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Search results 1 to 82 out of 82 for Stx17

3.874s
Type Details Score
Gene
Type: gene
Organism: human
Gene
Type: gene
Organism: chimpanzee
Gene
Type: gene
Organism: cattle
Gene
Type: gene
Organism: chicken
Gene
Type: gene
Organism: zebrafish
Gene
Type: gene
Organism: macaque, rhesus
Gene
Type: gene
Organism: rat
Gene
Type: gene
Organism: dog, domestic
Protein Domain
Type: Family
Description: Syntaxin-17 (STX17) belongs to the syntaxin family, which is a group of the membrane integrated proteins participating in exocytosis. Syntaxins are associated with various intracellular membrane compartments and have been implicated in various physiological processes such as axonal growth and cell division [].STX17 is required to maintain the architecture of ER-Golgi intermediate compartment and Golgi []. STX17 is also involved in the fusion of autophagosomes with endosomes/lysosomes. Its unique C-terminal hairpin structure mediated by two tandem transmembrane domains is essential for its association with the autophagosomal membrane [, ].
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Publication
First Author: Itakura E
Year: 2012
Journal: Cell
Title: The hairpin-type tail-anchored SNARE syntaxin 17 targets to autophagosomes for fusion with endosomes/lysosomes.
Volume: 151
Issue: 6
Pages: 1256-69
Gene
Type: gene
Organism: human
Publication
First Author: Muppirala M
Year: 2011
Journal: Biol Cell
Title: Syntaxin 17 cycles between the ER and ERGIC and is required to maintain the architecture of ERGIC and Golgi.
Volume: 103
Issue: 7
Pages: 333-50
Publication
First Author: Diao J
Year: 2015
Journal: Nature
Title: ATG14 promotes membrane tethering and fusion of autophagosomes to endolysosomes.
Volume: 520
Issue: 7548
Pages: 563-6
Protein
Organism: Mus musculus/domesticus
Length: 137  
Fragment?: true
Publication
First Author: Pereira S
Year: 2008
Journal: Gene
Title: Nuclear localization of a novel human syntaxin 1B isoform.
Volume: 423
Issue: 2
Pages: 160-71
Protein
Organism: Mus musculus/domesticus
Length: 301  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 276  
Fragment?: false
Publication  
First Author: Arasaki K
Year: 2017
Journal: Nat Commun
Title: Legionella effector Lpg1137 shuts down ER-mitochondria communication through cleavage of syntaxin 17.
Volume: 8
Pages: 15406
Publication  
First Author: Xu H
Year: 2023
Journal: Metabolism
Title: Syntaxin17 contributes to obesity cardiomyopathy through promoting mitochondrial Ca(2+) overload in a Parkin-MCUb-dependent manner.
Volume: 143
Pages: 155551
Publication  
First Author: Rong Y
Year: 2022
Journal: J Cell Biol
Title: STING controls energy stress-induced autophagy and energy metabolism via STX17.
Volume: 221
Issue: 7
Publication    
First Author: Xia Y
Year: 2019
Journal: Autophagy
Title: The macrophage-specific V-ATPase subunit ATP6V0D2 restricts inflammasome activation and bacterial infection by facilitating autophagosome-lysosome fusion.
Pages: 1-16
Publication
First Author: Hubert V
Year: 2016
Journal: Biol Open
Title: LAMP-2 is required for incorporating syntaxin-17 into autophagosomes and for their fusion with lysosomes.
