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Search results 1 to 100 out of 626 for Stat4

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Type Details Score
Gene
Type: gene
Organism: human
Gene
Type: gene
Organism: cattle
Gene
Type: gene
Organism: chimpanzee
Gene
Type: gene
Organism: chicken
Gene
Type: gene
Organism: zebrafish
Gene
Type: gene
Organism: macaque, rhesus
Gene
Type: gene
Organism: frog, western clawed
Gene
Type: gene
Organism: rat
Gene
Type: gene
Organism: dog, domestic
Protein Domain
Type: Family
Description: Signal transducer and activator of transcription 4 (STAT4) transduces interleukin-12, interleukin-23, and type I interferon cytokine signals in T cells and monocytes [, ]. It plays an important role in CD4+ Th1 lineage differentiation and IFN-gamma protein expression by CD4+ T cells []. It is crucial for both innate and adaptive immune responses to viral infection []. Variations of the STAT4 gene affect the susceptibility to autoimmune diseases [], such as systemic lupus erythematosus 11 (SLEB11) []and rheumatoid arthritis (RA) []. STAT proteins have a dual function: signal transduction and activation of transcription. When cytokines are bound to cell surface receptors, the associated Janus kinases (JAKs) are activated, leading to tyrosine phosphorylation of the given STAT proteins []. Phosphorylated STATs form dimers, translocate to the nucleus, and bind specific response elements to activate transcription of target genes []. STAT proteins contain an N-terminal domain (NTD), a coiled-coil domain (CCD), a DNA-binding domain (DBD), an α-helical linker domain (LD), an SH2 domain, and a transactivation domain (TAD). The SH2 domain is necessary for receptor association and tyrosine phosphodimer formation. There are seven mammalian STAT family members which have been identified: STAT1, STAT2, STAT3, STAT4, STAT5 (STAT5A and STAT5B), and STAT6 [].
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Publication
First Author: Morinobu A
Year: 2002
Journal: Proc Natl Acad Sci U S A
Title: STAT4 serine phosphorylation is critical for IL-12-induced IFN-gamma production but not for cell proliferation.
Volume: 99
Issue: 19
Pages: 12281-6
Publication
First Author: Dulek DE
Year: 2014
Journal: J Virol
Title: STAT4 deficiency fails to induce lung Th2 or Th17 immunity following primary or secondary respiratory syncytial virus (RSV) challenge but enhances the lung RSV-specific CD8+ T cell immune response to secondary challenge.
Volume: 88
Issue: 17
Pages: 9655-72
Gene
Type: gene
Organism: human
Publication
First Author: Remmers EF
Year: 2007
Journal: N Engl J Med
Title: STAT4 and the risk of rheumatoid arthritis and systemic lupus erythematosus.
Volume: 357
Issue: 10
Pages: 977-86
Publication
First Author: Kariuki SN
Year: 2009
Journal: J Immunol
Title: Cutting edge: autoimmune disease risk variant of STAT4 confers increased sensitivity to IFN-alpha in lupus patients in vivo.
Volume: 182
Issue: 1
Pages: 34-8
Publication
First Author: Wurster AL
Year: 2000
Journal: Oncogene
Title: The biology of Stat4 and Stat6.
Volume: 19
Issue: 21
Pages: 2577-84
Publication
First Author: Sugawara I
Year: 2003
Journal: J Med Microbiol
Title: Relative importance of STAT4 in murine tuberculosis.
Volume: 52
Issue: Pt 1
Pages: 29-34
Publication
First Author: Ota N
Year: 2004
Journal: Nat Immunol
Title: N-domain-dependent nonphosphorylated STAT4 dimers required for cytokine-driven activation.
Volume: 5
Issue: 2
Pages: 208-15
Publication
First Author: Taghavie-Moghadam PL
Year: 2015
Journal: Atherosclerosis
Title: STAT4 deficiency reduces the development of atherosclerosis in mice.
