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Search results 1 to 100 out of 491 for Stra6

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Type Details Score
Gene
Type: gene
Organism: human
Gene
Type: gene
Organism: cattle
Gene
Type: gene
Organism: zebrafish
Gene
Type: gene
Organism: macaque, rhesus
Gene
Type: gene
Organism: frog, western clawed
Gene
Type: gene
Organism: chicken
Gene
Type: gene
Organism: rat
Gene
Type: gene
Organism: dog, domestic
Gene
Type: gene
Organism: chimpanzee
Protein Domain
Type: Family
Description: Receptor for retinol uptake STRA6 (also known as "stimulated by retinoic acid gene 6 protein") is a multitransmembrane domain protein, which acts as a retinol transporter for the complex retinol-retinol binding protein (RBP/RBP4). It acts by removing retinol (vitamin A) from RBP/RBP4 and transports it across the plasma membrane, where it can be metabolized. This mechanism does not depend on endocytosis []. Vitamin A and its derivatives are essential for vision and many other biological processes. In humans, defects in STRA6 are the cause of microphthalmia syndromic type 9 (MCOPS9); also called Matthew-Wood syndrome or Spear syndrome. Microphthalmia is a clinically heterogeneous disorder of eye formation, ranging from small size of a single eye to complete bilateral absence of ocular tissues (anophthalmia). In many cases, microphthalmia/anophthalmia occurs in association with syndromes that include non-ocular abnormalities. MCOPS9 is a rare clinical entity including as main characteristics anophthalmia or severe microphthalmia, and pulmonary hypoplasia or aplasia [, , ].In addition to serving as a retinol transporter, STRA6 is a ligand-activated cell surface signaling receptor that activates JAK/STAT signaling upon binding to the retinol-RBP complex [].
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein
Organism: Mus musculus/domesticus
Length: 99  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 139  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 137  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 199  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 190  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 162  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 86  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 167  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 164  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 670  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 670  
Fragment?: false
Publication
First Author: Casey J
Year: 2011
Journal: Hum Mutat
Title: First implication of STRA6 mutations in isolated anophthalmia, microphthalmia, and coloboma: a new dimension to the STRA6 phenotype.
Volume: 32
Issue: 12
Pages: 1417-26
Publication
First Author: Pasutto F
Year: 2007
Journal: Am J Hum Genet
Title: Mutations in STRA6 cause a broad spectrum of malformations including anophthalmia, congenital heart defects, diaphragmatic hernia, alveolar capillary dysplasia, lung hypoplasia, and mental retardation.
Volume: 80
Issue: 3
Pages: 550-60
Publication
First Author: Amengual J
Year: 2014
Journal: Hum Mol Genet
Title: STRA6 is critical for cellular vitamin A uptake and homeostasis.
Volume: 23
Issue: 20
Pages: 5402-17
Gene
Type: gene
Organism: human
Publication
First Author: Kawaguchi R
Year: 2007
Journal: Science
Title: A membrane receptor for retinol binding protein mediates cellular uptake of vitamin A.
Volume: 315
Issue: 5813
Pages: 820-5
Publication
First Author: Golzio C
Year: 2007
Journal: Am J Hum Genet
Title: Matthew-Wood syndrome is caused by truncating mutations in the retinol-binding protein receptor gene STRA6.
Volume: 80
Issue: 6
Pages: 1179-87
Publication  
First Author: Noy N
Year: 2016
Journal: Subcell Biochem
Title: Vitamin A Transport and Cell Signaling by the Retinol-Binding Protein Receptor STRA6.
Volume: 81
Pages: 77-93
Publication
First Author: Berry DC
Year: 2013
Journal: J Biol Chem
Title: The STRA6 receptor is essential for retinol-binding protein-induced insulin resistance but not for maintaining vitamin A homeostasis in tissues other than the eye.
Volume: 288
Issue: 34
Pages: 24528-39
Publication
First Author: Gliniak CM
Year: 2017
Journal: J Biol Chem
Title: The retinol-binding protein receptor STRA6 regulates diurnal insulin responses.
Volume: 292
Issue: 36
Pages: 15080-15093
Publication
First Author: Zemany L
Year: 2014
Journal: Mol Cell Biol
Title: Downregulation of STRA6 in adipocytes and adipose stromovascular fraction in obesity and effects of adipocyte-specific STRA6 knockdown in vivo.
