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Search results 1 to 100 out of 757 for Spry2

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Categories

Hits by Pathway

Hits by Category

Hits by Strain

Type Details Score
Gene
10253 | SPRY2
Type: gene
Organism: human
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Gene
449471 | spry2
Type: gene
Organism: frog, western clawed
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Gene
306141 | Spry2
Type: gene
Organism: rat
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Gene
485504 | SPRY2
Type: gene
Organism: dog, domestic
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Gene
452616 | SPRY2
Type: gene
Organism: chimpanzee
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Gene
539090 | SPRY2
Type: gene
Organism: cattle
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Gene
395584 | SPRY2
Type: gene
Organism: chicken
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Gene
335098 | spry2
Type: gene
Organism: zebrafish
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Gene
702103 | SPRY2
Type: gene
Organism: macaque, rhesus
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Protein Domain
IPR030780 | SPRY2
Type: Family
Description: Protein sprouty homologue 2 (SPRY2) belongs to the sprouty family, whose members are inhibitors of the Ras-ERK pathway downstream of various receptor tyrosine kinases []. SPRY2 functions as a negative regulator of receptor tyrosine kinase/ERK signaling pathway and is involved in many biological processes, including cell growth, differentiation, migration, and embryonic lung branching morphogenesis [, ]. It inhibits FGF-RAS-ERK signaling by binding to growth factor receptor bound protein 2 (GRB2) during fibroblast growth factor receptor (FGFR) activation, disrupting the GRB2-SOS (son of sevenless) complex that transduces signals from FGFR to RAS [, ].
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Protein Coding Gene
MGI:1345138 | Spry2
Type: protein_coding_gene
Organism: mouse, laboratory
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Publication
17974561 | J:130605
First Author: Chandramouli S
Year: 2008
Journal: J Biol Chem
Title: Tesk1 interacts with Spry2 to abrogate its inhibition of ERK phosphorylation downstream of receptor tyrosine kinase signaling.
Volume: 283
Issue: 3
Pages: 1679-91
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GXD Expression
GXD Expression
Probe: MGI:1672456
Assay Type: RNA in situ
Annotation Date: 2010-05-13
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:3271124
Pattern: Not Specified
Stage: TS24
Assay Id: MGI:4450780
Age: embryonic day 16.5
Image: Spry2 - E16.5
Note: There is weak staining in the postmitotic neurons in the cortical plate of the cerebral cortex.
Specimen Label: Spry2 - E16.5
Detected: true
Specimen Num: 4
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GXD Expression
GXD Expression
 
Probe: MGI:1672456
Assay Type: RNA in situ
Annotation Date: 2010-05-13
Strength: Ambiguous
Sex: Not Specified
Emaps: EMAPS:3271220
Pattern: Not Specified
Stage: TS20
Assay Id: MGI:4450780
Age: embryonic day 12.5
Image: Spry2 - E12.5
Note: Staining is either absent or ubiquitous in the postmitotic neurons in the intermediate zone of the cerebral cortex.
Specimen Label: Spry2 - E12.5
Specimen Num: 2
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GXD Expression
GXD Expression
Probe: MGI:1672456
Assay Type: RNA in situ
Annotation Date: 2010-05-13
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:3271224
Pattern: Not Specified
Stage: TS24
Assay Id: MGI:4450780
Age: embryonic day 16.5
Image: Spry2 - E16.5
Note: There is weak staining in the postmitotic neurons in the intermediate zone of the cerebral cortex.
Specimen Label: Spry2 - E16.5
Detected: true
Specimen Num: 4
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GXD Expression
GXD Expression
Probe: MGI:1672456
Assay Type: RNA in situ
Annotation Date: 2010-05-13
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1754320
Pattern: Not Specified
Stage: TS20
Assay Id: MGI:4450780
Age: embryonic day 12.5
Image: Spry2 - E12.5
Note: There is moderate staining in the ventricular zone of the dorsal thalamus and prethalamus.
Specimen Label: Spry2 - E12.5
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
Probe: MGI:1672456
Assay Type: RNA in situ
Annotation Date: 2010-05-13
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1754324
Pattern: Not Specified
Stage: TS24
Assay Id: MGI:4450780
Age: embryonic day 16.5
Image: Spry2 - E16.5
Note: There is strong staining in the ventricular zone of the dorsal thalamus and prethalamus.
Specimen Label: Spry2 - E16.5
Detected: true
Specimen Num: 4
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GXD Expression
GXD Expression
 
