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Search results 1 to 100 out of 771 for Spry4

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0.048s
Type Details Score
Gene
Type: gene
Organism: human
Gene
Type: gene
Organism: cattle
Gene
Type: gene
Organism: chicken
Gene
Type: gene
Organism: zebrafish
Gene
Type: gene
Organism: macaque, rhesus
Gene
Type: gene
Organism: frog, western clawed
Gene
Type: gene
Organism: rat
Gene
Type: gene
Organism: dog, domestic
Gene
Type: gene
Organism: chimpanzee
Protein Domain
Type: Family
Description: Protein sprouty homologue 4 (SPRY4) belongs to the sprouty family, whose members are inhibitors of the Ras-ERK pathway downstream of various receptor tyrosine kinases. SPRY4 is a feedback negative regulator of FGFs-induced ERK1/2 signalling. It suppresses Ras-independent ERK activation by binding to Raf1 []. It may function as a tumour suppressor in endometrial adenocarcinoma []. It plays a critical role in developing inflammatory Th17 cells in Th17 cell-driven autoimmune diseases [].
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Publication
First Author: Fukaya T
Year: 2014
Journal: Biochem Biophys Res Commun
Title: Loss of Sprouty4 in T cells ameliorates experimental autoimmune encephalomyelitis in mice by negatively regulating IL-1β receptor expression.
Volume: 447
Issue: 3
Pages: 471-8
Gene
Type: gene
Organism: human
Gene
Type: gene
Organism: human
Publication
First Author: Kousa YA
Year: 2017
Journal: J Dent Res
Title: IRF6 and SPRY4 Signaling Interact in Periderm Development.
Volume: 96
Issue: 11
Pages: 1306-1313
Publication
First Author: Sasaki A
Year: 2003
Journal: Nat Cell Biol
Title: Mammalian Sprouty4 suppresses Ras-independent ERK activation by binding to Raf1.
Volume: 5
Issue: 5
Pages: 427-32
Publication
First Author: Li M
Year: 2014
Journal: Gynecol Endocrinol
Title: SPRY4-mediated ERK1/2 signaling inhibition abolishes 17β-estradiol-induced cell growth in endometrial adenocarcinoma cell.
Volume: 30
Issue: 8
Pages: 600-4
Protein
Organism: Mus musculus/domesticus
Length: 300  
Fragment?: false
Publication
First Author: Jäggi F
Year: 2008
Journal: Mol Cancer Res
Title: Modulation of endocrine pancreas development but not beta-cell carcinogenesis by Sprouty4.
Volume: 6
Issue: 3
Pages: 468-82
Publication
First Author: Charles C
Year: 2011
Journal: Development
Title: Regulation of tooth number by fine-tuning levels of receptor-tyrosine kinase signaling.
Volume: 138
Issue: 18
Pages: 4063-73
Publication
First Author: Zhao Z
Year: 2015
Journal: Nat Genet
Title: Cooperative loss of RAS feedback regulation drives myeloid leukemogenesis.
Volume: 47
Issue: 5
Pages: 539-43
Publication    
First Author: Kim S
Year: 2021
Journal: Elife
Title: Regulation of positive and negative selection and TCR signaling during thymic T cell development by capicua.
Volume: 10
Publication
First Author: Thongrong S
Year: 2016
Journal: Hippocampus
Title: Sprouty2 and -4 hypomorphism promotes neuronal survival and astrocytosis in a mouse model of kainic acid induced neuronal damage.
Volume: 26
Issue: 5
Pages: 658-67
Publication
First Author: Gong Y
Year: 2013
Journal: Angiogenesis
Title: Sprouty4 regulates endothelial cell migration via modulating integrin β3 stability through c-Src.
Volume: 16
Issue: 4
Pages: 861-75
Publication
First Author: Klein OD
Year: 2008
Journal: Development
Title: An FGF signaling loop sustains the generation of differentiated progeny from stem cells in mouse incisors.
Volume: 135
Issue: 2
Pages: 377-85
Publication
First Author: Klein OD
Year: 2006
Journal: Dev Cell
Title: Sprouty genes control diastema tooth development via bidirectional antagonism of epithelial-mesenchymal FGF signaling.
