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Search results 1 to 100 out of 105 for Srp72

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Hits by Pathway

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Hits by Strain

Type Details Score
Gene
6731 | SRP72
Type: gene
Organism: human
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Gene
496794 | srp72
Type: gene
Organism: frog, western clawed
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Protein Domain
IPR026270 | SRP72
Type: Family
Description: SRP72 is a core component of the signal recognition particle ribonucleoprotein complex that functions in targeting nascent secretory proteins to the endoplasmic reticulum membrane [, ]. SRP72 binds the 7S RNA only in presence of SRP68 [].
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Gene
498351 | Srp72
Type: gene
Organism: rat
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Gene
403944 | SRP72
Type: gene
Organism: dog, domestic
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Gene
461308 | SRP72
Type: gene
Organism: chimpanzee
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Gene
509430 | SRP72
Type: gene
Organism: cattle
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Gene
422626 | SRP72
Type: gene
Organism: chicken
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Gene
327335 | srp72
Type: gene
Organism: zebrafish
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Gene
694604 | SRP72
Type: gene
Organism: macaque, rhesus
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Protein Coding Gene
MGI:1333795 | Srp72
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein
A0PJ97
Organism: Mus musculus/domesticus
Length: 559  
Fragment?: true
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Protein
A0JLN1
Organism: Mus musculus/domesticus
Length: 559  
Fragment?: true
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Protein
Q9CS54
Organism: Mus musculus/domesticus
Length: 197  
Fragment?: true
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Protein
F8VQC1
Organism: Mus musculus/domesticus
Length: 671  
Fragment?: false
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Protein
E9Q740
Organism: Mus musculus/domesticus
Length: 610  
Fragment?: false
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Publication
10921896 | -
First Author: Mason N
Year: 2000
Journal: EMBO J
Title: Elongation arrest is a physiologically important function of signal recognition particle.
Volume: 19
Issue: 15
Pages: 4164-74
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Publication
11352936 | -
First Author: Grosshans H
Year: 2001
Journal: J Cell Biol
Title: Biogenesis of the signal recognition particle (SRP) involves import of SRP proteins into the nucleolus, assembly with the SRP-RNA, and Xpo1p-mediated export.
Volume: 153
Issue: 4
Pages: 745-62
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Publication
7925282 | -
First Author: Brown JD
Year: 1994
Journal: EMBO J
Title: Subunits of the Saccharomyces cerevisiae signal recognition particle required for its functional expression.
Volume: 13
Issue: 18
Pages: 4390-400
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Protein
Q3UU23
Organism: Mus musculus/domesticus
Length: 282  
Fragment?: true
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Protein
Q3UZL8
Organism: Mus musculus/domesticus
Length: 553  
Fragment?: true
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Protein Coding Gene
MGP_CAROLIEiJ_G0027323 | -
Type: protein_coding_gene
Organism: Mus caroli
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Protein Coding Gene
MGP_129S1SvImJ_G0029651 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AJ_G0029619 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AKRJ_G0029567 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_BALBcJ_G0029628 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C3HHeJ_G0029351 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI_C57BL6J_1333795 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C57BL6NJ_G0030082 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CASTEiJ_G0028759 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CBAJ_G0029320 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_DBA2J_G0029465 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_FVBNJ_G0029426 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_LPJ_G0029552 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NODShiLtJ_G0029454 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NZOHlLtJ_G0030115 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PWKPhJ_G0028482 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_WSBEiJ_G0028839 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PahariEiJ_G0017103 | -
Type: protein_coding_gene
Organism: Mus pahari
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Protein Coding Gene
MGP_SPRETEiJ_G0028317 | -
Type: protein_coding_gene
Organism: Mus spretus
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Publication
9857079 | J:51619
First Author: Utz PJ
Year: 1998
Journal: J Biol Chem
Title: The 72-kDa component of signal recognition particle is cleaved during apoptosis.
Volume: 273
Issue: 52
Pages: 35362-70
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Publication
11217851 | J:65060
First Author: Kawai J
Year: 2001
Journal: Nature
Title: Functional annotation of a full-length mouse cDNA collection.
Volume: 409
Issue: 6821
Pages: 685-90
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Publication
12466851 | J:80000
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
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Publication
10725249 | J:60984
First Author: Ko MS
Year: 2000
Journal: Development
Title: Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development.
Volume: 127
Issue: 8
Pages: 1737-49
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Publication
- | J:73065
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2001
Title: Gene Ontology Annotation by the MGI Curatorial Staff
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Publication
- | J:94790
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Mouse Synonym Curation
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Publication
- | J:84900
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Journal: Database Download
Title: Integrating Computational Gene Models into the Mouse Genome Informatics (MGI) Database
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Publication
- | J:80001
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: FANTOM2 Data Curation in Mouse Genome Informatics
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Publication
12904583 | J:85162
First Author: Hansen J
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome.
Volume: 100
Issue: 17
Pages: 9918-22
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Publication
17967808 | J:152068
First Author: Friedel RH
Year: 2007
Journal: Brief Funct Genomic Proteomic
Title: EUCOMM--the European conditional mouse mutagenesis program.
Volume: 6
Issue: 3
Pages: 180-5
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Publication
- | J:265051
     
