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Search results 1 to 100 out of 529 for Spry1

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0.045s
Type Details Score
Gene
Type: gene
Organism: human
Gene
Type: gene
Organism: chimpanzee
Gene
Type: gene
Organism: cattle
Gene
Type: gene
Organism: chicken
Gene
Type: gene
Organism: zebrafish
Gene
Type: gene
Organism: macaque, rhesus
Gene
Type: gene
Organism: frog, western clawed
Gene
Type: gene
Organism: rat
Gene
Type: gene
Organism: dog, domestic
Protein Domain
Type: Family
Description: Protein sprouty homologue 1 (SPRY1) belongs to the sprouty family, whose members are inhibitors of the Ras-ERK pathway downstream of various receptor tyrosine kinases. SPRY1 has been implicated with tumorigenesis of different types of cancers [, ].
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein
Organism: Mus musculus/domesticus
Length: 220  
Fragment?: false
Publication
First Author: Macià A
Year: 2014
Journal: Cell Death Differ
Title: Sprouty1 induces a senescence-associated secretory phenotype by regulating NFκB activity: implications for tumorigenesis.
Volume: 21
Issue: 2
Pages: 333-43
GXD Expression  
Probe: MGI:6283541
Assay Type: RNA in situ
Annotation Date: 2019-03-19
Strength: Present
Sex: Not Specified
Emaps: EMAPS:2760519
Pattern: Not Specified
Stage: TS19
Assay Id: MGI:6283603
Age: embryonic day 11.5
Image: 3 SPRY1 +/+
Specimen Label: 3 SPRY1 +/+
Detected: true
Specimen Num: 1
GXD Expression  
Probe: MGI:6283541
Assay Type: RNA in situ
Annotation Date: 2019-03-19
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1657719
Pattern: Not Specified
Stage: TS19
Assay Id: MGI:6283603
Age: embryonic day 11.5
Image: 3 SPRY1 +/+
Specimen Label: 3 SPRY1 +/+
Detected: true
Specimen Num: 1
GXD Expression
Probe: MGI:6283541
Assay Type: RNA in situ
Annotation Date: 2019-03-19
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:2760519
Pattern: Not Specified
Stage: TS19
Assay Id: MGI:6283603
Age: embryonic day 11.5
Image: 3 SPRY1 Eneo/Eneo
Note: Authors report reduced expression in nephric ducts and tips of mutant embryos.
Specimen Label: 3 SPRY1 Eneo/Eneo
Detected: true
Specimen Num: 2
GXD Expression
Probe: MGI:6283541
Assay Type: RNA in situ
Annotation Date: 2019-03-19
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1657719
Pattern: Not Specified
Stage: TS19
Assay Id: MGI:6283603
Age: embryonic day 11.5
Image: 3 SPRY1 Eneo/Eneo
Note: Authors report reduced expression in nephric ducts and tips of mutant embryos.
Specimen Label: 3 SPRY1 Eneo/Eneo
Detected: true
Specimen Num: 2
Publication
First Author: Mekkawy AH
Year: 2014
Journal: Tumour Biol
Title: Human Sprouty1 suppresses growth, migration, and invasion in human breast cancer cells.
Volume: 35
Issue: 5
Pages: 5037-48
Publication
First Author: Kuracha MR
Year: 2013
Journal: Dev Biol
Title: Spry1 and Spry2 are necessary for eyelid closure.
Volume: 383
Issue: 2
Pages: 227-38
Protein
Organism: Mus musculus/domesticus
Length: 313  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 313  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 105  
Fragment?: false
Publication
First Author: Sathyanarayana P
Year: 2012
Journal: Blood
Title: Spry1 as a novel regulator of erythropoiesis, EPO/EPOR target, and suppressor of JAK2.
Volume: 119
Issue: 23
Pages: 5522-31
Publication
First Author: Koledova Z
Year: 2016
Journal: Proc Natl Acad Sci U S A
Title: SPRY1 regulates mammary epithelial morphogenesis by modulating EGFR-dependent stromal paracrine signaling and ECM remodeling.
Volume: 113
Issue: 39
Pages: E5731-40
Publication
First Author: Michos O
Year: 2010
Journal: PLoS Genet
Title: Kidney development in the absence of Gdnf and Spry1 requires Fgf10.
Volume: 6
Issue: 1
Pages: e1000809
Publication
First Author: Yang X
Year: 2008
Journal: Dev Biol
Title: Overexpression of Spry1 in chondrocytes causes attenuated FGFR ubiquitination and sustained ERK activation resulting in chondrodysplasia.
Volume: 321
Issue: 1
Pages: 64-76
Publication  
First Author: Yang X
Year: 2010
Journal: BMC Dev Biol
Title: Conditional expression of Spry1 in neural crest causes craniofacial and cardiac defects.
