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Search results 1 to 100 out of 23840 for Sry

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Hits by Strain

Type Details Score
Gene
6736 | SRY
Type: gene
Organism: human
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Gene
280931 | SRY
Type: gene
Organism: cattle
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Gene
119868773 | SRY
Type: gene
Organism: dog, domestic
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Gene
key_39060 | SRY
Type: gene
Organism: pig, domestic
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Gene
key_64070 | SRY
Type: gene
Organism: orangutan, Bornean
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Gene
key_79723 | SRY
Type: gene
Organism: horse
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Gene
key_79713 | SRY
Type: gene
Organism: goat
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Gene
key_79714 | SRY
Type: gene
Organism: gorilla, western
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Gene
key_79715 | SRY
Type: gene
Organism: sheep
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Gene
25221 | Sry
Type: gene
Organism: rat
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Gene
449510 | SRY
Type: gene
Organism: chimpanzee
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Gene
574155 | SRY
Type: gene
Organism: macaque, rhesus
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Protein Domain
IPR017253 | SRY
Type: Family
Description: This entry represents the testis-determining factor Sry (Sex-determining Region Y). Sry is a transcriptional activator that regulates a genetic switch inmale development. It is necessary and sufficient for initiating male sex determination by directing the development of supporting cell precursors (pre-Sertoli cells) as Sertoli rather than granulosa cells []. Sry is involved in different aspects of gene regulation including promoter activation or repression and contains a high-mobility-group (HMG) box that recognises DNA by partial intercalation in the minor groove []. It binds to the DNA consensus sequence 5'-[AT]AACAA[AT]-3'. Sry also facilitates DNA bending and is involved in pre-mRNA splicing. It is also involved in maintenance of motor functions of dopaminergic neurons in the male adult brain. Sry interacts with a number of partners, including CALM, EP300 (modulates Sry DNA-binding activity), HDAC3, KPNB1, ZNF208 isoform KRAB-O, PARP1 (impaired Sry DNA-binding activity), SLC9A3R2 and WT1. The C-terminal nuclear localization signal in Sry HMG-box domain mediates nuclear import through importin beta 1 [].Defects in Sry can cause gonadal dysgenesis XY female type (GDXY) (OMIM:306100), which is also known as 'XY females' or Swyer syndrome []. Patients suffer rapid and early degeneration of their gonads, which prevents the development secondary sexual characteristics at puberty. Defects in Sry are also found Turner's Syndrome, a disease characterised by gonadal dysgenesis in a 45,X female type []. Defects in Sry can also cause true hermaphroditism (OMIM:235600), genetically heterogeneous condition whre patients have both mature ovarian and mature testicular tissue (46,XX, 46,XY or a mosaic of 46,XX/46,XY) [].
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Protein Coding Gene
MGI:98660 | Sry
Type: protein_coding_gene
Organism: mouse, laboratory
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GXD Expression
GXD Expression
Probe: MGI:6117272
Assay Type: RNA in situ
Annotation Date: 2018-02-21
Strength: Present
Sex: Male
Emaps: EMAPS:1738319
Pattern: Not Specified
Stage: TS19
Assay Id: MGI:6117300
Age: embryonic day 11.5
Image: 1Ba Sry -/-
Note: Authors state that expression is not altered in XY mutant gonads compared with wild-type
Specimen Label: 1Ba Sry -/-
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
 