Volume: 243
Issue: 1
Pages: 169-78
Publication  
First Author: Mehrpouya-Bahrami P
Year: 2021
Journal: JCI Insight
Title: STAT4 is expressed in neutrophils and promotes antimicrobial immunity.
Volume: 6
Issue: 14
Publication
First Author: Agerholm R
Year: 2019
Journal: EMBO Rep
Title: STAT3 but not STAT4 is critical for γδT17 cell responses and skin inflammation.
Volume: 20
Issue: 11
Pages: e48647
Publication
First Author: Kataoka TR
Year: 2008
Journal: Lab Invest
Title: Stat4 suppresses the proliferation of connective tissue-type mast cells.
Volume: 88
Issue: 8
Pages: 856-64
Publication
First Author: Chang HC
Year: 2003
Journal: J Biol Chem
Title: STAT4 requires the N-terminal domain for efficient phosphorylation.
Volume: 278
Issue: 34
Pages: 32471-7
Publication
First Author: Dobrian AD
Year: 2013
Journal: Diabetes
Title: STAT4 deficiency reduces obesity-induced insulin resistance and adipose tissue inflammation.
Volume: 62
Issue: 12
Pages: 4109-21
Publication
First Author: Mathur AN
Year: 2007
Journal: J Immunol
Title: Stat3 and Stat4 direct development of IL-17-secreting Th cells.
Volume: 178
Issue: 8
Pages: 4901-7
Publication
First Author: Pham D
Year: 2013
Journal: J Immunol
Title: Opposing roles of STAT4 and Dnmt3a in Th1 gene regulation.
Volume: 191
Issue: 2
Pages: 902-11
Publication
First Author: Simovic MO
Year: 2007
Journal: J Surg Res
Title: The STAT4 and STAT6 pathways in pancreatitis-associated lung injury.
Volume: 137
Issue: 1
Pages: 10-5
Publication
First Author: Shen XD
Year: 2003
Journal: Hepatology
Title: Stat4 and Stat6 signaling in hepatic ischemia/reperfusion injury in mice: HO-1 dependence of Stat4 disruption-mediated cytoprotection.
Volume: 37
Issue: 2
Pages: 296-303
Publication
First Author: Thierfelder WE
Year: 1996
Journal: Nature
Title: Requirement for Stat4 in interleukin-12-mediated responses of natural killer and T cells.
Volume: 382
Issue: 6587
Pages: 171-4
Publication  
First Author: Watford WT
Year: 2004
Journal: Immunol Rev
Title: Signaling by IL-12 and IL-23 and the immunoregulatory roles of STAT4.
Volume: 202
Pages: 139-56
Publication
First Author: Korman BD
Year: 2008
Journal: Curr Allergy Asthma Rep
Title: STAT4: genetics, mechanisms, and implications for autoimmunity.
Volume: 8
Issue: 5
Pages: 398-403
Publication  
First Author: Anderson K
Year: 2019
Journal: Front Immunol
Title: Immune Suppression Mediated by STAT4 Deficiency Promotes Lymphatic Metastasis in HNSCC.
Volume: 10
Pages: 3095
Publication
First Author: Kataoka TR
Year: 2005
Journal: Blood
Title: Involvement of connective tissue-type mast cells in Th1 immune responses via Stat4 expression.
