|  Help  |  About  |  Contact Us

Search our database by keyword

Examples

  • Search this entire website. Enter identifiers, names or keywords for genes, diseases, strains, ontology terms, etc. (e.g. Pax6, Parkinson, ataxia)
  • Use OR to search for either of two terms (e.g. OR mus) or quotation marks to search for phrases (e.g. "dna binding").
  • Boolean search syntax is supported: e.g. Balb* for partial matches or mus AND NOT embryo to exclude a term

Search results 1 to 74 out of 74 for Sprtn

0.035s

Categories

Hits by Pathway

Hits by Strain

Hits by Category

Type Details Score
Gene
83932 | SPRTN
Type: gene
Organism: human
•
•
•
•
•
Gene
534918 | SPRTN
Type: gene
Organism: cattle
•
•
•
•
•
Gene
421530 | SPRTN
Type: gene
Organism: chicken
•
•
•
•
•
Gene
713543 | SPRTN
Type: gene
Organism: macaque, rhesus
•
•
•
•
•
Gene
101886162 | sprtn
Type: gene
Organism: zebrafish
•
•
•
•
•
Gene
100127870 | sprtn
Type: gene
Organism: frog, western clawed
•
•
•
•
•
Gene
292101 | Sprtn
Type: gene
Organism: rat
•
•
•
•
•
Gene
488972 | SPRTN
Type: gene
Organism: dog, domestic
•
•
•
•
•
Gene
456494 | SPRTN
Type: gene
Organism: chimpanzee
•
•
•
•
•
Protein Coding Gene
MGI:2685351 | Sprtn
Type: protein_coding_gene
Organism: mouse, laboratory
•
•
•
•
•
Publication
27852435 | J:239182
   
First Author: Lopez-Mosqueda J
Year: 2016
Journal: Elife
Title: SPRTN is a mammalian DNA-binding metalloprotease that resolves DNA-protein crosslinks.
Volume: 5
•
•
•
•
•
Publication
25501849 | J:225198
 
First Author: Maskey RS
Year: 2014
Journal: Nat Commun
Title: Spartan deficiency causes genomic instability and progeroid phenotypes.
Volume: 5
Pages: 5744
•
•
•
•
•
Publication
32649882 | J:297179
First Author: Huang J
Year: 2020
Journal: Mol Cell
Title: Tandem Deubiquitination and Acetylation of SPRTN Promotes DNA-Protein Crosslink Repair and Protects against Aging.
Volume: 79
Issue: 5
Pages: 824-835.e5
•
•
•
•
•
Publication
28199696 | J:246108
First Author: Maskey RS
Year: 2017
Journal: Nucleic Acids Res
Title: Spartan deficiency causes accumulation of Topoisomerase 1 cleavage complexes and tumorigenesis.
Volume: 45
Issue: 8
Pages: 4564-4576
•
•
•
•
•
Protein Coding Gene
MGP_CAROLIEiJ_G0031716 | -
Type: protein_coding_gene
Organism: Mus caroli
•
•
•
•
•
Protein Coding Gene
MGP_129S1SvImJ_G0034282 | -
Type: protein_coding_gene
Organism: mouse, laboratory
•
•
•
•
•
Protein Coding Gene
MGP_AJ_G0034262 | -
Type: protein_coding_gene
Organism: mouse, laboratory
•
•
•
•
•
Protein Coding Gene
MGP_AKRJ_G0034189 | -
Type: protein_coding_gene
Organism: mouse, laboratory
•
•
•
•
•
Protein Coding Gene
MGP_BALBcJ_G0034255 | -
Type: protein_coding_gene
Organism: mouse, laboratory
•
•
•
•
•
Protein Coding Gene
MGP_C3HHeJ_G0033966 | -
Type: protein_coding_gene
Organism: mouse, laboratory
•
•
•
•
•
Protein Coding Gene
MGI_C57BL6J_2685351 | -
Type: protein_coding_gene
Organism: mouse, laboratory
•
•
•
•
•
Protein Coding Gene
MGP_C57BL6NJ_G0034775 | -
Type: protein_coding_gene
Organism: mouse, laboratory
•
•
•
•
•
Protein Coding Gene
MGP_CASTEiJ_G0033293 | -
Type: protein_coding_gene
Organism: mouse, laboratory
•
•
•
•
•
Protein Coding Gene
MGP_CBAJ_G0033939 | -
Type: protein_coding_gene
Organism: mouse, laboratory
•
•
•
•
•
Protein Coding Gene
MGP_DBA2J_G0034095 | -
Type: protein_coding_gene
Organism: mouse, laboratory
•
•
•
•
•
Protein Coding Gene
MGP_FVBNJ_G0034039 | -
Type: protein_coding_gene
Organism: mouse, laboratory
•
•
•
•
•
Protein Coding Gene
MGP_LPJ_G0034184 | -
Type: protein_coding_gene
Organism: mouse, laboratory
•
•
•
•
•
Protein Coding Gene
MGP_NODShiLtJ_G0034086 | -
Type: protein_coding_gene
Organism: mouse, laboratory
•
•
•
•
•
Protein Coding Gene
MGP_NZOHlLtJ_G0034794 | -
Type: protein_coding_gene
Organism: mouse, laboratory
•
•
•
•
•
Protein Coding Gene
MGP_PWKPhJ_G0032995 | -
Type: protein_coding_gene
Organism: mouse, laboratory
•
•
•
•
•
Protein Coding Gene
MGP_WSBEiJ_G0033410 | -
Type: protein_coding_gene
Organism: mouse, laboratory
•
•
•
•
•
Protein Coding Gene
MGP_PahariEiJ_G0023314 | -
Type: protein_coding_gene
Organism: Mus pahari
•
•
•
•
•
Protein Coding Gene
MGP_SPRETEiJ_G0032834 | -
Type: protein_coding_gene
Organism: Mus spretus
•
•
•
•
•
Publication
- | J:84900
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Journal: Database Download
Title: Integrating Computational Gene Models into the Mouse Genome Informatics (MGI) Database
•
•
•
•
•
Publication
- | J:326541
       