Volume: 10
Pages: 48
Publication
First Author: Ching ST
Year: 2014
Journal: Dev Biol
Title: Coordinated activity of Spry1 and Spry2 is required for normal development of the external genitalia.
Volume: 386
Issue: 1
Pages: 1-11
Publication
First Author: Yang X
Year: 2011
Journal: PLoS One
Title: Spry1 is expressed in hemangioblasts and negatively regulates primitive hematopoiesis and endothelial cell function.
Volume: 6
Issue: 4
Pages: e18374
Publication
First Author: Kuracha MR
Year: 2011
Journal: Invest Ophthalmol Vis Sci
Title: Spry1 and Spry2 are necessary for lens vesicle separation and corneal differentiation.
Volume: 52
Issue: 9
Pages: 6887-97
Publication
First Author: Collins S
Year: 2012
Journal: PLoS One
Title: Regulation of CD4⁺ and CD8⁺ effector responses by Sprouty-1.
Volume: 7
Issue: 11
Pages: e49801
Publication
First Author: Macià A
Year: 2012
Journal: Oncogene
Title: Sprouty1 is a candidate tumor-suppressor gene in medullary thyroid carcinoma.
Volume: 31
Issue: 35
Pages: 3961-72
Publication
First Author: Urs S
Year: 2012
Journal: Br J Nutr
Title: Tissue-specific expression of Sprouty1 in mice protects against high-fat diet-induced fat accumulation, bone loss and metabolic dysfunction.
Volume: 108
Issue: 6
Pages: 1025-33
Publication  
First Author: Yang X
Year: 2023
Journal: Atherosclerosis
Title: Sprouty1 has a protective role in atherogenesis and modifies the migratory and inflammatory phenotype of vascular smooth muscle cells.
Volume: 373
Pages: 17-28
Publication
First Author: Choi H
Year: 2006
Journal: J Immunol
Title: Dual effects of Sprouty1 on TCR signaling depending on the differentiation state of the T cell.
Volume: 176
Issue: 10
Pages: 6034-45
Publication
First Author: Alakoski T
Year: 2019
Journal: Basic Res Cardiol
Title: Inhibition of cardiomyocyte Sprouty1 protects from cardiac ischemia-reperfusion injury.
Volume: 114
Issue: 2
Pages: 7
Publication
First Author: Basson MA
Year: 2006
Journal: Dev Biol
Title: Branching morphogenesis of the ureteric epithelium during kidney development is coordinated by the opposing functions of GDNF and Sprouty1.
Volume: 299
Issue: 2
Pages: 466-77
Publication
First Author: Shea KL
Year: 2010
Journal: Cell Stem Cell
Title: Sprouty1 regulates reversible quiescence of a self-renewing adult muscle stem cell pool during regeneration.
Volume: 6
Issue: 2
Pages: 117-29
Publication
First Author: Chakkalakal JV
Year: 2012
Journal: Nature
Title: The aged niche disrupts muscle stem cell quiescence.
Volume: 490
Issue: 7420
Pages: 355-60
Publication
First Author: Urs S
Year: 2010
Journal: FASEB J
Title: Sprouty1 is a critical regulatory switch of mesenchymal stem cell lineage allocation.
Volume: 24
Issue: 9
Pages: 3264-73
Publication
First Author: Basson MA
Year: 2005
Journal: Dev Cell
Title: Sprouty1 is a critical regulator of GDNF/RET-mediated kidney induction.
Volume: 8
Issue: 2
Pages: 229-39
Publication
First Author: Percival CJ
Year: 2017
Journal: G3 (Bethesda)
Title: The Interaction of Genetic Background and Mutational Effects in Regulation of Mouse Craniofacial Shape.
Volume: 7
Issue: 5
Pages: 1439-1450
Publication
First Author: Balasooriya GI
Year: 2016
Journal: Dev Cell
Title: An FGFR1-SPRY2 Signaling Axis Limits Basal Cell Proliferation in the Steady-State Airway Epithelium.
Volume: 37
Issue: 1
Pages: 85-97
Publication
First Author: Schutzman JL
Year: 2012
Journal: Proc Natl Acad Sci U S A
Title: Sprouty genes function in suppression of prostate tumorigenesis.
Volume: 109
Issue: 49
Pages: 20023-8
Publication
First Author: Leclerc K
Year: 2016
Journal: Dev Dyn
Title: Mosaic analysis of cell rearrangements during ureteric bud branching in dissociated/reaggregated kidney cultures and in vivo.
Volume: 245
Issue: 4
Pages: 483-96
Publication
First Author: Akbulut S
Year: 2010
Journal: Mol Biol Cell
Title: Sprouty proteins inhibit receptor-mediated activation of phosphatidylinositol-specific phospholipase C.
