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Search results 1 to 100 out of 729 for Syk

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Type Details Score
Gene
6850 | SYK
Type: gene
Organism: human
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Gene
484196 | SYK
Type: gene
Organism: dog, domestic
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Gene
515515 | SYK
Type: gene
Organism: cattle
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Gene
427272 | SYK
Type: gene
Organism: chicken
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Gene
405769 | syk
Type: gene
Organism: zebrafish
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Gene
704102 | SYK
Type: gene
Organism: macaque, rhesus
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Gene
100486846 | syk
Type: gene
Organism: frog, western clawed
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Gene
key_31793 | SYK
Type: gene
Organism: pig, domestic
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Gene
25155 | Syk
Type: gene
Organism: rat
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Gene
464586 | SYK
Type: gene
Organism: chimpanzee
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Protein Coding Gene
MGI:99515 | Syk
Type: protein_coding_gene
Organism: mouse, laboratory
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Publication
7477353 | J:29797
First Author: Cheng AM
Year: 1995
Journal: Nature
Title: Syk tyrosine kinase required for mouse viability and B-cell development.
Volume: 378
Issue: 6554
Pages: 303-6
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Publication
33782605 | J:305203
First Author: Wang L
Year: 2021
Journal: Nat Genet
Title: Gain-of-function variants in SYK cause immune dysregulation and systemic inflammation in humans and mice.
Volume: 53
Issue: 4
Pages: 500-510
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Publication
7639745 | J:27983
First Author: Flück M
Year: 1995
Journal: Biochem Biophys Res Commun
Title: Molecular characterization of the murine syk protein tyrosine kinase cDNA, transcripts and protein.
Volume: 213
Issue: 1
Pages: 273-81
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Publication
19339971 | J:148538
First Author: Gross O
Year: 2009
Journal: Nature
Title: Syk kinase signalling couples to the Nlrp3 inflammasome for anti-fungal host defence.
Volume: 459
Issue: 7245
Pages: 433-6
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Publication
11940607 | J:180490
First Author: Obergfell A
Year: 2002
Journal: J Cell Biol
Title: Coordinate interactions of Csk, Src, and Syk kinases with [alpha]IIb[beta]3 initiate integrin signaling to the cytoskeleton.
Volume: 157
Issue: 2
Pages: 265-75
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Publication
15956283 | J:119368
First Author: Underhill DM
Year: 2005
Journal: Blood
Title: Dectin-1 activates Syk tyrosine kinase in a dynamic subset of macrophages for reactive oxygen production.
Volume: 106
Issue: 7
Pages: 2543-50
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Publication
19797524 | J:155479
First Author: Van Ziffle JA
Year: 2009
Journal: Blood
Title: Neutrophil-specific deletion of Syk kinase results in reduced host defense to bacterial infection.
Volume: 114
Issue: 23
Pages: 4871-82
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Publication
16456001 | J:129191
First Author: Yu M
Year: 2006
Journal: J Immunol
Title: Scaffolding adapter Grb2-associated binder 2 requires Syk to transmit signals from FcepsilonRI.
Volume: 176
Issue: 4
Pages: 2421-9
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Publication
11672534 | J:110529
First Author: Vines CM
Year: 2001
Journal: Immunity
Title: Inhibition of beta 2 integrin receptor and Syk kinase signaling in monocytes by the Src family kinase Fgr.
Volume: 15
Issue: 4
Pages: 507-19
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Publication
9171347 | J:40327
First Author: Poole A
Year: 1997
Journal: EMBO J
Title: The Fc receptor gamma-chain and the tyrosine kinase Syk are essential for activation of mouse platelets by collagen.
Volume: 16
Issue: 9
Pages: 2333-41
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Publication
19592646 | J:151601
First Author: Reeve JL
Year: 2009
Journal: J Immunol
Title: SLP-76 couples Syk to the osteoclast cytoskeleton.
Volume: 183
Issue: 3
Pages: 1804-12
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Publication
17353363 | J:120084
First Author: Zou W
Year: 2007
Journal: J Cell Biol
Title: Syk, c-Src, the alphavbeta3 integrin, and ITAM immunoreceptors, in concert, regulate osteoclastic bone resorption.
