphingosine kinase 2 promotes lipotoxicity in pancreatic β-cells and the progression of diabetes.
Volume: 33
Issue: 3
Pages: 3636-3646
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Publication
23273921 | J:194356
First Author: Liang J
Year: 2013
Journal: Cancer Cell
Title: Sphingosine-1-phosphate links persistent STAT3 activation, chronic intestinal inflammation, and development of colitis-associated cancer.
Volume: 23
Issue: 1
Pages: 107-20
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Publication
20220090 | J:160054
First Author: Sensken SC
Year: 2010
Journal: J Immunol
Title: Redistribution of sphingosine 1-phosphate by sphingosine kinase 2 contributes to lymphopenia.
Volume: 184
Issue: 8
Pages: 4133-42
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Publication
11777919 | J:114016
First Author: Xia P
Year: 2002
Journal: J Biol Chem
Title: Sphingosine kinase interacts with TRAF2 and dissects tumor necrosis factor-alpha signaling.
Volume: 277
Issue: 10
Pages: 7996-8003
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Publication
23301082 | J:195816
First Author: Snider AJ
Year: 2013
Journal: PLoS One
Title: Inhibition of sphingosine kinase-2 in a murine model of lupus nephritis.
Volume: 8
Issue: 1
Pages: e53521
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Publication
29748384 | J:264539
First Author: Panneer Selvam S
Year: 2018
Journal: J Biol Chem
Title: Balance between senescence and apoptosis is regulated by telomere damage-induced association between p16 and caspase-3.
Volume: 293
Issue: 25
Pages: 9784-9800
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Publication
35792869 | J:330024
First Author: Miao RR
Year: 2022
Journal: FASEB J
Title: Intestinal aberrant sphingolipid metabolism shaped-gut microbiome and bile acids metabolome in the development of hepatic steatosis.
Volume: 36
Issue: 8
Pages: e22398
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GXD Expression
GXD Expression
     
Probe: MGI:2148862
Assay Type: Northern blot
Annotation Date: 2001-08-30
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1610528
Stage: TS28
Assay Id: MGI:2148917
Age: postnatal adult
Specimen Label: heart
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
     
Probe: MGI:2148862
Assay Type: Northern blot
Annotation Date: 2001-08-30
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:2148917
Age: postnatal adult
Specimen Label: brain
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
     
Probe: MGI:2148862
Assay Type: Northern blot
Annotation Date: 2001-08-30
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1876728
Stage: TS28
Assay Id: MGI:2148917
Age: postnatal adult
Specimen Label: spleen
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
     
Probe: MGI:2148862
Assay Type: Northern blot
Annotation Date: 2001-08-30
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1672828
Stage: TS28
Assay Id: MGI:2148917
Age: postnatal adult
Specimen Label: lung
Detected: true
Specimen Num: 4
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GXD Expression
GXD Expression
     
Probe: MGI:2148862
Assay Type: Northern blot
Annotation Date: 2001-08-30
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1684628
Stage: TS28
Assay Id: MGI:2148917
Age: postnatal adult
Specimen Label: liver
Detected: true
Specimen Num: 5
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GXD Expression
GXD Expression
     
Probe: MGI:2148862
Assay Type: Northern blot
Annotation Date: 2001-08-30
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3598828
Stage: TS28
Assay Id: MGI:2148917
Age: postnatal adult
Specimen Label: skeletal muscle
Detected: true
Specimen Num: 6
•
•
•
•
•
GXD Expression
GXD Expression
     
Probe: MGI:2148862
Assay Type: Northern blot
Annotation Date: 2001-08-30
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1737328
Stage: TS28
Assay Id: MGI:2148917
Age: postnatal adult
Specimen Label: kidney
Detected: true
Specimen Num: 7
•
•
•
•
•
GXD Expression
GXD Expression
     
Probe: MGI:2148862
Assay Type: Northern blot
Annotation Date: 2001-08-30
Strength: Present
Sex: Male
Emaps: EMAPS:1797228
Stage: TS28
Assay Id: MGI:2148917
Age: postnatal adult
Specimen Label: testis
Detected: true
Specimen Num: 8
•
•
•
•
•
GXD Expression
GXD Expression
     
Probe: MGI:2148862
Assay Type: Northern blot
Annotation Date: 2001-08-30
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603910
Stage: TS10
Assay Id: MGI:2148919
Age: embryonic day 7.0
Specimen Label: E7
Detected: true
Specimen Num: 1
•
•
•
•
•
GXD Expression
GXD Expression
     
Probe: MGI:2148862
Assay Type: Northern blot
Annotation Date: 2001-08-30
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603918
Stage: TS18
Assay Id: MGI:2148919
Age: embryonic day 11.0
Specimen Label: E11
Detected: true
Specimen Num: 2
•
•
•
•
•
GXD Expression
GXD Expression
     
Probe: MGI:2148862
Assay Type: Northern blot
Annotation Date: 2001-08-30
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603923
Stage: TS23
Assay Id: MGI:2148919
Age: embryonic day 15.0
Specimen Label: E15
Detected: true
Specimen Num: 3
•
•
•
•
•




MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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