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Search results 1 to 100 out of 110 for Stn1

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Categories

Hits by Pathway

Hits by Category

Hits by Strain

Type Details Score
Gene
79991 | STN1
Type: gene
Organism: human
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Gene
294025 | Stn1
Type: gene
Organism: rat
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Gene
477812 | STN1
Type: gene
Organism: dog, domestic
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Gene
450715 | STN1
Type: gene
Organism: chimpanzee
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Gene
514213 | STN1
Type: gene
Organism: cattle
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Gene
393360 | stn1
Type: gene
Organism: zebrafish
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Gene
714968 | STN1
Type: gene
Organism: macaque, rhesus
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Gene
448268 | stn1
Type: gene
Organism: frog, western clawed
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Protein Domain
IPR014647 | Stn1
Type: Family
Description: Stn1 is a component of the CST complex, a complex that binds to single-stranded DNA and is required to protect telomeres from DNA degradation. The CST complex binds single-stranded DNA with high affinity in a sequence-independent manner, while isolated subunits bind DNA with low affinity by themselves. In addition to telomere protection, the CST complex has probably a more general role in DNA metabolism at non-telomeric sites [, ].
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Gene
423877 | STN1
Type: gene
Organism: chicken
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Protein Coding Gene
MGI:1915581 | Stn1
Type: protein_coding_gene
Organism: mouse, laboratory
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Publication
19854130 | J:159049
First Author: Miyake Y
Year: 2009
Journal: Mol Cell
Title: RPA-like mammalian Ctc1-Stn1-Ten1 complex binds to single-stranded DNA and protects telomeres independently of the Pot1 pathway.
Volume: 36
Issue: 2
Pages: 193-206
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Publication
19648609 | J:159057
First Author: Wan M
Year: 2009
Journal: J Biol Chem
Title: OB fold-containing protein 1 (OBFC1), a human homolog of yeast Stn1, associates with TPP1 and is implicated in telomere length regulation.
Volume: 284
Issue: 39
Pages: 26725-31
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Protein
Q3UXU8
Organism: Mus musculus/domesticus
Length: 351  
Fragment?: false
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Protein
Q8K2X3
Organism: Mus musculus/domesticus
Length: 378  
Fragment?: false
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Publication
37163605 | J:335558
First Author: Nguyen DD
Year: 2023
Journal: Sci Adv
Title: Deficiency in mammalian STN1 promotes colon cancer development via inhibiting DNA repair.
Volume: 9
Issue: 19
Pages: eadd8023
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Publication
19119139 | J:159131
First Author: Casteel DE
Year: 2009
Journal: J Biol Chem
Title: A DNA polymerase-{alpha}{middle dot}primase cofactor with homology to replication protein A-32 regulates DNA replication in mammalian cells.
Volume: 284
Issue: 9
Pages: 5807-18
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Protein Coding Gene
MGP_CAROLIEiJ_G0023057 | -
Type: protein_coding_gene
Organism: Mus caroli
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Protein Coding Gene
MGP_129S1SvImJ_G0025230 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AJ_G0025206 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AKRJ_G0025175 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_BALBcJ_G0025201 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C3HHeJ_G0024961 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI_C57BL6J_1915581 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C57BL6NJ_G0025644 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CASTEiJ_G0024426 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CBAJ_G0024941 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_DBA2J_G0025073 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_FVBNJ_G0025034 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_LPJ_G0025159 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NODShiLtJ_G0025065 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NZOHlLtJ_G0025702 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PWKPhJ_G0024175 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_WSBEiJ_G0024496 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PahariEiJ_G0014547 | -
Type: protein_coding_gene
Organism: Mus pahari
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Protein Coding Gene
MGP_SPRETEiJ_G0023978 | -
Type: protein_coding_gene
Organism: Mus spretus
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Publication
11217851 | J:65060
First Author: Kawai J
Year: 2001
Journal: Nature
Title: Functional annotation of a full-length mouse cDNA collection.
Volume: 409
Issue: 6821
Pages: 685-90
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Publication
12466851 | J:80000
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
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Publication
16141072 | J:99680
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
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Publication
- | J:265051
     
