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Search results 1 to 100 out of 22386 for Sry

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Type Details Score
Gene
Type: gene
Organism: human
Gene
Type: gene
Organism: macaque, rhesus
Gene
Type: gene
Organism: cattle
Gene
Type: gene
Organism: dog, domestic
Gene
Type: gene
Organism: pig, domestic
Gene
Type: gene
Organism: orangutan, Bornean
Gene
Type: gene
Organism: horse
Gene
Type: gene
Organism: goat
Gene
Type: gene
Organism: gorilla, western
Gene
Type: gene
Organism: sheep
Gene
Type: gene
Organism: rat
Gene
Type: gene
Organism: chimpanzee
Protein Domain
Type: Family
Description: This entry represents the testis-determining factor Sry (Sex-determining Region Y). Sry is a transcriptional activator that regulates a genetic switch inmale development. It is necessary and sufficient for initiating male sex determination by directing the development of supporting cell precursors (pre-Sertoli cells) as Sertoli rather than granulosa cells []. Sry is involved in different aspects of gene regulation including promoter activation or repression and contains a high-mobility-group (HMG) box that recognises DNA by partial intercalation in the minor groove []. It binds to the DNA consensus sequence 5'-[AT]AACAA[AT]-3'. Sry also facilitates DNA bending and is involved in pre-mRNA splicing. It is also involved in maintenance of motor functions of dopaminergic neurons in the male adult brain. Sry interacts with a number of partners, including CALM, EP300 (modulates Sry DNA-binding activity), HDAC3, KPNB1, ZNF208 isoform KRAB-O, PARP1 (impaired Sry DNA-binding activity), SLC9A3R2 and WT1. The C-terminal nuclear localization signal in Sry HMG-box domain mediates nuclear import through importin beta 1 [].Defects in Sry can cause gonadal dysgenesis XY female type (GDXY) (OMIM:306100), which is also known as 'XY females' or Swyer syndrome []. Patients suffer rapid and early degeneration of their gonads, which prevents the development secondary sexual characteristics at puberty. Defects in Sry are also found Turner's Syndrome, a disease characterised by gonadal dysgenesis in a 45,X female type []. Defects in Sry can also cause true hermaphroditism (OMIM:235600), genetically heterogeneous condition whre patients have both mature ovarian and mature testicular tissue (46,XX, 46,XY or a mosaic of 46,XX/46,XY) [].
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
GXD Expression
Probe: MGI:6117272
Assay Type: RNA in situ
Annotation Date: 2018-02-21
Strength: Present
Sex: Male
Emaps: EMAPS:1738319
Pattern: Not Specified
Stage: TS19
Assay Id: MGI:6117300
Age: embryonic day 11.5
Image: 1Ba Sry -/-
Note: Authors state that expression is not altered in XY mutant gonads compared with wild-type
Specimen Label: 1Ba Sry -/-
Detected: true
Specimen Num: 1
GXD Expression  
Probe: MGI:6117272
Assay Type: RNA in situ
Annotation Date: 2018-02-21
Strength: Present
Sex: Male
Emaps: EMAPS:1738319
Pattern: Not Specified
Stage: TS19
Assay Id: MGI:6117300
Age: embryonic day 11.5
Image: 1Ba Sry (lower pane)
Specimen Label: 1Ba Sry (lower pane)
Detected: true
Specimen Num: 2
Publication
First Author: Maier EM
Year: 2003
Journal: J Pediatr Endocrinol Metab
Title: True hermaphroditism in an XY individual due to a familial point mutation of the SRY gene.
Volume: 16
Issue: 4
Pages: 575-80
Publication
First Author: Phillips NB
Year: 2006
Journal: J Mol Biol
Title: SRY and human sex determination: the basic tail of the HMG box functions as a kinetic clamp to augment DNA bending.
Volume: 358
Issue: 1
Pages: 172-92
Publication
First Author: Kellermayer R
Year: 2005
Journal: Diagn Mol Pathol
Title: A novel frame shift mutation in the HMG box of the SRY gene in a patient with complete 46,XY pure gonadal dysgenesis.