First Author: MGI and IMPC
Year: 2018
Journal: Database Release
Title: MGI Load of Endonuclease-Mediated Alleles (CRISPR) from the International Mouse Phenotyping Consortium (IMPC)
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Publication
- | J:57656
     
First Author: Lennon G
Year: 1999
Journal: Database Download
Title: WashU-HHMI Mouse EST Project
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Publication
- | J:211773
     
First Author: Mouse Genome Informatics and the International Mouse Phenotyping Consortium (IMPC)
Year: 2014
Journal: Database Release
Title: Obtaining and Loading Phenotype Annotations from the International Mouse Phenotyping Consortium (IMPC) Database
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Publication
18799693 | J:142754
First Author: Hansen GM
Year: 2008
Journal: Genome Res
Title: Large-scale gene trapping in C57BL/6N mouse embryonic stem cells.
Volume: 18
Issue: 10
Pages: 1670-9
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Publication
- | J:157065
     
First Author: Helmholtz Zentrum Muenchen GmbH
Year: 2010
Journal: MGI Direct Data Submission
Title: Alleles produced for the EUCOMM and EUCOMMTools projects by the Helmholtz Zentrum Muenchen GmbH (Hmgu)
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Publication
- | J:85000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Title: MGI Sequence Curation Reference
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Publication
16141072 | J:99680
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
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Publication
38355793 | J:345621
First Author: Adams DJ
Year: 2024
Journal: Nature
Title: Genetic determinants of micronucleus formation in vivo.
Volume: 627
Issue: 8002
Pages: 130-136
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Publication
- | J:293217
       
First Author: GemPharmatech
Year: 2020
Title: GemPharmatech Website.
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Publication
- | J:141210
     
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
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Publication
- | J:326541
       
First Author: Cyagen Biosciences Inc.
Year: 2022
Title: Cyagen Biosciences Website.
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Publication
- | J:68900
     
First Author: The Jackson Laboratory Mouse Radiation Hybrid Database
Year: 2004
Journal: Database Release
Title: Mouse T31 Radiation Hybrid Data Load
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Publication
- | J:164563
       
