Type |
Details |
Score |
Gene |
Type: |
gene |
Organism: |
human |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
chimpanzee |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
cattle |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
chicken |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
macaque, rhesus |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
frog, western clawed |
|
•
•
•
•
•
|
Gene |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
dog, domestic |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Family |
Description: |
Protein sprouty homologue 3 (SPRY3) belongs to the sprouty family, whose members are inhibitors of the Ras-ERK pathway downstream of various receptor tyrosine kinases. SPRY3 plays an important role in the regulation of axonal branching of motoneurons []. It has been linked to cancers []. |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Publication |
First Author: |
Ning Z |
Year: |
2015 |
Journal: |
Hum Mol Genet |
Title: |
Regulation of SPRY3 by X chromosome and PAR2-linked promoters in an autism susceptibility region. |
Volume: |
24 |
Issue: |
18 |
Pages: |
5126-41 |
|
•
•
•
•
•
|
Publication |
First Author: |
Panagiotaki N |
Year: |
2010 |
Journal: |
Development |
Title: |
Characterisation of a new regulator of BDNF signalling, Sprouty3, involved in axonal morphogenesis in vivo. |
Volume: |
137 |
Issue: |
23 |
Pages: |
4005-15 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kalender Atak Z |
Year: |
2012 |
Journal: |
PLoS One |
Title: |
High accuracy mutation detection in leukemia on a selected panel of cancer genes. |
Volume: |
7 |
Issue: |
6 |
Pages: |
e38463 |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
288
|
Fragment?: |
false |
|
•
•
•
•
•
|
Publication |
First Author: |
Ning Z |
Year: |
2019 |
Journal: |
Front Psychiatry |
Title: |
Opposite Expression Patterns of Spry3 and p75NTR in Cerebellar Vermis Suggest a Male-Specific Mechanism of Autism Pathogenesis. |
Volume: |
10 |
|
Pages: |
416 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:1345257 |
Assay Type: |
Northern blot |
Annotation Date: |
2006-05-15 |
Strength: |
Absent |
Sex: |
Not Specified |
Emaps: |
EMAPS:1603910 |
|
Stage: |
TS10 |
Assay Id: |
MGI:3622306 |
Age: |
embryonic day 7.0 |
|
|
Specimen Label: |
None |
Detected: |
false |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:1345257 |
Assay Type: |
Northern blot |
Annotation Date: |
2006-05-15 |
Strength: |
Absent |
Sex: |
Not Specified |
Emaps: |
EMAPS:1603926 |
|
Stage: |
TS26 |
Assay Id: |
MGI:3622306 |
Age: |
embryonic day 18.0 |
|
|
Specimen Label: |
None |
Detected: |
false |
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:5447748 |
Assay Type: |
RT-PCR |
Annotation Date: |
2013-01-07 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:3185820 |
|
Stage: |
TS20 |
Assay Id: |
MGI:5447805 |
Age: |
embryonic day 12.5 |
Image: |
3 |
|
Specimen Label: |
b |
Detected: |
true |
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:5447849 |
Assay Type: |
Western blot |
Annotation Date: |
2013-01-07 |
Strength: |
Absent |
Sex: |
Not Specified |
Emaps: |
EMAPS:1750320 |
|
Stage: |
TS20 |
Assay Id: |
MGI:5447850 |
Age: |
embryonic day 12.5 |
|
|
Specimen Label: |
E12.5 |
Detected: |
false |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:5447849 |
Assay Type: |
Western blot |
Annotation Date: |
2013-01-07 |
Strength: |
Absent |
Sex: |
Not Specified |
Emaps: |
EMAPS:1750322 |
|
Stage: |
TS22 |
Assay Id: |
MGI:5447850 |
Age: |
embryonic day 14.5 |
|
|
Specimen Label: |
E14.5 |
Detected: |
false |
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:5447849 |
Assay Type: |
Western blot |
Annotation Date: |
2013-01-07 |
Strength: |
Absent |
Sex: |
Not Specified |
Emaps: |
EMAPS:1750324 |
|
Stage: |
TS24 |
Assay Id: |
MGI:5447850 |
Age: |
embryonic day 16.5 |
|
|
Specimen Label: |
E16.5 |
Detected: |
false |
Specimen Num: |