Volume: 11
Issue: 2
Pages: 181-90
Publication  
First Author: Lochovska K
Year: 2015
Journal: BMC Dev Biol
Title: Sprouty gene dosage influences temporal-spatial dynamics of primary enamel knot formation.
Volume: 15
Pages: 21
Publication
First Author: Percival CJ
Year: 2017
Journal: G3 (Bethesda)
Title: The Interaction of Genetic Background and Mutational Effects in Regulation of Mouse Craniofacial Shape.
Volume: 7
Issue: 5
Pages: 1439-1450
Publication
First Author: Lagronova-Churava S
Year: 2013
Journal: J Exp Zool B Mol Dev Evol
Title: The dynamics of supernumerary tooth development are differentially regulated by Sprouty genes.
Volume: 320
Issue: 5
Pages: 307-20
Publication  
First Author: Chen R
Year: 2022
Journal: Redox Biol
Title: Macrophage Sprouty4 deficiency diminishes sepsis-induced acute lung injury in mice.
Volume: 58
Pages: 102513
Publication
First Author: Sharma B
Year: 2012
Journal: J Biol Chem
Title: Sprouty proteins are negative regulators of interferon (IFN) signaling and IFN-inducible biological responses.
Volume: 287
Issue: 50
Pages: 42352-60
Publication
First Author: Morgani SM
Year: 2018
Journal: Dev Biol
Title: A Sprouty4 reporter to monitor FGF/ERK signaling activity in ESCs and mice.
Volume: 441
Issue: 1
Pages: 104-126
Publication  
First Author: Li-Villarreal N
Year: 2022
Journal: Development
Title: FOXO1 represses sprouty 2 and sprouty 4 expression to promote arterial specification and vascular remodeling in the mouse yolk sac.
Volume: 149
Issue: 7
Publication
First Author: Porntaveetus T
Year: 2010
Journal: Gene Expr Patterns
Title: Expression of Fgf signalling pathway related genes during palatal rugae development in the mouse.
Volume: 10
Issue: 4-5
Pages: 193-8
Publication
First Author: Miraoui H
Year: 2013
Journal: Am J Hum Genet
Title: Mutations in FGF17, IL17RD, DUSP6, SPRY4, and FLRT3 are identified in individuals with congenital hypogonadotropic hypogonadism.
Volume: 92
Issue: 5
Pages: 725-43
Publication
First Author: Kuracha MR
Year: 2013
Journal: Dev Biol
Title: Spry1 and Spry2 are necessary for eyelid closure.
Volume: 383
Issue: 2
Pages: 227-38
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus caroli
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus pahari
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus spretus
Publication
First Author: Taniguchi K
Year: 2009
Journal: Cancer Sci
Title: Sprouty4 deficiency potentiates Ras-independent angiogenic signals and tumor growth.
Volume: 100
Issue: 9
Pages: 1648-54
GXD Expression      
Probe: MGI:1345258
Assay Type: Northern blot
Annotation Date: 1999-10-06
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1610528
Stage: TS28
Assay Id: MGI:1345505
Age: postnatal adult
Specimen Label: adult heart
Detected: true
Specimen Num: 1
GXD Expression      
Probe: MGI:1345258
Assay Type: Northern blot
Annotation Date: 1999-10-06
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:1345505
Age: postnatal adult
Specimen Label: adult brain
Detected: true
Specimen Num: 2
GXD Expression      
Probe: MGI:1345258
Assay Type: Northern blot
Annotation Date: 1999-10-06
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1672828
Stage: TS28
Assay Id: MGI:1345505
Age: postnatal adult
Specimen Label: adult lung
Detected: true
Specimen Num: 3
GXD Expression      
Probe: MGI:1345258
Assay Type: Northern blot
Annotation Date: 1999-10-06
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1737328
Stage: TS28
Assay Id: MGI:1345505
Age: postnatal adult
Specimen Label: adult kidney
Detected: true
Specimen Num: 4
GXD Expression      
Probe: MGI:1345258
Assay Type: Northern blot
Annotation Date: 1999-10-06
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3598828
Stage: TS28