First Author: MGI and IMPC
Year: 2018
Journal: Database Release
Title: MGI Load of Endonuclease-Mediated Alleles (CRISPR) from the International Mouse Phenotyping Consortium (IMPC)
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Publication
12520002 | J:91812
First Author: Stryke D
Year: 2003
Journal: Nucleic Acids Res
Title: BayGenomics: a resource of insertional mutations in mouse embryonic stem cells.
Volume: 31
Issue: 1
Pages: 278-81
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Publication
- | J:57656
     
First Author: Lennon G
Year: 1999
Journal: Database Download
Title: WashU-HHMI Mouse EST Project
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Publication
18799693 | J:142754
First Author: Hansen GM
Year: 2008
Journal: Genome Res
Title: Large-scale gene trapping in C57BL/6N mouse embryonic stem cells.
Volume: 18
Issue: 10
Pages: 1670-9
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Publication
- | J:72247
       
First Author: DDB, FB, MGI, GOA, ZFIN curators
Year: 2001
Title: Gene Ontology annotation through association of InterPro records with GO terms
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Publication
- | J:85000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Title: MGI Sequence Curation Reference
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Publication
- | J:23000
       
First Author: MGD Nomenclature Committee
Year: 1995
Title: Nomenclature Committee Use
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Publication
14610273 | J:86696
First Author: Zambrowicz BP
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Volume: 100
Issue: 24
Pages: 14109-14
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Publication
- | J:141210
     
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
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Publication
- | J:342587
       
First Author: AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators
Year: 2011
Title: Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
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Publication
- | J:342605
       
First Author: GOA curators
Year: 2016
Title: Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
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Publication
- | J:68900
     
First Author: The Jackson Laboratory Mouse Radiation Hybrid Database
Year: 2004
Journal: Database Release
Title: Mouse T31 Radiation Hybrid Data Load
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Publication
- | J:164563
       