Probe: MGI:1672456
Assay Type: RNA in situ
Annotation Date: 2010-05-13
Strength: Ambiguous
Sex: Not Specified
Emaps: EMAPS:1753724
Pattern: Not Specified
Stage: TS24
Assay Id: MGI:4450780
Age: embryonic day 16.5
Image: Spry2 - E16.5
Note: Staining is either absent or ubiquitous in the mantle zone of the dorsal and ventral POAs, the PVH, SCH, DMH, VMH and ARH nuclei, the AVH, the DAH and the PH.
Specimen Label: Spry2 - E16.5
Specimen Num: 4
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GXD Expression
GXD Expression
Probe: MGI:1672456
Assay Type: RNA in situ
Annotation Date: 2010-05-13
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1753922
Pattern: Non-Uniform
Stage: TS22
Assay Id: MGI:4450780
Age: embryonic day 14.5
Image: Spry2 - E14.5
Note: There is moderate staining in the VZ of the anterior and posterior IDs and weak, scattered staining in the dorsal and ventral POAs, PVH nucleus and the AVH. Staining is either absent or ubiquitous in the VZ of the VMH and ARH nuclei.
Specimen Label: Spry2 - E14.5
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
Probe: MGI:1672456
Assay Type: RNA in situ
Annotation Date: 2010-05-13
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:3266520
Pattern: Non-Uniform
Stage: TS20
Assay Id: MGI:4450780
Age: embryonic day 12.5
Image: Spry2 - E12.5
Note: There is moderate staining in the ventricular zone of the ganglionic eminences. Staining is either absent or ubiquitous in the mantle zone of the ganglionic eminences.
Specimen Label: Spry2 - E12.5
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
 
Probe: MGI:1672456
Assay Type: RNA in situ
Annotation Date: 2010-05-13
Strength: Ambiguous
Sex: Not Specified
Emaps: EMAPS:3266524
Pattern: Not Specified
Stage: TS24
Assay Id: MGI:4450780
Age: embryonic day 16.5
Image: Spry2 - E16.5
Note: Staining is either absent or ubiquitous in the ventricular and mantle zones of the ganglionic eminences.
Specimen Label: Spry2 - E16.5
Specimen Num: 4
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GXD Expression
GXD Expression
Probe: MGI:1672456
Assay Type: RNA in situ
Annotation Date: 2010-05-13
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1754122
Pattern: Non-Uniform
Stage: TS22
Assay Id: MGI:4450780
Age: embryonic day 14.5
Image: Spry2 - E14.5
Note: There is moderate staining in the mantle zone of the dorsal thalamus. Staining is either absent or ubiquitous in the mantle zone of the prethalamus.
Specimen Label: Spry2 - E14.5
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
 
Probe: MGI:1672456
Assay Type: RNA in situ
Annotation Date: 2010-05-13
Strength: Ambiguous
Sex: Not Specified
Emaps: EMAPS:3271120
Pattern: Not Specified
Stage: TS20
Assay Id: MGI:4450780
Age: embryonic day 12.5
Image: Spry2 - E12.5
Note: Staining is either absent or ubiquitous in the postmitotic neurons in the cortical plate of the cerebral cortex.
Specimen Label: Spry2 - E12.5
Specimen Num: 2
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GXD Expression
GXD Expression
 
Probe: MGI:1672456
Assay Type: RNA in situ
Annotation Date: 2010-05-13
Strength: Ambiguous
Sex: Not Specified
Emaps: EMAPS:3271122
Pattern: Not Specified
Stage: TS22
Assay Id: MGI:4450780
Age: embryonic day 14.5
Image: Spry2 - E14.5
Note: Staining is either absent or ubiquitous in the postmitotic neurons in the cortical plate of the cerebral cortex.
Specimen Label: Spry2 - E14.5
Specimen Num: 3
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GXD Expression
GXD Expression
 