Volume: 176
Issue: 6
Pages: 877-88
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Publication
20601600 | J:162249
First Author: Colonna L
Year: 2010
Journal: J Immunol
Title: Therapeutic targeting of Syk in autoimmune diabetes.
Volume: 185
Issue: 3
Pages: 1532-43
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Publication
9632805 | J:48308
First Author: Kiefer F
Year: 1998
Journal: Mol Cell Biol
Title: The Syk protein tyrosine kinase is essential for Fcgamma receptor signaling in macrophages and neutrophils.
Volume: 18
Issue: 7
Pages: 4209-20
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Publication
7477352 | J:29796
First Author: Turner M
Year: 1995
Journal: Nature
Title: Perinatal lethality and blocked B-cell development in mice lacking the tyrosine kinase Syk.
Volume: 378
Issue: 6554
Pages: 298-302
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Publication
8790395 | J:36147
First Author: Mallick-Wood CA
Year: 1996
Journal: Proc Natl Acad Sci U S A
Title: Disruption of epithelial gamma delta T cell repertoires by mutation of the Syk tyrosine kinase.
Volume: 93
Issue: 18
Pages: 9704-9
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Publication
9275205 | J:42818
First Author: Cheng AM
Year: 1997
Journal: Proc Natl Acad Sci U S A
Title: The Syk and ZAP-70 SH2-containing tyrosine kinases are implicated in pre-T cell receptor signaling.
Volume: 94
Issue: 18
Pages: 9797-801
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Publication
10677523 | J:60647
First Author: Cornall RJ
Year: 2000
Journal: Proc Natl Acad Sci U S A
Title: Role of Syk in B-cell development and antigen-receptor signaling.
Volume: 97
Issue: 4
Pages: 1713-8
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Publication
29616043 | J:329779
 
First Author: Németh T
Year: 2018
Journal: Front Immunol
Title: Lineage-Specific Analysis of Syk Function in Autoantibody-Induced Arthritis.
Volume: 9
Pages: 555
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Publication
29235464 | J:260043
First Author: Knoll M
Year: 2017
Journal: Nat Commun
Title: SYK kinase mediates brown fat differentiation and activation.
Volume: 8
Issue: 1
Pages: 2115
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Publication
25556883 | J:263970
First Author: Wang X
Year: 2015
Journal: Allergy
Title: Syk mediates airway contractility independent of leukocyte function.
Volume: 70
Issue: 4
Pages: 429-35
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Publication
36257314 | J:334120
First Author: Ennerfelt H
Year: 2022
Journal: Cell
Title: SYK coordinates neuroprotective microglial responses in neurodegenerative disease.
Volume: 185
Issue: 22
Pages: 4135-4152.e22
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Publication
11970878 | J:76042
First Author: Mócsai A
Year: 2002
Journal: Immunity
Title: Syk is required for integrin signaling in neutrophils.
Volume: 16
Issue: 4
Pages: 547-58
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Publication
12522250 | J:111210
First Author: Abtahian F
Year: 2003
Journal: Science
Title: Regulation of blood and lymphatic vascular separation by signaling proteins SLP-76 and Syk.
Volume: 299
Issue: 5604
Pages: 247-51
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Publication
21881044 | J:178801
First Author: Andre P
Year: 2011
Journal: Blood
Title: Critical role for Syk in responses to vascular injury.
Volume: 118
Issue: 18
Pages: 5000-10
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Publication
16611990 | J:108437
First Author: Zhou F
Year: 2006
Journal: Mol Cell Biol
Title: Nucleocytoplasmic trafficking of the Syk protein tyrosine kinase.
Volume: 26
Issue: 9
Pages: 3478-91
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Publication
33878293 | J:307147
First Author: Sadras T
Year: 2021
Journal: Mol Cell
Title: Developmental partitioning of SYK and ZAP70 prevents autoimmunity and cancer.
Volume: 81
Issue: 10
Pages: 2094-2111.e9
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Publication
28768156 | J:249752
 
First Author: Benon A
Year: 2017
Journal: Neuroscience
Title: The Syk kinases orchestrate cerebellar granule cell tangential migration.
Volume: 360
Pages: 230-239
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Publication
11836527 | J:74994
First Author: Colucci F
Year: 2002
Journal: Nat Immunol
Title: Natural cytotoxicity uncoupled from the Syk and ZAP-70 intracellular kinases.
