Type |
Details |
Score |
Gene |
Type: |
gene |
Organism: |
human |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
chimpanzee |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
zebrafish |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
macaque, rhesus |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
frog, western clawed |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
cattle |
|
•
•
•
•
•
|
Gene |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
dog, domestic |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Publication |
First Author: |
Ye B |
Year: |
2020 |
Journal: |
EMBO J |
Title: |
The chromatin remodeler SRCAP promotes self-renewal of intestinal stem cells. |
Volume: |
39 |
Issue: |
13 |
Pages: |
e103786 |
|
•
•
•
•
•
|
Publication |
First Author: |
Chen CW |
Year: |
2023 |
Journal: |
Cell Stem Cell |
Title: |
SRCAP mutations drive clonal hematopoiesis through epigenetic and DNA repair dysregulation. |
Volume: |
30 |
Issue: |
11 |
Pages: |
1503-1519.e8 |
|
•
•
•
•
•
|
Publication |
First Author: |
Ruhl DD |
Year: |
2006 |
Journal: |
Biochemistry |
Title: |
Purification of a human SRCAP complex that remodels chromatin by incorporating the histone variant H2A.Z into nucleosomes. |
Volume: |
45 |
Issue: |
17 |
Pages: |
5671-7 |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
109
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
Mus caroli |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
Mus pahari |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
Mus spretus |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3815684 |
Assay Type: |
RT-PCR |
Annotation Date: |
2008-11-20 |
Strength: |
Present |
Sex: |
Female |
Emaps: |
EMAPS:3102528 |
|
Stage: |
TS28 |
Assay Id: |
MGI:3816488 |
Age: |
postnatal |
|
|
Specimen Label: |
Metaphase II |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3815684 |
Assay Type: |
RT-PCR |
Annotation Date: |
2008-11-20 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:360422 |
|
Stage: |
TS02 |
Assay Id: |
MGI:3816488 |
Age: |
embryonic day 1.5 |
|
|
Specimen Label: |
2-cell embryo |
Detected: |
true |
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3815684 |
Assay Type: |
RT-PCR |
Annotation Date: |
2008-11-20 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:360433 |
|
Stage: |
TS03 |
Assay Id: |
MGI:3816488 |
Age: |
embryonic day 2.0 |
|
|
Specimen Label: |
4-cell embryo |
Detected: |
true |
Specimen Num: |
3 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3815684 |
Assay Type: |
RT-PCR |
Annotation Date: |
2008-11-20 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:360443 |
|
Stage: |
TS03 |
Assay Id: |
MGI:3816488 |
Age: |
embryonic day 2.5 |
|
|
Specimen Label: |
8-cell embryo |
Detected: |
true |
Specimen Num: |
4 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3815684 |
Assay Type: |
RT-PCR |
Annotation Date: |
2008-11-20 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:360453 |
|
Stage: |
TS03 |
Assay Id: |
MGI:3816488 |
Age: |
embryonic day 3.0 |
|
|
Specimen Label: |
Morula |
Detected: |
true |
Specimen Num: |
5 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3815684 |
Assay Type: |
RT-PCR |
Annotation Date: |
2008-11-20 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:360464 |
|
Stage: |
TS04 |
Assay Id: |
MGI:3816488 |
Age: |
embryonic day 3.5 |
|
|
Specimen Label: |
E3.5 blastocyst |
Detected: |
true |
Specimen Num: |
6 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3815684 |
Assay Type: |
RT-PCR |
Annotation Date: |
2008-11-20 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:360465 |
|
Stage: |
TS05 |
Assay Id: |
MGI:3816488 |
Age: |
embryonic day 4.5 |
|
|
Specimen Label: |
E4.5 blastocyst |
Detected: |
true |
Specimen Num: |
7 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3815684 |
Assay Type: |
RT-PCR |
Annotation Date: |
2008-11-20 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:160415 |
|
Stage: |
TS05 |
Assay Id: |
MGI:3816488 |
Age: |
embryonic day 4.5 |
|
|