Probe: MGI:1672456
Assay Type: RNA in situ
Annotation Date: 2010-05-13
Strength: Ambiguous
Sex: Not Specified
Emaps: EMAPS:3271222
Pattern: Not Specified
Stage: TS22
Assay Id: MGI:4450780
Age: embryonic day 14.5
Image: Spry2 - E14.5
Note: Staining is either absent or ubiquitous in the postmitotic neurons in the intermediate zone of the cerebral cortex.
Specimen Label: Spry2 - E14.5
Specimen Num: 3
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GXD Expression
GXD Expression
Probe: MGI:1672456
Assay Type: RNA in situ
Annotation Date: 2010-05-13
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1754322
Pattern: Not Specified
Stage: TS22
Assay Id: MGI:4450780
Age: embryonic day 14.5
Image: Spry2 - E14.5
Note: There is weak staining in the ventricular zone of the dorsal thalamus and prethalamus.
Specimen Label: Spry2 - E14.5
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
 
Probe: MGI:1672456
Assay Type: RNA in situ
Annotation Date: 2010-05-13
Strength: Ambiguous
Sex: Not Specified
Emaps: EMAPS:1753720
Pattern: Not Specified
Stage: TS20
Assay Id: MGI:4450780
Age: embryonic day 12.5
Image: Spry2 - E12.5
Note: Staining is either absent or ubiquitous in the mantle zone of the dorsal and ventral POAs, PVH nucleus and the AVH.
Specimen Label: Spry2 - E12.5
Specimen Num: 2
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GXD Expression
GXD Expression
 
Probe: MGI:1672456
Assay Type: RNA in situ
Annotation Date: 2010-05-13
Strength: Ambiguous
Sex: Not Specified
Emaps: EMAPS:1753722
Pattern: Not Specified
Stage: TS22
Assay Id: MGI:4450780
Age: embryonic day 14.5
Image: Spry2 - E14.5
Note: Staining is either absent or ubiquitous in the mantle zone of the dorsal and ventral POAs, the PVH, VMH and ARH nuclei, the AVH and anterior and posterior IDs.
Specimen Label: Spry2 - E14.5
Specimen Num: 3
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GXD Expression
GXD Expression
 
Probe: MGI:1672456
Assay Type: RNA in situ
Annotation Date: 2010-05-13
Strength: Ambiguous
Sex: Not Specified
Emaps: EMAPS:1691319
Pattern: Not Specified
Stage: TS19
Assay Id: MGI:4450780
Age: embryonic day 11.5
Image: Spry2 - E11.5
Note: Staining is either absent or ubiquitous in the ventricular zone of the cerebral cortex and the ganglionic eminences.
Specimen Label: Spry2 - E11.5
Specimen Num: 1
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GXD Expression
GXD Expression
 
Probe: MGI:1672456
Assay Type: RNA in situ
Annotation Date: 2010-05-13
Strength: Ambiguous
Sex: Not Specified
Emaps: EMAPS:3271822
Pattern: Not Specified
Stage: TS22
Assay Id: MGI:4450780
Age: embryonic day 14.5
Image: Spry2 - E14.5
Note: Staining is either absent or ubiquitous in the mantle zone of the premam, mam and supramam zones and the TT.
Specimen Label: Spry2 - E14.5
Specimen Num: 3
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GXD Expression
GXD Expression
Probe: MGI:1672456
Assay Type: RNA in situ
Annotation Date: 2010-05-13
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:3271824
Pattern: Non-Uniform
Stage: TS24
Assay Id: MGI:4450780
Age: embryonic day 16.5
Image: Spry2 - E16.5
Note: There is moderate staining in the mantle zone of the premam zone. Staining is either absent or ubiquitous in the mantle zone of the mam and supramam zones.
Specimen Label: Spry2 - E16.5
Detected: true
Specimen Num: 4
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GXD Expression
GXD Expression
Probe: MGI:1672456
Assay Type: RNA in situ
Annotation Date: 2010-05-13
Strength: Very strong
Sex: Not Specified
Emaps: EMAPS:1690819
Pattern: Non-Uniform
Stage: TS19
Assay Id: MGI:4450780
Age: embryonic day 11.5
Image: Spry2 - E11.5
Note: There is very strong staining in the VZ of the dorsal thalamus, prethalamus & ventral POA. Staining is either absent or ubiquitous in the VZ of the dorsal POA, PVH, VMH & ARH nuclei, the AVH, anterior & posterior IDs, premam, mam & supramam zones & TT.
Specimen Label: Spry2 - E11.5
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
Probe: MGI:1672456
Assay Type: RNA in situ
Annotation Date: 2010-05-13
Strength: Very strong
Sex: Not Specified
Emaps: EMAPS:1753920
Pattern: Non-Uniform
Stage: TS20
Assay Id: MGI:4450780
Age: embryonic day 12.5
Image: Spry2 - E12.5
Note: There is very strong staining in the ventricular zone of the ventral POA and the AVH and weak, scattered staining in the PVH nucleus. Staining is either absent or ubiquitous in the ventricular zone of the dorsal POA.
Specimen Label: Spry2 - E12.5
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
Probe: MGI:1672456
Assay Type: RNA in situ
Annotation Date: 2010-05-13
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1753924
Pattern: Non-Uniform
Stage: TS24
Assay Id: MGI:4450780
Age: embryonic day 16.5
Image: Spry2 - E16.5
Note: There is strong staining in the ventricular zone of the PVH, SCH and DMH nuclei, the AVH and the DAH and weak staining in the dorsal and ventral POAs. Staining is either absent or ubiquitous in the ventricular zone of the VMH and ARH nuclei and the PH.
Specimen Label: Spry2 - E16.5
Detected: true
Specimen Num: 4
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GXD Expression
GXD Expression
 