First Author: The Gene Ontology Consortium
Year: 2010
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs
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Publication
- | J:75000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
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Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
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Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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UniProt Feature
UniProt Feature
Begin: 2
Description: CST complex subunit STN1
Type: chain
End: 378
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Protein
S4R297
Organism: Mus musculus/domesticus
Length: 99  
Fragment?: true
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Protein
Q3TLS0
Organism: Mus musculus/domesticus
Length: 190  
Fragment?: false
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Protein
A0A494B9T6
Organism: Mus musculus/domesticus
Length: 87  
Fragment?: false
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Publication
23177925 | -
First Author: Mason M
Year: 2013
Journal: Structure
Title: Cdc13 OB2 dimerization required for productive Stn1 binding and efficient telomere maintenance.
Volume: 21
Issue: 1
Pages: 109-120
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Protein
Q9D7K2
Organism: Mus musculus/domesticus
Length: 161  
Fragment?: false
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Protein
Q8CDJ8
Organism: Mus musculus/domesticus
Length: 730  
Fragment?: false
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Publication
19854131 | -
First Author: Surovtseva YV
Year: 2009
Journal: Mol Cell
Title: Conserved telomere maintenance component 1 interacts with STN1 and maintains chromosome ends in higher eukaryotes.
Volume: 36
Issue: 2
Pages: 207-18
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Publication
22748632 | -
First Author: Wu P
Year: 2012
Journal: Cell
Title: Telomeric 3' overhangs derive from resection by Exo1 and Apollo and fill-in by POT1b-associated CST.
Volume: 150
Issue: 1
Pages: 39-52
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GO Term
GO:1990879 | CST complex
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Protein Domain
IPR042617 | CTC1-like
Type: Family
Description: In animals and plants, CTC1 is a component of the CST complex (consists of Ten1, Stn1 and CTC1), a complex that binds to single-stranded DNA and is required to protect telomeres from DNA degradation []. Two distinct telomere capping complexes have evolved: CST complex in budding yeast and shelterin complex in vertebrates. Budding yeast CST is composed of Cdc13, Ten1 and Stn1 []. The homologues of Ten1 and Stn1 have been identified in vertebrates and plants. The vertebrate CST complex does not appear to play a primary role in telomere protection, but may complement the function of shelterin complex []. The mammalian CST complex may have both telomeric and non-telomeric function [].In plants, the contribution of the CST components to chromosome end protection, telomeric DNA replication or both processes remains to be determined [].
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Protein Domain
IPR038240 | Stn1_C_sf
Type: Homologous_superfamily
Description: Stn1 and Ten1 are DNA-binding proteins with specificity for telomeric DNA substrates and both protect chromosome termini from unregulated resection and regulate telomere length. Stn1 complexes with Ten1 and Cdc13 to function as a telomere-specific replication protein A (RPA)-like complex []. These three interacting proteins associate with the telomeric overhang in budding yeast, whereas a single protein known as Pot1 (protection of telomeres-1) performs this function in fission yeast. Two separate protein complexes are required for chromosome end protection in fission yeast while a two-subunit complex consisting of POT1 and TPP1 associates with telomeric ssDNA in humans. Protection of telomeres by multiple proteins with OB-fold domains is conserved in eukaryotic evolution [].This entry represents the C-terminal domain of Stn1 and consists of tandem winged helix-turn-helix motifs [, ].
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Protein Domain
IPR024263 | Stn1_C_fungi
Type: Domain
Description: Stn1 and Ten1 are DNA-binding proteins with specificity for telomeric DNA substrates and both protect chromosome termini from unregulated resection and regulate telomere length. Stn1 complexes with Ten1 and Cdc13 to function as a telomere-specific replication protein A (RPA)-like complex []. These three interacting proteins associate with the telomeric overhang in budding yeast, whereas a single protein known as Pot1 (protection of telomeres-1) performs this function in fission yeast. Two separate protein complexes are required for chromosome end protection in fission yeast while a two-subunit complex consisting of POT1 and TPP1 associates with telomeric ssDNA in humans. Protection of telomeres by multiple proteins with OB-fold domains is conserved in eukaryotic evolution [].This entry represents the C-terminal domain of Stn1 and consists of tandem winged helix-turn-helix motifs [, ].
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Protein Domain
IPR029156 | CTC1
Type: Family
