Type |
Details |
Score |
Gene |
Type: |
gene |
Organism: |
human |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
frog, western clawed |
|
•
•
•
•
•
|
Gene |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
dog, domestic |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
cattle |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
chimpanzee |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
chicken |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
zebrafish |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
macaque, rhesus |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Family |
Description: |
The surfeit locus gene SURF4 (or surf-4) encodes a conserved integral eukaryotic membrane protein of about 270 to 300 amino-acid residues that seems to be located in the endoplasmic reticulum []. |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:216619 |
Assay Type: |
RNA in situ |
Annotation Date: |
2009-01-15 |
Strength: |
Weak |
Sex: |
Not Specified |
Emaps: |
EMAPS:3564922 |
Pattern: |
Not Specified |
Stage: |
TS22 |
Assay Id: |
MGI:3826128 |
Age: |
embryonic day 14.5 |
Image: |
Additional file 4 Surf4 |
|
Specimen Label: |
Additional file 4 Surf4 |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
Publication |
First Author: |
Reeves JE |
Year: |
1995 |
Journal: |
Mol Membr Biol |
Title: |
The surf-4 gene encodes a novel 30 kDa integral membrane protein. |
Volume: |
12 |
Issue: |
2 |
Pages: |
201-8 |
|
•
•
•
•
•
|
Publication |
First Author: |
Emmer BT |
Year: |
2020 |
Journal: |
PLoS One |
Title: |
Murine Surf4 is essential for early embryonic development. |
Volume: |
15 |
Issue: |
1 |
Pages: |
e0227450 |
|
•
•
•
•
•
|
Publication |
First Author: |
Guo CG |
Year: |
2023 |
Journal: |
Mol Metab |
Title: |
Intestinal SURF4 is essential for apolipoprotein transport and lipoprotein secretion. |
Volume: |
79 |
|
Pages: |
101847 |
|
•
•
•
•
•
|
Publication |
First Author: |
Tang VT |
Year: |
2022 |
Journal: |
Elife |
Title: |
Hepatic inactivation of murine <i>Surf4</i> results in marked reduction in plasma cholesterol. |
Volume: |
11 |
|
|
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
269
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
269
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
124
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
82
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
269
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Publication |
First Author: |
Wang X |
Year: |
2021 |
Journal: |
Cell Metab |
Title: |
Receptor-Mediated ER Export of Lipoproteins Controls Lipid Homeostasis in Mice and Humans. |
Volume: |
33 |
Issue: |
2 |
Pages: |
350-366.e7 |
|
•
•
•
•
•
|
Publication |
First Author: |
Garson K |
Year: |
1995 |
Journal: |
Genomics |
Title: |
Surf5: a gene in the tightly clustered mouse surfeit locus is highly conserved and transcribed divergently from the rpL7A (Surf3) gene. |
Volume: |
30 |
Issue: |
2 |
Pages: |
163-70 |
|
•
•
•
•
•
|
Publication |
First Author: |
Wang B |
Year: |
2021 |
Journal: |
J Lipid Res |
Title: |
Atherosclerosis-associated hepatic secretion of VLDL but not PCSK9 is dependent on cargo receptor protein Surf4. |
Volume: |
62 |
|
Pages: |
100091 |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
Mus caroli |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
Mus pahari |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
Mus spretus |
|
•
•
•
•
•
|
Publication |
First Author: |
Caldwell SR |
Year: |
2001 |
Journal: |
J Biol Chem |
Title: |
Degradation of endoplasmic reticulum (ER) quality control substrates requires transport between the ER and Golgi. |
Volume: |
276 |
Issue: |
26 |
Pages: |
23296-303 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:2651415 |
Assay Type: |
RT-PCR |
Annotation Date: |
2003-03-17 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1603911 |
|
Stage: |
TS11 |
Assay Id: |
MGI:2651435 |
Age: |
embryonic day 7.5 |
|
|
Specimen Label: |