Volume: 3
Issue: 3
Pages: 288-94
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Publication
23955076 | J:208904
First Author: Hug E
Year: 2014
Journal: Oncogene
Title: Inducible expression of hyperactive Syk in B cells activates Blimp-1-dependent terminal differentiation.
Volume: 33
Issue: 28
Pages: 3730-41
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Publication
21918195 | J:179306
First Author: Elliott ER
Year: 2011
Journal: J Immunol
Title: Deletion of Syk in neutrophils prevents immune complex arthritis.
Volume: 187
Issue: 8
Pages: 4319-30
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Publication
16148119 | J:116730
First Author: Gevrey JC
Year: 2005
Journal: J Immunol
Title: Syk is required for monocyte/macrophage chemotaxis to CX3CL1 (Fractalkine).
Volume: 175
Issue: 6
Pages: 3737-45
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Publication
17606633 | J:125879
First Author: Palacios EH
Year: 2007
Journal: J Exp Med
Title: Distinct roles for Syk and ZAP-70 during early thymocyte development.
Volume: 204
Issue: 7
Pages: 1703-15
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Publication
20585042 | J:165882
First Author: Thomas DH
Year: 2010
Journal: Blood
Title: A novel histidine tyrosine phosphatase, TULA-2, associates with Syk and negatively regulates GPVI signaling in platelets.
Volume: 116
Issue: 14
Pages: 2570-8
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Publication
8798454 | J:35411
First Author: Latour S
Year: 1996
Journal: J Biol Chem
Title: Differential intrinsic enzymatic activity of Syk and Zap-70 protein-tyrosine kinases.
Volume: 271
Issue: 37
Pages: 22782-90
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Publication
31719149 | J:286548
First Author: Dasari TK
Year: 2020
Journal: J Biol Chem
Title: The nonreceptor tyrosine kinase SYK drives caspase-8/NLRP3 inflammasome-mediated autoinflammatory osteomyelitis.
Volume: 295
Issue: 11
Pages: 3394-3400
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Publication
16291755 | J:116388
First Author: Eliopoulos AG
Year: 2006
Journal: J Biol Chem
Title: The tyrosine kinase Syk regulates TPL2 activation signals.
Volume: 281
Issue: 3
Pages: 1371-80
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Publication
11675365 | J:72384
First Author: Yanagi S
Year: 2001
Journal: Blood
Title: Syk expression in endothelial cells and their morphologic defects in embryonic Syk-deficient mice.
Volume: 98
Issue: 9
Pages: 2869-71
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Publication
22796951 | J:188288
First Author: Huang ZY
Year: 2013
Journal: Mol Immunol
Title: Effect of locally administered Syk siRNA on allergen-induced arthritis and asthma.
Volume: 53
Issue: 1-2
Pages: 52-9
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Publication
19124738 | J:143491
First Author: Oda H
Year: 2009
Journal: J Immunol
Title: RhoH plays critical roles in Fc epsilon RI-dependent signal transduction in mast cells.
Volume: 182
Issue: 2
Pages: 957-62
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Publication
18981293 | J:146340
First Author: Young RM
Year: 2009
Journal: Blood
Title: Mouse models of non-Hodgkin lymphoma reveal Syk as an important therapeutic target.
Volume: 113
Issue: 11
Pages: 2508-16
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Publication
10194444 | J:106643
First Author: Law DA
Year: 1999
Journal: Blood
Title: Genetic and pharmacological analyses of Syk function in alphaIIbbeta3 signaling in platelets.
Volume: 93
Issue: 8
Pages: 2645-52
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Publication
21728173 | J:176982
First Author: Mourão-Sá D
Year: 2011
Journal: Eur J Immunol
Title: CLEC-2 signaling via Syk in myeloid cells can regulate inflammatory responses.
Volume: 41
Issue: 10
Pages: 3040-53
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Publication
11676469 | J:72653
First Author: Yanagi S
Year: 2001
Journal: Biochem Biophys Res Commun
Title: Syk expression and novel function in a wide variety of tissues.
Volume: 288
Issue: 3
Pages: 495-8
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Publication
12881490 | J:84787
First Author: Kawakami Y
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: A Ras activation pathway dependent on Syk phosphorylation of protein kinase C.
