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Search results 1 to 100 out of 642 for Stat4

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Hits by Strain

Type Details Score
Gene
6775 | STAT4
Type: gene
Organism: human
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Gene
100496013 | stat4
Type: gene
Organism: frog, western clawed
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Gene
367264 | Stat4
Type: gene
Organism: rat
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Gene
478845 | STAT4
Type: gene
Organism: dog, domestic
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Gene
515988 | STAT4
Type: gene
Organism: cattle
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Gene
100610925 | STAT4
Type: gene
Organism: chimpanzee
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Gene
768406 | STAT4
Type: gene
Organism: chicken
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Gene
368519 | stat4
Type: gene
Organism: zebrafish
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Gene
693854 | STAT4
Type: gene
Organism: macaque, rhesus
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Protein Domain
IPR029839 | STAT4
Type: Family
Description: Signal transducer and activator of transcription 4 (STAT4) transduces interleukin-12, interleukin-23, and type I interferon cytokine signals in T cells and monocytes [, ]. It plays an important role in CD4+ Th1 lineage differentiation and IFN-gamma protein expression by CD4+ T cells []. It is crucial for both innate and adaptive immune responses to viral infection []. Variations of the STAT4 gene affect the susceptibility to autoimmune diseases [], such as systemic lupus erythematosus 11 (SLEB11) []and rheumatoid arthritis (RA) []. STAT proteins have a dual function: signal transduction and activation of transcription. When cytokines are bound to cell surface receptors, the associated Janus kinases (JAKs) are activated, leading to tyrosine phosphorylation of the given STAT proteins []. Phosphorylated STATs form dimers, translocate to the nucleus, and bind specific response elements to activate transcription of target genes []. STAT proteins contain an N-terminal domain (NTD), a coiled-coil domain (CCD), a DNA-binding domain (DBD), an α-helical linker domain (LD), an SH2 domain, and a transactivation domain (TAD). The SH2 domain is necessary for receptor association and tyrosine phosphodimer formation. There are seven mammalian STAT family members which have been identified: STAT1, STAT2, STAT3, STAT4, STAT5 (STAT5A and STAT5B), and STAT6 [].
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Protein Coding Gene
MGI:103062 | Stat4
Type: protein_coding_gene
Organism: mouse, laboratory
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Publication
12213961 | J:79231
First Author: Morinobu A
Year: 2002
Journal: Proc Natl Acad Sci U S A
Title: STAT4 serine phosphorylation is critical for IL-12-induced IFN-gamma production but not for cell proliferation.
Volume: 99
Issue: 19
Pages: 12281-6
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Publication
24920804 | J:214442
First Author: Dulek DE
Year: 2014
Journal: J Virol
Title: STAT4 deficiency fails to induce lung Th2 or Th17 immunity following primary or secondary respiratory syncytial virus (RSV) challenge but enhances the lung RSV-specific CD8+ T cell immune response to secondary challenge.
Volume: 88
Issue: 17
Pages: 9655-72
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Gene
105373805 | STAT4-AS1
Type: gene
Organism: human
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Publication
17804842 | -
First Author: Remmers EF
Year: 2007
Journal: N Engl J Med
Title: STAT4 and the risk of rheumatoid arthritis and systemic lupus erythematosus.
Volume: 357
Issue: 10
Pages: 977-86
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Publication
19109131 | -
First Author: Kariuki SN
Year: 2009
Journal: J Immunol
Title: Cutting edge: autoimmune disease risk variant of STAT4 confers increased sensitivity to IFN-alpha in lupus patients in vivo.
Volume: 182
Issue: 1
Pages: 34-8
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Publication
10851056 | J:62693
First Author: Wurster AL
Year: 2000
Journal: Oncogene
Title: The biology of Stat4 and Stat6.
Volume: 19
Issue: 21
Pages: 2577-84
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Publication
12488562 | J:106129
First Author: Sugawara I
Year: 2003
Journal: J Med Microbiol
Title: Relative importance of STAT4 in murine tuberculosis.
Volume: 52
Issue: Pt 1
Pages: 29-34
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Publication
14704793 | J:331653
First Author: Ota N
Year: 2004
Journal: Nat Immunol
Title: N-domain-dependent nonphosphorylated STAT4 dimers required for cytokine-driven activation.
Volume: 5
Issue: 2
Pages: 208-15
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Publication
26386214 | J:331035
First Author: Taghavie-Moghadam PL
Year: 2015
Journal: Atherosclerosis
Title: STAT4 deficiency reduces the development of atherosclerosis in mice.
Volume: 243
Issue: 1
Pages: 169-78
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Publication
34138758 | J:313015
 