Volume: 14
Issue: 3
Pages: 159-63
Gene
Type: gene
Organism: human
Publication
First Author: Ogata T
Year: 1995
Journal: Hum Genet
Title: Turner syndrome and female sex chromosome aberrations: deduction of the principal factors involved in the development of clinical features.
Volume: 95
Issue: 6
Pages: 607-29
Publication
First Author: Forwood JK
Year: 2001
Journal: J Biol Chem
Title: The C-terminal nuclear localization signal of the sex-determining region Y (SRY) high mobility group domain mediates nuclear import through importin beta 1.
Volume: 276
Issue: 49
Pages: 46575-82
Publication
First Author: Anson BJ
Year: 1967
Journal: Arch Otolaryngol
Title: The vestibular system. Anatomic considerations.
Volume: 85
Issue: 5
Pages: 497-514
Gene
Type: gene
Organism: mouse, laboratory
Gene
Type: gene
Organism: mouse, laboratory
Publication
First Author: Zhang J
Year: 1999
Journal: Int J Dev Biol
Title: In vitro binding and expression studies demonstrate a role for the mouse Sry Q-rich domain in sex determination.
Volume: 43
Issue: 3
Pages: 219-27
Publication
First Author: Albrecht KH
Year: 2001
Journal: Dev Biol
Title: Evidence that Sry is expressed in pre-Sertoli cells and Sertoli and granulosa cells have a common precursor.
Volume: 240
Issue: 1
Pages: 92-107
Protein
Organism: Mus musculus/domesticus
Length: 392  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 234  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 233  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 416  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 302  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 300  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 232  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 231  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 395  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 315  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 304  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 232  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 317  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 306  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 374  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 303  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 315  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 233  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 143  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 315  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 314  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 314  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 318  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 303  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 318  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 315  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 316  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 232  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 321  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 418  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 399  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 314  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 306  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 304  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 299  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 314  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 300  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 420  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 234  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 230  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 231  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 232  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 299  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 321  
Fragment?: true
Publication
First Author: Pamilo P
Year: 1997
Journal: Mol Biol Evol
Title: Evolution of the Sry genes.
Volume: 14
Issue: 1
Pages: 49-55
Publication
First Author: Koopman P
Year: 1999
Journal: Cell Mol Life Sci
Title: Sry and Sox9: mammalian testis-determining genes.
Volume: 55
Issue: 6-7
Pages: 839-56
Publication
First Author: Dubin RA
Year: 1994
Journal: Mol Endocrinol
Title: Sry is a transcriptional activator.
Volume: 8
Issue: 9
Pages: 1182-92
Publication
First Author: Eicher EM
Year: 1995
Journal: Philos Trans R Soc Lond B Biol Sci
Title: Sex reversal in C57BL/6J-YPOS mice corrected by a Sry transgene.
Volume: 350
Issue: 1333
Pages: 263-8; discussion 268-9
Publication
First Author: Bradford ST
Year: 2007
Journal: Sex Dev
Title: Comparative analysis of anti-mouse SRY antibodies.
Volume: 1
Issue: 5
Pages: 305-10
Publication
First Author: Bullejos M
Year: 2000
Journal: Cytogenet Cell Genet
Title: The SRY gene HMG-box in micro- and megabats.
Volume: 88
Issue: 1-2
Pages: 30-4
Publication
First Author: Nagai K
Year: 2001
Journal: Gene
Title: Molecular evolution of Sry and Sox gene.
Volume: 270
Issue: 1-2
Pages: 161-9
Publication
First Author: Swain A
Year: 1998
Journal: Nature
Title: Dax1 antagonizes Sry action in mammalian sex determination.
Volume: 391
Issue: 6669
Pages: 761-7
Publication  
First Author: Goodfellow PN
Year: 1993
Journal: Annu Rev Genet
Title: SRY and sex determination in mammals.
Volume: 27
Pages: 71-92
Publication  
First Author: Song Y
Year: 2023
Journal: Life Sci Alliance
Title: Loss of circSRY reduces γH2AX level in germ cells and impairs mouse spermatogenesis.
Volume: 6
Issue: 2
Publication
First Author: Mayer A
Year: 2000
Journal: Neurogenetics
Title: Developmental profile of Sry transcripts in mouse brain.