Volume: 34
Issue: 6
Pages: 1170-86
Publication
First Author: Terra R
Year: 2013
Journal: PLoS One
Title: To investigate the necessity of STRA6 upregulation in T cells during T cell immune responses.
Volume: 8
Issue: 12
Pages: e82808
Publication
First Author: Tan L
Year: 2012
Journal: J Nutr
Title: Oral vitamin A and retinoic acid supplementation stimulates antibody production and splenic Stra6 expression in tetanus toxoid-immunized mice.
Volume: 142
Issue: 8
Pages: 1590-5
Publication
First Author: Bouillet P
Year: 1997
Journal: Mech Dev
Title: Developmental expression pattern of Stra6, a retinoic acid-responsive gene encoding a new type of membrane protein.
Volume: 63
Issue: 2
Pages: 173-86
Publication
First Author: Ruiz A
Year: 2012
Journal: Invest Ophthalmol Vis Sci
Title: Retinoid content, visual responses, and ocular morphology are compromised in the retinas of mice lacking the retinol-binding protein receptor, STRA6.
Volume: 53
Issue: 6
Pages: 3027-39
Publication
First Author: Chazaud C
Year: 1996
Journal: Dev Genet
Title: Restricted expression of a novel retinoic acid responsive gene during limb bud dorsoventral patterning and endochondral ossification.
Volume: 19
Issue: 1
Pages: 66-73
Publication
First Author: Muenzner M
Year: 2013
Journal: Mol Cell Biol
Title: Retinol-binding protein 4 and its membrane receptor STRA6 control adipogenesis by regulating cellular retinoid homeostasis and retinoic acid receptor α activity.
Volume: 33
Issue: 20
Pages: 4068-82
Publication
First Author: Sapin V
Year: 2000
Journal: Mech Dev
Title: Differential expression of retinoic acid-inducible (Stra) genes during mouse placentation.
Volume: 92
Issue: 2
Pages: 295-9
Publication
First Author: Berry DC
Year: 2011
Journal: Proc Natl Acad Sci U S A
Title: Signaling by vitamin A and retinol-binding protein regulates gene expression to inhibit insulin responses.
Volume: 108
Issue: 11
Pages: 4340-5
Publication
First Author: Kelly M
Year: 2016
Journal: FASEB J
Title: Transport of vitamin A across blood-tissue barriers is facilitated by STRA6.
Volume: 30
Issue: 8
Pages: 2985-95
Publication
First Author: Carrera S
Year: 2013
Journal: Cell Death Differ
Title: Stra6, a retinoic acid-responsive gene, participates in p53-induced apoptosis after DNA damage.
Volume: 20
Issue: 7
Pages: 910-9
Publication
First Author: Chen CH
Year: 2019
Journal: Biochim Biophys Acta Gen Subj
Title: O-GlcNAcylation disrupts STRA6-retinol signals in kidneys of diabetes.
Volume: 1863
Issue: 6
Pages: 1059-1069
Publication
First Author: Alapatt P
Year: 2013
Journal: J Biol Chem
Title: Liver retinol transporter and receptor for serum retinol-binding protein (RBP4).
Volume: 288
Issue: 2
Pages: 1250-65
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus caroli
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus pahari
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus spretus
GXD Expression      
Probe: MGI:3689613
Assay Type: RT-PCR
Annotation Date: 2006-12-08
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1741220
Stage: TS20
Assay Id: MGI:3690105
Age: embryonic day 12.5
Specimen Label: None
Detected: true
Specimen Num: 1
GXD Expression      
Probe: MGI:3689613
Assay Type: RT-PCR
Annotation Date: 2006-12-08
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1741220
Stage: TS20
Assay Id: MGI:3690105
Age: embryonic day 12.5
Specimen Label: None
Detected: true
Specimen Num: 2
GXD Expression    
Probe: MGI:3785878
Assay Type: RT-PCR
Annotation Date: 2008-05-22
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603922
Stage: TS22
Assay Id: MGI:3789056
Age: embryonic day 14.5
Image: 3
Specimen Label: wt
Detected: true
Specimen Num: 1
GXD Expression    
Probe: MGI:3785878
Assay Type: RT-PCR
Annotation Date: 2008-05-22
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603922
Stage: TS22
Assay Id: MGI:3789056
Age: embryonic day 14.5
Image: 3
Specimen Label: LRAT-/-RBP-/-
Detected: true
Specimen Num: 2
GXD Expression    
Probe: MGI:3785878