Volume: 105
Issue: 3
Pages: 1016-20
GXD Expression    
Probe: MGI:6184382
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689419
Pattern: Not Specified
Stage: TS19
Assay Id: MGI:6191400
Age: embryonic day 11.5
Specimen Label: Table S2 - E11.5 - Stat4
Detected: true
Specimen Num: 1
GXD Expression      
Probe: MGI:6184382
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Absent
Sex: Male
Emaps: EMAPS:1689426
Stage: TS26
Assay Id: MGI:6191400
Age: embryonic day 18.5
Specimen Label: Table S2 - E18.5 - Stat4
Detected: false
Specimen Num: 4
GXD Expression    
Probe: MGI:6184382
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6191400
Age: postnatal day 28
Specimen Label: Table S2 - P28 - Stat4
Detected: true
Specimen Num: 7
GXD Expression    
Probe: MGI:6184382
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689421
Pattern: Not Specified
Stage: TS21
Assay Id: MGI:6191400
Age: embryonic day 13.5
Specimen Label: Table S2 - E13.5 - Stat4
Detected: true
Specimen Num: 2
GXD Expression    
Probe: MGI:6184382
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689424
Pattern: Not Specified
Stage: TS24
Assay Id: MGI:6191400
Age: embryonic day 15.5
Specimen Label: Table S2 - E15.5 - Stat4
Detected: true
Specimen Num: 3
GXD Expression      
Probe: MGI:6184382
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Absent
Sex: Male
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:6191400
Age: postnatal day 4
Specimen Label: Table S2 - P4 - Stat4
Detected: false
Specimen Num: 5
GXD Expression    
Probe: MGI:6184382
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6191400
Age: postnatal day 14
Specimen Label: Table S2 - P14 - Stat4
Detected: true
Specimen Num: 6
Publication
First Author: Buzzelli AA
Year: 2023
Journal: J Immunol
Title: Intrinsic STAT4 Expression Controls Effector CD4 T Cell Migration and Th17 Pathogenicity.
Volume: 210
Issue: 11
Pages: 1667-1676
Publication
First Author: O'Sullivan A
Year: 2004
Journal: J Biol Chem
Title: STAT4 is required for interleukin-12-induced chromatin remodeling of the CD25 locus.
Volume: 279
Issue: 8
Pages: 7339-45
Protein
Organism: Mus musculus/domesticus
Length: 749  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 748  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 748  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 466  
Fragment?: true
Publication
First Author: Oghumu S
Year: 2014
Journal: Eur J Immunol
Title: STAT4 is critical for immunity but not for antileishmanial activity of antimonials in experimental visceral leishmaniasis.
Volume: 44
Issue: 2
Pages: 450-9
Publication
First Author: Good SR
Year: 2009
Journal: J Immunol
Title: Temporal induction pattern of STAT4 target genes defines potential for Th1 lineage-specific programming.
Volume: 183
Issue: 6
Pages: 3839-47
Protein
Organism: Mus musculus/domesticus
Length: 254  
Fragment?: false
Publication
First Author: Kamezaki K
Year: 2004
Journal: Int Immunol
Title: The role of Tyk2, Stat1 and Stat4 in LPS-induced endotoxin signals.
Volume: 16
Issue: 8
Pages: 1173-9
Publication
First Author: Berenson LS
Year: 2006
Journal: J Immunol
Title: Distinct characteristics of murine STAT4 activation in response to IL-12 and IFN-alpha.
Volume: 177
Issue: 8
Pages: 5195-203
Publication
First Author: Wang Y
Year: 2014
Journal: Am J Pathol
Title: STAT4 knockout mice are more susceptible to concanavalin A-induced T-cell hepatitis.
Volume: 184
Issue: 6
Pages: 1785-94
Publication  
First Author: McWilliams IL
Year: 2015
Journal: J Neuroinflammation
Title: STAT4 controls GM-CSF production by both Th1 and Th17 cells during EAE.
Volume: 12
Pages: 128
Publication
First Author: Levy DE
Year: 2002
Journal: Nat Rev Mol Cell Biol
Title: Stats: transcriptional control and biological impact.
Volume: 3
Issue: 9
Pages: 651-62
Publication
First Author: Shuai K
Year: 2003
Journal: Nat Rev Immunol
Title: Regulation of JAK-STAT signalling in the immune system.
Volume: 3
Issue: 11
Pages: 900-11
Publication
First Author: Takakuma K
Year: 2013
Journal: PLoS One
Title: Novel multiplexed assay for identifying SH2 domain antagonists of STAT family proteins.