First Author: Mehrpouya-Bahrami P
Year: 2021
Journal: JCI Insight
Title: STAT4 is expressed in neutrophils and promotes antimicrobial immunity.
Volume: 6
Issue: 14
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Publication
31549795 | J:282095
First Author: Agerholm R
Year: 2019
Journal: EMBO Rep
Title: STAT3 but not STAT4 is critical for γδT17 cell responses and skin inflammation.
Volume: 20
Issue: 11
Pages: e48647
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Publication
23939393 | J:208928
First Author: Dobrian AD
Year: 2013
Journal: Diabetes
Title: STAT4 deficiency reduces obesity-induced insulin resistance and adipose tissue inflammation.
Volume: 62
Issue: 12
Pages: 4109-21
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Publication
12805384 | J:85186
First Author: Chang HC
Year: 2003
Journal: J Biol Chem
Title: STAT4 requires the N-terminal domain for efficient phosphorylation.
Volume: 278
Issue: 34
Pages: 32471-7
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Publication
18521064 | J:138166
First Author: Kataoka TR
Year: 2008
Journal: Lab Invest
Title: Stat4 suppresses the proliferation of connective tissue-type mast cells.
Volume: 88
Issue: 8
Pages: 856-64
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Publication
17404271 | J:145196
First Author: Mathur AN
Year: 2007
Journal: J Immunol
Title: Stat3 and Stat4 direct development of IL-17-secreting Th cells.
Volume: 178
Issue: 8
Pages: 4901-7
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Publication
23772023 | J:204817
First Author: Pham D
Year: 2013
Journal: J Immunol
Title: Opposing roles of STAT4 and Dnmt3a in Th1 gene regulation.
Volume: 191
Issue: 2
Pages: 902-11
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Publication
17109890 | J:128064
First Author: Simovic MO
Year: 2007
Journal: J Surg Res
Title: The STAT4 and STAT6 pathways in pancreatitis-associated lung injury.
Volume: 137
Issue: 1
Pages: 10-5
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Publication
12540779 | J:105818
First Author: Shen XD
Year: 2003
Journal: Hepatology
Title: Stat4 and Stat6 signaling in hepatic ischemia/reperfusion injury in mice: HO-1 dependence of Stat4 disruption-mediated cytoprotection.
Volume: 37
Issue: 2
Pages: 296-303
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Publication
8700208 | J:34060
First Author: Thierfelder WE
Year: 1996
Journal: Nature
Title: Requirement for Stat4 in interleukin-12-mediated responses of natural killer and T cells.
Volume: 382
Issue: 6587
Pages: 171-4
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Publication
15546391 | -
 
First Author: Watford WT
Year: 2004
Journal: Immunol Rev
Title: Signaling by IL-12 and IL-23 and the immunoregulatory roles of STAT4.
Volume: 202
Pages: 139-56
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Publication
18682104 | -
First Author: Korman BD
Year: 2008
Journal: Curr Allergy Asthma Rep
Title: STAT4: genetics, mechanisms, and implications for autoimmunity.
Volume: 8
Issue: 5
Pages: 398-403
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Publication
32010142 | J:287938
 
First Author: Anderson K
Year: 2019
Journal: Front Immunol
Title: Immune Suppression Mediated by STAT4 Deficiency Promotes Lymphatic Metastasis in HNSCC.
Volume: 10
Pages: 3095
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Publication
15459017 | J:96609
First Author: Kataoka TR
Year: 2005
Journal: Blood
Title: Involvement of connective tissue-type mast cells in Th1 immune responses via Stat4 expression.
Volume: 105
Issue: 3
Pages: 1016-20
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GXD Expression
GXD Expression
   
Probe: MGI:6184382
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689424
Pattern: Not Specified
Stage: TS24
Assay Id: MGI:6191400
Age: embryonic day 15.5
Specimen Label: Table S2 - E15.5 - Stat4
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
   
Probe: MGI:6184382
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6191400
Age: postnatal day 14
Specimen Label: Table S2 - P14 - Stat4
Detected: true
Specimen Num: 6
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GXD Expression
GXD Expression
   