Assay Type: RT-PCR
Annotation Date: 2008-05-22
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3568928
Stage: TS28
Assay Id: MGI:3789059
Age: postnatal
Image: 4
Specimen Label: wt
Detected: true
Specimen Num: 1
GXD Expression    
Probe: MGI:3785878
Assay Type: RT-PCR
Annotation Date: 2008-05-22
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3568928
Stage: TS28
Assay Id: MGI:3789059
Age: postnatal
Image: 4
Specimen Label: LRAT-/-RBP-/-
Detected: true
Specimen Num: 2
GXD Expression    
Probe: MGI:1095394
Assay Type: Northern blot
Annotation Date: 2015-04-28
Strength: Present
Sex: Female
Emaps: EMAPS:1795928
Stage: TS28
Assay Id: MGI:5633923
Age: postnatal adult
Image: 2
Specimen Label: 1
Detected: true
Specimen Num: 1
GXD Expression    
Probe: MGI:1095394
Assay Type: Northern blot
Annotation Date: 2015-04-28
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:5633924
Age: postnatal adult
Image: 3
Specimen Label: Br
Detected: true
Specimen Num: 1
GXD Expression    
Probe: MGI:1095394
Assay Type: Northern blot
Annotation Date: 2015-04-28
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1610528
Stage: TS28
Assay Id: MGI:5633924
Age: postnatal adult
Image: 3
Specimen Label: He
Detected: true
Specimen Num: 2
GXD Expression    
Probe: MGI:1095394
Assay Type: Northern blot
Annotation Date: 2015-04-28
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1672828
Stage: TS28
Assay Id: MGI:5633924
Age: postnatal adult
Image: 3
Specimen Label: Lu
Detected: true
Specimen Num: 3
GXD Expression    
Probe: MGI:1095394
Assay Type: Northern blot
Annotation Date: 2015-04-28
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1737328
Stage: TS28
Assay Id: MGI:5633924
Age: postnatal adult
Image: 3
Specimen Label: Ki
Detected: true
Specimen Num: 5
GXD Expression    
Probe: MGI:1095394
Assay Type: Northern blot
Annotation Date: 2015-04-28
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1876728
Stage: TS28
Assay Id: MGI:5633924
Age: postnatal adult
Image: 3
Specimen Label: Sp
Detected: true
Specimen Num: 6
GXD Expression    
Probe: MGI:1095394
Assay Type: Northern blot
Annotation Date: 2015-04-28
Strength: Present
Sex: Male
Emaps: EMAPS:1797228
Stage: TS28
Assay Id: MGI:5633924
Age: postnatal adult
Image: 3
Specimen Label: Te
Detected: true
Specimen Num: 8
GXD Expression    
Probe: MGI:1095394
Assay Type: Northern blot
Annotation Date: 2015-04-28
Strength: Present
Sex: Female
Emaps: EMAPS:1795928
Stage: TS28
Assay Id: MGI:5633924
Age: postnatal adult
Image: 3
Specimen Label: Fgt
Detected: true
Specimen Num: 7
GXD Expression    
Probe: MGI:1095394
Assay Type: Northern blot
Annotation Date: 2015-04-28
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1684628
Stage: TS28
Assay Id: MGI:5633924
Age: postnatal adult
Image: 3
Specimen Label: Li
Detected: true
Specimen Num: 4
GXD Expression    
Probe: MGI:6402311
Assay Type: RT-PCR
Annotation Date: 2020-03-31
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1702521
Stage: TS21
Assay Id: MGI:6402326
Age: embryonic day 13.5
Image: 1
Specimen Label: Tlx1+/-
Detected: true
Specimen Num: 1
GXD Expression    
Probe: MGI:6402311
Assay Type: RT-PCR
Annotation Date: 2020-03-31
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1702521
Stage: TS21
Assay Id: MGI:6402326
Age: embryonic day 13.5
Image: 1
Specimen Label: Tlx1-/-
Detected: true
Specimen Num: 2
GXD Expression  
Probe: MGI:3689597
Assay Type: RNA in situ
Annotation Date: 2006-12-06
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1741220
Pattern: Not Specified
Stage: TS20
Assay Id: MGI:3689905
Age: embryonic day 12.5
Image: S4E Wild type
Specimen Label: S4E Wild type
Detected: true
Specimen Num: 1
GXD Expression
Probe: MGI:3689597
Assay Type: RNA in situ
Annotation Date: 2006-12-06
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1741220
Pattern: Not Specified
Stage: TS20
Assay Id: MGI:3689905
Age: embryonic day 12.5
Image: S4E HoxD Del1-13
Note: Expression was lower in the mutant compared to wild type.