Volume: 21
Issue: 19
Pages: 3487-96
Publication  
First Author: Zhao G
Year: 2018
Journal: Exp Eye Res
Title: Negative regulation of lens fiber cell differentiation by RTK antagonists Spry and Spred.
Volume: 170
Pages: 148-159
Publication
First Author: Gardiner JR
Year: 2012
Journal: Development
Title: Localised inhibition of FGF signalling in the third pharyngeal pouch is required for normal thymus and parathyroid organogenesis.
Volume: 139
Issue: 18
Pages: 3456-66
Publication
First Author: Waters ST
Year: 2006
Journal: Development
Title: A threshold requirement for Gbx2 levels in hindbrain development.
Volume: 133
Issue: 10
Pages: 1991-2000
Publication
First Author: Altés G
Year: 2022
Journal: Cell Mol Life Sci
Title: A dominant negative mutation uncovers cooperative control of caudal Wolffian duct development by Sprouty genes.
Volume: 79
Issue: 10
Pages: 514
Publication
First Author: Porntaveetus T
Year: 2010
Journal: Gene Expr Patterns
Title: Expression of Fgf signalling pathway related genes during palatal rugae development in the mouse.
Volume: 10
Issue: 4-5
Pages: 193-8
Publication  
First Author: Wright KD
Year: 2015
Journal: BMC Dev Biol
Title: Cooperative and independent functions of FGF and Wnt signaling during early inner ear development.
Volume: 15
Pages: 33
Publication
First Author: Li JY
Year: 2005
Journal: Development
Title: New regulatory interactions and cellular responses in the isthmic organizer region revealed by altering Gbx2 expression.
Volume: 132
Issue: 8
Pages: 1971-81
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus caroli
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus pahari
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus spretus
Publication
First Author: Lim J
Year: 2000
Journal: J Biol Chem
Title: Sprouty proteins are targeted to membrane ruffles upon growth factor receptor tyrosine kinase activation. Identification of a novel translocation domain.
Volume: 275
Issue: 42
Pages: 32837-45
Publication
First Author: Shin EH
Year: 2015
Journal: Dev Biol
Title: Sprouty gain of function disrupts lens cellular processes and growth by restricting RTK signaling.
Volume: 406
Issue: 2
Pages: 129-46
Publication
First Author: Thum T
Year: 2008
Journal: Nature
Title: MicroRNA-21 contributes to myocardial disease by stimulating MAP kinase signalling in fibroblasts.
Volume: 456
Issue: 7224
Pages: 980-4
Publication
First Author: Lee JS
Year: 2009
Journal: J Immunol
Title: Recruitment of Sprouty1 to immune synapse regulates T cell receptor signaling.
Volume: 183
Issue: 11
Pages: 7178-86
Publication
First Author: Vaquero M
Year: 2016
Journal: Endocr Relat Cancer
Title: Sprouty1 haploinsufficiency accelerates pheochromocytoma development in Pten+/- mice.
Volume: 23
Issue: 4
Pages: L7-L11
GXD Expression      
Probe: MGI:1345255
Assay Type: Northern blot
Annotation Date: 1999-10-06
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1610528
Stage: TS28
Assay Id: MGI:1345503
Age: postnatal adult
Specimen Label: adult heart
Detected: true
Specimen Num: 1
GXD Expression      
Probe: MGI:1345255
Assay Type: Northern blot
Annotation Date: 1999-10-06
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:1345503
Age: postnatal adult
Specimen Label: adult brain
Detected: true
Specimen Num: 2
GXD Expression      
Probe: MGI:1345255
Assay Type: Northern blot
Annotation Date: 1999-10-06
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1672828
Stage: TS28
Assay Id: MGI:1345503
Age: postnatal adult
Specimen Label: adult lung
Detected: true
Specimen Num: 3
GXD Expression      
Probe: MGI:1345255
Assay Type: Northern blot
Annotation Date: 1999-10-06
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1737328
Stage: TS28
Assay Id: MGI:1345503
Age: postnatal adult
Specimen Label: adult kidney
Detected: true
Specimen Num: 4
GXD Expression      
Probe: MGI:1345255
Assay Type: Northern blot
Annotation Date: 1999-10-06
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3598828
Stage: TS28
Assay Id: MGI:1345503
Age: postnatal adult
Specimen Label: adult skeletal muscle
Detected: true
Specimen Num: 5
GXD Expression    
Probe: MGI:5447746
Assay Type: RT-PCR
Annotation Date: 2013-01-07
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3185820
Stage: TS20
Assay Id: MGI:5447803
Age: embryonic day 12.5
Image: 3
Specimen Label: b
Detected: true
Specimen Num: 2
GXD Expression    
Probe: MGI:5447746
Assay Type: RT-PCR
Annotation Date: 2013-01-07