First Author: The Gene Ontology Consortium
Year: 2010
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs
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Publication
21267068 | J:153498
First Author: Diez-Roux G
Year: 2011
Journal: PLoS Biol
Title: A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Volume: 9
Issue: 1
Pages: e1000582
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Publication
- | J:75000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
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Publication
- | J:157972
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
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Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
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Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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Publication
15588816 | -
First Author: Iakhiaeva E
Year: 2005
Journal: J Mol Biol
Title: Identification of an RNA-binding domain in human SRP72.
Volume: 345
Issue: 4
Pages: 659-66
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Protein Domain
IPR013699 | Signal_recog_part_SRP72_RNA-bd
Type: Domain
Description: The signal recognition particle (SRP) is a multimeric protein, which along with its conjugate receptor (SR), is involved in targeting secretory proteins to the rough endoplasmic reticulum (RER) membrane in eukaryotes, or to the plasma membrane in prokaryotes [, ]. SRP recognises the signal sequence of the nascent polypeptide on the ribosome. In eukaryotes this retards its elongation until SRP docks the ribosome-polypeptide complex to the RER membrane via the SR receptor []. Eukaryotic SRP consists of six polypeptides (SRP9, SRP14, SRP19, SRP54, SRP68 and SRP72) and a single 300 nucleotide 7S RNA molecule. The RNA component catalyses the interaction of SRP with its SR receptor []. In higher eukaryotes, the SRP complex consists of the Alu domain and the S domain linked by the SRP RNA. The Alu domain consists of a heterodimer of SRP9 and SRP14 bound to the 5' and 3' terminal sequences of SRP RNA. This domain is necessary for retarding the elongation of the nascent polypeptide chain, which gives SRP time to dock the ribosome-polypeptide complex to the RER membrane. In archaea, the SRP complex contains 7S RNA like its eukaryotic counterpart, yet only includes two of the six protein subunits found in the eukarytic complex: SRP19 and SRP54 [].This entry represents the RNA binding domain of the SRP72 subunit. This domain is responsible for the binding of SRP72 to the 7S SRP RNA [].
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Publication
16672232 | -
First Author: Iakhiaeva E
Year: 2006
Journal: Protein Sci
Title: Protein SRP68 of human signal recognition particle: identification of the RNA and SRP72 binding domains.
Volume: 15
Issue: 6
Pages: 1290-302
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Publication
27899666 | -
First Author: Becker MM
Year: 2017
Journal: Nucleic Acids Res
Title: Structures of human SRP72 complexes provide insights into SRP RNA remodeling and ribosome interaction.
Volume: 45
Issue: 1
Pages: 470-481
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Protein
Q8K258
Organism: Mus musculus/domesticus
Length: 334  
Fragment?: false
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Publication
17254600 | -
First Author: Menichelli E
Year: 2007
Journal: J Mol Biol
Title: Protein-induced conformational changes of RNA during the assembly of human signal recognition particle.
Volume: 367
Issue: 1
Pages: 187-203
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Protein Domain
IPR026258 | SRP68
Type: Family
Description: The signal recognition particle (SRP) is a large ribonucleoprotein complex that targets secretory and membrane proteins to the endoplasmic reticulum membrane [, ]. The mammalian SRP contains a 303-nucleotide SRP RNA and six proteins, named SRP9, SRP14, SRP19, SRP54, SRP68, and SRP72. Among them, the two largest, SRP68 and SRP72, form a stable SRP68/72 heterodimer of unknown structure, which is required for sorting secretory proteins []. SRP68 binds to SRP RNA directly, while SRP72 binds the SRP RNA largely via non-specific electrostatic interaction. The binding of SRP72 with SRP RNA enhances the affinity of SRP68 for the RNA.
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Publication
16469117 | -
First Author: Römisch K
Year: 2006
Journal: Arthritis Res Ther
Title: Human autoantibodies against the 54 kDa protein of the signal recognition particle block function at multiple stages.
Volume: 8
Issue: 2
Pages: R39
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Publication
17622352 | -
First Author: Reyes CL
Year: 2007
Journal: PLoS One
Title: X-ray structures of the signal recognition particle receptor reveal targeting cycle intermediates.
Volume: 2
Issue: 7
Pages: e607
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Publication
17507650 | -
First Author: Bradshaw N
Year: 2007
Journal: Mol Biol Cell
Title: The signal recognition particle (SRP) RNA links conformational changes in the SRP to protein targeting.
Volume: 18
Issue: 7
Pages: 2728-34
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Publication
12364595 | -
First Author: Tozik I
Year: 2002
Journal: Nucleic Acids Res
Title: Reconstitution of the signal recognition particle of the halophilic archaeon Haloferax volcanii.
Volume: 30
Issue: 19
Pages: 4166-75
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Publication
12605305 | -
 