Volume: 100
Issue: 16
Pages: 9470-5
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Publication
12917394 | J:86129
First Author: Pradip D
Year: 2003
Journal: J Biol Chem
Title: Rac2 specificity in macrophage integrin signaling: potential role for Syk kinase.
Volume: 278
Issue: 43
Pages: 41661-9
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Publication
25352128 | J:220779
First Author: Hughes CE
Year: 2015
Journal: Blood
Title: The N-terminal SH2 domain of Syk is required for (hem)ITAM, but not integrin, signaling in mouse platelets.
Volume: 125
Issue: 1
Pages: 144-54
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Publication
22186994 | J:181715
First Author: Finney BA
Year: 2012
Journal: Blood
Title: CLEC-2 and Syk in the megakaryocytic/platelet lineage are essential for development.
Volume: 119
Issue: 7
Pages: 1747-56
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Publication
27102960 | J:246857
First Author: van Eeuwijk JM
Year: 2016
Journal: Arterioscler Thromb Vasc Biol
Title: The Novel Oral Syk Inhibitor, Bl1002494, Protects Mice From Arterial Thrombosis and Thromboinflammatory Brain Infarction.
Volume: 36
Issue: 6
Pages: 1247-53
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Publication
28107345 | J:246127
First Author: Salehi S
Year: 2017
Journal: PLoS One
Title: Syk Regulates Neutrophilic Airway Hyper-Responsiveness in a Chronic Mouse Model of Allergic Airways Inflammation.
Volume: 12
Issue: 1
Pages: e0163614
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Publication
29545260 | J:331846
 
First Author: Furusho A
Year: 2018
Journal: J Am Heart Assoc
Title: Involvement of B Cells, Immunoglobulins, and Syk in the Pathogenesis of Abdominal Aortic Aneurysm.
Volume: 7
Issue: 6
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Publication
9099676 | J:39598
First Author: Keshvara LM
Year: 1997
Journal: J Biol Chem
Title: Syk activation and dissociation from the B-cell antigen receptor is mediated by phosphorylation of tyrosine 130.
Volume: 272
Issue: 16
Pages: 10377-81
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Publication
16410013 | J:200298
First Author: Groesch TD
Year: 2006
Journal: J Mol Biol
Title: Structural basis for the requirement of two phosphotyrosine residues in signaling mediated by Syk tyrosine kinase.
Volume: 356
Issue: 5
Pages: 1222-36
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Publication
15576379 | J:96907
First Author: Simon M
Year: 2005
Journal: J Biol Chem
Title: Distinct roles for the linker region tyrosines of Syk in FcepsilonRI signaling in primary mast cells.
Volume: 280
Issue: 6
Pages: 4510-7
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Publication
20138367 | J:160648
First Author: Lin YC
Year: 2010
Journal: Mol Immunol
Title: Anti-inflammatory actions of Syk inhibitors in macrophages involve non-specific inhibition of toll-like receptors-mediated JNK signaling pathway.
Volume: 47
Issue: 7-8
Pages: 1569-78
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Publication
23335753 | J:193494
First Author: Stepanek O
Year: 2013
Journal: J Immunol
Title: Nonredundant roles of Src-family kinases and Syk in the initiation of B-cell antigen receptor signaling.
Volume: 190
Issue: 4
Pages: 1807-18
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Publication
16950126 | J:112805
First Author: Sebzda E
Year: 2006
Journal: Dev Cell
Title: Syk and Slp-76 mutant mice reveal a cell-autonomous hematopoietic cell contribution to vascular development.
Volume: 11
Issue: 3
Pages: 349-61
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Publication
25033445 | J:247074
First Author: Whitney PG
Year: 2014
Journal: PLoS Pathog
Title: Syk signaling in dendritic cells orchestrates innate resistance to systemic fungal infection.
Volume: 10
Issue: 7
Pages: e1004276
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Publication
24376657 | J:225168
First Author: Choi SH
Year: 2013
Journal: PLoS One
Title: Polyoxygenated cholesterol ester hydroperoxide activates TLR4 and SYK dependent signaling in macrophages.