First Author: Cyagen Biosciences Inc.
Year: 2022
Title: Cyagen Biosciences Website.
•
•
•
•
•
Publication
- | J:342605
       
First Author: GOA curators
Year: 2016
Title: Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
•
•
•
•
•
Publication
16141072 | J:99680
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
•
•
•
•
•
Publication
- | J:23000
       
First Author: MGD Nomenclature Committee
Year: 1995
Title: Nomenclature Committee Use
•
•
•
•
•
Publication
- | J:141210
     
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
•
•
•
•
•
Publication
- | J:293217
       
First Author: GemPharmatech
Year: 2020
Title: GemPharmatech Website.
•
•
•
•
•
Publication
- | J:60000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2000
Title: Gene Ontology Annotation by electronic association of SwissProt Keywords with GO terms
•
•
•
•
•
Publication
- | J:342587
       
First Author: AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators
Year: 2011
Title: Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
•
•
•
•
•
Publication
- | J:164563
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Title: Human to Mouse ISO GO annotation transfer
•
•
•
•
•
Publication
- | J:57747
     
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
•
•
•
•
•
Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
•
•
•
•
•
Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
•
•
•
•
•
Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
•
•
•
•
•
Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
•
•
•
•
•
Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
•
•
•
•
•
Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
•
•
•
•
•
Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
•
•
•
•
•
Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
•
•
•
•
•
Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
•
•
•
•
•
Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
•
•
•
•
•
Protein
G3X912
Organism: Mus musculus/domesticus
Length: 497  
Fragment?: false
•
•
•
•
•
UniProt Feature
UniProt Feature
Begin: 1
Description: DNA-dependent metalloprotease SPRTN
Type: chain
End: 497
•
•
•
•
•
Publication
27871365 | -
First Author: Stingele J
Year: 2016
Journal: Mol Cell
Title: Mechanism and Regulation of DNA-Protein Crosslink Repair by the DNA-Dependent Metalloprotease SPRTN.
Volume: 64
Issue: 4
Pages: 688-703
•
•
•
•
•
Publication
31316063 | -
First Author: Halder S
Year: 2019
Journal: Nat Commun
Title: SPRTN protease and checkpoint kinase 1 cross-activation loop safeguards DNA replication.
Volume: 10
Issue: 1
Pages: 3142
•
•
•
•
•
Publication
25261934 | -
First Author: Lessel D
Year: 2014
Journal: Nat Genet
Title: Mutations in SPRTN cause early onset hepatocellular carcinoma, genomic instability and progeroid features.
Volume: 46
Issue: 11
Pages: 1239-44
•
•
•
•
•
Publication
30595436 | -
First Author: Larsen NB
Year: 2019
Journal: Mol Cell
Title: Replication-Coupled DNA-Protein Crosslink Repair by SPRTN and the Proteasome in Xenopus Egg Extracts.
Volume: 73
Issue: 3
Pages: 574-588.e7
•
•
•
•
•
DO Term
DOID:0111264 | Ruijs-Aalfs syndrome
•
•
•
•
•
Publication
30893605 | -
First Author: Li F
Year: 2019
Journal: Cell Rep
Title: Structural Insight into DNA-Dependent Activation of Human Metalloprotease Spartan.
Volume: 26
Issue: 12
Pages: 3336-3346.e4
•
•
•
•
•
Protein Domain
IPR044245 | Spartan
Type: Family
Description: Covalent DNA-protein crosslinks (DPCs) are toxic DNA lesions that interfere with essential chromatin transactions, such as replication and transcription. Spartan (SPRTN) is a DNA-dependent metalloprotease which cleaves DPCs and plays a key role in maintaining genomic integrity []. SPRTN consists of an N-terminal SprT domain (responsible for the proteolytic cleavage of DPCs) followed by a basic region (BR, a DNA-binding element), both contributing to DNA binding. The C-terminal motifs and domains interact with proliferating cell nuclear antigen (PCNA) and ubiquitin, which collectively recruit SPRTN and the associated ATPase p97 or valosin-containing protein (p97 or VCP) to