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Search results 1 to 100 out of 917 for Stra8

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Categories

Hits by Strain

Hits by Category

Type Details Score
Gene
key_980111 | Stra8
Type: gene
Organism: Not Specified
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Gene
346673 | STRA8
Type: gene
Organism: human
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Gene
785714 | STRA8
Type: gene
Organism: cattle
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Gene
417938 | STRA8
Type: gene
Organism: chicken
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Gene
713651 | STRA8
Type: gene
Organism: macaque, rhesus
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Gene
100489701 | stra8
Type: gene
Organism: frog, western clawed
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Gene
500079 | Stra8
Type: gene
Organism: rat
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Gene
610269 | STRA8
Type: gene
Organism: dog, domestic
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Gene
737711 | STRA8
Type: gene
Organism: chimpanzee
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Protein Domain
IPR033537 | Stra8
Type: Family
Description: Stimulated by Retinoic Acid Gene 8 (Stra8) is required for the transition into meiosis in both female and male germ cells. In mammals, Stra8 is expressed in embryonic ovaries just before meiotic initiation, whereas its expression in testes is first detected after birth []. Retinoic acid signalling is required for the expression of Stra8 and thereby meiotic initiation in embryonic ovaries [, ].
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Protein Coding Gene
MGI:107917 | Stra8
Type: protein_coding_gene
Organism: mouse, laboratory
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Publication
17115059 | J:116498
First Author: Baltus AE
Year: 2006
Journal: Nat Genet
Title: In germ cells of mouse embryonic ovaries, the decision to enter meiosis precedes premeiotic DNA replication.
Volume: 38
Issue: 12
Pages: 1430-4
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Publication
16461896 | J:107319
First Author: Koubova J
Year: 2006
Journal: Proc Natl Acad Sci U S A
Title: Retinoic acid regulates sex-specific timing of meiotic initiation in mice.
Volume: 103
Issue: 8
Pages: 2474-9
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Protein
P70278
Organism: Mus musculus/domesticus
Length: 393  
Fragment?: false
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Protein
V9GXG4
Organism: Mus musculus/domesticus
Length: 146  
Fragment?: true
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Protein
F2Z435
Organism: Mus musculus/domesticus
Length: 282  
Fragment?: false
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Publication
26764212 | -
 
First Author: Li M
Year: 2016
Journal: Gen Comp Endocrinol
Title: Retinoic acid triggers meiosis initiation via stra8-dependent pathway in Southern catfish, Silurus meridionalis.
Volume: 232
Pages: 191-8
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GXD Expression
GXD Expression
     
Probe: MGI:6720902
Assay Type: Western blot
Annotation Date: 2021-07-14
Strength: Absent
Sex: Male
Emaps: EMAPS:1797228
Stage: TS28
Assay Id: MGI:6721097
Age: postnatal day 18
Specimen Label: Stra8 KO
Detected: false
Specimen Num: 2
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Publication
19805549 | J:158227
First Author: Tedesco M
Year: 2009
Journal: J Biol Chem
Title: STRA8 shuttles between nucleus and cytoplasm and displays transcriptional activity.
Volume: 284
Issue: 51
Pages: 35781-93
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Publication
30106128 | J:329583
First Author: Shen X
Year: 2018
Journal: Int J Mol Med
Title: Stra8 may inhibit apoptosis during mouse spermatogenesis via the AKT signaling pathway.
Volume: 42
Issue: 5
Pages: 2819-2830
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Publication
33959758 | J:336344
First Author: Sinha N
Year: 2021
Journal: Biol Reprod
Title: Roles of Stra8 and Tcerg1l in retinoic acid induced spermatogonial differentiation in mouse†.
Volume: 105
Issue: 2
Pages: 503-518
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Publication
32090428 | J:333219
First Author: Niu C
Year: 2020
Journal: J Cell Mol Med
Title: Meiotic gatekeeper STRA8 regulates cell cycle by interacting with SETD8 during spermatogenesis.
Volume: 24
Issue: 7
Pages: 4194-4211
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Publication
18799751 | J:142748
First Author: Anderson EL
Year: 2008
Journal: Proc Natl Acad Sci U S A
Title: Stra8 and its inducer, retinoic acid, regulate meiotic initiation in both spermatogenesis and oogenesis in mice.
Volume: 105
Issue: 39
Pages: 14976-80
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GXD Expression
GXD Expression
     