Probe: MGI:6184382
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689419
Pattern: Not Specified
Stage: TS19
Assay Id: MGI:6191400
Age: embryonic day 11.5
Specimen Label: Table S2 - E11.5 - Stat4
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
   
Probe: MGI:6184382
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689421
Pattern: Not Specified
Stage: TS21
Assay Id: MGI:6191400
Age: embryonic day 13.5
Specimen Label: Table S2 - E13.5 - Stat4
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
     
Probe: MGI:6184382
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Absent
Sex: Male
Emaps: EMAPS:1689426
Stage: TS26
Assay Id: MGI:6191400
Age: embryonic day 18.5
Specimen Label: Table S2 - E18.5 - Stat4
Detected: false
Specimen Num: 4
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GXD Expression
GXD Expression
     
Probe: MGI:6184382
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Absent
Sex: Male
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:6191400
Age: postnatal day 4
Specimen Label: Table S2 - P4 - Stat4
Detected: false
Specimen Num: 5
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GXD Expression
GXD Expression
   
Probe: MGI:6184382
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6191400
Age: postnatal day 28
Specimen Label: Table S2 - P28 - Stat4
Detected: true
Specimen Num: 7
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Publication
37093664 | J:340106
First Author: Buzzelli AA
Year: 2023
Journal: J Immunol
Title: Intrinsic STAT4 Expression Controls Effector CD4 T Cell Migration and Th17 Pathogenicity.
Volume: 210
Issue: 11
Pages: 1667-1676
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Publication
14660657 | J:88966
First Author: O'Sullivan A
Year: 2004
Journal: J Biol Chem
Title: STAT4 is required for interleukin-12-induced chromatin remodeling of the CD25 locus.
Volume: 279
Issue: 8
Pages: 7339-45
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Protein
P42228
Organism: Mus musculus/domesticus
Length: 749  
Fragment?: false
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Protein
Q4G0C1
Organism: Mus musculus/domesticus
Length: 748  
Fragment?: false
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Protein
Q3V157
Organism: Mus musculus/domesticus
Length: 748  
Fragment?: false
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Protein
Q3U098
Organism: Mus musculus/domesticus
Length: 466  
Fragment?: true
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Protein
Q8C2A4
Organism: Mus musculus/domesticus
Length: 254  
Fragment?: false
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Publication
24242758 | J:209091
First Author: Oghumu S
Year: 2014
Journal: Eur J Immunol
Title: STAT4 is critical for immunity but not for antileishmanial activity of antimonials in experimental visceral leishmaniasis.
Volume: 44
Issue: 2
Pages: 450-9
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Publication
19710469 | J:152297
First Author: Good SR
Year: 2009
Journal: J Immunol
Title: Temporal induction pattern of STAT4 target genes defines potential for Th1 lineage-specific programming.
Volume: 183
Issue: 6
Pages: 3839-47
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Publication
12209125 | -
First Author: Levy DE
Year: 2002
Journal: Nat Rev Mol Cell Biol
Title: Stats: transcriptional control and biological impact.
Volume: 3
Issue: 9
Pages: 651-62
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Publication
14668806 | -
First Author: Shuai K
Year: 2003
Journal: Nat Rev Immunol
Title: Regulation of JAK-STAT signalling in the immune system.
Volume: 3
Issue: 11
Pages: 900-11
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Publication
23977103 | -
First Author: Takakuma K
Year: 2013
Journal: PLoS One
Title: Novel multiplexed assay for identifying SH2 domain antagonists of STAT family proteins.
Volume: 8
Issue: 8
Pages: e71646
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Publication
17015705 | J:139447
First Author: Berenson LS
Year: 2006
Journal: J Immunol
Title: Distinct characteristics of murine STAT4 activation in response to IL-12 and IFN-alpha.
Volume: 177
Issue: 8
Pages: 5195-203
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Publication
24731448 | J:211092
First Author: Wang Y
Year: 2014
Journal: Am J Pathol
Title: STAT4 knockout mice are more susceptible to concanavalin A-induced T-cell hepatitis.
Volume: 184
Issue: 6
Pages: 1785-94
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Publication
15226272 | J:91540
First Author: Kamezaki K
Year: 2004
Journal: Int Immunol
Title: The role of Tyk2, Stat1 and Stat4 in LPS-induced endotoxin signals.
Volume: 16
Issue: 8
Pages: 1173-9
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Publication
26123499 | J:318804
 