Probe: MGI:1672456
Assay Type: RNA in situ
Annotation Date: 2010-05-13
Strength: Ambiguous
Sex: Not Specified
Emaps: EMAPS:1691119
Pattern: Not Specified
Stage: TS19
Assay Id: MGI:4450780
Age: embryonic day 11.5
Image: Spry2 - E11.5
Note: Staining is either absent or ubiquitous in the postmitotic neurons in the intermediate zone and cortical plate of the cerebral cortex and in the mantle zone of the ganglionic eminences.
Specimen Label: Spry2 - E11.5
Specimen Num: 1
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GXD Expression
GXD Expression
 
Probe: MGI:1672456
Assay Type: RNA in situ
Annotation Date: 2010-05-13
Strength: Ambiguous
Sex: Not Specified
Emaps: EMAPS:1754720
Pattern: Not Specified
Stage: TS20
Assay Id: MGI:4450780
Age: embryonic day 12.5
Image: Spry2 - E12.5
Note: Staining is either absent or ubiquitous in the ventricular zone of the cerebral cortex.
Specimen Label: Spry2 - E12.5
Specimen Num: 2
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GXD Expression
GXD Expression
 
Probe: MGI:1672456
Assay Type: RNA in situ
Annotation Date: 2010-05-13
Strength: Ambiguous
Sex: Not Specified
Emaps: EMAPS:1754722
Pattern: Not Specified
Stage: TS22
Assay Id: MGI:4450780
Age: embryonic day 14.5
Image: Spry2 - E14.5
Note: Staining is either absent or ubiquitous in the ventricular zone of the cerebral cortex.
Specimen Label: Spry2 - E14.5
Specimen Num: 3
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GXD Expression
GXD Expression
Probe: MGI:1672456
Assay Type: RNA in situ
Annotation Date: 2010-05-13
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1754724
Pattern: Not Specified
Stage: TS24
Assay Id: MGI:4450780
Age: embryonic day 16.5
Image: Spry2 - E16.5
Note: There is weak staining in the ventricular zone of the cerebral cortex.
Specimen Label: Spry2 - E16.5
Detected: true
Specimen Num: 4
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GXD Expression
GXD Expression
Probe: MGI:1672456
Assay Type: RNA in situ
Annotation Date: 2010-05-13
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:3271022
Pattern: Non-Uniform
Stage: TS22
Assay Id: MGI:4450780
Age: embryonic day 14.5
Image: Spry2 - E14.5
Note: There is moderate staining in the ventricular zone of the TT. Staining is either absent or ubiquitous in the ventricular zone of the premam, mam and supramam zones.
Specimen Label: Spry2 - E14.5
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
 