Description: In animals and plants, CTC1 is a component of the CST complex (consists of Ten1, Stn1 and CTC1), a complex that binds to single-stranded DNA and is required to protect telomeres from DNA degradation []. Two distinct telomere capping complexes have evolved: CST complex in budding yeast and shelterin complex in vertebrates. Budding yeast CST is composed of Cdc13, Ten1 and Stn1 []. The homologues of Ten1 and Stn1 have been identified in vertebrates and plants. The vertebrate CST complex does not appear to play a primary role in telomere protection, but may complement the function of shelterin complex []. The mammalian CST complex may have both telomeric and non-telomeric function [].In plants, the contribution of the CST components to chromosome end protection, telomeric DNA replication or both processes remains to be determined [].
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Protein Domain
IPR042082 | CST_Stn1_wHTH1_sf
Type: Homologous_superfamily
Description: Stn1 is a component of the CST complex, a complex that binds to single-stranded DNA and is required to protect telomeres from DNA degradation. The CST complex binds single-stranded DNA with high affinity in a sequence-independent manner, while isolated subunits bind DNA with low affinity by themselves. In addition to telomere protection, the CST complex has probably a more general role in DNA metabolism at non-telomeric sites [, ]. The C-terminal domain of Stn1 has two winged helix-turn-helix (wHTH) motifs, wHTH1 and wHTH2. This superfamily represents the wHTH1 motif, which is structurally similar to that in RPA32 with an additional large insertion between helices α2 and α3, unique to Stn1 [, ]. This additional wHTH1 motif may allow interaction with a different set of proteins that function at telomeres such as Ctc1 [].
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Protein
Q5SUQ9
Organism: Mus musculus/domesticus
Length: 1212  
Fragment?: false
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Protein
E0CXE7
Organism: Mus musculus/domesticus
Length: 965  
Fragment?: false
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Publication
17293872 | -
First Author: Gao H
Year: 2007
Journal: Nat Struct Mol Biol
Title: RPA-like proteins mediate yeast telomere function.
Volume: 14
Issue: 3
Pages: 208-14
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Publication
17715303 | -
First Author: Martín V
Year: 2007
Journal: Proc Natl Acad Sci U S A
Title: Protection of telomeres by a conserved Stn1-Ten1 complex.
Volume: 104
Issue: 35
Pages: 14038-43
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Publication
19854124 | -
First Author: Wellinger RJ
Year: 2009
Journal: Mol Cell
Title: The CST complex and telomere maintenance: the exception becomes the rule.
Volume: 36
Issue: 2
Pages: 168-9
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Protein Domain
IPR018856 | Stn1_N
Type: Domain
Description: The budding yeast protein Stn1 is a DNA-binding protein which has specificity for telomeric DNA. Structural profiling has predicted an OB-fold []. This entry represents the N-terminal part of the molecule, which adopts the OB fold. Protection of telomeres by multiple proteins with OB-fold domains is conserved in eukaryotic evolution [].
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Protein Domain
IPR024222 | Ten1_fungal
Type: Family
Description: Stn1 and Ten1 are DNA-binding proteins with specificity for telomeric DNA substrates and both protect chromosome termini from unregulated resection and regulate telomere length []. Stn1 complexes with Ten1 and Cdc13 to function as a telomere-specific replication protein A (RPA)-like complex []. These three interacting proteins associate with the telomeric overhang in budding yeast, whereas a single protein known as Pot1 (protection of telomeres-1) performs this function in fission yeast, and a two-subunit complex consisting of POT1 and TPP1 associates with telomeric ssDNA in humans. S.pombe has Stn1- and Ten1-like proteins that are essential for chromosome end protection. Stn1 orthologues exist in all species that have Pot1, whereas Ten1-like proteins can be found in all fungi. Fission yeast Stn1 and Ten1 localise at telomeres in a manner that correlates with the length of the ssDNA overhang, suggesting that they specifically associate with the telomeric ssDNA. Two separate protein complexes are required for chromosome end protection in fission yeast. Protection of telomeres by multiple proteins with OB-fold domains is conserved in eukaryotic evolution []. Ten1 is one of the three components of the CST complex, which, in conjunction with the Shelterin complex helps protect telomeres from attack by DNA-repair mechanisms [].This entry represent Ten1 from fungi.
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Publication
20008938 | -
First Author: Sun J
Year: 2009
Journal: Genes Dev
Title: Stn1-Ten1 is an Rpa2-Rpa3-like complex at telomeres.
Volume: 23
Issue: 24
Pages: 2900-14
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Publication
19884503 | -
First Author: Gelinas AD
Year: 2009
Journal: Proc Natl Acad Sci U S A
Title: Telomere capping proteins are structurally related to RPA with an additional telomere-specific domain.
Volume: 106
Issue: 46
Pages: 19298-303
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Publication
20697207 | -
First Author: Price CM
Year: 2010
Journal: Cell Cycle
Title: Evolution of CST function in telomere maintenance.
Volume: 9
Issue: 16
Pages: 3157-65
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Protein Domain
IPR040650 | Cdc13_OB2
Type: Domain