Specimen Label: |
E4.5 inner cell mass |
Detected: |
true |
Specimen Num: |
8 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3815685 |
Assay Type: |
RT-PCR |
Annotation Date: |
2008-11-20 |
Strength: |
Present |
Sex: |
Female |
Emaps: |
EMAPS:3102528 |
|
Stage: |
TS28 |
Assay Id: |
MGI:3816489 |
Age: |
postnatal |
|
|
Specimen Label: |
Metaphase II |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3815685 |
Assay Type: |
RT-PCR |
Annotation Date: |
2008-11-20 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:360422 |
|
Stage: |
TS02 |
Assay Id: |
MGI:3816489 |
Age: |
embryonic day 1.5 |
|
|
Specimen Label: |
2-cell embryo |
Detected: |
true |
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3815685 |
Assay Type: |
RT-PCR |
Annotation Date: |
2008-11-20 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:360433 |
|
Stage: |
TS03 |
Assay Id: |
MGI:3816489 |
Age: |
embryonic day 2.0 |
|
|
Specimen Label: |
4-cell embryo |
Detected: |
true |
Specimen Num: |
3 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3815685 |
Assay Type: |
RT-PCR |
Annotation Date: |
2008-11-20 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:360443 |
|
Stage: |
TS03 |
Assay Id: |
MGI:3816489 |
Age: |
embryonic day 2.5 |
|
|
Specimen Label: |
8-cell embryo |
Detected: |
true |
Specimen Num: |
4 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3815685 |
Assay Type: |
RT-PCR |
Annotation Date: |
2008-11-20 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:360453 |
|
Stage: |
TS03 |
Assay Id: |
MGI:3816489 |
Age: |
embryonic day 3.0 |
|
|
Specimen Label: |
Morula |
Detected: |
true |
Specimen Num: |
5 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3815685 |
Assay Type: |
RT-PCR |
Annotation Date: |
2008-11-20 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:360464 |
|
Stage: |
TS04 |
Assay Id: |
MGI:3816489 |
Age: |
embryonic day 3.5 |
|
|
Specimen Label: |
E3.5 blastocyst |
Detected: |
true |
Specimen Num: |
6 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3815685 |
Assay Type: |
RT-PCR |
Annotation Date: |
2008-11-20 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:360465 |
|
Stage: |
TS05 |
Assay Id: |
MGI:3816489 |
Age: |
embryonic day 4.5 |
|
|
Specimen Label: |
E4.5 blastocyst |
Detected: |
true |
Specimen Num: |
7 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3815685 |
Assay Type: |
RT-PCR |
Annotation Date: |
2008-11-20 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:160415 |
|
Stage: |
TS05 |
Assay Id: |
MGI:3816489 |
Age: |
embryonic day 4.5 |
|
|
Specimen Label: |
E4.5 inner cell mass |
Detected: |
true |
Specimen Num: |
8 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4426712 |
Assay Type: |
RNA in situ |
Annotation Date: |
2023-09-12 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:3271122 |
Pattern: |
Not Specified |
Stage: |
TS22 |
Assay Id: |
MGI:7525240 |
Age: |
embryonic day 14.5 |
|
|
Specimen Label: |
Supplementary table 2 |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4426712 |
Assay Type: |
RNA in situ |
Annotation Date: |
2023-09-12 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1754722 |
Pattern: |
Not Specified |
Stage: |
TS22 |
Assay Id: |
MGI:7525240 |
Age: |
embryonic day 14.5 |
|
|
Specimen Label: |
Supplementary table 2 |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
Publication |
First Author: |
MGI and IMPC |
Year: |
2017 |
Journal: |
MGI Direct Data Submission |
Title: |
MGI Curation of Endonuclease-Mediated Alleles (CRISPR) from the International Mouse Phenotyping Consortium (IMPC) |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Guo G |
Year: |
2010 |
Journal: |
Dev Cell |
Title: |
Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst. |
Volume: |
18 |
Issue: |
4 |
Pages: |
675-85 |
|
•
•
•
•
•
|
Publication |
First Author: |
Hansen J |
Year: |
2003 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome. |
Volume: |
100 |
Issue: |
17 |
Pages: |
9918-22 |
|
•
•
•
•
•
|
Publication |
First Author: |
Friedel RH |
Year: |
2007 |
Journal: |