Probe: MGI:6720902
Assay Type: Immunohistochemistry
Annotation Date: 2021-07-14
Strength: Absent
Sex: Male
Emaps: EMAPS:3147628
Stage: TS28
Assay Id: MGI:6721099
Age: postnatal day 18
Specimen Label: 2G Stra8 KO
Detected: false
Specimen Num: 11
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GXD Expression
GXD Expression
     
Probe: MGI:6720902
Assay Type: Immunohistochemistry
Annotation Date: 2021-07-14
Strength: Absent
Sex: Male
Emaps: EMAPS:3147628
Stage: TS28
Assay Id: MGI:6721099
Age: postnatal day 10
Specimen Label: 1H (p10) Stra8 KO
Detected: false
Specimen Num: 14
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GXD Expression
GXD Expression
     
Probe: MGI:6720902
Assay Type: Immunohistochemistry
Annotation Date: 2021-07-14
Strength: Absent
Sex: Male
Emaps: EMAPS:3147628
Stage: TS28
Assay Id: MGI:6721099
Age: postnatal day 18
Specimen Label: 2H (p18) Stra8 KO
Detected: false
Specimen Num: 17
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GXD Expression
GXD Expression
     
Probe: MGI:6720902
Assay Type: Immunohistochemistry
Annotation Date: 2021-07-14
Strength: Absent
Sex: Male
Emaps: EMAPS:3147628
Stage: TS28
Assay Id: MGI:6721099
Age: postnatal week 8
Specimen Label: 2H (8w) Stra8 KO
Detected: false
Specimen Num: 20
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GXD Expression
GXD Expression
     
Probe: MGI:6720902
Assay Type: Immunohistochemistry
Annotation Date: 2021-07-14
Strength: Absent
Sex: Male
Emaps: EMAPS:3147628
Stage: TS28
Assay Id: MGI:6721099
Age: postnatal week 8
Specimen Label: 2L Stra8 KO
Detected: false
Specimen Num: 24
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Publication
21621532 | J:175257
First Author: Krentz AD
Year: 2011
Journal: Dev Biol
Title: DMRT1 promotes oogenesis by transcriptional activation of Stra8 in the mammalian fetal ovary.
Volume: 356
Issue: 1
Pages: 63-70
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Publication
31059511 | J:275030
First Author: Ferder IC
Year: 2019
Journal: PLoS Genet
Title: Meiotic gatekeeper STRA8 suppresses autophagy by repressing Nr1d1 expression during spermatogenesis in mice.
Volume: 15
Issue: 5
Pages: e1008084
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Publication
27606421 | J:237277
First Author: Wu Q
Year: 2016
Journal: PLoS Biol
Title: Sexual Fate Change of XX Germ Cells Caused by the Deletion of SMAD4 and STRA8 Independent of Somatic Sex Reprogramming.
Volume: 14
Issue: 9
Pages: e1002553
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GXD Expression
GXD Expression
Probe: MGI:6694237
Assay Type: Immunohistochemistry
Annotation Date: 2021-04-28
Strength: Present
Sex: Male
Emaps: EMAPS:1797528
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6695333
Age: postnatal day 8
Image: 5d 8-dpp Meioc-/-
Note: Stra8 expression was relatively normal in the mutant at 8-dpp.
Specimen Label: 5d 8-dpp Meioc-/-
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
Probe: MGI:6694237
Assay Type: Immunohistochemistry
Annotation Date: 2021-04-28
Strength: Present
Sex: Male
Emaps: EMAPS:1797528
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6695333
Age: postnatal day 16
Image: 5d 16-dpp Meioc-/-
Note: An abundance of cells still expressed Stra8 in the mutant.
Specimen Label: 5d 16-dpp Meioc-/-
Detected: true
Specimen Num: 5
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GXD Expression
GXD Expression
 