3 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:5447748 |
Assay Type: |
RT-PCR |
Annotation Date: |
2013-01-07 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1750320 |
|
Stage: |
TS20 |
Assay Id: |
MGI:5447805 |
Age: |
embryonic day 12.5 |
Image: |
3 |
|
Specimen Label: |
a |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:1345257 |
Assay Type: |
Northern blot |
Annotation Date: |
2006-05-15 |
Strength: |
Present |
Sex: |
Male |
Emaps: |
EMAPS:1797228 |
|
Stage: |
TS28 |
Assay Id: |
MGI:3622306 |
Age: |
postnatal adult |
|
|
Specimen Label: |
None |
Detected: |
true |
Specimen Num: |
4 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:1345257 |
Assay Type: |
Northern blot |
Annotation Date: |
2006-05-15 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1689428 |
|
Stage: |
TS28 |
Assay Id: |
MGI:3622306 |
Age: |
postnatal adult |
|
|
Specimen Label: |
None |
Detected: |
true |
Specimen Num: |
3 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:1345257 |
Assay Type: |
RNA in situ |
Annotation Date: |
2006-05-15 |
Strength: |
Absent |
Sex: |
Not Specified |
Emaps: |
EMAPS:1603910 |
|
Stage: |
TS10 |
Assay Id: |
MGI:3622309 |
Age: |
embryonic day 7.0 |
|
|
Specimen Label: |
None |
Detected: |
false |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:1345257 |
Assay Type: |
RNA in situ |
Annotation Date: |
2006-05-15 |
Strength: |
Absent |
Sex: |
Not Specified |
Emaps: |
EMAPS:1603919 |
|
Stage: |
TS19 |
Assay Id: |
MGI:3622309 |
Age: |
embryonic day 11.5 |
|
|
Specimen Label: |
None |
Detected: |
false |
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6378517 |
Assay Type: |
RNA in situ |
Annotation Date: |
2019-12-02 |
Strength: |
Absent |
Sex: |
Not Specified |
Emaps: |
EMAPS:1689417 |
|
Stage: |
TS17 |
Assay Id: |
MGI:6378765 |
Age: |
embryonic day 10.5 |
|
|
Specimen Label: |
WT |
Detected: |
false |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6378517 |
Assay Type: |
RNA in situ |
Annotation Date: |
2019-12-02 |
Strength: |
Absent |
Sex: |
Not Specified |
Emaps: |
EMAPS:1689417 |
|
Stage: |
TS17 |
Assay Id: |
MGI:6378765 |
Age: |
embryonic day 10.5 |
|
|
Specimen Label: |
Mutant |
Detected: |
false |
Specimen Num: |
2 |
|
•
•
•
•
•
|
Publication |
First Author: |
Impagnatiello MA |
Year: |
2001 |
Journal: |
J Cell Biol |
Title: |
Mammalian sprouty-1 and -2 are membrane-anchored phosphoprotein inhibitors of growth factor signaling in endothelial cells. |
Volume: |
152 |
Issue: |
5 |
Pages: |
1087-98 |
|
•
•
•
•
•
|
Publication |
First Author: |
Sharma B |
Year: |
2012 |
Journal: |
J Biol Chem |
Title: |
Sprouty proteins are negative regulators of interferon (IFN) signaling and IFN-inducible biological responses. |
Volume: |
287 |
Issue: |
50 |
Pages: |
42352-60 |
|
•
•
•
•
•
|
Publication |
First Author: |
Cabrita MA |
Year: |
2006 |
Journal: |
J Biol Chem |
Title: |
A functional interaction between sprouty proteins and caveolin-1. |
Volume: |
281 |
Issue: |
39 |
Pages: |
29201-12 |
|
•
•
•
•
•
|
Publication |
First Author: |
Minowada G |
Year: |
1999 |
Journal: |
Development |
Title: |
Vertebrate Sprouty genes are induced by FGF signaling and can cause chondrodysplasia when overexpressed. |
Volume: |
126 |
Issue: |
20 |
Pages: |
4465-75 |
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2017 |
|
Title: |
Mouse Contig Sequence-to-Marker Association Load |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Ozaki K |
Year: |
2005 |
Journal: |
J Cell Sci |
Title: |
Efficient suppression of FGF-2-induced ERK activation by the cooperative interaction among mammalian Sprouty isoforms. |
Volume: |
118 |
Issue: |
Pt 24 |
Pages: |
5861-71 |
|
•
•
•
•
•
|
Publication |
First Author: |
Waters ST |
Year: |
2006 |
Journal: |
Development |
Title: |
A threshold requirement for Gbx2 levels in hindbrain development. |
Volume: |
133 |
Issue: |
10 |
Pages: |
1991-2000 |
|
•
•
•
•
•
|
Publication |
First Author: |
Balasooriya GI |
Year: |
2016 |