First Author: McWilliams IL
Year: 2015
Journal: J Neuroinflammation
Title: STAT4 controls GM-CSF production by both Th1 and Th17 cells during EAE.
Volume: 12
Pages: 128
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Publication
18832727 | J:140753
First Author: Mo C
Year: 2008
Journal: J Immunol
Title: Stat4 isoforms differentially regulate inflammation and demyelination in experimental allergic encephalomyelitis.
Volume: 181
Issue: 8
Pages: 5681-90
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Publication
31562212 | J:280935
First Author: Dulson SJ
Year: 2019
Journal: J Immunol
Title: STAT4 Directs a Protective Innate Lymphoid Cell Response to Gastrointestinal Infection.
Volume: 203
Issue: 9
Pages: 2472-2484
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Publication
17339437 | J:144293
First Author: Hildner KM
Year: 2007
Journal: J Immunol
Title: Targeting of the transcription factor STAT4 by antisense phosphorothioate oligonucleotides suppresses collagen-induced arthritis.
Volume: 178
Issue: 6
Pages: 3427-36
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Publication
11687437 | J:102411
First Author: Godshall CJ
Year: 2001
Journal: Clin Diagn Lab Immunol
Title: STAT4 is required for antibacterial defense but enhances mortality during polymicrobial sepsis.
Volume: 8
Issue: 6
Pages: 1044-8
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Publication
15356157 | J:92750
First Author: Deng JC
Year: 2004
Journal: J Immunol
Title: STAT4 is a critical mediator of early innate immune responses against pulmonary Klebsiella infection.
Volume: 173
Issue: 6
Pages: 4075-83
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Publication
11418001 | J:70643
First Author: Zhang SS
Year: 2001
Journal: Exp Mol Pathol
Title: Dysfunction of Stat4 leads to accelerated incidence of chemical-induced thymic lymphomas in mice.
Volume: 70
Issue: 3
Pages: 231-8
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Publication
12372421 | J:239213
First Author: Yamamoto K
Year: 2002
Journal: Biochem Biophys Res Commun
Title: The human perforin gene is a direct target of STAT4 activated by IL-12 in NK cells.
Volume: 297
Issue: 5
Pages: 1245-52
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Publication
10881177 | J:63283
First Author: Farrar JD
Year: 2000
Journal: Nat Immunol
Title: Selective loss of type I interferon-induced STAT4 activation caused by a minisatellite insertion in mouse Stat2.
Volume: 1
Issue: 1
Pages: 65-9
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Publication
10553062 | J:107047
First Author: Holz A
Year: 1999
Journal: J Immunol
Title: Disruption of the STAT4 signaling pathway protects from autoimmune diabetes while retaining antiviral immune competence.
Volume: 163
Issue: 10
Pages: 5374-82
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Publication
16713741 | J:113234
First Author: Xu Z
Year: 2006
Journal: Clin Immunol
Title: STAT4 deficiency reduces autoantibody production and glomerulonephritis in a mouse model of lupus.
Volume: 120
Issue: 2
Pages: 189-98
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Publication
21525389 | J:173182
First Author: Xu J
Year: 2011
Journal: J Immunol
Title: Stat4 is critical for the balance between Th17 cells and regulatory T cells in colitis.
Volume: 186
Issue: 11
Pages: 6597-606
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Publication
12707364 | J:123824
First Author: Singh RR
Year: 2003
Journal: J Immunol
Title: Differential contribution of IL-4 and STAT6 vs STAT4 to the development of lupus nephritis.
Volume: 170
Issue: 9
Pages: 4818-25
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Publication
28107529 | J:245711
First Author: Cunnion KM
Year: 2017
Journal: PLoS One
Title: Complement Activation and STAT4 Expression Are Associated with Early Inflammation in Diabetic Wounds.
Volume: 12
Issue: 1
Pages: e0170500
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Publication
29212666 | J:284613
First Author: Weinstein JS
Year: 2018
Journal: J Exp Med
Title: STAT4 and T-bet control follicular helper T cell development in viral infections.
Volume: 215
Issue: 1
Pages: 337-355
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Publication
18802110 | J:142733
First Author: O'Malley JT
Year: 2008
Journal: J Immunol
Title: STAT4 isoforms differentially regulate Th1 cytokine production and the severity of inflammatory bowel disease.
Volume: 181
Issue: 7
Pages: 5062-70
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Publication
22718836 | J:187832
First Author: Svensson A
Year: 2012
Journal: J Virol
Title: STAT4 regulates antiviral gamma interferon responses and recurrent disease during herpes simplex virus 2 infection.
Volume: 86
Issue: 17
Pages: 9409-15
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Publication
17380127 | J:122523
First Author: Yu Q
Year: 2007
Journal: EMBO J
Title: Stat4 limits DNA methyltransferase recruitment and DNA methylation of the IL-18Ralpha gene during Th1 differentiation.
Volume: 26
Issue: 8
Pages: 2052-60
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Publication
11441063 | J:120508
First Author: White SJ
Year: 2001
Journal: J Immunol
Title: Cutting edge: differential requirements for Stat4 in expression of glycosyltransferases responsible for selectin ligand formation in Th1 cells.
Volume: 167
Issue: 2
Pages: 628-31
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Publication
11544280 | J:71460
First Author: Chitnis T
Year: 2001
Journal: J Clin Invest
Title: Effect of targeted disruption of STAT4 and STAT6 on the induction of experimental autoimmune encephalomyelitis.
Volume: 108
Issue: 5
Pages: 739-47
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Publication
11207258 | J:126694
First Author: Schindler H
Year: 2001
Journal: J Immunol
Title: The production of IFN-gamma by IL-12/IL-18-activated macrophages requires STAT4 signaling and is inhibited by IL-4.
Volume: 166
Issue: 5
Pages: 3075-82
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Publication
12709397 | J:84825
First Author: Yokota N
Year: 2003
Journal: Am J Physiol Renal Physiol
Title: Contrasting roles for STAT4 and STAT6 signal transduction pathways in murine renal ischemia-reperfusion injury.
Volume: 285
Issue: 2
Pages: F319-25
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Publication
24285835 | J:207092
First Author: Eva MM
Year: 2014
Journal: J Immunol
Title: Altered IFN-γ-mediated immunity and transcriptional expression patterns in N-Ethyl-N-nitrosourea-induced STAT4 mutants confer susceptibility to acute typhoid-like disease.
Volume: 192
Issue: 1
Pages: 259-70
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Publication
15307169 | J:91789
First Author: Berenson LS
Year: 2004
Journal: Eur J Immunol
Title: Frontline: absence of functional STAT4 activation despite detectable tyrosine phosphorylation induced by murine IFN-alpha.
Volume: 34
Issue: 9
Pages: 2365-74
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Publication
12874250 | J:120665
First Author: Jacob CO
Year: 2003
Journal: J Immunol
Title: Pivotal role of Stat4 and Stat6 in the pathogenesis of the lupus-like disease in the New Zealand mixed 2328 mice.
Volume: 171
Issue: 3
Pages: 1564-71
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Publication
19646904 | J:151873
First Author: Saraiva M
Year: 2009
Journal: Immunity
Title: Interleukin-10 production by Th1 cells requires interleukin-12-induced STAT4 transcription factor and ERK MAP kinase activation by high antigen dose.
Volume: 31
Issue: 2
Pages: 209-19
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Publication
18453585 | J:134955
First Author: Furuta S
Year: 2008
Journal: J Immunol
Title: Overlapping and distinct roles of STAT4 and T-bet in the regulation of T cell differentiation and allergic airway inflammation.
Volume: 180
Issue: 10
Pages: 6656-62
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Publication
22968462 | J:191417
First Author: Gil MP
Year: 2012
Journal: Blood
Title: Regulating type 1 IFN effects in CD8 T cells during viral infections: changing STAT4 and STAT1 expression for function.
Volume: 120
Issue: 18
Pages: 3718-28
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Publication
11067913 | J:119580
First Author: Zhou P
Year: 2000
Journal: J Immunol
Title: Role of STAT4 and STAT6 signaling in allograft rejection and CTLA4-Ig-mediated tolerance.
Volume: 165
Issue: 10
Pages: 5580-7
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Publication
16717115 | J:124379
First Author: Zhang F
Year: 2006
Journal: J Exp Med
Title: T helper type 1-specific Brg1 recruitment and remodeling of nucleosomes positioned at the IFN-gamma promoter are Stat4 dependent.
Volume: 203
Issue: 6
Pages: 1493-505
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Publication
20104254 | J:161827
 