Brief Funct Genomic Proteomic |
Title: |
EUCOMM--the European conditional mouse mutagenesis program. |
Volume: |
6 |
Issue: |
3 |
Pages: |
180-5 |
|
•
•
•
•
•
|
Publication |
First Author: |
Bedogni F |
Year: |
2021 |
Journal: |
Front Mol Neurosci |
Title: |
Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development. |
Volume: |
14 |
|
Pages: |
686034 |
|
•
•
•
•
•
|
Publication |
First Author: |
Gray PA |
Year: |
2004 |
Journal: |
Science |
Title: |
Mouse brain organization revealed through direct genome-scale TF expression analysis. |
Volume: |
306 |
Issue: |
5705 |
Pages: |
2255-7 |
|
•
•
•
•
•
|
Publication |
First Author: |
Stryke D |
Year: |
2003 |
Journal: |
Nucleic Acids Res |
Title: |
BayGenomics: a resource of insertional mutations in mouse embryonic stem cells. |
Volume: |
31 |
Issue: |
1 |
Pages: |
278-81 |
|
•
•
•
•
•
|
Publication |
First Author: |
Hansen GM |
Year: |
2008 |
Journal: |
Genome Res |
Title: |
Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. |
Volume: |
18 |
Issue: |
10 |
Pages: |
1670-9 |
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics and the International Mouse Phenotyping Consortium (IMPC) |
Year: |
2014 |
Journal: |
Database Release |
Title: |
Obtaining and Loading Phenotype Annotations from the International Mouse Phenotyping Consortium (IMPC) Database |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Magdaleno S |
Year: |
2006 |
Journal: |
PLoS Biol |
Title: |
BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system. |
Volume: |
4 |
Issue: |
4 |
Pages: |
e86 |
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2003 |
|
Title: |
MGI Sequence Curation Reference |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
MGD Nomenclature Committee |
Year: |
1995 |
|
Title: |
Nomenclature Committee Use |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI) |
Year: |
2008 |
Journal: |
Database Download |
Title: |
Mouse Gene Trap Data Load from dbGSS |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Zambrowicz BP |
Year: |
2003 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. |
Volume: |
100 |
Issue: |
24 |
Pages: |
14109-14 |
|
•
•
•
•
•
|
Publication |
First Author: |
GemPharmatech |
Year: |
2020 |
|
Title: |
GemPharmatech Website. |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Okazaki Y |
Year: |
2002 |
Journal: |
Nature |
Title: |
Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. |
Volume: |
420 |
Issue: |
6915 |
Pages: |
563-73 |
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2010 |
|
Title: |
Human to Mouse ISO GO annotation transfer |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Diez-Roux G |
Year: |
2011 |
Journal: |
PLoS Biol |
Title: |
A high-resolution anatomical atlas of the transcriptome in the mouse embryo. |
Volume: |
9 |
Issue: |
1 |
Pages: |
e1000582 |
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2010 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2). |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2002 |
|
Title: |
Mouse Genome Informatics Computational Sequence to Gene Associations |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas |
Year: |
2010 |
|
Title: |
Annotation inferences using phylogenetic trees |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Bairoch A |
Year: |
1999 |
Journal: |
Database Release |
Title: |
SWISS-PROT Annotated protein sequence database |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2005 |
|
Title: |
Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2005 |
|
Title: |
Obtaining and loading genome assembly coordinates from NCBI annotations |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI) |
Year: |
2010 |
Journal: |
Database Download |
Title: |
Consensus CDS project |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Database and National Center for Biotechnology Information |
Year: |
2000 |
Journal: |
Database Release |
Title: |
Entrez Gene Load |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Allen Institute for Brain Science |
Year: |
2004 |
Journal: |