Description: Cdc13 is an essential yeast protein required for telomere length regulation and genome stability. Cdc13, like a number of single-stranded telomere binding proteins, consists of several oligonucleotide-oligosaccharide binding (OB) folds. These folds potentially arise from evolutionary gene duplication and are involved in multiple functions, including nucleic acid and protein binding and Cdc13 dimerization. This entry represents the OB2 domain, second OB-fold counting from the N terminus of Cdc13. Biochemical assays indicate OB2 is not involved in telomeric DNA or Stn1 binding. However, disruption of the OB2 dimer in full-length Cdc13 affects Cdc13-Stn1 association, leading to telomere length deregulation, increased temperature sensitivity, and Stn1 binding defects. Hence it is suggested that the dimerization of the OB2 domain of Cdc13 is required for proper Cdc13, Stn1, Ten1 (CST) assembly and productive telomere capping [].
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Publication
23826127 | -
First Author: Bryan C
Year: 2013
Journal: PLoS One
Title: Structure of the human telomeric Stn1-Ten1 capping complex.
Volume: 8
Issue: 6
Pages: e66756
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Publication
25329641 | -
First Author: Renfrew KB
Year: 2014
Journal: PLoS Genet
Title: POT1a and components of CST engage telomerase and regulate its activity in Arabidopsis.
Volume: 10
Issue: 10
Pages: e1004738
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Protein Domain
IPR029146 | Ten1_animal_plant
Type: Family
Description: This entry represents the CST complex subunit Ten1 homologue from plants and animals []. Even though the protein sequence similarity is very low between budding yeast Ten1 () and animal/plant Ten1, they are evolutionarily related. Ten1 is essential for telomere integrity and it negatively regulates telomerase activity [].Two distinct telomere capping complexes have evolved: CST complex in budding yeast and shelterin complex in vertebrates. Budding yeast CST is composed of Cdc13, Ten1 and Stn1 []. The homologues of Ten1 and Stn1 have been identified in vertebrates and plants. The vertebrate CST complex does not appear to play a primary role in telomere protection, but may complement the function of shelterin complex [].Similar to budding yeast Ten1, mammalian Ten1 forms the CST complex with Stn1 homologue and binds to single strand DNA (ssDNA). However, unlike budding yeast CST, the binding of mammalian CST to ssDNA is not sequence specific. The mammalian CST complex may have both telomeric and non-telomeric functions [].In plants, the CST complex is structurally analogous to mammalian CST and it plays a role in chromosome end protection [].
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Protein Coding Gene
MGI:1916785 | Ten1
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Domain
IPR040260 | RFA2-like
Type: Family
Description: This entry contains proteins with a winged helix DNA-binding domain, including replication factor A protein 2 (RFA2) and CST complex subunit STN1.Rfa2 (also known as RPA32) is a component of the replication protein A (RPA) complex, which binds to and removes secondary structure from ssDNA. The RPA complex is involved in DNA replication, repair, and recombination []. Stn1 is a component of the CST complex, a complex that binds to single-stranded DNA and is required to protect telomeres from DNA degradation. The CST complex binds single-stranded DNA with high affinity in a sequence-independent manner, while isolated subunits bind DNA with low affinity by themselves. In addition to telomere protection, the CST complex has probably a more general role in DNA metabolism at non-telomeric sites [, ].
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Protein Domain
IPR015253 | CST_STN1_C
Type: Domain
Description: Stn1 is a component of the CST complex, a complex that binds to single-stranded DNA and is required to protect telomeres from DNA degradation. The CST complex binds single-stranded DNA with high affinity in a sequence-independent manner, while isolated subunits bind DNA with low affinity by themselves. In addition to telomere protection, the CST complex has probably a more general role in DNA metabolism at non-telomeric sites [, ]. This entry represents the C-terminal domain of Stn1, which has two winged helix-turn-helix (wHTH) motifs, wHTH1 and wHTH2 [, ]. wHTH1 is structurally similar to that in RPA32 with an additional large insertion between helices alpha2 and alpha3, unique to Stn1, and it may allow interaction with a different set of proteins that function at telomeres such as Ctc1 []. wHTH2 is most similar to the DNA-binding wHTH motifs of the pur operon repressor and RepE replication initiator, but it does not bind double-stranded DNA [].
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Publication
20012581 | -
 
First Author: Broderick S
Year: 2010
Journal: Subcell Biochem
Title: Eukaryotic single-stranded DNA binding proteins: central factors in genome stability.
Volume: 50
Pages: 143-63
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Protein
Q8CEX6
Organism: Mus musculus/domesticus
Length: 84  
Fragment?: false
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Protein
F6V8R7
Organism: Mus musculus/domesticus
Length: 70  
Fragment?: true
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Protein Coding Gene
MGI:1916214 | Ctc1
Type: protein_coding_gene
Organism: mouse, laboratory
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