Probe: MGI:6117272
Assay Type: RNA in situ
Annotation Date: 2018-02-21
Strength: Present
Sex: Male
Emaps: EMAPS:1738319
Pattern: Not Specified
Stage: TS19
Assay Id: MGI:6117300
Age: embryonic day 11.5
Image: 1Ba Sry (lower pane)
Specimen Label: 1Ba Sry (lower pane)
Detected: true
Specimen Num: 2
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Publication
12793612 | -
First Author: Maier EM
Year: 2003
Journal: J Pediatr Endocrinol Metab
Title: True hermaphroditism in an XY individual due to a familial point mutation of the SRY gene.
Volume: 16
Issue: 4
Pages: 575-80
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Publication
16106197 | -
First Author: Kellermayer R
Year: 2005
Journal: Diagn Mol Pathol
Title: A novel frame shift mutation in the HMG box of the SRY gene in a patient with complete 46,XY pure gonadal dysgenesis.
Volume: 14
Issue: 3
Pages: 159-63
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Publication
16504207 | -
First Author: Phillips NB
Year: 2006
Journal: J Mol Biol
Title: SRY and human sex determination: the basic tail of the HMG box functions as a kinetic clamp to augment DNA bending.
Volume: 358
Issue: 1
Pages: 172-92
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Gene
108178989 | LOC108178989
Type: gene
Organism: human
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Publication
11535586 | -
First Author: Forwood JK
Year: 2001
Journal: J Biol Chem
Title: The C-terminal nuclear localization signal of the sex-determining region Y (SRY) high mobility group domain mediates nuclear import through importin beta 1.
Volume: 276
Issue: 49
Pages: 46575-82
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Publication
5297880 | -
First Author: Anson BJ
Year: 1967
Journal: Arch Otolaryngol
Title: The vestibular system. Anatomic considerations.
Volume: 85
Issue: 5
Pages: 497-514
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Publication
7789944 | -
First Author: Ogata T
Year: 1995
Journal: Hum Genet
Title: Turner syndrome and female sex chromosome aberrations: deduction of the principal factors involved in the development of clinical features.
Volume: 95
Issue: 6
Pages: 607-29
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Gene
MGI:2178114 | Sryip2
Type: gene
Organism: mouse, laboratory
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Gene
MGI:2178115 | Sryip3
Type: gene
Organism: mouse, laboratory
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Publication
10410901 | J:75423
First Author: Zhang J
Year: 1999
Journal: Int J Dev Biol
Title: In vitro binding and expression studies demonstrate a role for the mouse Sry Q-rich domain in sex determination.
Volume: 43
Issue: 3
Pages: 219-27
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Publication
11784049 | J:73280
First Author: Albrecht KH
Year: 2001
Journal: Dev Biol
Title: Evidence that Sry is expressed in pre-Sertoli cells and Sertoli and granulosa cells have a common precursor.
Volume: 240
Issue: 1
Pages: 92-107
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Protein
Q05738
Organism: Mus musculus/domesticus
Length: 392  
Fragment?: false
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Protein
O35858
Organism: Mus musculus/domesticus
Length: 234  
Fragment?: false
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Protein
O35860
Organism: Mus musculus/domesticus
Length: 233  
Fragment?: false
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Protein
O35957
Organism: Mus musculus/domesticus
Length: 416  
Fragment?: false
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Protein
H8ZX66
Organism: Mus musculus/domesticus
Length: 302  
Fragment?: true
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Protein
H8ZX96
Organism: Mus musculus/domesticus
Length: 300  
Fragment?: true
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Protein
H8ZX84
Organism: Mus musculus/domesticus
Length: 232  
Fragment?: true
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Protein
O35966
Organism: Mus musculus/domesticus
Length: 231  
Fragment?: false
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Protein
Q53WV7
Organism: Mus musculus/domesticus
Length: 395  
Fragment?: false
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Protein
H8ZX83
Organism: Mus musculus/domesticus
Length: 315  
Fragment?: true
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Protein
H8ZX57
Organism: Mus musculus/domesticus
Length: 304  
Fragment?: true
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Protein
H8ZX72
Organism: Mus musculus/domesticus
Length: 232  
Fragment?: true
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Protein
H8ZX79
Organism: Mus musculus/domesticus
Length: 317  
Fragment?: true
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Protein
H8ZX63
Organism: Mus musculus/domesticus
Length: 306  
Fragment?: true
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Protein
Q2T9H0
Organism: Mus musculus/domesticus
Length: 374  
Fragment?: false
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Protein
H8ZX99
Organism: Mus musculus/domesticus
Length: 303  
Fragment?: true
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Protein
H8ZX59
Organism: Mus musculus/domesticus
Length: 315  
Fragment?: true
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Protein
H8ZX91
Organism: Mus musculus/domesticus
Length: 233  
Fragment?: true
