Type |
Details |
Score |
Gene |
Type: |
gene |
Organism: |
human |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
frog, western clawed |
|
•
•
•
•
•
|
Gene |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
dog, domestic |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
chimpanzee |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
cattle |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
chicken |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
zebrafish |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
macaque, rhesus |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Family |
Description: |
The synaptonemal complex (SC) is a tripartite structure that physically links homologous chromosomes during prophase I. The SC has a zipper-like structure composed of two lateral elements (LEs) and a central element (CE). Transverse filaments, composed of SYCP1 molecules, bridge the gap between one LE and the CE.Syce2/CESC1 localises to the CE and interacts with the transverse filament protein SYCP1. Its localization to the CE is dependent on recruitment by SYCP1 []. Syce2/ CESC1 is required for synaptonemal complex assembly and also for double strand break repair and homologous recombination []. |
|
•
•
•
•
•
|
Publication |
First Author: |
Bolcun-Filas E |
Year: |
2007 |
Journal: |
J Cell Biol |
Title: |
SYCE2 is required for synaptonemal complex assembly, double strand break repair, and homologous recombination. |
Volume: |
176 |
Issue: |
6 |
Pages: |
741-7 |
|
•
•
•
•
•
|
Publication |
First Author: |
Costa Y |
Year: |
2005 |
Journal: |
J Cell Sci |
Title: |
Two novel proteins recruited by synaptonemal complex protein 1 (SYCP1) are at the centre of meiosis. |
Volume: |
118 |
Issue: |
Pt 12 |
Pages: |
2755-62 |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
171
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
177
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
171
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Publication |
First Author: |
Hamer G |
Year: |
2006 |
Journal: |
J Cell Sci |
Title: |
Characterization of a novel meiosis-specific protein within the central element of the synaptonemal complex. |
Volume: |
119 |
Issue: |
Pt 19 |
Pages: |
4025-32 |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
Mus caroli |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
Mus pahari |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
Mus spretus |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:5629377 |
Assay Type: |
Immunohistochemistry |
Annotation Date: |
2015-04-13 |
Strength: |
Present |
Sex: |
Male |
Emaps: |
EMAPS:3570728 |
Pattern: |
Not Specified |
Stage: |
TS28 |
Assay Id: |
MGI:5629502 |
Age: |
postnatal |
|
|
Specimen Label: |
6 preleptotene |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:5629377 |
Assay Type: |
Immunohistochemistry |
Annotation Date: |
2015-04-13 |
Strength: |
Present |
Sex: |
Male |
Emaps: |
EMAPS:3570728 |
Pattern: |
Not Specified |
Stage: |
TS28 |
Assay Id: |
MGI:5629502 |
Age: |
postnatal |
|
|
Specimen Label: |
6 leptotene |
Detected: |
true |
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:5629377 |
Assay Type: |
Immunohistochemistry |
Annotation Date: |
2015-04-13 |
Strength: |
Present |
Sex: |
Male |
Emaps: |
EMAPS:3570728 |
Pattern: |
Not Specified |
Stage: |
TS28 |
Assay Id: |
MGI:5629502 |
Age: |
postnatal |
|
|
Specimen Label: |
6 zygotene |
Detected: |
true |
Specimen Num: |
3 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:5629377 |
Assay Type: |
Immunohistochemistry |
Annotation Date: |
2015-04-13 |
Strength: |
Present |
Sex: |
Male |
Emaps: |
EMAPS:3570728 |
Pattern: |
Regionally restricted |
Stage: |
TS28 |
Assay Id: |
MGI:5629502 |
Age: |
postnatal |
|
Note: |
Eqxpression is in the synaptonemal complex. |
Specimen Label: |
6 pachytene |
Detected: |
true |
Specimen Num: |
4 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:5629377 |
Assay Type: |
Immunohistochemistry |
Annotation Date: |
2015-04-13 |
Strength: |
Present |
Sex: |
Male |
Emaps: |
EMAPS:3570728 |