Volume: 8
Issue: 12
Pages: e83145
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Publication
16872848 | J:113463
First Author: Hirahashi J
Year: 2006
Journal: Immunity
Title: Mac-1 signaling via Src-family and Syk kinases results in elastase-dependent thrombohemorrhagic vasculopathy.
Volume: 25
Issue: 2
Pages: 271-83
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Publication
9103201 | J:39570
First Author: Ota Y
Year: 1997
Journal: Science
Title: The product of the proto-oncogene c-cbl: a negative regulator of the Syk tyrosine kinase.
Volume: 276
Issue: 5311
Pages: 418-20
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Publication
20940318 | J:165501
First Author: Heizmann B
Year: 2010
Journal: Proc Natl Acad Sci U S A
Title: Syk is a dual-specificity kinase that self-regulates the signal output from the B-cell antigen receptor.
Volume: 107
Issue: 43
Pages: 18563-8
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Publication
28410990 | J:254534
First Author: Gurung P
Year: 2017
Journal: Immunity
Title: Tyrosine Kinase SYK Licenses MyD88 Adaptor Protein to Instigate IL-1α-Mediated Inflammatory Disease.
Volume: 46
Issue: 4
Pages: 635-648
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Publication
9324357 | J:43156
First Author: Gong Q
Year: 1997
Journal: Immunity
Title: Restoration of thymocyte development and function in zap-70-/- mice by the Syk protein tyrosine kinase.
Volume: 7
Issue: 3
Pages: 369-77
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Publication
23071339 | J:190693
First Author: Uckun FM
Year: 2012
Journal: Proc Natl Acad Sci U S A
Title: Serine phosphorylation by SYK is critical for nuclear localization and transcription factor function of Ikaros.
Volume: 109
Issue: 44
Pages: 18072-7
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Publication
10438908 | J:56756
First Author: Colucci F
Year: 1999
Journal: J Immunol
Title: Redundant role of the Syk protein tyrosine kinase in mouse NK cell differentiation.
Volume: 163
Issue: 4
Pages: 1769-74
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Publication
25862820 | J:324122
First Author: Ackermann JA
Year: 2015
Journal: J Immunol
Title: Syk tyrosine kinase is critical for B cell antibody responses and memory B cell survival.
Volume: 194
Issue: 10
Pages: 4650-6
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Publication
31545231 | J:290347
 
First Author: Guo Y
Year: 2019
Journal: Biomed Pharmacother
Title: MiR-377 mediates the expression of Syk to attenuate atherosclerosis lesion development in ApoE-/- mice.
Volume: 118
Pages: 109332
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Publication
20713593 | J:165730
First Author: Falet H
Year: 2010
Journal: J Exp Med
Title: A novel interaction between FlnA and Syk regulates platelet ITAM-mediated receptor signaling and function.
Volume: 207
Issue: 9
Pages: 1967-79
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Publication
18200499 | J:131360
First Author: Dennehy KM
Year: 2008
Journal: Eur J Immunol
Title: Syk kinase is required for collaborative cytokine production induced through Dectin-1 and Toll-like receptors.
Volume: 38
Issue: 2
Pages: 500-6
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Publication
25915733 | J:232837
First Author: Deng Z
Year: 2015
Journal: Nat Immunol
Title: Tyrosine phosphatase SHP-2 mediates C-type lectin receptor-induced activation of the kinase Syk and anti-fungal TH17 responses.
Volume: 16
Issue: 6
Pages: 642-52
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Publication
22265677 | J:181290
First Author: Strasser D
Year: 2012
Journal: Immunity
Title: Syk kinase-coupled C-type lectin receptors engage protein kinase C-σ to elicit Card9 adaptor-mediated innate immunity.
Volume: 36
Issue: 1
Pages: 32-42
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Publication
21830208 | J:179524
First Author: Wex E
Year: 2011
Journal: Eur J Immunol
Title: Induced Syk deletion leads to suppressed allergic responses but has no effect on neutrophil or monocyte migration in vivo.
Volume: 41
Issue: 11
Pages: 3208-18
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Publication
9396770 | J:111364
First Author: Turner M
Year: 1997
Journal: J Exp Med
Title: Syk tyrosine kinase is required for the positive selection of immature B cells into the recirculating B cell pool.
