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Search results 1 to 81 out of 81 for Stap1

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Hits by Pathway

Hits by Category

Hits by Strain

Type Details Score
Gene
26228 | STAP1
Type: gene
Organism: human
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Gene
101733660 | stap1
Type: gene
Organism: frog, western clawed
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Gene
305269 | Stap1
Type: gene
Organism: rat
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Gene
482171 | STAP1
Type: gene
Organism: dog, domestic
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Gene
471228 | STAP1
Type: gene
Organism: chimpanzee
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Gene
507296 | STAP1
Type: gene
Organism: cattle
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Gene
428761 | STAP1
Type: gene
Organism: chicken
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Gene
711834 | STAP1
Type: gene
Organism: macaque, rhesus
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Protein Coding Gene
MGI:1926193 | Stap1
Type: protein_coding_gene
Organism: mouse, laboratory
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Publication
33228548 | J:299744
First Author: Kanuri B
Year: 2020
Journal: BMC Med Genet
Title: Mice lacking global Stap1 expression do not manifest hypercholesterolemia.
Volume: 21
Issue: 1
Pages: 234
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Publication
31996024 | J:292412
First Author: Loaiza N
Year: 2020
Journal: Arterioscler Thromb Vasc Biol
Title: Taking One Step Back in Familial Hypercholesterolemia: STAP1 Does Not Alter Plasma LDL (Low-Density Lipoprotein) Cholesterol in Mice and Humans.
Volume: 40
Issue: 4
Pages: 973-985
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Protein Coding Gene
MGP_CAROLIEiJ_G0027337 | -
Type: protein_coding_gene
Organism: Mus caroli
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Protein Coding Gene
MGP_129S1SvImJ_G0029664 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AJ_G0029632 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AKRJ_G0029580 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_BALBcJ_G0029641 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C3HHeJ_G0029364 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI_C57BL6J_1926193 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C57BL6NJ_G0030095 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CASTEiJ_G0028772 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CBAJ_G0029333 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_DBA2J_G0029478 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_FVBNJ_G0029439 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_LPJ_G0029565 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NODShiLtJ_G0029467 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NZOHlLtJ_G0030128 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PWKPhJ_G0028496 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_WSBEiJ_G0028853 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PahariEiJ_G0017116 | -
Type: protein_coding_gene
Organism: Mus pahari
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Protein Coding Gene
MGP_SPRETEiJ_G0028330 | -
Type: protein_coding_gene
Organism: Mus spretus
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Publication
33175848 | J:298913
First Author: Kashiwakura JI
Year: 2020
Journal: PLoS One
Title: Expression of signal-transducing adaptor protein-1 attenuates experimental autoimmune hepatitis via down-regulating activation and homeostasis of invariant natural killer T cells.
Volume: 15
Issue: 11
Pages: e0241440
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Publication
32661325 | J:297893
First Author: Toda J
Year: 2020
Journal: Oncogene
Title: Signal-transducing adapter protein-1 is required for maintenance of leukemic stem cells in CML.
Volume: 39
Issue: 34
Pages: 5601-5615
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Publication
38315039 | J:360545
First Author: Kagohashi K
Year: 2024
Journal: J Immunol
Title: Role of Signal-Transducing Adaptor Protein-1 for T Cell Activation and Pathogenesis of Autoimmune Demyelination and Airway Inflammation.
Volume: 212
Issue: 6
Pages: 951-961
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Publication
11716489 | J:73112
First Author: Yokohari K
Year: 2001
Journal: Biochem Biophys Res Commun
Title: Isoform-dependent interaction of BRDG1 with Tec kinase.
Volume: 289
Issue: 2
Pages: 414-20
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Publication
19100238 | J:144524
First Author: Stoecker K
Year: 2009
Journal: Biochem Biophys Res Commun
Title: Induction of STAP-1 promotes neurotoxic activation of microglia.
Volume: 379
Issue: 1
Pages: 121-6
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Publication
10679268 | J:64951
First Author: Masuhara M
Year: 2000
Journal: Biochem Biophys Res Commun
Title: Molecular cloning of murine STAP-1, the stem-cell-specific adaptor protein containing PH and SH2 domains.
Volume: 268
Issue: 3
Pages: 697-703
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Publication
18468998 | J:138112
First Author: Lyssand JS
Year: 2008
Journal: J Biol Chem
Title: Blood pressure is regulated by an alpha1D-adrenergic receptor/dystrophin signalosome.
Volume: 283
Issue: 27
Pages: 18792-800
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Publication
16897342 | J:111669
First Author: Sollars VE
Year: 2006
Journal: Mamm Genome
Title: Analysis of expansion of myeloid progenitors in mice to identify leukemic susceptibility genes.
Volume: 17
Issue: 8
Pages: 808-21
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Publication
16934000 | J:115983
First Author: Ghazalpour A
Year: 2006
Journal: PLoS Genet
Title: Integrating genetic and network analysis to characterize genes related to mouse weight.
Volume: 2
Issue: 8
Pages: e130
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Protein
B7ZP01
Organism: Mus musculus/domesticus
Length: 259  
Fragment?: false
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Publication
23012479 | J:190322
First Author: Archambaud C
Year: 2012
Journal: Proc Natl Acad Sci U S A
Title: Impact of lactobacilli on orally acquired listeriosis.
Volume: 109
Issue: 41
Pages: 16684-9
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Publication
- | J:80155
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations for FANTOM2 data
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Publication
- | J:57656
     
First Author: Lennon G
Year: 1999
Journal: Database Download
Title: WashU-HHMI Mouse EST Project
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Publication
- | J:148605
     