Pattern: |
Regionally restricted |
Stage: |
TS28 |
Assay Id: |
MGI:5629502 |
Age: |
postnatal |
|
Note: |
Eqxpression is in the synaptonemal complex. |
Specimen Label: |
6 diplotene |
Detected: |
true |
Specimen Num: |
5 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:1083606 |
Assay Type: |
RNA in situ |
Annotation Date: |
2014-02-07 |
Strength: |
Absent |
Sex: |
Male |
Emaps: |
EMAPS:1737328 |
|
Stage: |
TS28 |
Assay Id: |
MGI:5538821 |
Age: |
postnatal day 84 |
Image: |
GUDMAP:15648 |
|
Specimen Label: |
GUDMAP:15648 |
Detected: |
false |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6431541 |
Assay Type: |
Immunohistochemistry |
Annotation Date: |
2020-06-04 |
Strength: |
Present |
Sex: |
Male |
Emaps: |
EMAPS:3148428 |
Pattern: |
Not Specified |
Stage: |
TS28 |
Assay Id: |
MGI:6431542 |
Age: |
postnatal |
|
Note: |
Expression is seen in the synaptonemal complex of pachytene spermatocytes; it is continuously expressed along the chromosome axes. |
Specimen Label: |
not shown |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6431541 |
Assay Type: |
Immunohistochemistry |
Annotation Date: |
2020-06-04 |
Strength: |
Present |
Sex: |
Male |
Emaps: |
EMAPS:3148428 |
Pattern: |
Not Specified |
Stage: |
TS28 |
Assay Id: |
MGI:6431542 |
Age: |
postnatal |
|
Note: |
Expression is seen in the synaptonemal complex of pachytene-like spermatocytes; unlike in wild type, the expression appears as discrete dots. |
Specimen Label: |
not shown |
Detected: |
true |
Specimen Num: |
2 |
|
•
•
•
•
•
|
Publication |
First Author: |
Fraune J |
Year: |
2013 |
Journal: |
Genetics |
Title: |
Phylogenies of central element proteins reveal the dynamic evolutionary history of the mammalian synaptonemal complex: ancient and recent components. |
Volume: |
195 |
Issue: |
3 |
Pages: |
781-93 |
|
•
•
•
•
•
|
Publication |
First Author: |
Modzelewski AJ |
Year: |
2012 |
Journal: |
Dev Cell |
Title: |
AGO4 regulates entry into meiosis and influences silencing of sex chromosomes in the male mouse germline. |
Volume: |
23 |
Issue: |
2 |
Pages: |
251-64 |
|
•
•
•
•
•
|
Publication |
First Author: |
Schücker K |
Year: |
2015 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Elucidation of synaptonemal complex organization by super-resolution imaging with isotropic resolution. |
Volume: |
112 |
Issue: |
7 |
Pages: |
2029-33 |
|
•
•
•
•
•
|
Publication |
First Author: |
Schramm S |
Year: |
2011 |
Journal: |
PLoS Genet |
Title: |
A novel mouse synaptonemal complex protein is essential for loading of central element proteins, recombination, and fertility. |
Volume: |
7 |
Issue: |
5 |
Pages: |
e1002088 |
|
•
•
•
•
•
|
Publication |
First Author: |
Shi YQ |
Year: |
2013 |
Journal: |
Gene |
Title: |
SYCP3-like X-linked 2 is expressed in meiotic germ cells and interacts with synaptonemal complex central element protein 2 and histone acetyltransferase TIP60. |
Volume: |
527 |
Issue: |
1 |
Pages: |
352-9 |
|
•
•
•
•
•
|
Publication |
First Author: |
Wojtasz L |
Year: |
2009 |
Journal: |
PLoS Genet |
Title: |
Mouse HORMAD1 and HORMAD2, two conserved meiotic chromosomal proteins, are depleted from synapsed chromosome axes with the help of TRIP13 AAA-ATPase. |
Volume: |
5 |
Issue: |
10 |
Pages: |
e1000702 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kumar R |
Year: |
2015 |
Journal: |
J Cell Sci |
Title: |
MEI4 – a central player in the regulation of meiotic DNA double-strand break formation in the mouse. |
Volume: |
128 |
Issue: |
9 |
Pages: |
1800-11 |
|
•
•
•
•
•
|
Publication |
First Author: |
Jordan PW |
Year: |
2012 |
Journal: |
J Cell Sci |
Title: |
Polo-like kinase is required for synaptonemal complex disassembly and phosphorylation in mouse spermatocytes. |
Volume: |
125 |
Issue: |
Pt 21 |
Pages: |
5061-72 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:5629360 |
Assay Type: |
Western blot |
Annotation Date: |
2015-04-13 |
Strength: |
Present |
Sex: |
Male |
Emaps: |
EMAPS:1797228 |
|
Stage: |
TS28 |
Assay Id: |
MGI:5629362 |
Age: |
postnatal adult |
|
|
Specimen Label: |
Syce2 KO |