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1750320
Stage: TS20
Assay Id: MGI:5447803
Age: embryonic day 12.5
Image: 3
Specimen Label: a
Detected: true
Specimen Num: 1
GXD Expression      
Probe: MGI:6474268
Assay Type: Western blot
Annotation Date: 2020-12-01
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689427
Stage: TS27
Assay Id: MGI:6476703
Age: postnatal newborn
Specimen Label: Y53ANeo/Y53ANeo
Detected: true
Specimen Num: 5
GXD Expression      
Probe: MGI:6474268
Assay Type: Western blot
Annotation Date: 2020-12-01
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689427
Stage: TS27
Assay Id: MGI:6476703
Age: postnatal newborn
Specimen Label: Y53ANeo/Y53ANeo
Detected: true
Specimen Num: 6
GXD Expression      
Probe: MGI:6474268
Assay Type: Western blot
Annotation Date: 2020-12-01
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689427
Stage: TS27
Assay Id: MGI:6476703
Age: postnatal newborn
Specimen Label: Y53ANeo/Y53ANeo
Detected: true
Specimen Num: 7
GXD Expression      
Probe: MGI:6474268
Assay Type: Western blot
Annotation Date: 2020-12-01
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689427
Stage: TS27
Assay Id: MGI:6476703
Age: postnatal newborn
Specimen Label: Y53ANeo/Y53ANeo
Detected: true
Specimen Num: 8
GXD Expression      
Probe: MGI:6474268
Assay Type: Western blot
Annotation Date: 2020-12-01
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689427
Stage: TS27
Assay Id: MGI:6476703
Age: postnatal newborn
Specimen Label: Y53ANeo/Y53ANeo
Detected: true
Specimen Num: 9
GXD Expression      
Probe: MGI:6474268
Assay Type: Western blot
Annotation Date: 2020-12-01
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689427
Stage: TS27
Assay Id: MGI:6476703
Age: postnatal newborn
Specimen Label: Y53ANeo/Y53ANeo
Detected: true
Specimen Num: 10
GXD Expression      
Probe: MGI:6474268
Assay Type: Western blot
Annotation Date: 2020-12-01
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1689427
Stage: TS27
Assay Id: MGI:6476703
Age: postnatal newborn
Specimen Label: -/-
Detected: false
Specimen Num: 11
GXD Expression      
Probe: MGI:6474268
Assay Type: Western blot
Annotation Date: 2020-12-01
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689427
Stage: TS27
Assay Id: MGI:6476703
Age: postnatal newborn
Specimen Label: +/+
Detected: true
Specimen Num: 1
GXD Expression      
Probe: MGI:6474268
Assay Type: Western blot
Annotation Date: 2020-12-01
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689427
Stage: TS27
Assay Id: MGI:6476703
Age: postnatal newborn
Specimen Label: +/+
Detected: true
Specimen Num: 2
GXD Expression      
Probe: MGI:6474268
Assay Type: Western blot
Annotation Date: 2020-12-01
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689427
Stage: TS27
Assay Id: MGI:6476703
Age: postnatal newborn
Specimen Label: +/+
Detected: true
Specimen Num: 3
GXD Expression      
Probe: MGI:6474268
Assay Type: Western blot
Annotation Date: 2020-12-01
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689427
Stage: TS27
Assay Id: MGI:6476703
Age: postnatal newborn
Specimen Label: +/+
Detected: true
Specimen Num: 4
GXD Expression      
Probe: MGI:6474262
Assay Type: RT-PCR
Annotation Date: 2020-12-01
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689427
Stage: TS27
Assay Id: MGI:6476712
Age: postnatal newborn
Specimen Label: +/+
Detected: true
Specimen Num: 1
GXD Expression      
Probe: MGI:6474268
Assay Type: Western blot
Annotation Date: 2020-12-01
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1737321
Stage: TS21
Assay Id: MGI:6476713
Age: embryonic day 13.5
Specimen Label: Y53ANeo/Y53ANeo
Detected: true
Specimen Num: 1
GXD Expression      
Probe: MGI:6474268
Assay Type: Western blot
Annotation Date: 2020-12-01
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1737321
Stage: TS21
Assay Id: MGI:6476713
Age: embryonic day 13.5
Specimen Label: Y53ANeo/Y53ANeo
Detected: true
Specimen Num: 2
GXD Expression      
Probe: MGI:6474268
Assay Type: Western blot
Annotation Date: 2020-12-01
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1737321
Stage: TS21
Assay Id: MGI:6476713
Age: embryonic day 13.5
Specimen Label: +/+
Detected: true
Specimen Num: 3
GXD Expression      
Probe: MGI:6474268
Assay Type: Western blot
Annotation Date: 2020-12-01
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1737321
Stage: TS21
Assay Id: MGI:6476713
Age: embryonic day 13.5
Specimen Label: +/+
Detected: true
Specimen Num: 4