Probe: MGI:1672456
Assay Type: RNA in situ
Annotation Date: 2010-05-13
Strength: Ambiguous
Sex: Not Specified
Emaps: EMAPS:3271024
Pattern: Not Specified
Stage: TS24
Assay Id: MGI:4450780
Age: embryonic day 16.5
Image: Spry2 - E16.5
Note: Staining is either absent or ubiquitous in the ventricular zone of the premam, mam and supramam zones.
Specimen Label: Spry2 - E16.5
Specimen Num: 4
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GXD Expression
GXD Expression
Probe: MGI:1672456
Assay Type: RNA in situ
Annotation Date: 2010-05-13
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:3266522
Pattern: Non-Uniform
Stage: TS22
Assay Id: MGI:4450780
Age: embryonic day 14.5
Image: Spry2 - E14.5
Note: There is moderate staining in the ventricular zone of the ganglionic eminences. Staining is either absent or ubiquitous in the mantle zone of the ganglionic eminences.
Specimen Label: Spry2 - E14.5
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
Probe: MGI:1672456
Assay Type: RNA in situ
Annotation Date: 2010-05-13
Strength: Very strong
Sex: Not Specified
Emaps: EMAPS:1690619
Pattern: Non-Uniform
Stage: TS19
Assay Id: MGI:4450780
Age: embryonic day 11.5
Image: Spry2 - E11.5
Note: There is very strong staining in the MZ of the dorsal thalamus & prethalamus. Staining is either absent or ubiquitous in the MZ of the dorsal & ventral POAs, the PVH, VMH & ARH nuclei, the AVH, anterior & posterior IDs, premam, mam & supramam zones & TT.
Specimen Label: Spry2 - E11.5
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
 
Probe: MGI:1672456
Assay Type: RNA in situ
Annotation Date: 2010-05-13
Strength: Ambiguous
Sex: Not Specified
Emaps: EMAPS:1754120
Pattern: Not Specified
Stage: TS20
Assay Id: MGI:4450780
Age: embryonic day 12.5
Image: Spry2 - E12.5
Note: Staining is either absent or ubiquitous in the mantle zone of the dorsal thalamus and prethalamus.
Specimen Label: Spry2 - E12.5
Specimen Num: 2
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GXD Expression
GXD Expression
Probe: MGI:1672456
Assay Type: RNA in situ
Annotation Date: 2010-05-13
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1754124
Pattern: Non-Uniform
Stage: TS24
Assay Id: MGI:4450780
Age: embryonic day 16.5
Image: Spry2 - E16.5
Note: There is moderate staining in the mantle zone of the dorsal thalamus. Staining is either absent or ubiquitous in the mantle zone of the prethalamus.
Specimen Label: Spry2 - E16.5
Detected: true
Specimen Num: 4
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Publication
25399781 | -
First Author: Sanui T
Year: 2015
Journal: J Cell Biochem
Title: Mutation of Spry2 induces proliferation and differentiation of osteoblasts but inhibits proliferation of gingival epithelial cells.
Volume: 116
Issue: 4
Pages: 628-39
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Publication
24055172 | J:203791
First Author: Kuracha MR
Year: 2013
Journal: Dev Biol
Title: Spry1 and Spry2 are necessary for eyelid closure.
Volume: 383
Issue: 2
Pages: 227-38
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Publication
17516543 | -
First Author: Ding W
Year: 2007
Journal: J Cell Physiol
Title: Sprouty2 downregulation plays a pivotal role in mediating crosstalk between TGF-beta1 signaling and EGF as well as FGF receptor tyrosine kinase-ERK pathways in mesenchymal cells.
Volume: 212
Issue: 3
Pages: 796-806
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Publication
24469046 | -
First Author: Yim DG
Year: 2015
Journal: Oncogene
Title: Casein kinase 1 regulates Sprouty2 in FGF-ERK signaling.
Volume: 34
Issue: 4
Pages: 474-84
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Publication
17693063 | J:125229
First Author: Welsh IC
Year: 2007
Journal: Mech Dev
Title: A dosage-dependent role for Spry2 in growth and patterning during palate development.
Volume: 124
Issue: 9-10
Pages: 746-61
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Protein
Q9QXV8
Organism: Mus musculus/domesticus
Length: 315  
Fragment?: false
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Protein
B2RS85
Organism: Mus musculus/domesticus
Length: 315  
Fragment?: false
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Publication
12402043 | -
First Author: Hanafusa H
Year: 2002
Journal: Nat Cell Biol
Title: Sprouty1 and Sprouty2 provide a control mechanism for the Ras/MAPK signalling pathway.
Volume: 4
Issue: 11
Pages: 850-8
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Publication
22328578 | J:356701
First Author: Purcell P
Year: 2012
Journal: J Dent Res
Title: Spry1 and spry2 are essential for development of the temporomandibular joint.
Volume: 91
Issue: 4
Pages: 387-93
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Publication
22617155 | J:316627
First Author: Wang C
Year: 2012
Journal: J Hepatol
Title: Inactivation of Spry2 accelerates AKT-driven hepatocarcinogenesis via activation of MAPK and PKM2 pathways.
Volume: 57
Issue: 3
Pages: 577-83
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Publication
22649008 | J:262509
First Author: Gao M
Year: 2012
Journal: EMBO Mol Med
Title: SPRY2 loss enhances ErbB trafficking and PI3K/AKT signalling to drive human and mouse prostate carcinogenesis.
Volume: 4
Issue: 8
Pages: 776-90
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Publication
24361260 | J:206582
First Author: Ching ST
Year: 2014
Journal: Dev Biol
Title: Coordinated activity of Spry1 and Spry2 is required for normal development of the external genitalia.
Volume: 386
Issue: 1
Pages: 1-11
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Publication
21743007 | J:181400
First Author: Kuracha MR
Year: 2011
Journal: Invest Ophthalmol Vis Sci
Title: Spry1 and Spry2 are necessary for lens vesicle separation and corneal differentiation.
Volume: 52
Issue: 9
Pages: 6887-97
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Publication
11960706 | J:76546
First Author: Lin W
Year: 2002
Journal: Mech Dev
Title: Cloning of the mouse Sef gene and comparative analysis of its expression with Fgf8 and Spry2 during embryogenesis.
Volume: 113
Issue: 2
Pages: 163-8
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Publication
28246293 | J:247093
First Author: Pappalardo Z
Year: 2017
Journal: Diabetes
Title: A Whole-Genome RNA Interference Screen Reveals a Role for Spry2 in Insulin Transcription and the Unfolded Protein Response.
Volume: 66
Issue: 6
Pages: 1703-1712
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Publication
26809508 | J:232635
First Author: Shukla A
Year: 2016
Journal: Blood
Title: Sprouty 2: a novel attenuator of B-cell receptor and MAPK-Erk signaling in CLL.
Volume: 127
Issue: 19
Pages: 2310-21
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Publication
24718286 | J:215098
First Author: Zhang X
Year: 2014
Journal: PLoS One
Title: Modulation of fibroblast growth factor signaling is essential for mammary epithelial morphogenesis.
Volume: 9
Issue: 4
Pages: e92735
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Publication
23150596 | J:192348
First Author: Schutzman JL
Year: 2012
Journal: Proc Natl Acad Sci U S A
Title: Sprouty genes function in suppression of prostate tumorigenesis.
Volume: 109
Issue: 49
Pages: 20023-8
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Publication
18216176 | J:131764
First Author: Basson MA
Year: 2008
Journal: Development
Title: Specific regions within the embryonic midbrain and cerebellum require different levels of FGF signaling during development.
Volume: 135
Issue: 5
Pages: 889-98
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Publication
27621461 | J:238344
First Author: Koledova Z
Year: 2016
Journal: Proc Natl Acad Sci U S A
Title: SPRY1 regulates mammary epithelial morphogenesis by modulating EGFR-dependent stromal paracrine signaling and ECM remodeling.
Volume: 113
Issue: 39
Pages: E5731-40
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Publication
33684096 | J:305803
First Author: Sripada A
Year: 2021
Journal: PLoS Biol
Title: Sprouty2 positively regulates T cell function and airway inflammation through regulation of CSK and LCK kinases.
Volume: 19
Issue: 3
Pages: e3001063
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Publication
26655476 | J:353165
 
