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Search results 1 to 100 out of 450 for Syn1

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0.067s
Type Details Score
Gene
Type: gene
Organism: human
Gene
Type: gene
Organism: chimpanzee
Gene
Type: gene
Organism: cattle
Gene
Type: gene
Organism: dog, domestic
Gene
Type: gene
Organism: zebrafish
Gene
Type: gene
Organism: macaque, rhesus
Gene
Type: gene
Organism: frog, western clawed
Gene
Type: gene
Organism: rat
Protein Domain
Type: Family
Description: The synapsins are a family of neuron-specific phosphoproteins that coatsynaptic vesicles and are involved in the binding between these vesiclesand the cytoskeleton (including actin filaments). The family comprises 5homologous proteins 1a, 1b, 2a, 2b and 3. Synapsins 1, 2, and 3 areencoded by 3 different genes. The a and b isoforms of synapsin 1 and 2 aresplice variants of the primary transcripts [].This entry represents synapsin-1 (SYN1). Synapsin I is mainly associated with regulation of neurotransmitter release from presynaptic neuron terminals []. Mutations in SYN1 gene cause epilepsy X-linked, with variable learning disabilities and behavior disorders (XELBD) [].
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Publication
First Author: Lignani G
Year: 2013
Journal: Hum Mol Genet
Title: Epileptogenic Q555X SYN1 mutant triggers imbalances in release dynamics and short-term plasticity.
Volume: 22
Issue: 11
Pages: 2186-99
Publication
First Author: Fassio A
Year: 2011
Journal: Hum Mol Genet
Title: SYN1 loss-of-function mutations in autism and partial epilepsy cause impaired synaptic function.
Volume: 20
Issue: 12
Pages: 2297-307
Publication
First Author: Garcia CC
Year: 2004
Journal: J Med Genet
Title: Identification of a mutation in synapsin I, a synaptic vesicle protein, in a family with epilepsy.
Volume: 41
Issue: 3
Pages: 183-6
Publication
First Author: Nomura M
Year: 2000
Journal: Neurosci Res
Title: Upregulation of synapsin IIa and IIb mRNAs in the paraventricular and supraoptic nuclei in chronic salt loaded and lactating rats.
Volume: 37
Issue: 3
Pages: 201-10
Publication
First Author: LlinĂ¡s R
Year: 1985
Journal: Proc Natl Acad Sci U S A
Title: Intraterminal injection of synapsin I or calcium/calmodulin-dependent protein kinase II alters neurotransmitter release at the squid giant synapse.
Volume: 82
Issue: 9
Pages: 3035-9
Protein
Organism: Mus musculus/domesticus
Length: 706  
Fragment?: false
GXD Expression    
Probe: MGI:6184571
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689419
Pattern: Not Specified
Stage: TS19
Assay Id: MGI:6191408
Age: embryonic day 11.5
Specimen Label: Table S2 - E11.5 - Syn1
Detected: true
Specimen Num: 1
GXD Expression    
Probe: MGI:6184571
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689421
Pattern: Not Specified
Stage: TS21
Assay Id: MGI:6191408
Age: embryonic day 13.5
Specimen Label: Table S2 - E13.5 - Syn1
Detected: true
Specimen Num: 2
GXD Expression    
Probe: MGI:6184571
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689424
Pattern: Not Specified
Stage: TS24
Assay Id: MGI:6191408
Age: embryonic day 15.5
Specimen Label: Table S2 - E15.5 - Syn1
Detected: true
Specimen Num: 3
GXD Expression    
Probe: MGI:6184571
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689426
Pattern: Not Specified
Stage: TS26
Assay Id: MGI:6191408
Age: embryonic day 18.5
Specimen Label: Table S2 - E18.5 - Syn1
Detected: true
Specimen Num: 4
GXD Expression    
Probe: MGI:6184571
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6191408
Age: postnatal day 4
Specimen Label: Table S2 - P4 - Syn1
Detected: true
Specimen Num: 5
GXD Expression    
Probe: MGI:6184571
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6191408
Age: postnatal day 14
Specimen Label: Table S2 - P14 - Syn1
Detected: true
Specimen Num: 6
GXD Expression    
Probe: MGI:6184571
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6191408
Age: postnatal day 28
Specimen Label: Table S2 - P28 - Syn1
Detected: true
Specimen Num: 7
Publication
First Author: Yan P
Year: 2022
Journal: Cell Death Dis
Title: Crosstalk of Synapsin1 palmitoylation and phosphorylation controls the dynamicity of synaptic vesicles in neurons.