Detected: |
true |
Specimen Num: |
2 |
|
•
•
•
•
•
|
Publication |
First Author: |
Liu H |
Year: |
2019 |
Journal: |
Nucleic Acids Res |
Title: |
SCRE serves as a unique synaptonemal complex fastener and is essential for progression of meiosis prophase I in mice. |
Volume: |
47 |
Issue: |
11 |
Pages: |
5670-5683 |
|
•
•
•
•
•
|
Publication |
First Author: |
Daniel K |
Year: |
2011 |
Journal: |
Nat Cell Biol |
Title: |
Meiotic homologue alignment and its quality surveillance are controlled by mouse HORMAD1. |
Volume: |
13 |
Issue: |
5 |
Pages: |
599-610 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kouznetsova A |
Year: |
2011 |
Journal: |
PLoS One |
Title: |
Meiosis in mice without a synaptonemal complex. |
Volume: |
6 |
Issue: |
12 |
Pages: |
e28255 |
|
•
•
•
•
•
|
Publication |
First Author: |
Fukuda T |
Year: |
2014 |
Journal: |
EMBO J |
Title: |
STAG3-mediated stabilization of REC8 cohesin complexes promotes chromosome synapsis during meiosis. |
Volume: |
33 |
Issue: |
11 |
Pages: |
1243-55 |
|
•
•
•
•
•
|
Publication |
First Author: |
MGI and IMPC |
Year: |
2017 |
Journal: |
MGI Direct Data Submission |
Title: |
MGI Curation of Endonuclease-Mediated Alleles (CRISPR) from the International Mouse Phenotyping Consortium (IMPC) |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2003 |
|
Title: |
Data Curation Using Mouse Genome Assembly |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2002 |
|
Title: |
Mouse Genome Informatics Computational Sequence to Gene Associations for FANTOM2 data |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Wellcome Trust Sanger Institute |
Year: |
2010 |
Journal: |
MGI Direct Data Submission |
Title: |
Alleles produced for the EUCOMM and EUCOMMTools projects by the Wellcome Trust Sanger Institute |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
GUDMAP Consortium |
Year: |
2004 |
Journal: |
www.gudmap.org |
Title: |
GUDMAP: the GenitoUrinary Development Molecular Anatomy Project |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics and the International Mouse Phenotyping Consortium (IMPC) |
Year: |
2014 |
Journal: |
Database Release |
Title: |
Obtaining and Loading Phenotype Annotations from the International Mouse Phenotyping Consortium (IMPC) Database |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Hansen GM |
Year: |
2008 |
Journal: |
Genome Res |
Title: |
Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. |
Volume: |
18 |
Issue: |
10 |
Pages: |
1670-9 |
|
•
•
•
•
•
|
Publication |
First Author: |
Helmholtz Zentrum Muenchen GmbH |
Year: |
2010 |
Journal: |
MGI Direct Data Submission |
Title: |
Alleles produced for the EUCOMM and EUCOMMTools projects by the Helmholtz Zentrum Muenchen GmbH (Hmgu) |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2002 |
|
Title: |
Chromosome assignment of mouse genes using the Mouse Genome Sequencing Consortium (MGSC) assembly and the ENSEMBL Database |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Carninci P |
Year: |
2005 |
Journal: |
Science |
Title: |
The transcriptional landscape of the mammalian genome. |
Volume: |
309 |
Issue: |
5740 |
Pages: |
1559-63 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kawai J |
Year: |
2001 |
Journal: |
Nature |
Title: |
Functional annotation of a full-length mouse cDNA collection. |
Volume: |
409 |
Issue: |
6821 |
Pages: |
685-90 |
|
•
•
•
•
•
|
Publication |
First Author: |
Adams DJ |
Year: |
2024 |
Journal: |
Nature |
Title: |
Genetic determinants of micronucleus formation in vivo. |
Volume: |
627 |
Issue: |
8002 |
Pages: |
130-136 |
|
•
•
•
•
•
|
Publication |
First Author: |
Zambrowicz BP |
Year: |
2003 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. |
Volume: |
100 |
Issue: |
24 |
Pages: |
14109-14 |
|
•
•
•
•
•
|
Publication |
First Author: |
Skarnes WC |
Year: |
2011 |
Journal: |
Nature |
Title: |
A conditional knockout resource for the genome-wide study of mouse gene function. |
Volume: |
474 |
Issue: |
7351 |
Pages: |
337-42 |
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI) |
Year: |
2008 |
Journal: |