First Author: Klimaschewski L
Year: 2016
Journal: Neurosci Lett
Title: siRNA mediated down-regulation of Sprouty2/4 diminishes ischemic brain injury.
Volume: 612
Pages: 48-51
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Publication
23232625 | J:320778
First Author: Peier M
Year: 2013
Journal: Angiogenesis
Title: Sprouty2 expression controls endothelial monolayer integrity and quiescence.
Volume: 16
Issue: 2
Pages: 455-68
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Publication
25104556 | J:242191
First Author: Marvaldi L
Year: 2015
Journal: Dev Neurobiol
Title: Enhanced axon outgrowth and improved long-distance axon regeneration in sprouty2 deficient mice.
Volume: 75
Issue: 3
Pages: 217-31
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Publication
19147787 | J:146534
First Author: Frank MJ
Year: 2009
Journal: Blood
Title: Expression of sprouty2 inhibits B-cell proliferation and is epigenetically silenced in mouse and human B-cell lymphomas.
Volume: 113
Issue: 11
Pages: 2478-87
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Publication
18508928 | J:225489
First Author: Sayed D
Year: 2008
Journal: Mol Biol Cell
Title: MicroRNA-21 targets Sprouty2 and promotes cellular outgrowths.
Volume: 19
Issue: 8
Pages: 3272-82
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Publication
18708576 | J:138982
First Author: Feller J
Year: 2008
Journal: Genes Dev
Title: Noncyclic Notch activity in the presomitic mesoderm demonstrates uncoupling of somite compartmentalization and boundary formation.
Volume: 22
Issue: 16
Pages: 2166-71
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Publication
18713620 | J:141038
First Author: Ding W
Year: 2008
Journal: Biochem Biophys Res Commun
Title: Down-regulation of Sprouty2 via p38 MAPK plays a key role in the induction of cellular apoptosis by tumor necrosis factor-alpha.
Volume: 375
Issue: 3
Pages: 460-4
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Publication
32038175 | J:286084
 
