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Search results 1 to 84 out of 84 for Sppl2b

0.046s

Categories

Hits by Pathway

Hits by Strain

Hits by Category

Type Details Score
Gene
56928 | SPPL2B
Type: gene
Organism: human
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Gene
750100 | SPPL2B
Type: gene
Organism: chimpanzee
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Gene
504285 | SPPL2B
Type: gene
Organism: cattle
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Gene
710493 | SPPL2B
Type: gene
Organism: macaque, rhesus
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Gene
780336 | sppl2b
Type: gene
Organism: frog, western clawed
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Gene
362828 | Sppl2b
Type: gene
Organism: rat
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Gene
485071 | SPPL2B
Type: gene
Organism: dog, domestic
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Protein Coding Gene
MGI:1920468 | Sppl2b
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Domain
IPR033149 | SPPL2B
Type: Family
Description: Signal peptide peptidase-like 2B (MEROPS identifier A22.004) is a transmembrane, aspartic endopeptidase that performs regulated intramembrane proteolysis of type II transmembrane proteins []. It is primarily expressed at the cell surface []. It is known to cleave tumour necrosis factor alpha at multiple sites, releasing an intracellular domain that moves to the nucleus and triggers interleukin-12 production [, ]. Other proteins are cleaved, including the membrane stubs of transferrin receptor 1, the British dementia protein 2 and neuroregulin 1 following the shedding of the ectodomain mediated by other peptidases such as ADAM-10 and BACE-1 [, , ].
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Publication
21896273 | J:176424
First Author: Behnke J
Year: 2011
Journal: FEBS Lett
Title: Signal-peptide-peptidase-like 2a (SPPL2a) is targeted to lysosomes/late endosomes by a tyrosine motif in its C-terminal tail.
Volume: 585
Issue: 19
Pages: 2951-7
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Publication
36047592 | J:329412
     
First Author: Ballin M
Year: 2022
Journal: FEBS J
Title: The intramembrane proteases SPPL2a and SPPL2b regulate the homeostasis of selected SNARE proteins.
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Protein
Q3TD49
Organism: Mus musculus/domesticus
Length: 578  
Fragment?: false
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Publication
16829952 | -
First Author: Friedmann E
Year: 2006
Journal: Nat Cell Biol
Title: SPPL2a and SPPL2b promote intramembrane proteolysis of TNFalpha in activated dendritic cells to trigger IL-12 production.
Volume: 8
Issue: 8
Pages: 843-8
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Protein
A0A1W2P7P8
Organism: Mus musculus/domesticus
Length: 266  
Fragment?: false
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Protein
A0A1W2P794
Organism: Mus musculus/domesticus
Length: 259  
Fragment?: true
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Protein
Q8BXJ5
Organism: Mus musculus/domesticus
Length: 383  
Fragment?: false
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Protein
A0A1W2P6U2
Organism: Mus musculus/domesticus
Length: 239  
Fragment?: true
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Protein
A0A1W2P8D1
Organism: Mus musculus/domesticus
Length: 374  
Fragment?: true
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Publication
16829951 | -
First Author: Fluhrer R
Year: 2006
Journal: Nat Cell Biol
Title: A gamma-secretase-like intramembrane cleavage of TNFalpha by the GxGD aspartyl protease SPPL2b.
Volume: 8
Issue: 8
Pages: 894-6
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Publication
23384347 | -
First Author: Zahn C
Year: 2013
Journal: FEBS J
Title: The transferrin receptor-1 membrane stub undergoes intramembrane proteolysis by signal peptide peptidase-like 2b.
Volume: 280
Issue: 7
Pages: 1653-63
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Publication
17965014 | -
First Author: Martin L
Year: 2008
Journal: J Biol Chem
Title: Regulated intramembrane proteolysis of Bri2 (Itm2b) by ADAM10 and SPPL2a/SPPL2b.
Volume: 283
Issue: 3
Pages: 1644-52
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Publication
26574544 | -
First Author: Fleck D
Year: 2016
Journal: J Biol Chem
Title: Proteolytic Processing of Neuregulin 1 Type III by Three Intramembrane-cleaving Proteases.
Volume: 291
Issue: 1
Pages: 318-33
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Publication
25824657 | -
First Author: Mentrup T
Year: 2015
Journal: Traffic
Title: A Cell-Based Assay Reveals Nuclear Translocation of Intracellular Domains Released by SPPL Proteases.
Volume: 16
Issue: 8
Pages: 871-92
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Publication
24492962 | J:213519
First Author: Schneppenheim J
Year: 2014
Journal: Mol Cell Biol
Title: The intramembrane proteases signal Peptide peptidase-like 2a and 2b have distinct functions in vivo.
Volume: 34
Issue: 8
Pages: 1398-411
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Protein Coding Gene
MGP_CAROLIEiJ_G0015608 | -
Type: protein_coding_gene
Organism: Mus caroli
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Protein Coding Gene
MGP_129S1SvImJ_G0017525 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AJ_G0017503 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AKRJ_G0017464 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_BALBcJ_G0017465 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C3HHeJ_G0017288 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI_C57BL6J_1920468 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C57BL6NJ_G0017919 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CASTEiJ_G0016855 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CBAJ_G0017260 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_DBA2J_G0017366 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_FVBNJ_G0017360 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_LPJ_G0017437 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NODShiLtJ_G0017386 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NZOHlLtJ_G0017960 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PWKPhJ_G0016636 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_WSBEiJ_G0016915 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PahariEiJ_G0031021 | -
Type: protein_coding_gene
Organism: Mus pahari
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Protein Coding Gene
MGP_SPRETEiJ_G0016426 | -
Type: protein_coding_gene
Organism: Mus spretus
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GXD Expression
GXD Expression
   