Database Download |
Title: |
Mouse Gene Trap Data Load from dbGSS |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
UniProt-GOA |
Year: |
2012 |
|
Title: |
Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
The Jackson Laboratory Mouse Radiation Hybrid Database |
Year: |
2004 |
Journal: |
Database Release |
Title: |
Mouse T31 Radiation Hybrid Data Load |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Okazaki Y |
Year: |
2002 |
Journal: |
Nature |
Title: |
Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. |
Volume: |
420 |
Issue: |
6915 |
Pages: |
563-73 |
|
•
•
•
•
•
|
Publication |
First Author: |
The Gene Ontology Consortium |
Year: |
2010 |
|
Title: |
Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2002 |
|
Title: |
Mouse Genome Informatics Computational Sequence to Gene Associations |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2010 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2). |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas |
Year: |
2010 |
|
Title: |
Annotation inferences using phylogenetic trees |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Database and National Center for Biotechnology Information |
Year: |
2000 |
Journal: |
Database Release |
Title: |
Entrez Gene Load |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Allen Institute for Brain Science |
Year: |
2004 |
Journal: |
Allen Institute |
Title: |
Allen Brain Atlas: mouse riboprobes |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2009 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI) |
Year: |
2010 |
Journal: |
Database Download |
Title: |
Consensus CDS project |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Group |
Year: |
2003 |
Journal: |
Database Procedure |
Title: |
Automatic Encodes (AutoE) Reference |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Bairoch A |
Year: |
1999 |
Journal: |
Database Release |
Title: |
SWISS-PROT Annotated protein sequence database |
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Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2005 |
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Title: |
Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations |
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Publication |
First Author: |
Mouse Genome Informatics |
Year: |
2010 |
Journal: |
Database Release |
Title: |
Protein Ontology Association Load. |
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Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2005 |
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Title: |
Obtaining and loading genome assembly coordinates from NCBI annotations |
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Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2009 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform |
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Publication |
First Author: |
Lei WL |
Year: |
2023 |
Journal: |
Int J Biol Sci |
Title: |
SRSF1-mediated alternative splicing is required for spermatogenesis. |
Volume: |
19 |
Issue: |
15 |
Pages: |
4883-4897 |
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Publication |
First Author: |
Bolcun-Filas E |
Year: |
2009 |
Journal: |
PLoS Genet |
Title: |
Mutation of the mouse Syce1 gene disrupts synapsis and suggests a link between synaptonemal complex structural components and DNA repair. |
Volume: |
5 |
Issue: |
2 |
Pages: |
e1000393 |
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Publication |
First Author: |
Hernández-Hernández A |
Year: |
2016 |
Journal: |
J Cell Sci |
Title: |
The central element of the synaptonemal complex in mice is organized as a bilayered junction structure. |
Volume: |
129 |
Issue: |
11 |
Pages: |
2239-49 |
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Publication |
First Author: |
Bocco BM |
Year: |
2016 |
Journal: |
Endocrinology |
Title: |
Type 2 Deiodinase Disruption in Astrocytes Results in Anxiety-Depressive-Like Behavior in Male Mice. |
Volume: |
157 |
Issue: |
9 |
Pages: |
3682-95 |
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