First Author: Wellcome Trust Sanger Institute
Year: 2009
Journal: MGI Direct Data Submission
Title: Alleles produced for the KOMP project by the Wellcome Trust Sanger Institute
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Publication
- | J:211773
     
First Author: Mouse Genome Informatics and the International Mouse Phenotyping Consortium (IMPC)
Year: 2014
Journal: Database Release
Title: Obtaining and Loading Phenotype Annotations from the International Mouse Phenotyping Consortium (IMPC) Database
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Publication
- | J:342604
       
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
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Publication
- | J:78475
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Chromosome assignment of mouse genes using the Mouse Genome Sequencing Consortium (MGSC) assembly and the ENSEMBL Database
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Publication
16141072 | J:99680
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
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Publication
38355793 | J:345621
First Author: Adams DJ
Year: 2024
Journal: Nature
Title: Genetic determinants of micronucleus formation in vivo.
Volume: 627
Issue: 8002
Pages: 130-136
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Publication
- | J:23000
       
First Author: MGD Nomenclature Committee
Year: 1995
Title: Nomenclature Committee Use
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Publication
21677750 | J:173534
First Author: Skarnes WC
Year: 2011
Journal: Nature
Title: A conditional knockout resource for the genome-wide study of mouse gene function.
Volume: 474
Issue: 7351
Pages: 337-42
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Publication
- | J:342605
       
First Author: GOA curators
Year: 2016
Title: Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
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Publication
- | J:68900
     
First Author: The Jackson Laboratory Mouse Radiation Hybrid Database
Year: 2004
Journal: Database Release
Title: Mouse T31 Radiation Hybrid Data Load
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Publication
12466851 | J:80000
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
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Publication
- | J:164563
       
First Author: The Gene Ontology Consortium
Year: 2010
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs
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Publication
21267068 | J:153498
First Author: Diez-Roux G
Year: 2011
Journal: PLoS Biol
Title: A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Volume: 9
Issue: 1
Pages: e1000582
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Publication
- | J:157972
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
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Publication
- | J:57747
     
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
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Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
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Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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Protein Domain
IPR035877 | STAP1_SH2
Type: Domain
Description: STAP1 is a signal-transducing adaptor protein. It is composed of a Pleckstrin Homology (PH) and SH2 domains along with several tyrosine phosphorylation sites. STAP-1 is an orthologue of BRDG1 (also known as BCR downstream signaling 1). STAP1 protein functions as a docking protein acting downstream of Tec tyrosine kinase in B cell antigen receptor signaling. The protein is phosphorylated by Tec and participates in a positive feedback loop, increasing Tec activity []. STAP-1 has been shown to interact with STAT5 []. This entry represents the SH2 domain of STAP1.In general SH2 domains are involved in signal transduction. They typically bind pTyr-containing ligands via two surface pockets, a pTyr and hydrophobic binding pocket, allowing proteins with SH2 domains to localize to tyrosine phosphorylated sites [, , ].
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Publication
10518561 | -
First Author: Ohya K
Year: 1999
Journal: Proc Natl Acad Sci U S A
Title: Molecular cloning of a docking protein, BRDG1, that acts downstream of the Tec tyrosine kinase.
Volume: 96
Issue: 21
Pages: 11976-81
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Publication
15611091 | J:97253
First Author: Sekine Y
Year: 2005
Journal: J Biol Chem
Title: Physical and functional interactions between STAP-2/BKS and STAT5.
Volume: 280
Issue: 9
Pages: 8188-96
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Protein Domain
IPR039111 | STAP1/STAP2
Type: Family
Description: STAP1 and STAP2 are signal-transducing adaptor proteins. They contain Pleckstrin Homology (PH) and SH2 domains along with several tyrosine phosphorylation sites.STAP1 functions as a docking protein acting downstream of Tec tyrosine kinase in B cell antigen receptor signaling. It is phosphorylated by Tec and participates in a positive feedback loop, increasing Tec activity []. STAP-1 has been shown to interact with STAT5 []. STAP2 is a substrate of breast tumour kinase, an Src-type non-receptor tyrosine kinase that mediates the interactions linking proteins involved in signal transduction pathways [].
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Publication
9551546 | -
First Author: Barford D
Year: 1998
Journal: Structure
Title: Revealing mechanisms for SH2 domain mediated regulation of the protein tyrosine phosphatase SHP-2.
Volume: 6
Issue: 3
Pages: 249-54
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Publication
21205088 | -
First Author: Ikeda O
Year: 2011
Journal: Cancer Sci
Title: Involvement of STAP-2 in Brk-mediated phosphorylation and activation of STAT5 in breast cancer cells.
Volume: 102
Issue: 4
Pages: 756-61
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Protein
A0A0H2UKC0
Organism: Mus musculus/domesticus
Length: 259  
Fragment?: false
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Protein
Q9JM90
Organism: Mus musculus/domesticus
Length: 297  
Fragment?: false
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Publication
19273114 | -
 
First Author: Kasembeli MM
Year: 2009
Journal: Front Biosci (Landmark Ed)
Title: SH2 domain binding to phosphopeptide ligands: potential for drug targeting.
Volume: 14
Pages: 1010-22
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Protein
Q8R0L1
Organism: Mus musculus/domesticus
Length: 411  
Fragment?: false
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Publication
19926274 | -
First Author: Filippakopoulos P
Year: 2009
Journal: Curr Opin Struct Biol
Title: SH2 domains: modulators of nonreceptor tyrosine kinase activity.
Volume: 19
Issue: 6
Pages: 643-9
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Publication
15489334 | -
First Author: Gerhard DS
Year: 2004
Journal: Genome Res
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Volume: 14
Issue: 10B
Pages: 2121-7
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