Journal: |
Dev Cell |
Title: |
An FGFR1-SPRY2 Signaling Axis Limits Basal Cell Proliferation in the Steady-State Airway Epithelium. |
Volume: |
37 |
Issue: |
1 |
Pages: |
85-97 |
|
•
•
•
•
•
|
Publication |
First Author: |
Zhang H |
Year: |
2016 |
Journal: |
PLoS Genet |
Title: |
Elevated Fibroblast Growth Factor Signaling Is Critical for the Pathogenesis of the Dwarfism in Evc2/Limbin Mutant Mice. |
Volume: |
12 |
Issue: |
12 |
Pages: |
e1006510 |
|
•
•
•
•
•
|
Publication |
First Author: |
Li-Villarreal N |
Year: |
2022 |
Journal: |
Development |
Title: |
FOXO1 represses sprouty 2 and sprouty 4 expression to promote arterial specification and vascular remodeling in the mouse yolk sac. |
Volume: |
149 |
Issue: |
7 |
|
|
•
•
•
•
•
|
Publication |
First Author: |
Sylvestersen KB |
Year: |
2011 |
Journal: |
Gene Expr Patterns |
Title: |
Fgf9 signalling stimulates Spred and Sprouty expression in embryonic mouse pancreas mesenchyme. |
Volume: |
11 |
Issue: |
1-2 |
Pages: |
105-11 |
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2005 |
|
Title: |
Mouse Synonym Curation |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2003 |
Journal: |
Database Download |
Title: |
Integrating Computational Gene Models into the Mouse Genome Informatics (MGI) Database |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
DDB, FB, MGI, GOA, ZFIN curators |
Year: |
2001 |
|
Title: |
Gene Ontology annotation through association of InterPro records with GO terms |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2003 |
|
Title: |
MGI Sequence Curation Reference |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
GemPharmatech |
Year: |
2020 |
|
Title: |
GemPharmatech Website. |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
UniProt-GOA |
Year: |
2012 |
|
Title: |
Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators |
Year: |
2011 |
|
Title: |
Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
The Gene Ontology Consortium |
Year: |
2010 |
|
Title: |
Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Diez-Roux G |
Year: |
2011 |
Journal: |
PLoS Biol |
Title: |
A high-resolution anatomical atlas of the transcriptome in the mouse embryo. |
Volume: |
9 |
Issue: |
1 |
Pages: |
e1000582 |
|
•
•
•
•
•
|
Publication |
First Author: |
MGI Genome Annotation Group and UniGene Staff |
Year: |
2015 |
Journal: |
Database Download |
Title: |
MGI-UniGene Interconnection Effort |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas |
Year: |
2010 |
|
Title: |
Annotation inferences using phylogenetic trees |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Database and National Center for Biotechnology Information |
Year: |
2000 |
Journal: |
Database Release |
Title: |
Entrez Gene Load |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Bairoch A |
Year: |
1999 |
Journal: |
Database Release |
Title: |
SWISS-PROT Annotated protein sequence database |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Group |
Year: |
2003 |
Journal: |
Database Procedure |
Title: |
Automatic Encodes (AutoE) Reference |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics |
Year: |
2010 |
Journal: |
Database Release |
Title: |
Protein Ontology Association Load. |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2009 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Allen Institute for Brain Science |
Year: |
2004 |
Journal: |
Allen Institute |
Title: |
Allen Brain Atlas: mouse riboprobes |
|
|
|
|
•
•
•
•
•
|
Allele |
Name: |
transgene insertion MR74, GENSAT Project at Rockefeller University |
Allele Type: |
Transgenic |
Attribute String: |
Reporter |
|
•
•
•
•
•
|
Strain |
Attribute String: |
mutant stock, transgenic |
|
•
•
•
•
•
|
Publication |
First Author: |
The Gene Expression Nervous System Atlas (GENSAT) Project, The Rockefeller University (New York, NY) |
Year: |
2005 |
Journal: |
Database Download |
Title: |
MGI download of GENSAT transgene data |
|
|
|
|
•
•
•
•
•
|