Probe: MGI:6720903
Assay Type: Immunohistochemistry
Annotation Date: 2021-07-14
Strength: Present
Sex: Male
Emaps: EMAPS:3147628
Pattern: Regionally restricted
Stage: TS28
Assay Id: MGI:6721100
Age: postnatal day 18
Note: Expression localized in nuclei of Stra8 KO mice.
Specimen Label: 2G Stra8 KO
Detected: true
Specimen Num: 12
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Publication
33574039 | J:303699
 
First Author: Feng CW
Year: 2021
Journal: Development
Title: Identification of regulatory elements required for Stra8 expression in fetal ovarian germ cells of the mouse.
Volume: 148
Issue: 5
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Publication
37279768 | J:339445
First Author: Ahmed AA
Year: 2023
Journal: Biol Reprod
Title: Generation of a novel Stra8-driven Cre recombinase strain for use in pre-meiotic germ cells in mice†.
Volume: 109
Issue: 2
Pages: 184-191
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Publication
30810530 | J:273739
   
First Author: Kojima ML
Year: 2019
Journal: Elife
Title: Amplification of a broad transcriptional program by a common factor triggers the meiotic cell cycle in mice.
Volume: 8
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Publication
37439366 | J:344887
First Author: Zhang Q
Year: 2023
Journal: Nucleic Acids Res
Title: The FLIP-FIGNL1 complex regulates the dissociation of RAD51/DMC1 in homologous recombination and replication fork restart.
Volume: 51
Issue: 16
Pages: 8606-8622
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Publication
18799790 | J:139646
First Author: Mark M
Year: 2008
Journal: J Cell Sci
Title: STRA8-deficient spermatocytes initiate, but fail to complete, meiosis and undergo premature chromosome condensation.
Volume: 121
Issue: Pt 19
Pages: 3233-42
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Publication
23770609 | J:204418
First Author: Dokshin GA
Year: 2013
Journal: Nat Genet
Title: Oocyte differentiation is genetically dissociable from meiosis in mice.
Volume: 45
Issue: 8
Pages: 877-83
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Publication
29848833 | J:317706
First Author: Ma HT
Year: 2018
Journal: Asian J Androl
Title: Stimulated by retinoic acid gene 8 (Stra8) plays important roles in many stages of spermatogenesis.
Volume: 20
Issue: 5
Pages: 479-487
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Publication
18322276 | J:209945
First Author: Zhou Q
Year: 2008
Journal: Biol Reprod
Title: Expression of stimulated by retinoic acid gene 8 (Stra8) in spermatogenic cells induced by retinoic acid: an in vivo study in vitamin A-sufficient postnatal murine testes.
Volume: 79
Issue: 1
Pages: 35-42
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Publication
34913465 | J:316913
 