Volume: 186
Issue: 12
Pages: 2013-21
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Publication
19829710 | J:154093
First Author: Sung YM
Year: 2009
Journal: PLoS One
Title: Tumor suppressor function of Syk in human MCF10A in vitro and normal mouse mammary epithelium in vivo.
Volume: 4
Issue: 10
Pages: e7445
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Publication
9564041 | J:47646
First Author: Latour S
Year: 1998
Journal: EMBO J
Title: A unique insert in the linker domain of Syk is necessary for its function in immunoreceptor signalling.
Volume: 17
Issue: 9
Pages: 2584-95
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Publication
28760774 | J:248722
 
First Author: Weis V
Year: 2017
Journal: Mol Cell Biol
Title: Unperturbed Immune Function despite Mutation of C-Terminal Tyrosines in Syk Previously Implicated in Signaling and Activity Regulation.
Volume: 37
Issue: 21
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Publication
16713566 | J:114816
First Author: Siegel R
Year: 2006
Journal: Cell
Title: Nontranscriptional regulation of SYK by the coactivator OCA-B is required at multiple stages of B cell development.
Volume: 125
Issue: 4
Pages: 761-74
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Publication
34465030 | J:311549
First Author: Zajta E
Year: 2021
Journal: mBio
Title: Signaling through Syk or CARD9 Mediates Species-Specific Anti-Candida Protection in Bone Marrow Chimeric Mice.
Volume: 12
Issue: 4
Pages: e0160821
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Publication
31134061 | J:284399
 
First Author: Csete D
Year: 2019
Journal: Front Immunol
Title: Hematopoietic or Osteoclast-Specific Deletion of Syk Leads to Increased Bone Mass in Experimental Mice.
Volume: 10
Pages: 937
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Publication
10453000 | J:57092
First Author: Chu DH
Year: 1999
Journal: J Immunol
Title: Pre-T cell receptor signals are responsible for the down-regulation of Syk protein tyrosine kinase expression.
Volume: 163
Issue: 5
Pages: 2610-20
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Publication
9314552 | J:78301
First Author: Crowley MT
Year: 1997
Journal: J Exp Med
Title: A critical role for Syk in signal transduction and phagocytosis mediated by Fcgamma receptors on macrophages.
Volume: 186
Issue: 7
Pages: 1027-39
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Publication
26708990 | J:251430
First Author: Yin H
Year: 2016
Journal: Biochim Biophys Acta
Title: Syk negatively regulates TLR4-mediated IFNβ and IL-10 production and promotes inflammatory responses in dendritic cells.
Volume: 1860
Issue: 3
Pages: 588-98
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Publication
25605870 | J:245276
First Author: Lin YC
Year: 2015
Journal: J Leukoc Biol
Title: Syk is involved in NLRP3 inflammasome-mediated caspase-1 activation through adaptor ASC phosphorylation and enhanced oligomerization.
Volume: 97
Issue: 5
Pages: 825-835
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Publication
15536084 | J:96158
First Author: Moon KD
Year: 2005
Journal: J Biol Chem
Title: Molecular basis for a direct interaction between the Syk protein-tyrosine kinase and phosphoinositide 3-kinase.
Volume: 280
Issue: 2
Pages: 1543-51
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Publication
18295889 | J:134479
First Author: Parsa KV
Year: 2008
Journal: Mol Immunol
Title: The tyrosine kinase Syk promotes phagocytosis of Francisella through the activation of Erk.
Volume: 45
Issue: 10
Pages: 3012-21
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Publication
37350973 | J:346941
 
First Author: Rohila D
Year: 2023
Journal: Front Immunol
Title: Targeting macrophage Syk enhances responses to immune checkpoint blockade and radiotherapy in high-risk neuroblastoma.
Volume: 14
Pages: 1148317
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Publication
25946330 | J:325866
First Author: Choi SH
Year: 2015
Journal: Autophagy
Title: SYK regulates macrophage MHC-II expression via activation of autophagy in response to oxidized LDL.
Volume: 11
Issue: 5
Pages: 785-95
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Publication
27122172 | J:235677
First Author: Noraz N
Year: 2016
Journal: Development
Title: Syk kinases are required for spinal commissural axon repulsion at the midline via the ephrin/Eph pathway.
Volume: 143
Issue: 12
Pages: 2183-93
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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