First Author: Allen SJ
Year: 2010
Journal: Mol Vis
Title: Involvement of STAT4 in IgG subtype switching and ocular HSV-1 replication in mice.
Volume: 16
Pages: 98-104
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Publication
29524223 | J:265084
First Author: Mikami Y
Year: 2018
Journal: Eur J Immunol
Title: NCR+ ILC3 maintain larger STAT4 reservoir via T-BET to regulate type 1 features upon IL-23 stimulation in mice.
Volume: 48
Issue: 7
Pages: 1174-1180
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Publication
29055004 | J:251269
First Author: Taghavie-Moghadam PL
Year: 2017
Journal: J Immunol
Title: STAT4 Regulates the CD8+ Regulatory T Cell/T Follicular Helper Cell Axis and Promotes Atherogenesis in Insulin-Resistant Ldlr-/- Mice.
Volume: 199
Issue: 10
Pages: 3453-3465
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20980973 | J:186884
First Author: Menke J
Year: 2011
Journal: Kidney Int
Title: Targeting transcription factor Stat4 uncovers a role for interleukin-18 in the pathogenesis of severe lupus nephritis in mice.
Volume: 79
Issue: 4
Pages: 452-63
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Publication
17846149 | J:126055
First Author: Miyagi T
Year: 2007
Journal: J Exp Med
Title: High basal STAT4 balanced by STAT1 induction to control type 1 interferon effects in natural killer cells.
Volume: 204
Issue: 10
Pages: 2383-96
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Publication
12555666 | J:115538
First Author: Buxbaum LU
Year: 2002
Journal: Eur J Immunol
Title: Control of New World cutaneous leishmaniasis is IL-12 independent but STAT4 dependent.
Volume: 32
Issue: 11
Pages: 3206-15
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Publication
17114437 | J:140597
First Author: Syrbe U
Year: 2006
Journal: J Immunol
Title: Microenvironment-dependent requirement of STAT4 for the induction of P-selectin ligands and effector cytokines on CD4+ T cells in healthy and parasite-infected mice.
Volume: 177
Issue: 11
Pages: 7673-9
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Publication
9247188 | J:41793
 