Assay Id: MGI:1345505
Age: postnatal adult
Specimen Label: adult skeletal muscle
Detected: true
Specimen Num: 5
GXD Expression    
Probe: MGI:5447749
Assay Type: RT-PCR
Annotation Date: 2013-01-07
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3185820
Stage: TS20
Assay Id: MGI:5447808
Age: embryonic day 12.5
Image: 3
Specimen Label: b
Detected: true
Specimen Num: 2
GXD Expression    
Probe: MGI:5447779
Assay Type: Western blot
Annotation Date: 2013-01-07
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1750320
Stage: TS20
Assay Id: MGI:5447810
Age: embryonic day 12.5
Image: 3
Specimen Label: E12.5
Detected: false
Specimen Num: 2
GXD Expression    
Probe: MGI:5447779
Assay Type: Western blot
Annotation Date: 2013-01-07
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1750322
Stage: TS22
Assay Id: MGI:5447810
Age: embryonic day 14.5
Image: 3
Specimen Label: E14.5
Detected: false
Specimen Num: 3
GXD Expression    
Probe: MGI:5447779
Assay Type: Western blot
Annotation Date: 2013-01-07
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1750324
Stage: TS24
Assay Id: MGI:5447810
Age: embryonic day 16.5
Image: 3
Specimen Label: E16.5
Detected: false
Specimen Num: 4
GXD Expression    
Probe: MGI:5447749
Assay Type: RT-PCR
Annotation Date: 2013-01-08
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1706719
Stage: TS19
Assay Id: MGI:5448056
Age: embryonic day 11.5
Image: 4
Specimen Label: epithelium
Detected: true
Specimen Num: 1
GXD Expression    
Probe: MGI:5447749
Assay Type: RT-PCR
Annotation Date: 2013-01-08
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1706719
Stage: TS19
Assay Id: MGI:5448056
Age: embryonic day 11.5
Image: 4
Specimen Label: mesenchyme
Detected: true
Specimen Num: 2
GXD Expression    
Probe: MGI:5586879
Assay Type: RT-PCR
Annotation Date: 2014-10-09
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1611715
Stage: TS15
Assay Id: MGI:5586975
Age: embryonic day 9.5
Image: 8
Specimen Label: Spry1-/-;Spry2-/-
Detected: true
Specimen Num: 1
GXD Expression    
Probe: MGI:5586879
Assay Type: RT-PCR
Annotation Date: 2014-10-09
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1611715
Stage: TS15
Assay Id: MGI:5586975
Age: embryonic day 9.5
Image: 8
Specimen Label: Spry1-/-;Spry2-/-;Tbx1+/-
Detected: true
Specimen Num: 2
GXD Expression      
Probe: MGI:5754791
Assay Type: RT-PCR
Annotation Date: 2016-03-31
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1640619
Stage: TS19
Assay Id: MGI:5755253
Age: embryonic day 11.5
Specimen Label: 45ss wt
Detected: true
Specimen Num: 1
GXD Expression      
Probe: MGI:5754791
Assay Type: RT-PCR
Annotation Date: 2016-03-31
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1640619
Stage: TS19
Assay Id: MGI:5755253
Age: embryonic day 11.5
Specimen Label: 45ss Lp/Lp
Detected: true
Specimen Num: 2
GXD Expression    
Probe: MGI:5447749
Assay Type: RT-PCR
Annotation Date: 2013-01-07
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1750320
Stage: TS20
Assay Id: MGI:5447808
Age: embryonic day 12.5
Image: 3
Specimen Label: a
Detected: true
Specimen Num: 1
GXD Expression    
Probe: MGI:6286268
Assay Type: RT-PCR
Annotation Date: 2019-04-09
Strength: Present
Sex: Not Specified
Emaps: EMAPS:360464
Stage: TS04
Assay Id: MGI:6286483
Age: embryonic day 3.75
Image: S3
Specimen Label: wt
Detected: true
Specimen Num: 1
GXD Expression    
Probe: MGI:6286268
Assay Type: RT-PCR
Annotation Date: 2019-04-09
Strength: Present
Sex: Not Specified
Emaps: EMAPS:360464
Stage: TS04
Assay Id: MGI:6286483
Age: embryonic day 3.75
Image: S3
Specimen Label: het
Detected: true
Specimen Num: 2
GXD Expression    
Probe: MGI:6286268
Assay Type: RT-PCR
Annotation Date: 2019-04-09
Strength: Present
Sex: Not Specified