Volume: 13
Issue: 9
Pages: 786
Publication
First Author: Baldelli P
Year: 2007
Journal: J Neurosci
Title: Lack of synapsin I reduces the readily releasable pool of synaptic vesicles at central inhibitory synapses.
Volume: 27
Issue: 49
Pages: 13520-31
Publication
First Author: Giannandrea M
Year: 2013
Journal: PLoS One
Title: Nonsense-mediated mRNA decay and loss-of-function of the protein underlie the X-linked epilepsy associated with the W356Ă— mutation in synapsin I.
Volume: 8
Issue: 6
Pages: e67724
Publication  
First Author: BĂ¼nger I
Year: 2023
Journal: Front Immunol
Title: Maternal synapsin autoantibodies are associated with neurodevelopmental delay.
Volume: 14
Pages: 1101087
Publication
First Author: Michetti C
Year: 2017
Journal: Cereb Cortex
Title: The Knockout of Synapsin II in Mice Impairs Social Behavior and Functional Connectivity Generating an ASD-like Phenotype.
Volume: 27
Issue: 10
Pages: 5014-5023
Publication
First Author: Paemka L
Year: 2013
Journal: PLoS One
Title: PRICKLE1 interaction with SYNAPSIN I reveals a role in autism spectrum disorders.
Volume: 8
Issue: 12
Pages: e80737
Publication  
First Author: Greco B
Year: 2013
Journal: Behav Brain Res
Title: Autism-related behavioral abnormalities in synapsin knockout mice.
Volume: 251
Pages: 65-74
Publication
First Author: Poeta L
Year: 2019
Journal: Hum Mol Genet
Title: Histone demethylase KDM5C is a SAHA-sensitive central hub at the crossroads of transcriptional axes involved in multiple neurodevelopmental disorders.
Volume: 28
Issue: 24
Pages: 4089-4102
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus caroli
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus pahari
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus spretus
Publication
First Author: Kushner SA
Year: 2005
Journal: J Neurosci
Title: Modulation of presynaptic plasticity and learning by the H-ras/extracellular signal-regulated kinase/synapsin I signaling pathway.
Volume: 25
Issue: 42
Pages: 9721-34
Publication
First Author: Marte A
Year: 2019
Journal: J Neurochem
Title: Leucine-rich repeat kinase 2 phosphorylation on synapsin I regulates glutamate release at pre-synaptic sites.
Volume: 150
Issue: 3
Pages: 264-281
Publication
First Author: Takei Y
Year: 1995
Journal: J Cell Biol
Title: Synapsin I deficiency results in the structural change in the presynaptic terminals in the murine nervous system.
Volume: 131
Issue: 6 Pt 2
Pages: 1789-800
Publication
First Author: Terada S
Year: 1999
Journal: J Cell Biol
Title: Impairment of inhibitory synaptic transmission in mice lacking synapsin I.
Volume: 145
Issue: 5
Pages: 1039-48
Publication
First Author: Rosahl TW
Year: 1993
Journal: Cell
Title: Short-term synaptic plasticity is altered in mice lacking synapsin I.
Volume: 75
Issue: 4
Pages: 661-70
Publication
First Author: Tu Y
Year: 2003
Journal: J Biol Chem
Title: Phosphorylation-regulated inhibition of the Gz GTPase-activating protein activity of RGS proteins by synapsin I.