First Author: Koch HG
Year: 2003
Journal: Rev Physiol Biochem Pharmacol
Title: Signal recognition particle-dependent protein targeting, universal to all kingdoms of life.
Volume: 146
Pages: 55-94
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Protein
Q8BMA6
Organism: Mus musculus/domesticus
Length: 625  
Fragment?: false
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Protein
A2AAN2
Organism: Mus musculus/domesticus
Length: 587  
Fragment?: false
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Publication
19693936 | -
First Author: Iakhiaeva E
Year: 2009
Journal: Protein Sci
Title: Characterization of the SRP68/72 interface of human signal recognition particle by systematic site-directed mutagenesis.
Volume: 18
Issue: 10
Pages: 2183-95
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Publication
34020957 | -
 
First Author: Lee JH
Year: 2021
Journal: Sci Adv
Title: Receptor compaction and GTPase rearrangement drive SRP-mediated cotranslational protein translocation into the ER.
Volume: 7
Issue: 21
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Protein Domain
IPR038253 | SRP68_N_sf
Type: Homologous_superfamily
Description: Signal recognition particles (SRPs) are ribonucleoprotein complexes that target particular nascent pre-secretory proteins to the endoplasmic reticulum. The SRP complex targets the ribosome-nascent chain complex to the SRP receptor (SR), which is anchored in the ER, where SR compaction and GTPase rearrangement drive cotranslational protein translocation into the ER []. SRP68 is one of the two largest proteins found in SRPs (the other being SRP72), and it forms a heterodimer with SRP72. Heterodimer formation is essential for SRP function []. SRP68 binds to SRP RNA directly, while SRP72 binds the SRP RNA largely via nonspecific electrostatic interaction. The binding of SRP72 with SRP RNA enhances the affinity of SRP68 for the RNA. This entry describes the N-terminal RNA-binding domain (RBD) of SRP68, a tetratricopeptide-like module. Interactions between SRP68-RBD and SRP RNA (7SL RNA) are thought to facilitate a conformation of SRP RNA that is required for interactions with ribosomal RNA [, , ].
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Protein Domain
IPR034652 | SRP68-RBD
Type: Domain
Description: Signal recognition particles (SRPs) are ribonucleoprotein complexes that target particular nascent pre-secretory proteins to the endoplasmic reticulum. The SRP complex targets the ribosome-nascent chain complex to the SRP receptor (SR), which is anchored in the ER, where SR compaction and GTPase rearrangement drive cotranslational protein translocation into the ER []. SRP68 is one of the two largest proteins found in SRPs (the other being SRP72), and it forms a heterodimer with SRP72. Heterodimer formation is essential for SRP function []. SRP68 binds to SRP RNA directly, while SRP72 binds the SRP RNA largely via nonspecific electrostatic interaction. The binding of SRP72 with SRP RNA enhances the affinity of SRP68 for the RNA. This entry describes the N-terminal RNA-binding domain (RBD) of SRP68, a tetratricopeptide-like module. Interactions between SRP68-RBD and SRP RNA (7SL RNA) are thought to facilitate a conformation of SRP RNA that is required for interactions with ribosomal RNA [, , ].
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Publication
24700861 | -
First Author: Grotwinkel JT
Year: 2014
Journal: Science
Title: SRP RNA remodeling by SRP68 explains its role in protein translocation.
Volume: 344
Issue: 6179
Pages: 101-4
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Publication
19131326 | -
First Author: Sweet SM
Year: 2009
Journal: Mol Cell Proteomics
Title: Large scale localization of protein phosphorylation by use of electron capture dissociation mass spectrometry.
Volume: 8
Issue: 5
Pages: 904-12
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Publication
23806337 | J:203468
First Author: Park J
Year: 2013
Journal: Mol Cell
Title: SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways.
Volume: 50
Issue: 6
Pages: 919-30
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Publication
17242355 | -
First Author: Villén J
Year: 2007
Journal: Proc Natl Acad Sci U S A
Title: Large-scale phosphorylation analysis of mouse liver.
Volume: 104
Issue: 5
Pages: 1488-93
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Publication
11042159 | J:68323
First Author: Carninci P
Year: 2000
Journal: Genome Res
Title: Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes.
Volume: 10
Issue: 10
Pages: 1617-30
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Publication
10349636 | J:80645
 
First Author: Carninci P
Year: 1999
Journal: Methods Enzymol
Title: High-efficiency full-length cDNA cloning.
Volume: 303
Pages: 19-44
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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