Emaps: EMAPS:360464
Stage: TS04
Assay Id: MGI:6286483
Age: embryonic day 3.75
Image: S3
Specimen Label: homo
Detected: true
Specimen Num: 3
GXD Expression    
Probe: MGI:6406312
Assay Type: RT-PCR
Annotation Date: 2020-04-28
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1674815
Stage: TS15
Assay Id: MGI:6406500
Age: embryonic day 9.25
Image: S9
Specimen Label: Control
Detected: true
Specimen Num: 1
GXD Expression    
Probe: MGI:6406312
Assay Type: RT-PCR
Annotation Date: 2020-04-28
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1674815
Stage: TS15
Assay Id: MGI:6406500
Age: embryonic day 9.25
Image: S9
Specimen Label: TCre/+;Taf10
Detected: true
Specimen Num: 2
GXD Expression    
Probe: MGI:6436476
Assay Type: RT-PCR
Annotation Date: 2020-06-24
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1672826
Stage: TS26
Assay Id: MGI:6436505
Age: embryonic day 19.5
Image: 7
Specimen Label: WT
Detected: true
Specimen Num: 1
GXD Expression    
Probe: MGI:6436476
Assay Type: RT-PCR
Annotation Date: 2020-06-24
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1672826
Stage: TS26
Assay Id: MGI:6436505
Age: embryonic day 19.5
Image: 7
Specimen Label: Dip2a-/-
Detected: true
Specimen Num: 2
GXD Expression    
Probe: MGI:6443661
Assay Type: RT-PCR
Annotation Date: 2020-07-22
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1745821
Stage: TS21
Assay Id: MGI:6444104
Age: embryonic day 13.0
Image: 4
Specimen Label: Control
Detected: true
Specimen Num: 1
GXD Expression    
Probe: MGI:6443661
Assay Type: RT-PCR
Annotation Date: 2020-07-22
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1745821
Stage: TS21
Assay Id: MGI:6444104
Age: embryonic day 13.0
Image: 4
Specimen Label: rdf
Detected: true
Specimen Num: 2
GXD Expression      
Probe: MGI:6724272
Assay Type: RT-PCR
Annotation Date: 2021-07-20
Strength: Present
Sex: Female
Emaps: EMAPS:1796220
Stage: TS20
Assay Id: MGI:6724336
Age: embryonic day 12.5
Specimen Label: E12.5 XX
Detected: true
Specimen Num: 1
GXD Expression      
Probe: MGI:6724272
Assay Type: RT-PCR
Annotation Date: 2021-07-20
Strength: Present
Sex: Male
Emaps: EMAPS:1797220
Stage: TS20
Assay Id: MGI:6724336
Age: embryonic day 12.5
Specimen Label: E12.5 XY
Detected: true
Specimen Num: 2
GXD Expression      
Probe: MGI:6724272
Assay Type: RT-PCR
Annotation Date: 2021-07-20
Strength: Present
Sex: Female
Emaps: EMAPS:1796221
Stage: TS21
Assay Id: MGI:6724336
Age: embryonic day 13.5
Specimen Label: E13.5 XX
Detected: true
Specimen Num: 3
GXD Expression      
Probe: MGI:6724272
Assay Type: RT-PCR
Annotation Date: 2021-07-20
Strength: Present
Sex: Male
Emaps: EMAPS:1797221
Stage: TS21
Assay Id: MGI:6724336
Age: embryonic day 13.5
Specimen Label: E13.5 XY
Detected: true
Specimen Num: 4
GXD Expression    
Probe: MGI:7482777
Assay Type: RT-PCR
Annotation Date: 2023-05-23
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1752528
Stage: TS28
Assay Id: MGI:7484147
Age: postnatal day 7
Image: 5
Specimen Label: 5C wt
Detected: true
Specimen Num: 1
GXD Expression    
Probe: MGI:7482777
Assay Type: RT-PCR
Annotation Date: 2023-05-23
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1752528
Stage: TS28
Assay Id: MGI:7484147
Age: postnatal day 7
Image: 5
Specimen Label: 5C Kras
Detected: true
Specimen Num: 2
GXD Expression  
Probe: MGI:1345258
Assay Type: RNA in situ
Annotation Date: 2019-04-09
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1611814
Pattern: Not Specified
Stage: TS14
Assay Id: MGI:6286488
Age: embryonic day 9.0
Image: S7C left
Specimen Label: S7C left
Detected: true
Specimen Num: 9
GXD Expression  
Probe: MGI:1345258
Assay Type: RNA in situ
Annotation Date: 2019-04-09
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1611817