+/+ |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:2651415 |
Assay Type: |
RT-PCR |
Annotation Date: |
2003-03-17 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1603911 |
|
Stage: |
TS11 |
Assay Id: |
MGI:2651435 |
Age: |
embryonic day 7.5 |
|
|
Specimen Label: |
-/- |
Detected: |
true |
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:2651415 |
Assay Type: |
RT-PCR |
Annotation Date: |
2003-03-17 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1603911 |
|
Stage: |
TS11 |
Assay Id: |
MGI:2651435 |
Age: |
embryonic day 7.5 |
|
|
Specimen Label: |
-/- |
Detected: |
true |
Specimen Num: |
3 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:2651415 |
Assay Type: |
RT-PCR |
Annotation Date: |
2003-03-17 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1603911 |
|
Stage: |
TS11 |
Assay Id: |
MGI:2651435 |
Age: |
embryonic day 7.5 |
|
|
Specimen Label: |
-/- |
Detected: |
true |
Specimen Num: |
4 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:2651415 |
Assay Type: |
RT-PCR |
Annotation Date: |
2003-03-17 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1603911 |
|
Stage: |
TS11 |
Assay Id: |
MGI:2651435 |
Age: |
embryonic day 7.5 |
|
|
Specimen Label: |
-/- |
Detected: |
true |
Specimen Num: |
5 |
|
•
•
•
•
•
|
Publication |
First Author: |
Wang X |
Year: |
2023 |
Journal: |
Nat Cell Biol |
Title: |
Manganese regulation of COPII condensation controls circulating lipid homeostasis. |
Volume: |
25 |
Issue: |
11 |
Pages: |
1650-1663 |
|
•
•
•
•
•
|
Publication |
First Author: |
Everett LA |
Year: |
2024 |
Journal: |
JCI Insight |
Title: |
LMAN1 serves as a cargo receptor for thrombopoietin. |
Volume: |
9 |
Issue: |
24 |
|
|
•
•
•
•
•
|
Publication |
First Author: |
Huxley C |
Year: |
1990 |
Journal: |
Mol Cell Biol |
Title: |
The mouse surfeit locus contains a cluster of six genes associated with four CpG-rich islands in 32 kilobases of genomic DNA. |
Volume: |
10 |
Issue: |
2 |
Pages: |
605-14 |
|
•
•
•
•
•
|
Publication |
First Author: |
Magoulas C |
Year: |
1996 |
Journal: |
DNA Cell Biol |
Title: |
The Surf-6 gene of the mouse surfeit locus encodes a novel nucleolar protein. |
Volume: |
15 |
Issue: |
4 |
Pages: |
305-16 |
|
•
•
•
•
•
|
Publication |
First Author: |
Yu LC |
Year: |
1993 |
Journal: |
Biochem J |
Title: |
Primary structure and characterization of an androgen-stimulated autoantigen purified from mouse seminal-vesicle secretion. |
Volume: |
296 ( Pt 3) |
|
Pages: |
571-6 |
|
•
•
•
•
•
|
Publication |
First Author: |
Huang D |
Year: |
2021 |
Journal: |
Cell Metab |
Title: |
TMEM41B acts as an ER scramblase required for lipoprotein biogenesis and lipid homeostasis. |
Volume: |
33 |
Issue: |
8 |
Pages: |
1655-1670.e8 |
|
•
•
•
•
•
|
Publication |
First Author: |
Giallongo A |
Year: |
1989 |
Journal: |
Mol Cell Biol |
Title: |
Ribosomal protein L7a is encoded by a gene (Surf-3) within the tightly clustered mouse surfeit locus. |
Volume: |
9 |
Issue: |
1 |
Pages: |
224-31 |
|
•
•
•
•
•
|
Publication |
First Author: |
Matsuzaki F |
Year: |
2011 |
Journal: |
Mol Biol Cell |
Title: |
Protrudin serves as an adaptor molecule that connects KIF5 and its cargoes in vesicular transport during process formation. |
Volume: |
22 |
Issue: |
23 |
Pages: |
4602-20 |
|
•
•
•
•
•
|
Publication |
First Author: |
Agostino A |
Year: |
2003 |
Journal: |
Hum Mol Genet |
Title: |
Constitutive knockout of Surf1 is associated with high embryonic lethality, mitochondrial disease and cytochrome c oxidase deficiency in mice. |
Volume: |
12 |
Issue: |
4 |
Pages: |
399-413 |
|
•
•
•
•
•
|
Publication |
First Author: |
Hoffman BG |
Year: |
2008 |
Journal: |
Genome Biol |
Title: |
Identification of transcripts with enriched expression in the developing and adult pancreas. |
Volume: |
9 |
Issue: |
6 |
Pages: |
R99 |
|
•
•
•
•
•
|
Publication |
First Author: |
International Committee on Standardized Genetic Nomenclature for Mice |
Year: |
1993 |
|
Title: |