Volume: 8
Issue: 8
Pages: e71646
Publication
First Author: Dulson SJ
Year: 2019
Journal: J Immunol
Title: STAT4 Directs a Protective Innate Lymphoid Cell Response to Gastrointestinal Infection.
Volume: 203
Issue: 9
Pages: 2472-2484
Publication
First Author: Mo C
Year: 2008
Journal: J Immunol
Title: Stat4 isoforms differentially regulate inflammation and demyelination in experimental allergic encephalomyelitis.
Volume: 181
Issue: 8
Pages: 5681-90
Publication
First Author: Godshall CJ
Year: 2001
Journal: Clin Diagn Lab Immunol
Title: STAT4 is required for antibacterial defense but enhances mortality during polymicrobial sepsis.
Volume: 8
Issue: 6
Pages: 1044-8
Publication
First Author: Hildner KM
Year: 2007
Journal: J Immunol
Title: Targeting of the transcription factor STAT4 by antisense phosphorothioate oligonucleotides suppresses collagen-induced arthritis.
Volume: 178
Issue: 6
Pages: 3427-36
Publication
First Author: Deng JC
Year: 2004
Journal: J Immunol
Title: STAT4 is a critical mediator of early innate immune responses against pulmonary Klebsiella infection.
Volume: 173
Issue: 6
Pages: 4075-83
Publication
First Author: Zhang SS
Year: 2001
Journal: Exp Mol Pathol
Title: Dysfunction of Stat4 leads to accelerated incidence of chemical-induced thymic lymphomas in mice.
Volume: 70
Issue: 3
Pages: 231-8
Publication
First Author: Yamamoto K
Year: 2002
Journal: Biochem Biophys Res Commun
Title: The human perforin gene is a direct target of STAT4 activated by IL-12 in NK cells.
Volume: 297
Issue: 5
Pages: 1245-52
Publication
First Author: Farrar JD
Year: 2000
Journal: Nat Immunol
Title: Selective loss of type I interferon-induced STAT4 activation caused by a minisatellite insertion in mouse Stat2.
Volume: 1
Issue: 1
Pages: 65-9
Publication
First Author: Xu Z
Year: 2006
Journal: Clin Immunol
Title: STAT4 deficiency reduces autoantibody production and glomerulonephritis in a mouse model of lupus.
Volume: 120
Issue: 2
Pages: 189-98
Publication
First Author: Holz A
Year: 1999
Journal: J Immunol
Title: Disruption of the STAT4 signaling pathway protects from autoimmune diabetes while retaining antiviral immune competence.
Volume: 163
Issue: 10
Pages: 5374-82
Publication
First Author: Xu J
Year: 2011
Journal: J Immunol
Title: Stat4 is critical for the balance between Th17 cells and regulatory T cells in colitis.
Volume: 186
Issue: 11
Pages: 6597-606
Publication
First Author: Singh RR
Year: 2003
Journal: J Immunol
Title: Differential contribution of IL-4 and STAT6 vs STAT4 to the development of lupus nephritis.
Volume: 170
Issue: 9
Pages: 4818-25
Publication
First Author: Svensson A
Year: 2012
Journal: J Virol
Title: STAT4 regulates antiviral gamma interferon responses and recurrent disease during herpes simplex virus 2 infection.
Volume: 86
Issue: 17
Pages: 9409-15
Publication
First Author: Weinstein JS
Year: 2018
Journal: J Exp Med
Title: STAT4 and T-bet control follicular helper T cell development in viral infections.
Volume: 215
Issue: 1
Pages: 337-355
Publication
First Author: O'Malley JT
Year: 2008
Journal: J Immunol
Title: STAT4 isoforms differentially regulate Th1 cytokine production and the severity of inflammatory bowel disease.
Volume: 181
Issue: 7
Pages: 5062-70
Publication
First Author: Cunnion KM
Year: 2017
Journal: PLoS One
Title: Complement Activation and STAT4 Expression Are Associated with Early Inflammation in Diabetic Wounds.