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Protein
Q62272
Organism: Mus musculus/domesticus
Length: 143  
Fragment?: true
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Protein
H8ZX62
Organism: Mus musculus/domesticus
Length: 315  
Fragment?: true
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Protein
H8ZX82
Organism: Mus musculus/domesticus
Length: 314  
Fragment?: true
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Protein
H8ZX58
Organism: Mus musculus/domesticus
Length: 314  
Fragment?: true
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Protein
H8ZX61
Organism: Mus musculus/domesticus
Length: 318  
Fragment?: true
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Protein
H8ZX69
Organism: Mus musculus/domesticus
Length: 303  
Fragment?: true
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Protein
H8ZX80
Organism: Mus musculus/domesticus
Length: 318  
Fragment?: true
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Protein
H8ZX77
Organism: Mus musculus/domesticus
Length: 315  
Fragment?: true
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Protein
H8ZX87
Organism: Mus musculus/domesticus
Length: 316  
Fragment?: true
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Protein
H8ZXA3
Organism: Mus musculus/domesticus
Length: 232  
Fragment?: true
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Protein
H8ZX88
Organism: Mus musculus/domesticus
Length: 321  
Fragment?: true
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Protein
O35862
Organism: Mus musculus/domesticus
Length: 418  
Fragment?: false
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Protein
O35863
Organism: Mus musculus/domesticus
Length: 399  
Fragment?: false
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Protein
H8ZX78
Organism: Mus musculus/domesticus
Length: 314  
Fragment?: true
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Protein
H8ZX60
Organism: Mus musculus/domesticus
Length: 306  
Fragment?: true
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Protein
H8ZX70
Organism: Mus musculus/domesticus
Length: 304  
Fragment?: true
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Protein
H8ZX98
Organism: Mus musculus/domesticus
Length: 299  
Fragment?: true
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Protein
H8ZX68
Organism: Mus musculus/domesticus
Length: 314  
Fragment?: true
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Protein
H8ZX97
Organism: Mus musculus/domesticus
Length: 300  
Fragment?: true
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Protein
O35861
Organism: Mus musculus/domesticus
Length: 420  
Fragment?: false
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Protein
O35859
Organism: Mus musculus/domesticus
Length: 234  
Fragment?: false
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Protein
Q91V39
Organism: Mus musculus/domesticus
Length: 230  
Fragment?: false
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Protein
H8ZXA2
Organism: Mus musculus/domesticus
Length: 231  
Fragment?: true
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Protein
O35968
Organism: Mus musculus/domesticus
Length: 232  
Fragment?: false
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Protein
H8ZX67
Organism: Mus musculus/domesticus
Length: 299  
Fragment?: true
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Protein
H8ZX76
Organism: Mus musculus/domesticus
Length: 321  
Fragment?: true
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Publication
9000753 | J:38284
First Author: Pamilo P
Year: 1997
Journal: Mol Biol Evol
Title: Evolution of the Sry genes.
Volume: 14
Issue: 1
Pages: 49-55
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Publication
10412367 | J:56154
First Author: Koopman P
Year: 1999
Journal: Cell Mol Life Sci
Title: Sry and Sox9: mammalian testis-determining genes.
Volume: 55
Issue: 6-7
Pages: 839-56
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Publication
7838151 | J:20437
First Author: Dubin RA
Year: 1994
Journal: Mol Endocrinol
Title: Sry is a transcriptional activator.
Volume: 8
Issue: 9
Pages: 1182-92
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Publication
8570690 | J:31072
First Author: Eicher EM
Year: 1995
Journal: Philos Trans R Soc Lond B Biol Sci
Title: Sex reversal in C57BL/6J-YPOS mice corrected by a Sry transgene.
Volume: 350
Issue: 1333
Pages: 263-8; discussion 268-9
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Publication
18391542 | J:137460
First Author: Bradford ST
Year: 2007
Journal: Sex Dev
Title: Comparative analysis of anti-mouse SRY antibodies.
Volume: 1
Issue: 5
Pages: 305-10
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Publication
10773660 | J:61554
First Author: Bullejos M
Year: 2000
Journal: Cytogenet Cell Genet
Title: The SRY gene HMG-box in micro- and megabats.
Volume: 88
Issue: 1-2
Pages: 30-4
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Publication
11404013 | J:70143
First Author: Nagai K
Year: 2001
Journal: Gene
Title: Molecular evolution of Sry and Sox gene.
Volume: 270
Issue: 1-2
Pages: 161-9
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Publication
9486644 | J:45884
First Author: Swain A
Year: 1998
Journal: Nature
Title: Dax1 antagonizes Sry action in mammalian sex determination.
Volume: 391
Issue: 6669
Pages: 761-7
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Publication
8122913 | J:16143
 