Specimen Label: S4E HoxD Del1-13
Detected: true
Specimen Num: 2
GXD Expression  
Probe: MGI:4428945
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1801023
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4828513
Age: embryonic day 14.5
Image: euxassay_017150_02
Specimen Label: euxassay_017150_02
Detected: true
Specimen Num: 1
GXD Expression  
Probe: MGI:4428945
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1777423
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4828513
Age: embryonic day 14.5
Image: euxassay_017150_02
Specimen Label: euxassay_017150_02
Detected: true
Specimen Num: 1
GXD Expression  
Probe: MGI:4428945
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1801023
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4828513
Age: embryonic day 14.5
Image: euxassay_017150_03
Specimen Label: euxassay_017150_03
Detected: true
Specimen Num: 2
GXD Expression  
Probe: MGI:4428945
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1679723
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4828513
Age: embryonic day 14.5
Image: euxassay_017150_03
Specimen Label: euxassay_017150_03
Detected: true
Specimen Num: 2
GXD Expression  
Probe: MGI:4428945
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1777423
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4828513
Age: embryonic day 14.5
Image: euxassay_017150_03
Specimen Label: euxassay_017150_03
Detected: true
Specimen Num: 2
GXD Expression  
Probe: MGI:4428945
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1801023
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4828513
Age: embryonic day 14.5
Image: euxassay_017150_04
Specimen Label: euxassay_017150_04
Detected: true
Specimen Num: 3
GXD Expression  
Probe: MGI:4428945
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1679723
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4828513
Age: embryonic day 14.5
Image: euxassay_017150_04
Specimen Label: euxassay_017150_04
Detected: true
Specimen Num: 3
GXD Expression  
Probe: MGI:4428945
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1777423
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4828513
Age: embryonic day 14.5
Image: euxassay_017150_04
Specimen Label: euxassay_017150_04
Detected: true
Specimen Num: 3
GXD Expression  
Probe: MGI:4428945
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1801023
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4828513
Age: embryonic day 14.5
Image: euxassay_017150_05
Specimen Label: euxassay_017150_05
Detected: true
Specimen Num: 4
GXD Expression  
Probe: MGI:4428945
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1679723
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4828513
Age: embryonic day 14.5
Image: euxassay_017150_05
Specimen Label: euxassay_017150_05
Detected: true
Specimen Num: 4
GXD Expression  
Probe: MGI:4428945
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1777423
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4828513
Age: embryonic day 14.5
Image: euxassay_017150_05
Specimen Label: euxassay_017150_05
Detected: true
Specimen Num: 4
GXD Expression  
Probe: MGI:4428945
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1737323
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4828513
Age: embryonic day 14.5
Image: euxassay_017150_05
Specimen Label: euxassay_017150_05
Detected: true
Specimen Num: 4
GXD Expression  
Probe: MGI:4428945
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1679723
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4828513
Age: embryonic day 14.5
Image: euxassay_017150_06
Specimen Label: euxassay_017150_06
Detected: true
Specimen Num: 5
GXD Expression  
Probe: MGI:4428945
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1679523
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4828513
Age: embryonic day 14.5
Image: euxassay_017150_06
Specimen Label: euxassay_017150_06
Detected: true
Specimen Num: 5
GXD Expression  
Probe: MGI:4428945
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1777423
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4828513
Age: embryonic day 14.5
Image: euxassay_017150_06
Specimen Label: euxassay_017150_06
Detected: true
Specimen Num: 5
GXD Expression  
Probe: MGI:4428945
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1666823
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4828513
Age: embryonic day 14.5
Image: euxassay_017150_06
Specimen Label: euxassay_017150_06
Detected: true
Specimen Num: 5
GXD Expression  
Probe: MGI:4428945
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1737323
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4828513
Age: embryonic day 14.5
Image: euxassay_017150_06
Specimen Label: euxassay_017150_06
Detected: true
Specimen Num: 5
GXD Expression  
Probe: MGI:4428945
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1679723
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4828513
Age: embryonic day 14.5
Image: euxassay_017150_07
Specimen Label: euxassay_017150_07
Detected: true
Specimen Num: 6