Probe: MGI:3323082
Assay Type: RNA in situ
Annotation Date: 2009-01-23
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1603911
Pattern: Ubiquitous
Stage: TS11
Assay Id: MGI:3828555
Age: embryonic day 7.5
Specimen Label: E7.5
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
   
Probe: MGI:3323082
Assay Type: RNA in situ
Annotation Date: 2009-01-23
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1603913
Pattern: Ubiquitous
Stage: TS13
Assay Id: MGI:3828555
Age: embryonic day 8.5
Specimen Label: E8.5
Detected: true
Specimen Num: 2
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Publication
30819724 | J:275231
First Author: Mentrup T
Year: 2019
Journal: J Exp Med
Title: Atherogenic LOX-1 signaling is controlled by SPPL2-mediated intramembrane proteolysis.
Volume: 216
Issue: 4
Pages: 807-830
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Publication
18973680 | J:141291
 
First Author: Tamplin OJ
Year: 2008
Journal: BMC Genomics
Title: Microarray analysis of Foxa2 mutant mouse embryos reveals novel gene expression and inductive roles for the gastrula organizer and its derivatives.
Volume: 9
Pages: 511
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Publication
10512203 | J:93290
First Author: Araki K
Year: 1999
Journal: Cell Mol Biol (Noisy-le-grand)
Title: Exchangeable gene trap using the Cre/mutated lox system.
Volume: 45
Issue: 5
Pages: 737-50
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Publication
15840001 | J:110088
First Author: Taniwaki T
Year: 2005
Journal: Dev Growth Differ
Title: Characterization of an exchangeable gene trap using pU-17 carrying a stop codon-beta geo cassette.
Volume: 47
Issue: 3
Pages: 163-72
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Publication
- | J:73065
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2001
Title: Gene Ontology Annotation by the MGI Curatorial Staff
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Publication
- | J:265051
     
First Author: MGI and IMPC
Year: 2018
Journal: Database Release
Title: MGI Load of Endonuclease-Mediated Alleles (CRISPR) from the International Mouse Phenotyping Consortium (IMPC)
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Publication
- | J:136110
     
First Author: Velocigene
Year: 2008
Journal: MGI Direct Data Submission
Title: Alleles produced for the KOMP project by Velocigene (Regeneron Pharmaceuticals)
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Publication
- | J:157065
     
First Author: Helmholtz Zentrum Muenchen GmbH
Year: 2010
Journal: MGI Direct Data Submission
Title: Alleles produced for the EUCOMM and EUCOMMTools projects by the Helmholtz Zentrum Muenchen GmbH (Hmgu)
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Publication
- | J:342605
       
First Author: GOA curators
Year: 2016
Title: Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
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Publication
- | J:342604
       
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
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Publication
16141072 | J:99680
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
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Publication
11217851 | J:65060
First Author: Kawai J
Year: 2001
Journal: Nature
Title: Functional annotation of a full-length mouse cDNA collection.
Volume: 409
Issue: 6821
Pages: 685-90
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Publication
- | J:23000
       
First Author: MGD Nomenclature Committee
Year: 1995
Title: Nomenclature Committee Use
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Publication
- | J:141210
     
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
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Publication
- | J:293217
       
First Author: GemPharmatech
Year: 2020
Title: GemPharmatech Website.
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Publication
- | J:342587
       
First Author: AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators
Year: 2011
Title: Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
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Publication
- | J:68900
     
First Author: The Jackson Laboratory Mouse Radiation Hybrid Database
Year: 2004
Journal: Database Release
Title: Mouse T31 Radiation Hybrid Data Load
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Publication
12466851 | J:80000
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
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Publication
- | J:164563
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Title: Human to Mouse ISO GO annotation transfer
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Publication
21267068 | J:153498
First Author: Diez-Roux G
Year: 2011
Journal: PLoS Biol
Title: A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Volume: 9
Issue: 1
Pages: e1000582
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Publication
- | J:75000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
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Publication
- | J:157972
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
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Publication
- | J:57747
     
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
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Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
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Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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UniProt Feature
UniProt Feature
Begin: 34
Description: Cleavage; by SPPL2A or SPPL2B
Type: site
End: 35
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UniProt Feature
UniProt Feature
Begin: 39
Description: Cleavage; by SPPL2A or SPPL2B
Type: site
End: 40
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UniProt Feature
UniProt Feature
Begin: 49
Description: Cleavage; by SPPL2A or SPPL2B
Type: site
End: 50
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UniProt Feature
UniProt Feature
Begin: 51
Description: Cleavage; by SPPL2A or SPPL2B
Type: site
End: 52
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Protein
Q3TD49-2
Organism: Mus musculus/domesticus
Length: 504  
Fragment?: false
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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