First Author: Chen J
Year: 2021
Journal: Development
Title: The microRNA miR-202 prevents precocious spermatogonial differentiation and meiotic initiation during mouse spermatogenesis.
Volume: 148
Issue: 24
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Publication
12489526 | J:80524
First Author: Miyamoto T
Year: 2002
Journal: J Assist Reprod Genet
Title: Isolation and expression analysis of the testis-specific gene, STRA8, stimulated by retinoic acid gene 8.
Volume: 19
Issue: 11
Pages: 531-5
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Publication
18032419 | J:135434
First Author: Zhou Q
Year: 2008
Journal: Biol Reprod
Title: Expression of stimulated by retinoic acid gene 8 (Stra8) and maturation of murine gonocytes and spermatogonia induced by retinoic acid in vitro.
Volume: 78
Issue: 3
Pages: 537-45
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Publication
32017896 | J:286260
First Author: Wang X
Year: 2020
Journal: Mol Cell
Title: LARP7-Mediated U6 snRNA Modification Ensures Splicing Fidelity and Spermatogenesis in Mice.
Volume: 77
Issue: 5
Pages: 999-1013.e6
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Publication
8896602 | J:36069
First Author: Oulad-Abdelghani M
Year: 1996
Journal: J Cell Biol
Title: Characterization of a premeiotic germ cell-specific cytoplasmic protein encoded by Stra8, a novel retinoic acid-responsive gene.
Volume: 135
Issue: 2
Pages: 469-77
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Publication
23677978 | J:202057
First Author: Chihara M
Year: 2013
Journal: Biol Reprod
Title: Mice stage-specific claudin 3 expression regulates progression of meiosis in early stage spermatocytes.
Volume: 89
Issue: 1
Pages: 3
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Publication
36114296 | J:333861
First Author: Qin J
Year: 2023
Journal: Cell Death Differ
Title: Bud31-mediated alternative splicing is required for spermatogonial stem cell self-renewal and differentiation.
Volume: 30
Issue: 1
Pages: 184-194
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Publication
34850470 | J:324152
First Author: Qi M
Year: 2022
Journal: Cell Prolif
Title: m6 A reader protein YTHDF2 regulates spermatogenesis by timely clearance of phase-specific transcripts.
Volume: 55
Issue: 1
Pages: e13164
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Publication
37493331 | J:341543
First Author: Meng TG
Year: 2023
Journal: Adv Sci (Weinh)
Title: NLRP14 Safeguards Calcium Homeostasis via Regulating the K27 Ubiquitination of Nclx in Oocyte-to-Embryo Transition.
Volume: 10
Issue: 27
Pages: e2301940
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Publication
21224842 | J:222363
 
First Author: Kumar S
Year: 2011
Journal: Nat Commun
Title: Sex-specific timing of meiotic initiation is regulated by Cyp26b1 independent of retinoic acid signalling.
Volume: 2
Pages: 151
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Publication
32094118 | J:286601
 
First Author: Jiang Y
Year: 2020
Journal: Development
Title: CXXC finger protein 1-mediated histone H3 lysine-4 trimethylation is essential for proper meiotic crossover formation in mice.
Volume: 147
Issue: 6
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Publication
33236849 | J:313962
First Author: Desimio MG
Year: 2021
Journal: J Cell Mol Med
Title: Stimulated by retinoic acid gene 8 (STRA8) interacts with the germ cell specific bHLH factor SOHLH1 and represses c-KIT expression in vitro.
Volume: 25
Issue: 1
Pages: 383-396
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Publication
26892828 | J:234736
 
First Author: Bowles J
Year: 2016
Journal: Nat Commun
Title: ALDH1A1 provides a source of meiosis-inducing retinoic acid in mouse fetal ovaries.
Volume: 7
Pages: 10845
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Publication
37880249 | J:342011
First Author: Shimada R
Year: 2023
Journal: Nat Commun
Title: STRA8-RB interaction is required for timely entry of meiosis in mouse female germ cells.
Volume: 14
Issue: 1
Pages: 6443
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Publication
25102060 | J:215225
First Author: Koubova J
Year: 2014
Journal: PLoS Genet
Title: Retinoic acid activates two pathways required for meiosis in mice.
Volume: 10
Issue: 8
Pages: e1004541
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Publication
28914256 | J:250428
First Author: Lin Z
Year: 2017
Journal: Cell Res
Title: Mettl3-/Mettl14-mediated mRNA N6-methyladenosine modulates murine spermatogenesis.
Volume: 27
Issue: 10
Pages: 1216-1230
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Publication
35951695 | J:332641
First Author: Kang JY
Year: 2022
Journal: Science
Title: LLPS of FXR1 drives spermiogenesis by activating translation of stored mRNAs.
Volume: 377
Issue: 6607
Pages: eabj6647
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Publication
32032549 | J:290712
First Author: Ishiguro KI
Year: 2020
Journal: Dev Cell
Title: MEIOSIN Directs the Switch from Mitosis to Meiosis in Mammalian Germ Cells.
Volume: 52
Issue: 4
Pages: 429-445.e10
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Publication
32494737 | J:299356
First Author: Chassot AA
Year: 2020
Journal: Sci Adv
Title: Retinoic acid synthesis by ALDH1A proteins is dispensable for meiosis initiation in the mouse fetal ovary.
Volume: 6
Issue: 21
Pages: eaaz1261
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Publication
30102701 | J:266305
First Author: Zhou Y
Year: 2018
Journal: PLoS Genet
Title: Wdr62 is involved in meiotic initiation via activating JNK signaling and associated with POI in humans.
Volume: 14
Issue: 8
Pages: e1007463
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Publication
22071108 | J:178676
First Author: Le Bouffant R
Year: 2011
Journal: Development
Title: Msx1 and Msx2 promote meiosis initiation.
Volume: 138
Issue: 24
Pages: 5393-402
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Publication
26742488 | J:231231
 