First Author: Goodfellow PN
Year: 1993
Journal: Annu Rev Genet
Title: SRY and sex determination in mammals.
Volume: 27
Pages: 71-92
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Publication
36414375 | J:331366
 
First Author: Song Y
Year: 2023
Journal: Life Sci Alliance
Title: Loss of circSRY reduces γH2AX level in germ cells and impairs mouse spermatogenesis.
Volume: 6
Issue: 2
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Publication
11085593 | J:74052
First Author: Mayer A
Year: 2000
Journal: Neurogenetics
Title: Developmental profile of Sry transcripts in mouse brain.
Volume: 3
Issue: 1
Pages: 25-30
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Publication
2247149 | J:15310
First Author: Berta P
Year: 1990
Journal: Nature
Title: Genetic evidence equating SRY and the testis-determining factor.
Volume: 348
Issue: 6300
Pages: 448-50
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Publication
8793057 | J:36134
First Author: Daneau I
Year: 1996
Journal: Biol Reprod
Title: Porcine SRY gene locus and genital ridge expression.
Volume: 55
Issue: 1
Pages: 47-53
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Publication
22186409 | J:181719
First Author: Katoh-Fukui Y
Year: 2012
Journal: Endocrinology
Title: Cbx2, a polycomb group gene, is required for Sry gene expression in mice.
Volume: 153
Issue: 2
Pages: 913-24
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Publication
25870930 | J:242533
 
First Author: Itoh Y
Year: 2015
Journal: BMC Res Notes
Title: Four core genotypes mouse model: localization of the Sry transgene and bioassay for testicular hormone levels.
Volume: 8
Pages: 69
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Publication
12750339 | J:127090
First Author: Albrecht KH
Year: 2003
Journal: Genetics
Title: Sry expression level and protein isoform differences play a role in abnormal testis development in C57BL/6J mice carrying certain Sry alleles.
Volume: 164
Issue: 1
Pages: 277-88
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Publication
11376487 | J:69779
First Author: Bullejos M
Year: 2001
Journal: Dev Dyn
Title: Spatially dynamic expression of Sry in mouse genital ridges.
Volume: 221
Issue: 2
Pages: 201-5
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Publication
7826621 | J:20854
First Author: Harley VR
Year: 1994
Journal: Mol Reprod Dev
Title: The biochemical role of SRY in sex determination.
Volume: 39
Issue: 2
Pages: 184-93
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Publication
19549635 | J:151715
First Author: Bradford ST
Year: 2009
Journal: Hum Mol Genet
Title: A cell-autonomous role for WT1 in regulating Sry in vivo.
Volume: 18
Issue: 18
Pages: 3429-38
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Publication
11105052 | J:66816
First Author: Bergstrom DE
Year: 2000
Journal: Genesis
Title: Related function of mouse SOX3, SOX9, and SRY HMG domains assayed by male sex determination.
Volume: 28
Issue: 3-4
Pages: 111-24
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Publication
22539273 | J:184604
First Author: Silversides DW
Year: 2012
Journal: Dev Dyn
Title: Transgenic mouse analysis of Sry expression during the pre- and peri-implantation stage.
Volume: 241
Issue: 7
Pages: 1192-204
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Publication
19036799 | J:142923
First Author: Hiramatsu R
Year: 2009
Journal: Development
Title: A critical time window of Sry action in gonadal sex determination in mice.
Volume: 136
Issue: 1
Pages: 129-38
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Publication
11818535 | J:74507
First Author: Ohe K
Year: 2002
Journal: Proc Natl Acad Sci U S A
Title: A direct role of SRY and SOX proteins in pre-mRNA splicing.
Volume: 99
Issue: 3
Pages: 1146-51
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Publication
15680364 | J:96340
First Author: Bullejos M
Year: 2005
Journal: Dev Biol
Title: Delayed Sry and Sox9 expression in developing mouse gonads underlies B6-Y(DOM) sex reversal.
Volume: 278
Issue: 2
Pages: 473-81
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Publication
1518820 | J:2258
First Author: Gubbay J
Year: 1992
Journal: Proc Natl Acad Sci U S A
Title: Inverted repeat structure of the Sry locus in mice.
Volume: 89
Issue: 17
Pages: 7953-7
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Publication
- | J:4048
   
First Author: Lovell-Badge R
Year: 1992
Title: The Role of Sry in Mammalian Sex Determination
Volume: 165
Pages: 162-182
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Publication
15680367 | J:96334
First Author: Kidokoro T
Year: 2005
Journal: Dev Biol
Title: Influence on spatiotemporal patterns of a male-specific Sox9 activation by ectopic Sry expression during early phases of testis differentiation in mice.
Volume: 278
Issue: 2
Pages: 511-25
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Publication
15385158 | J:93564
First Author: Sekido R
Year: 2004
Journal: Dev Biol
Title: SOX9 is up-regulated by the transient expression of SRY specifically in Sertoli cell precursors.
Volume: 274
Issue: 2
Pages: 271-9
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Publication
35315790 | J:325977
First Author: Warr N
Year: 2022
Journal: Reproduction
Title: Gadd45g is required for timely Sry expression independently of RSPO1 activity.
Volume: 163
Issue: 6
Pages: 333-340
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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