Pattern: Not Specified
Stage: TS17
Assay Id: MGI:6286488
Age: embryonic day 10.5
Image: S7D pharyngeal arches
Specimen Label: S7D pharyngeal arches
Detected: true
Specimen Num: 12
GXD Expression  
Probe: MGI:1345258
Assay Type: RNA in situ
Annotation Date: 2019-04-09
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1611815
Pattern: Not Specified
Stage: TS15
Assay Id: MGI:6286488
Age: embryonic day 9.0
Image: S7A E9.0
Specimen Label: S7A E9.0
Detected: true
Specimen Num: 4
GXD Expression  
Probe: MGI:1345258
Assay Type: RNA in situ
Annotation Date: 2019-04-09
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1611815
Pattern: Not Specified
Stage: TS15
Assay Id: MGI:6286488
Age: embryonic day 9.5
Image: S7A E9.5
Specimen Label: S7A E9.5
Detected: true
Specimen Num: 5
GXD Expression    
Assay Type: In situ reporter (knock in)
Annotation Date: 2019-04-05
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1611813
Pattern: Not Specified
Stage: TS13
Assay Id: MGI:6286316
Age: embryonic day 8.5
Image: 9A
Specimen Label: 9A
Detected: true
Specimen Num: 25
GXD Expression    
Assay Type: In situ reporter (knock in)
Annotation Date: 2019-04-05
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1611814
Pattern: Not Specified
Stage: TS14
Assay Id: MGI:6286316
Age: embryonic day 8.75
Image: 9B
Specimen Label: 9B
Detected: true
Specimen Num: 26
GXD Expression
Probe: MGI:6378518
Assay Type: RNA in situ
Annotation Date: 2019-12-02
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1691617
Pattern: Regionally restricted
Stage: TS17
Assay Id: MGI:6378735
Age: embryonic day 10.5
Image: 6O
Note: Expression is flanking the isthmus.
Specimen Label: 6O
Detected: true
Specimen Num: 1
GXD Expression
Probe: MGI:6378518
Assay Type: RNA in situ
Annotation Date: 2019-12-02
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1691617
Pattern: Regionally restricted
Stage: TS17
Assay Id: MGI:6378735
Age: embryonic day 10.5
Image: 6P
Note: The expression domain has expanded caudally and mediolaterally into the anterior region of rhombomere 1 in this mutant.
Specimen Label: 6P
Detected: true
Specimen Num: 2
GXD Expression
Probe: MGI:1345258
Assay Type: RNA in situ
Annotation Date: 1999-10-06
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1675215
Pattern: Not Specified
Stage: TS15
Assay Id: MGI:1345458
Age: embryonic day 9.5
Image: 2.H
Note: Expression is seen in a distinct stripe that appears to mark the region of presomitic mesoderm in which the next somite will segment.
Specimen Label: 2.H
Detected: true
Specimen Num: 2
GXD Expression  
Probe: MGI:532011
Assay Type: RNA in situ
Annotation Date: 2003-03-03
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1675215
Pattern: Not Specified
Stage: TS15
Assay Id: MGI:2450395
Age: embryonic day 9.5
Image: 2C
Specimen Label: 2C
Detected: true
Specimen Num: 3
GXD Expression  
Probe: MGI:532011
Assay Type: RNA in situ
Annotation Date: 2003-03-03
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1675215
Pattern: Not Specified
Stage: TS15
Assay Id: MGI:2450395
Age: embryonic day 9.5
Image: 2E
Specimen Label: 2E
Detected: true
Specimen Num: 5
GXD Expression  
Probe: MGI:532011
Assay Type: RNA in situ
Annotation Date: 2003-03-03
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1675217
Pattern: Not Specified
Stage: TS17
Assay Id: MGI:2450395
Age: embryonic day 10.5
Image: 2F
Specimen Label: 2F
Detected: true
Specimen Num: 6
GXD Expression  
Probe: MGI:1345258
Assay Type: RNA in situ
Annotation Date: 2019-04-09
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1675215
Pattern: Not Specified
Stage: TS15
Assay Id: MGI:6286488
Age: embryonic day 9.0
Image: S7A E9.0
Specimen Label: S7A E9.0
Detected: true
Specimen Num: 4