First Author: Jamsuwan S
Year: 2019
Journal: Front Cell Neurosci
Title: Simultaneous Knockdown of Sprouty2 and PTEN Promotes Axon Elongation of Adult Sensory Neurons.
Volume: 13
Pages: 583
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Publication
23624922 | J:212597
First Author: Ordóñez-Morán P
Year: 2014
Journal: Oncogene
Title: SPROUTY2 is a β-catenin and FOXO3a target gene indicative of poor prognosis in colon cancer.
Volume: 33
Issue: 15
Pages: 1975-85
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Publication
29540470 | J:262267
 
First Author: Patel R
Year: 2018
Journal: EMBO Mol Med
Title: Sprouty2 loss-induced IL6 drives castration-resistant prostate cancer through scavenger receptor B1.
Volume: 10
Issue: 4
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Publication
23665174 | J:199590
First Author: Zhu W
Year: 2013
Journal: Dev Biol
Title: PI3K regulates branch initiation and extension of cultured mammary epithelia via Akt and Rac1 respectively.
Volume: 379
Issue: 2
Pages: 235-45
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Publication
15809037 | J:98303
First Author: Shim K
Year: 2005
Journal: Dev Cell
Title: Sprouty2, a mouse deafness gene, regulates cell fate decisions in the auditory sensory epithelium by antagonizing FGF signaling.
Volume: 8
Issue: 4
Pages: 553-64
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Publication
22158968 | J:183644
First Author: Okur MN
Year: 2012
Journal: Mol Cell Biol
Title: Intersectin 1 enhances Cbl ubiquitylation of epidermal growth factor receptor through regulation of Sprouty2-Cbl interaction.
Volume: 32
Issue: 4
Pages: 817-25
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Publication
22207734 | J:182438
First Author: Biyashev D
Year: 2012
Journal: Blood
Title: miR-27b controls venous specification and tip cell fate.
Volume: 119
Issue: 11
Pages: 2679-87
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Publication
26540287 | J:244326
First Author: Thongrong S
Year: 2016
Journal: Hippocampus
Title: Sprouty2 and -4 hypomorphism promotes neuronal survival and astrocytosis in a mouse model of kainic acid induced neuronal damage.
Volume: 26
Issue: 5
Pages: 658-67
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Publication
27130872 | J:235521
 
First Author: Joo A
Year: 2016
Journal: Bone
Title: Sprouty2 regulates endochondral bone formation by modulation of RTK and BMP signaling.
Volume: 88
Pages: 170-179
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Publication
21070764 | J:168025
First Author: Miyamoto R
Year: 2011
Journal: Dev Biol
Title: Loss of Sprouty2 partially rescues renal hypoplasia and stomach hypoganglionosis but not intestinal aganglionosis in Ret Y1062F mutant mice.
Volume: 349
Issue: 2
Pages: 160-8
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Publication
28280213 | J:269350
First Author: Percival CJ
Year: 2017
Journal: G3 (Bethesda)
Title: The Interaction of Genetic Background and Mutational Effects in Regulation of Mouse Craniofacial Shape.
Volume: 7
Issue: 5
Pages: 1439-1450
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Publication
17599098 | J:141354
First Author: Gross I
Year: 2007
Journal: Cell Death Differ
Title: Sprouty2 inhibits BDNF-induced signaling and modulates neuronal differentiation and survival.
Volume: 14
Issue: 10
Pages: 1802-12
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Publication
27046834 | J:240228
First Author: Balasooriya GI
Year: 2016
Journal: Dev Cell
Title: An FGFR1-SPRY2 Signaling Axis Limits Basal Cell Proliferation in the Steady-State Airway Epithelium.
Volume: 37
Issue: 1
Pages: 85-97
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Publication
18070883 | J:131584
First Author: Edwin F
Year: 2008
Journal: J Biol Chem
Title: A novel role of Sprouty 2 in regulating cellular apoptosis.
Volume: 283
Issue: 6
Pages: 3181-90
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Publication
20237272 | J:159106
First Author: Faedo A
Year: 2010
Journal: J Neurosci
Title: Repression of Fgf signaling by sprouty1-2 regulates cortical patterning in two distinct regions and times.
Volume: 30
Issue: 11
Pages: 4015-23
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Publication
25897685 | J:221422
 