Volume: 12
Issue: 1
Pages: e0170500
Publication
First Author: Yu Q
Year: 2007
Journal: EMBO J
Title: Stat4 limits DNA methyltransferase recruitment and DNA methylation of the IL-18Ralpha gene during Th1 differentiation.
Volume: 26
Issue: 8
Pages: 2052-60
Publication
First Author: White SJ
Year: 2001
Journal: J Immunol
Title: Cutting edge: differential requirements for Stat4 in expression of glycosyltransferases responsible for selectin ligand formation in Th1 cells.
Volume: 167
Issue: 2
Pages: 628-31
Publication
First Author: Chitnis T
Year: 2001
Journal: J Clin Invest
Title: Effect of targeted disruption of STAT4 and STAT6 on the induction of experimental autoimmune encephalomyelitis.
Volume: 108
Issue: 5
Pages: 739-47
Publication
First Author: Schindler H
Year: 2001
Journal: J Immunol
Title: The production of IFN-gamma by IL-12/IL-18-activated macrophages requires STAT4 signaling and is inhibited by IL-4.
Volume: 166
Issue: 5
Pages: 3075-82
Publication
First Author: Yokota N
Year: 2003
Journal: Am J Physiol Renal Physiol
Title: Contrasting roles for STAT4 and STAT6 signal transduction pathways in murine renal ischemia-reperfusion injury.
Volume: 285
Issue: 2
Pages: F319-25
Publication
First Author: Eva MM
Year: 2014
Journal: J Immunol
Title: Altered IFN-γ-mediated immunity and transcriptional expression patterns in N-Ethyl-N-nitrosourea-induced STAT4 mutants confer susceptibility to acute typhoid-like disease.
Volume: 192
Issue: 1
Pages: 259-70
Publication
First Author: Berenson LS
Year: 2004
Journal: Eur J Immunol
Title: Frontline: absence of functional STAT4 activation despite detectable tyrosine phosphorylation induced by murine IFN-alpha.
Volume: 34
Issue: 9
Pages: 2365-74
Publication
First Author: Jacob CO
Year: 2003
Journal: J Immunol
Title: Pivotal role of Stat4 and Stat6 in the pathogenesis of the lupus-like disease in the New Zealand mixed 2328 mice.
Volume: 171
Issue: 3
Pages: 1564-71
Publication
First Author: Saraiva M
Year: 2009
Journal: Immunity
Title: Interleukin-10 production by Th1 cells requires interleukin-12-induced STAT4 transcription factor and ERK MAP kinase activation by high antigen dose.
Volume: 31
Issue: 2
Pages: 209-19
Publication
First Author: Gil MP
Year: 2012
Journal: Blood
Title: Regulating type 1 IFN effects in CD8 T cells during viral infections: changing STAT4 and STAT1 expression for function.
Volume: 120
Issue: 18
Pages: 3718-28
Publication
First Author: Furuta S
Year: 2008
Journal: J Immunol
Title: Overlapping and distinct roles of STAT4 and T-bet in the regulation of T cell differentiation and allergic airway inflammation.
Volume: 180
Issue: 10
Pages: 6656-62
Publication
First Author: Zhou P
Year: 2000
Journal: J Immunol
Title: Role of STAT4 and STAT6 signaling in allograft rejection and CTLA4-Ig-mediated tolerance.
Volume: 165
Issue: 10
Pages: 5580-7
Publication
First Author: Zhang F
Year: 2006
Journal: J Exp Med
Title: T helper type 1-specific Brg1 recruitment and remodeling of nucleosomes positioned at the IFN-gamma promoter are Stat4 dependent.
Volume: 203
Issue: 6
Pages: 1493-505
Publication  
First Author: Allen SJ
Year: 2010
Journal: Mol Vis
Title: Involvement of STAT4 in IgG subtype switching and ocular HSV-1 replication in mice.