Allen Institute |
Title: |
Allen Brain Atlas: mouse riboprobes |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2009 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Group |
Year: |
2003 |
Journal: |
Database Procedure |
Title: |
Automatic Encodes (AutoE) Reference |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2009 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform |
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Publication |
First Author: |
Xu M |
Year: |
2021 |
Journal: |
Development |
Title: |
The SRCAP chromatin remodeling complex promotes oxidative metabolism during prenatal heart development. |
Volume: |
148 |
Issue: |
8 |
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Publication |
First Author: |
Ye B |
Year: |
2017 |
Journal: |
Nat Commun |
Title: |
Suppression of SRCAP chromatin remodelling complex and restriction of lymphoid lineage commitment by Pcid2. |
Volume: |
8 |
Issue: |
1 |
Pages: |
1518 |
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Publication |
First Author: |
Liang X |
Year: |
2016 |
Journal: |
Nat Struct Mol Biol |
Title: |
Structural basis of H2A.Z recognition by SRCAP chromatin-remodeling subunit YL1. |
Volume: |
23 |
Issue: |
4 |
Pages: |
317-23 |
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Publication |
First Author: |
Eissenberg JC |
Year: |
2005 |
Journal: |
Mol Cell Biol |
Title: |
Human SRCAP and Drosophila melanogaster DOM are homologs that function in the notch signaling pathway. |
Volume: |
25 |
Issue: |
15 |
Pages: |
6559-69 |
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DO Term |
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Protein Domain |
Type: |
Family |
Description: |
This entry include a group of proteins involved in chromatin remodelling, including Vps72 (vacuolar protein sorting-associated protein 72) from budding yeasts. Vps72 is a Htz1-binding component of the SWR1 complex, which is required for the incorporation of the histone variant H2AZ into chromatin []. It is also required for vacuolar protein sorting in budding yeasts [].The Vps72 homologue from animals, YL-1, is a deposition-and-exchange histone chaperone specific for H2AZ1, specifically chaperones H2AZ1 and deposits it into nucleosomes. It is component of the SRCAP and Tip60 complexes, and mediates the ATP-dependent exchange of histone H2AZ1/H2B dimers for nucleosomal H2A/H2B, leading to transcriptional regulation of selected genes by chromatin remodeling [, ]. |
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Publication |
First Author: |
Cuadrado A |
Year: |
2010 |
Journal: |
EMBO J |
Title: |
Essential role of p18Hamlet/SRCAP-mediated histone H2A.Z chromatin incorporation in muscle differentiation. |
Volume: |
29 |
Issue: |
12 |
Pages: |
2014-25 |
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Publication |
First Author: |
Zhao B |
Year: |
2019 |
Journal: |
Nat Commun |
Title: |
Znhit1 controls intestinal stem cell maintenance by regulating H2A.Z incorporation. |
Volume: |
10 |
Issue: |
1 |
Pages: |
1071 |
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Publication |
First Author: |
Shi Y |
Year: |
2022 |
Journal: |
JCI Insight |
Title: |
Critical role of Znhit1 for postnatal heart function and vacuolar cardiomyopathy. |
Volume: |
7 |
Issue: |
6 |
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Protein Domain |
Type: |
Domain |
Description: |
This entry include a group of proteins involved in chromatin remodelling, including Vps72 (vacuolar protein sorting-associated protein 72) from budding yeasts. Vps72 is a Htz1-binding component of the SWR1 complex, which is required for the incorporation of the histone variant H2AZ into chromatin []. It is also required for vacuolar protein sorting in budding yeasts [].The Vps72 homologue from animals, YL-1, is a deposition-and-exchangehistone chaperone specific for H2AZ1, specifically chaperones H2AZ1 and deposits it into nucleosomes. It is component of the SRCAP and Tip60 complexes, and mediates the ATP-dependent exchange of histone H2AZ1/H2B dimers for nucleosomal H2A/H2B, leading to transcriptional regulation of selected genes by chromatin remodeling [, ].This is the N-terminal region from Vps72/YL1, which covers the aspartate- and glutamate-rich N-terminal domain and the central DNA-binding domain [, ]. |