Volume: 5
Issue: 10
Pages: 1516-1529
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus caroli
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus pahari
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus spretus
GXD Expression  
Probe: MGI:657220
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1842723
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4828524
Age: embryonic day 14.5
Image: euxassay_006759_10
Specimen Label: euxassay_006759_10
Detected: true
Specimen Num: 1
GXD Expression  
Probe: MGI:657220
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1842723
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4828524
Age: embryonic day 14.5
Image: euxassay_006759_11
Specimen Label: euxassay_006759_11
Detected: true
Specimen Num: 2
GXD Expression  
Probe: MGI:657220
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1842723
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4828524
Age: embryonic day 14.5
Image: euxassay_006759_12
Specimen Label: euxassay_006759_12
Detected: true
Specimen Num: 3
GXD Expression  
Probe: MGI:657220
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1842723
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4828524
Age: embryonic day 14.5
Image: euxassay_006759_19
Specimen Label: euxassay_006759_19
Detected: true
Specimen Num: 4
GXD Expression  
Probe: MGI:657220
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1842723
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4828524
Age: embryonic day 14.5
Image: euxassay_006759_20
Specimen Label: euxassay_006759_20
Detected: true
Specimen Num: 5
GXD Expression  
Probe: MGI:657220
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1842723
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4828524
Age: embryonic day 14.5
Image: euxassay_006759_21
Specimen Label: euxassay_006759_21
Detected: true
Specimen Num: 6
GXD Expression  
Probe: MGI:657220
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1842723
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4828524
Age: embryonic day 14.5
Image: euxassay_006759_22
Specimen Label: euxassay_006759_22
Detected: true
Specimen Num: 7
Publication      
First Author: The Jackson Laboratory
Year: 2012
Journal: MGI Direct Data Submission
Title: Alleles produced for the KOMP project by The Jackson Laboratory
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2001
Title: Gene Ontology Annotation by the MGI Curatorial Staff
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations for FANTOM2 data
Publication      
First Author: Wellcome Trust Sanger Institute
Year: 2009
Journal: MGI Direct Data Submission
Title: Alleles produced for the KOMP project by the Wellcome Trust Sanger Institute
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Title: Rat to Mouse ISO GO annotation transfer
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Title: MGI Sequence Curation Reference
Publication
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
Publication
First Author: Kawai J
Year: 2001
Journal: Nature
Title: Functional annotation of a full-length mouse cDNA collection.
Volume: 409
Issue: 6821
Pages: 685-90
Publication
First Author: Skarnes WC
Year: 2011
Journal: Nature
Title: A conditional knockout resource for the genome-wide study of mouse gene function.
Volume: 474
Issue: 7351
Pages: 337-42
Publication        
First Author: GemPharmatech
Year: 2020
Title: GemPharmatech Website.
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2001
Title: Gene Ontology Annotation by the MGI Curatorial Staff
Publication      
First Author: The Jackson Laboratory Mouse Radiation Hybrid Database
Year: 2004
Journal: Database Release
Title: Mouse T31 Radiation Hybrid Data Load
Publication
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2000
Title: Gene Ontology Annotation by electronic association of SwissProt Keywords with GO terms
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Title: Human to Mouse ISO GO annotation transfer
Publication
First Author: Diez-Roux G
Year: 2011
Journal: PLoS Biol
Title: A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Volume: 9
Issue: 1
Pages: e1000582
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
Publication      
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
Publication
First Author: Gaudet P
Year: 2011
Journal: Brief Bioinform
Title: Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.
Volume: 12
Issue: 5
Pages: 449-62
Publication      
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
Publication      
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
Publication      
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
Publication      
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
Publication      
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
Publication      
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
Publication
First Author: Arasaki K
Year: 2017
Journal: Autophagy
Title: Legionella blocks autophagy by cleaving STX17 (syntaxin 17).
Volume: 13
Issue: 11
Pages: 2008-2009
Protein Domain
Type: Family
Description: This family includes serine proteases such as L. pneumophila effector Lpg1137 []. Lpg1137, is a serine protease that targets the mitochondria-associated ER membrane (MAM) and degrades STX17 (syntaxin 17), a SNARE implicated in macroautophagy/autophagy as well as mitochondria dynamics and membrane trafficking in fed cells. Lpg1137 has a sequence (-Gly-Leu-Ser68-Gly-Gly-) that matches the consensus sequence for the active site of serine proteases (Gly-X-Ser-X-Gly/Ala, where X is any residue). It exhibits proteolytic activity toward STX17 in vitro, whereas an active site mutant in which Ser68 is replaced by Ala does not. Expressed Lpg1137 localizes to the MAM and mitochondria, in addition to the cytosol, and binds to STX17 [].
Publication
First Author: Cheng X
Year: 2019
Journal: Mol Cell
Title: Pacer Is a Mediator of mTORC1 and GSK3-TIP60 Signaling in Regulation of Autophagosome Maturation and Lipid Metabolism.
Volume: 73
Issue: 4
Pages: 788-802.e7