Volume: 3
Issue: 1
Pages: 25-30
Publication
First Author: Berta P
Year: 1990
Journal: Nature
Title: Genetic evidence equating SRY and the testis-determining factor.
Volume: 348
Issue: 6300
Pages: 448-50
Publication
First Author: Daneau I
Year: 1996
Journal: Biol Reprod
Title: Porcine SRY gene locus and genital ridge expression.
Volume: 55
Issue: 1
Pages: 47-53
Publication
First Author: Katoh-Fukui Y
Year: 2012
Journal: Endocrinology
Title: Cbx2, a polycomb group gene, is required for Sry gene expression in mice.
Volume: 153
Issue: 2
Pages: 913-24
Publication  
First Author: Itoh Y
Year: 2015
Journal: BMC Res Notes
Title: Four core genotypes mouse model: localization of the Sry transgene and bioassay for testicular hormone levels.
Volume: 8
Pages: 69
Publication
First Author: Albrecht KH
Year: 2003
Journal: Genetics
Title: Sry expression level and protein isoform differences play a role in abnormal testis development in C57BL/6J mice carrying certain Sry alleles.
Volume: 164
Issue: 1
Pages: 277-88
Publication
First Author: Bullejos M
Year: 2001
Journal: Dev Dyn
Title: Spatially dynamic expression of Sry in mouse genital ridges.
Volume: 221
Issue: 2
Pages: 201-5
Publication
First Author: Harley VR
Year: 1994
Journal: Mol Reprod Dev
Title: The biochemical role of SRY in sex determination.
Volume: 39
Issue: 2
Pages: 184-93
Publication
First Author: Bradford ST
Year: 2009
Journal: Hum Mol Genet
Title: A cell-autonomous role for WT1 in regulating Sry in vivo.
Volume: 18
Issue: 18
Pages: 3429-38
Publication
First Author: Bergstrom DE
Year: 2000
Journal: Genesis
Title: Related function of mouse SOX3, SOX9, and SRY HMG domains assayed by male sex determination.
Volume: 28
Issue: 3-4
Pages: 111-24
Publication
First Author: Ohe K
Year: 2002
Journal: Proc Natl Acad Sci U S A
Title: A direct role of SRY and SOX proteins in pre-mRNA splicing.
Volume: 99
Issue: 3
Pages: 1146-51
Publication
First Author: Silversides DW
Year: 2012
Journal: Dev Dyn
Title: Transgenic mouse analysis of Sry expression during the pre- and peri-implantation stage.
Volume: 241
Issue: 7
Pages: 1192-204
Publication
First Author: Hiramatsu R
Year: 2009
Journal: Development
Title: A critical time window of Sry action in gonadal sex determination in mice.
Volume: 136
Issue: 1
Pages: 129-38
Publication
First Author: Bullejos M
Year: 2005
Journal: Dev Biol
Title: Delayed Sry and Sox9 expression in developing mouse gonads underlies B6-Y(DOM) sex reversal.
Volume: 278
Issue: 2
Pages: 473-81
Publication
First Author: Kidokoro T
Year: 2005
Journal: Dev Biol
Title: Influence on spatiotemporal patterns of a male-specific Sox9 activation by ectopic Sry expression during early phases of testis differentiation in mice.
Volume: 278
Issue: 2
Pages: 511-25
Publication
First Author: Gubbay J
Year: 1992
Journal: Proc Natl Acad Sci U S A
Title: Inverted repeat structure of the Sry locus in mice.
Volume: 89
Issue: 17
Pages: 7953-7
Publication    
First Author: Lovell-Badge R
Year: 1992
Title: The Role of Sry in Mammalian Sex Determination
Volume: 165
Pages: 162-182
Publication
First Author: Sekido R
Year: 2004
Journal: Dev Biol
Title: SOX9 is up-regulated by the transient expression of SRY specifically in Sertoli cell precursors.
Volume: 274
Issue: 2
Pages: 271-9
Publication
First Author: Warr N
Year: 2022
Journal: Reproduction
Title: Gadd45g is required for timely Sry expression independently of RSPO1 activity.
Volume: 163
Issue: 6
Pages: 333-340