First Author: Herrada G
Year: 1997
Journal: J Cell Sci
Title: The mouse transcription factor Stat4 is expressed in haploid male germ cells and is present in the perinuclear theca of spermatozoa.
Volume: 110 ( Pt 14)
Pages: 1543-53
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Publication
37783748 | J:341935
First Author: Zhang XL
Year: 2023
Journal: Commun Biol
Title: Myeloid cell deficiency of the inflammatory transcription factor Stat4 protects long-term synaptic plasticity from the effects of a high-fat, high-cholesterol diet.
Volume: 6
Issue: 1
Pages: 967
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Publication
27578456 | J:249859
First Author: Varikuti S
Year: 2016
Journal: Int Immunol
Title: STAT4 is required for the generation of Th1 and Th2, but not Th17 immune responses during monophosphoryl lipid A adjuvant activity.
Volume: 28
Issue: 11
Pages: 565-570
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Publication
12165484 | J:120706
First Author: Freudenberg MA
Year: 2002
Journal: J Immunol
Title: Cutting edge: a murine, IL-12-independent pathway of IFN-gamma induction by gram-negative bacteria based on STAT4 activation by Type I IFN and IL-18 signaling.
Volume: 169
Issue: 4
Pages: 1665-8
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Publication
12370372 | J:79543
First Author: Nishikomori R
Year: 2002
Journal: J Immunol
Title: Activated STAT4 has an essential role in Th1 differentiation and proliferation that is independent of its role in the maintenance of IL-12R beta 2 chain expression and signaling.
Volume: 169
Issue: 8
Pages: 4388-98
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Publication
37396582 | J:337749
 
First Author: Keeter WC
Year: 2023
Journal: Front Cardiovasc Med
Title: Neutrophil-specific STAT4 deficiency attenuates atherosclerotic burden and improves plaque stability via reduction in neutrophil activation and recruitment into aortas of Ldlr(-/-) mice.
Volume: 10
Pages: 1175673
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Publication
23761633 | J:204820
First Author: Williams CL
Year: 2013
Journal: J Immunol
Title: STAT4 and T-bet are required for the plasticity of IFN-γ expression across Th2 ontogeny and influence changes in Ifng promoter DNA methylation.
Volume: 191
Issue: 2
Pages: 678-87
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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