sites of DNA damage. The structure of the human SPRTN revealed a Zn2-binding sub-domain (ZBD) in SprTdomain that shields its active site located in the metalloprotease sub-domain (MPD). The ZBD contains an ssDNA-binding site, with a DNA-base-binding pocket formed by aromatic residues and is thought to contribute to the ssDNA specificity of SPRTN, restricts the access of globular substrates, and positions DPCs, which may need to be partially unfolded, for optimal cleavage []. The proteolytic activity of SPRTN is regulated by various mechanisms. To prevent the recruitment of SPRTN to chromatin, SPRTN undergoes monoubiquitylation, which can then be deubiquitylated by an unknown ubiquitin protease triggered by DPC induction. Once SPRTN is recruited to chromatin, DNA binding stimulates its protease activity. It has been shown that SPRTN is uniquely activated by single-stranded DNA (ssDNA). Moreover, SPRTN can degrade itself, which may switch off its proteolytic function when repair is complete [].SPRTN is also an activator of CHK1 (checkpoint kinase 1) during normal DNA replication by mediating proteolytic cleavage of CHK1, thereby promoting CHK1 removal from chromatin and subsequent activation. CHK1 phosphorylate SPRTN at the C-terminal regulatory domain and induces SPRTN recruitment to chromatin promoting DNA replication fork progression and DPC repair [].In humans mutations of SPRTN are linked to human Ruijs-Aalfs syndrome (RJALS), a syndrome characterised by is characterised by genomic instability, premature aging, and hepatocellular carcinoma []. In mice, loss of SPRTN is embryonically lethal, and conditional inactivation of SPRTN in murine embryonic fibroblasts (MEFs) blocks cell proliferation [].
•
•
•
•
•
Publication
25904330 | -
First Author: Zhang X
Year: 2015
Journal: Mol Biol Cell
Title: Cell cycle regulation of VCIP135 deubiquitinase activity and function in p97/p47-mediated Golgi reassembly.
Volume: 26
Issue: 12
Pages: 2242-51
•
•
•
•
•
Publication
28584101 | -
First Author: Tsai YC
Year: 2017
Journal: Proc Natl Acad Sci U S A
Title: Deubiquitinating enzyme VCIP135 dictates the duration of botulinum neurotoxin type A intoxication.
Volume: 114
Issue: 26
Pages: E5158-E5166
•
•
•
•
•
Protein Domain
IPR039087 | VCPIP1
Type: Family
Description: VCPIP1, also known as VCIP135, is a deubiquitinating enzyme that functions in p97/p47-mediated Golgi reassembly []. It hydrolyzes 'Lys-11'- and 'Lys-48'-linked polyubiquitin chains []. It has also been found to dictate the duration of botulinum neurotoxin type A intoxication []. VCPIP1 can also deubiquitinate SPRTN (a metalloprotease that cleaves DNA-protein crosslinks) and promotes its chromatin relocalization []. VCPIP1 is a member of peptidase family C64.
•
•
•
•
•
Publication
23827681 | -
First Author: Mevissen TE
Year: 2013
Journal: Cell
Title: OTU deubiquitinases reveal mechanisms of linkage specificity and enable ubiquitin chain restriction analysis.
Volume: 154
Issue: 1
Pages: 169-84
•
•
•
•
•
Protein
Q8CDG3
Organism: Mus musculus/domesticus
Length: 1220  
Fragment?: false
•
•
•
•
•
Protein
A0A0R4J0M9
Organism: Mus musculus/domesticus
Length: 1220  
Fragment?: false
•
•
•
•
•
Protein
Q05DM9
Organism: Mus musculus/domesticus
Length: 739  
Fragment?: true
•
•
•
•
•
Protein
Q3UMT4
Organism: Mus musculus/domesticus
Length: 729  
Fragment?: true
•
•
•
•
•
Protein
Q80T83
Organism: Mus musculus/domesticus
Length: 1245  
Fragment?: true
•
•
•
•
•
Publication
15489334 | -
First Author: Gerhard DS
Year: 2004
Journal: Genome Res
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Volume: 14
Issue: 10B
Pages: 2121-7
•
•
•
•
•
Publication
19468303 | -
First Author: Church DM
Year: 2009
Journal: PLoS Biol
Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.
Volume: 7
Issue: 5
Pages: e1000112
•
•
•
•
•




MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

Copyright © 2017 by The Jackson Laboratory. All Rights Reserved

© 2002 - 2017 Department of Genetics, University of Cambridge, Downing Street,
Cambridge CB2 3EH, United Kingdom