First Author: Lochovska K
Year: 2015
Journal: BMC Dev Biol
Title: Sprouty gene dosage influences temporal-spatial dynamics of primary enamel knot formation.
Volume: 15
Pages: 21
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Publication
23606267 | J:199200
First Author: Lagronova-Churava S
Year: 2013
Journal: J Exp Zool B Mol Dev Evol
Title: The dynamics of supernumerary tooth development are differentially regulated by Sprouty genes.
Volume: 320
Issue: 5
Pages: 307-20
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Publication
23434594 | J:196384
First Author: Patel R
Year: 2013
Journal: J Clin Invest
Title: Sprouty2, PTEN, and PP2A interact to regulate prostate cancer progression.
Volume: 123
Issue: 3
Pages: 1157-75
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Publication
20719962 | J:182830
First Author: Akbulut S
Year: 2010
Journal: Mol Biol Cell
Title: Sprouty proteins inhibit receptor-mediated activation of phosphatidylinositol-specific phospholipase C.
Volume: 21
Issue: 19
Pages: 3487-96
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Publication
31480885 | J:320741
First Author: Vesela B
Year: 2019
Journal: Organogenesis
Title: Specification of Sprouty2 functions in osteogenesis in in vivo context.
Volume: 15
Issue: 4
Pages: 111-119
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Publication
37341808 | J:338204
First Author: Luzzio A
Year: 2023
Journal: Mamm Genome
Title: The spontaneous mouse mutant low set ears (Lse) is caused by tandem duplication of Fgf3 and Fgf4.
Volume: 34
Issue: 3
Pages: 453-463
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Publication
21362415 | J:173123
First Author: Mahoney Rogers AA
Year: 2011
Journal: Dev Biol
Title: Sprouty1 and Sprouty2 limit both the size of the otic placode and hindbrain Wnt8a by antagonizing FGF signaling.
Volume: 353
Issue: 1
Pages: 94-104
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Publication
29501879 | J:287039
 
First Author: Zhao G
Year: 2018
Journal: Exp Eye Res
Title: Negative regulation of lens fiber cell differentiation by RTK antagonists Spry and Spred.
Volume: 170
Pages: 148-159
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Publication
35297995 | J:323097
 
First Author: Li-Villarreal N
Year: 2022
Journal: Development
Title: FOXO1 represses sprouty 2 and sprouty 4 expression to promote arterial specification and vascular remodeling in the mouse yolk sac.
Volume: 149
Issue: 7
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Publication
21693512 | J:173529
First Author: Yu T
Year: 2011
Journal: Development
Title: Sprouty genes prevent excessive FGF signalling in multiple cell types throughout development of the cerebellum.
Volume: 138
Issue: 14
Pages: 2957-68
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Publication
21655085 | J:173447
First Author: Petersen CI
Year: 2011
Journal: PLoS Genet
Title: FGF signaling regulates the number of posterior taste papillae by controlling progenitor field size.
Volume: 7
Issue: 6
Pages: e1002098
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Publication
20348033 | J:160766
First Author: Porntaveetus T
Year: 2010
Journal: Gene Expr Patterns
Title: Expression of Fgf signalling pathway related genes during palatal rugae development in the mouse.
Volume: 10
Issue: 4-5
Pages: 193-8
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Publication
20934536 | J:168653
First Author: Sylvestersen KB
Year: 2011
Journal: Gene Expr Patterns
Title: Fgf9 signalling stimulates Spred and Sprouty expression in embryonic mouse pancreas mesenchyme.
Volume: 11
Issue: 1-2
Pages: 105-11
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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