Volume: 16
Pages: 98-104
Publication
First Author: Mikami Y
Year: 2018
Journal: Eur J Immunol
Title: NCR+ ILC3 maintain larger STAT4 reservoir via T-BET to regulate type 1 features upon IL-23 stimulation in mice.
Volume: 48
Issue: 7
Pages: 1174-1180
Publication
First Author: Taghavie-Moghadam PL
Year: 2017
Journal: J Immunol
Title: STAT4 Regulates the CD8+ Regulatory T Cell/T Follicular Helper Cell Axis and Promotes Atherogenesis in Insulin-Resistant Ldlr-/- Mice.
Volume: 199
Issue: 10
Pages: 3453-3465
Publication
First Author: Menke J
Year: 2011
Journal: Kidney Int
Title: Targeting transcription factor Stat4 uncovers a role for interleukin-18 in the pathogenesis of severe lupus nephritis in mice.
Volume: 79
Issue: 4
Pages: 452-63
Publication
First Author: Miyagi T
Year: 2007
Journal: J Exp Med
Title: High basal STAT4 balanced by STAT1 induction to control type 1 interferon effects in natural killer cells.
Volume: 204
Issue: 10
Pages: 2383-96
Publication
First Author: Buxbaum LU
Year: 2002
Journal: Eur J Immunol
Title: Control of New World cutaneous leishmaniasis is IL-12 independent but STAT4 dependent.
Volume: 32
Issue: 11
Pages: 3206-15
Publication
First Author: Varikuti S
Year: 2016
Journal: Int Immunol
Title: STAT4 is required for the generation of Th1 and Th2, but not Th17 immune responses during monophosphoryl lipid A adjuvant activity.
Volume: 28
Issue: 11
Pages: 565-570
Publication  
First Author: Herrada G
Year: 1997
Journal: J Cell Sci
Title: The mouse transcription factor Stat4 is expressed in haploid male germ cells and is present in the perinuclear theca of spermatozoa.
Volume: 110 ( Pt 14)
Pages: 1543-53
Publication
First Author: Syrbe U
Year: 2006
Journal: J Immunol
Title: Microenvironment-dependent requirement of STAT4 for the induction of P-selectin ligands and effector cytokines on CD4+ T cells in healthy and parasite-infected mice.
Volume: 177
Issue: 11
Pages: 7673-9
Publication
First Author: Zhang XL
Year: 2023
Journal: Commun Biol
Title: Myeloid cell deficiency of the inflammatory transcription factor Stat4 protects long-term synaptic plasticity from the effects of a high-fat, high-cholesterol diet.
Volume: 6
Issue: 1
Pages: 967
Publication
First Author: Freudenberg MA
Year: 2002
Journal: J Immunol
Title: Cutting edge: a murine, IL-12-independent pathway of IFN-gamma induction by gram-negative bacteria based on STAT4 activation by Type I IFN and IL-18 signaling.
Volume: 169
Issue: 4
Pages: 1665-8
Publication
First Author: Nishikomori R
Year: 2002
Journal: J Immunol
Title: Activated STAT4 has an essential role in Th1 differentiation and proliferation that is independent of its role in the maintenance of IL-12R beta 2 chain expression and signaling.
Volume: 169
Issue: 8
Pages: 4388-98
Publication  
First Author: Keeter WC
Year: 2023
Journal: Front Cardiovasc Med
Title: Neutrophil-specific STAT4 deficiency attenuates atherosclerotic burden and improves plaque stability via reduction in neutrophil activation and recruitment into aortas of Ldlr(-/-) mice.
Volume: 10
Pages: 1175673
Publication
First Author: Williams CL
Year: 2013
Journal: J Immunol
Title: STAT4 and T-bet are required for the plasticity of IFN-γ expression across Th2 ontogeny and influence changes in Ifng promoter DNA methylation.
Volume: 191
Issue: 2
Pages: 678-87