First Author: Abby E
Year: 2016
Journal: Nat Commun
Title: Implementation of meiosis prophase I programme requires a conserved retinoid-independent stabilizer of meiotic transcripts.
Volume: 7
Pages: 10324
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Publication
32302290 | J:307649
First Author: Satirapod C
Year: 2020
Journal: Aging (Albany NY)
Title: Estrogen regulation of germline stem cell differentiation as a mechanism contributing to female reproductive aging.
Volume: 12
Issue: 8
Pages: 7313-7333
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Publication
37082953 | J:342526
 
First Author: Lin H
Year: 2023
Journal: Development
Title: The DOT1L-MLLT10 complex regulates male fertility and promotes histone removal during spermiogenesis.
Volume: 150
Issue: 9
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Publication
29716999 | J:263889
First Author: Zuo X
Year: 2018
Journal: J Biol Chem
Title: The histone methyltransferase SETD2 is required for expression of acrosin-binding protein 1 and protamines and essential for spermiogenesis in mice.
Volume: 293
Issue: 24
Pages: 9188-9197
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Publication
30061742 | J:267507
First Author: Chen Y
Year: 2018
Journal: Cell Res
Title: Single-cell RNA-seq uncovers dynamic processes and critical regulators in mouse spermatogenesis.
Volume: 28
Issue: 9
Pages: 879-896
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Publication
14550793 | J:86170
First Author: Menke DB
Year: 2003
Journal: Dev Biol
Title: Sexual differentiation of germ cells in XX mouse gonads occurs in an anterior-to-posterior wave.
Volume: 262
Issue: 2
Pages: 303-12
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Publication
29339164 | J:258304
 