Volume: 278
Issue: 52
Pages: 52273-81
Publication
First Author: Lin TY
Year: 2012
Journal: Toxicol Appl Pharmacol
Title: Hispidulin inhibits the release of glutamate in rat cerebrocortical nerve terminals.
Volume: 263
Issue: 2
Pages: 233-43
Publication
First Author: Chin LS
Year: 1995
Journal: Proc Natl Acad Sci U S A
Title: Impairment of axonal development and of synaptogenesis in hippocampal neurons of synapsin I-deficient mice.
Volume: 92
Issue: 20
Pages: 9230-4
Publication
First Author: Walaas SI
Year: 2000
Journal: Synapse
Title: Decrease in phorbol ester-induced potentiation of noradrenaline release in synapsin I-deficient mice.
Volume: 36
Issue: 2
Pages: 114-9
Publication
First Author: Valente P
Year: 2012
Journal: J Neurosci
Title: Site-specific synapsin I phosphorylation participates in the expression of post-tetanic potentiation and its enhancement by BDNF.
Volume: 32
Issue: 17
Pages: 5868-79
Publication
First Author: Ryan TA
Year: 1996
Journal: J Cell Biol
Title: Synaptic vesicle recycling in synapsin I knock-out mice.
Volume: 134
Issue: 5
Pages: 1219-27
Publication
First Author: Verstegen AM
Year: 2014
Journal: J Neurosci
Title: Phosphorylation of synapsin I by cyclin-dependent kinase-5 sets the ratio between the resting and recycling pools of synaptic vesicles at hippocampal synapses.
Volume: 34
Issue: 21
Pages: 7266-80
Publication
First Author: Yang-Feng TL
Year: 1986
Journal: Proc Natl Acad Sci U S A
Title: Genes for synapsin I, a neuronal phosphoprotein, map to conserved regions of human and murine X chromosomes.
Volume: 83
Issue: 22
Pages: 8679-83
Publication
First Author: Thiel G
Year: 1994
Journal: J Biol Chem
Title: Regulation of synapsin I gene expression by the zinc finger transcription factor zif268/egr-1.
Volume: 269
Issue: 21
Pages: 15294-301
Publication
First Author: Baines AJ
Year: 1995
Journal: Biochem Soc Trans
Title: Synapsin I and the cytoskeleton: calmodulin regulation of interactions.
Volume: 23
Issue: 1
Pages: 65-70
Publication
First Author: Schoch S
Year: 1996
Journal: J Biol Chem
Title: Neuron-specific gene expression of synapsin I. Major role of a negative regulatory mechanism.
Volume: 271
Issue: 6
Pages: 3317-23
Publication
First Author: Weiner JA
Year: 1997
Journal: J Neurosci
Title: Maternally derived immunoglobulin light chain is present in the fetal mammalian CNS.
Volume: 17
Issue: 9
Pages: 3148-56
Publication
First Author: Hurley SL
Year: 2004
Journal: Biochem Biophys Res Commun
Title: Cytoskeletal interactions of synapsin I in non-neuronal cells.
Volume: 317
Issue: 1
Pages: 16-23
Publication
First Author: Wang S
Year: 2011
Journal: J Neurosci
Title: Synapsin I is an oligomannose-carrying glycoprotein, acts as an oligomannose-binding lectin, and promotes neurite outgrowth and neuronal survival when released via glia-derived exosomes.
Volume: 31
Issue: 20
Pages: 7275-90
Publication
First Author: Orlando M
Year: 2014
Journal: J Neurosci
Title: Functional role of ATP binding to synapsin I in synaptic vesicle trafficking and release dynamics.