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
368
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Fragment?: |
false |
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Publication |
First Author: |
Watanabe S |
Year: |
2013 |
Journal: |
Science |
Title: |
A histone acetylation switch regulates H2A.Z deposition by the SWR-C remodeling enzyme. |
Volume: |
340 |
Issue: |
6129 |
Pages: |
195-9 |
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Publication |
First Author: |
Kusch T |
Year: |
2004 |
Journal: |
Science |
Title: |
Acetylation by Tip60 is required for selective histone variant exchange at DNA lesions. |
Volume: |
306 |
Issue: |
5704 |
Pages: |
2084-7 |
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Publication |
First Author: |
Latrick CM |
Year: |
2016 |
Journal: |
Nat Struct Mol Biol |
Title: |
Molecular basis and specificity of H2A.Z-H2B recognition and deposition by the histone chaperone YL1. |
Volume: |
23 |
Issue: |
4 |
Pages: |
309-16 |
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Publication |
First Author: |
Eguchi K |
Year: |
2019 |
Journal: |
Sci Rep |
Title: |
Prevention of respiratory syncytial virus infection with probiotic lactic acid bacterium Lactobacillus gasseri SBT2055. |
Volume: |
9 |
Issue: |
1 |
Pages: |
4812 |
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Publication |
First Author: |
Squatrito M |
Year: |
2006 |
Journal: |
Trends Cell Biol |
Title: |
Tip60 in DNA damage response and growth control: many tricks in one HAT. |
Volume: |
16 |
Issue: |
9 |
Pages: |
433-42 |
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Publication |
First Author: |
Negishi M |
Year: |
2009 |
Journal: |
Genes Cells |
Title: |
Dmap1 plays an essential role in the maintenance of genome integrity through the DNA repair process. |
Volume: |
14 |
Issue: |
11 |
Pages: |
1347-57 |
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Publication |
First Author: |
Lee GE |
Year: |
2010 |
Journal: |
J Biol Chem |
Title: |
DNA methyltransferase 1-associated protein (DMAP1) is a co-repressor that stimulates DNA methylation globally and locally at sites of double strand break repair. |
Volume: |
285 |
Issue: |
48 |
Pages: |
37630-40 |
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Protein Domain |
Type: |
Family |
Description: |
This entry consists of the SWR1-complex protein 4 (Swc4) from yeast, also known as EAF2, and its mammalian homologue DNA methyltransferase 1-associated protein 1 (Dmap1) []. They are components of the NuA4 histone acetyltransferase (HAT) complex, which is highly conserved in eukaryotes. NuA4 acetylates the nucleosomal histones H4 and H2A and plays primary roles in transcription, DNA repair, and cell cycle control [, ].The subunits of the NuA4 complex are shared by the ATP-dependent chromatin-remodeling SWR1 complex in yeast and its human orthologue, Snf 2-related CREB-binding protein (CBP) activator protein (SRCAP) complex. The mammalian NuA4 complex includes the SRCAP complex, and thus combines the functions of the yeast NuA4 and Swr1 complexes []. The SWR1/SRCAP complex mediates the ATP-dependent exchange of histone H2A for the H2A variant HZT1 leading to transcriptional regulation of selected genes by chromatin remodeling [, , ]. Dmap1 was originally identified as an interacting molecule with DNA methyltransferase 1 (DNMT1) and plays a crucial role in DNA repair. It is indispensable for the maintenance of chromosomal integrity and might function as a tumor suppressor []. |
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
468
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Fragment?: |
false |
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