Nomenclature rule change to delete hyphens and parentheses from mouse locus symbols |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2005 |
|
Title: |
Mouse Synonym Curation |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
The Jackson Laboratory |
Year: |
2012 |
Journal: |
MGI Direct Data Submission |
Title: |
Alleles produced for the KOMP project by The Jackson Laboratory |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Velocigene |
Year: |
2008 |
Journal: |
MGI Direct Data Submission |
Title: |
Alleles produced for the KOMP project by Velocigene (Regeneron Pharmaceuticals) |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Wellcome Trust Sanger Institute |
Year: |
2010 |
Journal: |
MGI Direct Data Submission |
Title: |
Alleles produced for the EUCOMM and EUCOMMTools projects by the Wellcome Trust Sanger Institute |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics and the International Mouse Phenotyping Consortium (IMPC) |
Year: |
2014 |
Journal: |
Database Release |
Title: |
Obtaining and Loading Phenotype Annotations from the International Mouse Phenotyping Consortium (IMPC) Database |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Helmholtz Zentrum Muenchen GmbH |
Year: |
2010 |
Journal: |
MGI Direct Data Submission |
Title: |
Alleles produced for the EUCOMM and EUCOMMTools projects by the Helmholtz Zentrum Muenchen GmbH (Hmgu) |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
UniProt-GOA |
Year: |
2012 |
|
Title: |
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Carninci P |
Year: |
2005 |
Journal: |
Science |
Title: |
The transcriptional landscape of the mammalian genome. |
Volume: |
309 |
Issue: |
5740 |
Pages: |
1559-63 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kawai J |
Year: |
2001 |
Journal: |
Nature |
Title: |
Functional annotation of a full-length mouse cDNA collection. |
Volume: |
409 |
Issue: |
6821 |
Pages: |
685-90 |
|
•
•
•
•
•
|
Publication |
First Author: |
Adams DJ |
Year: |
2024 |
Journal: |
Nature |
Title: |
Genetic determinants of micronucleus formation in vivo. |
Volume: |
627 |
Issue: |
8002 |
Pages: |
130-136 |
|
•
•
•
•
•
|
Publication |
First Author: |
Zambrowicz BP |
Year: |
2003 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. |
Volume: |
100 |
Issue: |
24 |
Pages: |
14109-14 |
|
•
•
•
•
•
|
Publication |
First Author: |
GemPharmatech |
Year: |
2020 |
|
Title: |
GemPharmatech Website. |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Skarnes WC |
Year: |
2011 |
Journal: |
Nature |
Title: |
A conditional knockout resource for the genome-wide study of mouse gene function. |
Volume: |
474 |
Issue: |
7351 |
Pages: |
337-42 |
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI) |
Year: |
2008 |
Journal: |
Database Download |
Title: |
Mouse Gene Trap Data Load from dbGSS |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Cyagen Biosciences Inc. |
Year: |
2022 |
|
Title: |
Cyagen Biosciences Website. |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators |
Year: |
2011 |
|
Title: |
Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
GOA curators |
Year: |
2016 |
|
Title: |
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
The Jackson Laboratory Mouse Radiation Hybrid Database |
Year: |
2004 |
Journal: |
Database Release |
Title: |
Mouse T31 Radiation Hybrid Data Load |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
The Gene Ontology Consortium |
Year: |
2010 |
|
Title: |
Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Diez-Roux G |
Year: |
2011 |
Journal: |
PLoS Biol |
Title: |
A high-resolution anatomical atlas of the transcriptome in the mouse embryo. |
Volume: |
9 |
Issue: |
1 |
Pages: |
e1000582 |
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2002 |
|
Title: |
Mouse Genome Informatics Computational Sequence to Gene Associations |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2010 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2). |
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|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas |
Year: |
2010 |
|
Title: |
Annotation inferences using phylogenetic trees |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Database and National Center for Biotechnology Information |
Year: |
2000 |
Journal: |
Database Release |
Title: |
Entrez Gene Load |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Allen Institute for Brain Science |
Year: |
2004 |
Journal: |
Allen Institute |
Title: |
Allen Brain Atlas: mouse riboprobes |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2009 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI) |
Year: |
2010 |
Journal: |
Database Download |
Title: |
Consensus CDS project |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Group |
Year: |
2003 |
Journal: |
Database Procedure |
Title: |
Automatic Encodes (AutoE) Reference |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Bairoch A |
Year: |
1999 |
Journal: |
Database Release |
Title: |
SWISS-PROT Annotated protein sequence database |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2005 |
|
Title: |
Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics |
Year: |
2010 |
Journal: |
Database Release |
Title: |
Protein Ontology Association Load. |
|
|
|
|
•
•
•
•
•
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Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2005 |
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Title: |
Obtaining and loading genome assembly coordinates from NCBI annotations |
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Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2009 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform |
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HT Experiment |
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Experiment Type: |
RNA-Seq |
Study Type: |
WT vs. Mutant |
Source: |
GEO |
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Publication |
First Author: |
Chang X |
Year: |
2021 |
Journal: |
Front Cardiovasc Med |
Title: |
Loss of Hepatic Surf4 Depletes Lipid Droplets in the Adrenal Cortex but Does Not Impair Adrenal Hormone Production. |
Volume: |
8 |
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Pages: |
764024 |
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Publication |
First Author: |
Stomberski CT |
Year: |
2022 |
Journal: |
Cell Rep |
Title: |
A multienzyme S-nitrosylation cascade regulates cholesterol homeostasis. |
Volume: |
41 |
Issue: |
4 |
Pages: |
111538 |
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Publication |
First Author: |
Deng Z |
Year: |
2020 |
Journal: |
J Exp Med |
Title: |
A defect in COPI-mediated transport of STING causes immune dysregulation in COPA syndrome. |
Volume: |
217 |
Issue: |
11 |
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Protein Domain |
Type: |
Family |
Description: |
This entry includes SURF1 and Shy1 proteins. The surfeit locus 1 gene (SURF1 or surf-1) encodes a conserved protein of about 300 amino-acid residues that seems to be involved in the biogenesis ofcytochrome c oxidase []. Vertebrate SURF1 is evolutionary related to yeastprotein Shy1, which is a mitochondrial inner membrane protein required for assembly of cytochrome c oxidase []. There seems to be two transmembrane regions in these proteins,one in the N-terminal, the other in the C-terminal.Defects in SURF1 are a cause of Leigh syndrome (LS). LS is a severe neurological disorder characterised by bilaterally symmetrical necrotic lesions in subcortical brain regions that is commonly associated with systemic cytochrome c oxidase (COX) deficiency [, , ]. The surfeit locus gene SURF4 (or surf-4) encodes a conserved integral eukaryotic membrane protein of about 270 to 300 amino-acid residues that seems to be located in the endoplasmic reticulum []. |
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
306
 |
Fragment?: |
false |
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
63
 |
Fragment?: |
true |
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