First Author: Pui HP
Year: 2018
Journal: Mech Dev
Title: NANOS2 acts as an intrinsic regulator of gonocytes-to-spermatogonia transition in the murine testes.
Volume: 149
Pages: 27-40
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Publication
26378784 | J:228910
First Author: Soh YQ
Year: 2015
Journal: PLoS Genet
Title: A Gene Regulatory Program for Meiotic Prophase in the Fetal Ovary.
Volume: 11
Issue: 9
Pages: e1005531
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Publication
34910909 | J:316789
First Author: Liu R
Year: 2021
Journal: Cell Rep
Title: YTHDC2 is essential for pachytene progression and prevents aberrant microtubule-driven telomere clustering in male meiosis.
Volume: 37
Issue: 11
Pages: 110110
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Publication
23486062 | J:194892
First Author: Yokobayashi S
Year: 2013
Journal: Nature
Title: PRC1 coordinates timing of sexual differentiation of female primordial germ cells.
Volume: 495
Issue: 7440
Pages: 236-40
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Protein Coding Gene
MGP_CAROLIEiJ_G0028215 | -
Type: protein_coding_gene
Organism: Mus caroli
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Protein Coding Gene
MGP_129S1SvImJ_G0030566 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AJ_G0030539 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AKRJ_G0030466 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_BALBcJ_G0030549 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C3HHeJ_G0030262 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI_C57BL6J_107917 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C57BL6NJ_G0031003 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CASTEiJ_G0029664 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CBAJ_G0030240 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_DBA2J_G0030384 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_FVBNJ_G0030338 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_LPJ_G0030471 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NODShiLtJ_G0030374 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NZOHlLtJ_G0031033 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PWKPhJ_G0029378 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_WSBEiJ_G0029740 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PahariEiJ_G0021972 | -
Type: protein_coding_gene
Organism: Mus pahari
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Protein Coding Gene
MGP_SPRETEiJ_G0029214 | -
Type: protein_coding_gene
Organism: Mus spretus
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Publication
37405912 | J:338427
First Author: Zhang X
Year: 2023
Journal: Cell Rep
Title: Transcriptional metabolic reprogramming implements meiotic fate decision in mouse testicular germ cells.
Volume: 42
Issue: 7
Pages: 112749
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Publication
24478393 | J:209944
First Author: Busada JT
Year: 2014
Journal: Biol Reprod
Title: Retinoic acid induces multiple hallmarks of the prospermatogonia-to-spermatogonia transition in the neonatal mouse.
Volume: 90
Issue: 3
Pages: 64
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GXD Expression
GXD Expression
   
Probe: MGI:3652374
Assay Type: RT-PCR
Annotation Date: 2006-08-22
Strength: Absent
Sex: Male
Emaps: EMAPS:1797220
Stage: TS20
Assay Id: MGI:3652394
Age: embryonic day 12.5
Image: 1
Specimen Label: E12.5 male
Detected: false
Specimen Num: 1
•
•
•
•
•
GXD Expression
GXD Expression
   
Probe: MGI:3652374
Assay Type: RT-PCR
Annotation Date: 2006-08-22
Strength: Absent
Sex: Male
Emaps: EMAPS:1797221
Stage: TS21
Assay Id: MGI:3652394
Age: embryonic day 13.5
Image: 1
Specimen Label: E13.5 male
Detected: false
Specimen Num: 3
•
•
•
•
•
GXD Expression
GXD Expression
   
Probe: MGI:3652374
Assay Type: RT-PCR
Annotation Date: 2006-08-22
Strength: Absent
Sex: Male
Emaps: EMAPS:1797222
Stage: TS22
Assay Id: MGI:3652394
Age: embryonic day 14.5
Image: 1
Specimen Label: E14.5 male
Detected: false
Specimen Num: 5
•
•
•
•
•
GXD Expression
GXD Expression
   
Probe: MGI:3652374
Assay Type: RT-PCR
Annotation Date: 2006-08-22
Strength: Present
Sex: Female
Emaps: EMAPS:1796220
Stage: TS20
Assay Id: MGI:3652394
Age: embryonic day 12.5
Image: 1
Specimen Label: E12.5 female
Detected: true
Specimen Num: 2
•
•
•
•
•
GXD Expression
GXD Expression
   
Probe: MGI:3652374
Assay Type: RT-PCR
Annotation Date: 2006-08-22
Strength: Present
Sex: Female
Emaps: EMAPS:1796221
Stage: TS21
Assay Id: MGI:3652394
Age: embryonic day 13.5
Image: 1
Specimen Label: E13.5 female
Detected: true
Specimen Num: 4
•
•
•
•
•
GXD Expression
GXD Expression
   
Probe: MGI:3652374
Assay Type: RT-PCR
Annotation Date: 2006-08-22
Strength: Present
Sex: Female
Emaps: EMAPS:1796222
Stage: TS22
Assay Id: MGI:3652394
Age: embryonic day 14.5
Image: 1
Specimen Label: E14.5 female
Detected: true
Specimen Num: 6
•
•
•
•
•




MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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