Volume: 34
Issue: 44
Pages: 14752-68
GXD Expression    
Probe: MGI:3582292
Assay Type: Western blot
Annotation Date: 2005-07-21
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689424
Stage: TS24
Assay Id: MGI:3582294
Age: embryonic day 16.5
Image: 4
Specimen Label: E16
Detected: true
Specimen Num: 3
GXD Expression    
Probe: MGI:3582292
Assay Type: Western blot
Annotation Date: 2005-07-21
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689424
Stage: TS24
Assay Id: MGI:3582294
Age: embryonic day 16.5
Image: 4
Specimen Label: R1-/- E16
Detected: true
Specimen Num: 4
GXD Expression    
Probe: MGI:3582292
Assay Type: Western blot
Annotation Date: 2005-07-21
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689424
Stage: TS24
Assay Id: MGI:3582294
Age: embryonic day 16.5
Image: 4
Specimen Label: R2-/- E16
Detected: true
Specimen Num: 5
GXD Expression    
Probe: MGI:3582292
Assay Type: Western blot
Annotation Date: 2005-07-21
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689420
Stage: TS20
Assay Id: MGI:3582294
Age: embryonic day 12.5
Image: 4
Specimen Label: E12
Detected: true
Specimen Num: 1
GXD Expression    
Probe: MGI:3582292
Assay Type: Western blot
Annotation Date: 2005-07-21
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689422
Stage: TS22
Assay Id: MGI:3582294
Age: embryonic day 14.5
Image: 4
Specimen Label: E14
Detected: true
Specimen Num: 2
GXD Expression    
Probe: MGI:3582292
Assay Type: Western blot
Annotation Date: 2005-07-21
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689427
Stage: TS27
Assay Id: MGI:3582294
Age: postnatal day 1
Image: 4
Specimen Label: P1
Detected: true
Specimen Num: 6
GXD Expression    
Probe: MGI:3582292
Assay Type: Western blot
Annotation Date: 2005-07-21
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689427
Stage: TS27
Assay Id: MGI:3582294
Age: postnatal day 1
Image: 4
Specimen Label: R1-/- P1
Detected: true
Specimen Num: 7
GXD Expression    
Probe: MGI:3582292
Assay Type: Western blot
Annotation Date: 2005-07-21
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689427
Stage: TS27
Assay Id: MGI:3582294
Age: postnatal day 1
Image: 4
Specimen Label: R1-/- P1
Detected: true
Specimen Num: 8
GXD Expression    
Probe: MGI:3582292
Assay Type: Western blot
Annotation Date: 2005-07-22
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689424
Stage: TS24
Assay Id: MGI:3582304
Age: embryonic day 16.5
Image: 5
Specimen Label: WT
Detected: true
Specimen Num: 1
GXD Expression    
Probe: MGI:3582292
Assay Type: Western blot
Annotation Date: 2005-07-22
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689424
Stage: TS24
Assay Id: MGI:3582304
Age: embryonic day 16.5
Image: 5
Specimen Label: R1-/-
Detected: true
Specimen Num: 2
GXD Expression    
Probe: MGI:3582292
Assay Type: Western blot
Annotation Date: 2005-07-22
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689424
Stage: TS24
Assay Id: MGI:3582304
Age: embryonic day 16.5
Image: 5
Specimen Label: R1+/-
Detected: true
Specimen Num: 4
GXD Expression    
Probe: MGI:3641090
Assay Type: Western blot
Annotation Date: 2006-08-17
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689526
Stage: TS26
Assay Id: MGI:3641136
Age: embryonic day 18.0
Image: 6
Specimen Label: C
Detected: true
Specimen Num: 1
GXD Expression    
Probe: MGI:3832440
Assay Type: RT-PCR
Annotation Date: 2009-02-19
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689423
Stage: TS23
Assay Id: MGI:3832441
Age: embryonic day 15.0
Image: 3
Specimen Label: 4
Detected: true
Specimen Num: 4
GXD Expression    
Probe: MGI:3832440
Assay Type: RT-PCR
Annotation Date: 2009-02-19
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:3832441
Age: postnatal adult
Image: 3
Specimen Label: 3
Detected: true
Specimen Num: 3
GXD Expression      
Probe: MGI:5637351
Assay Type: Western blot
Annotation Date: 2015-05-26
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:5637353
Age: postnatal
Specimen Label: H
Detected: true
Specimen Num: 1
GXD Expression    
Probe: MGI:5647907
Assay Type: Western blot
Annotation Date: 2015-08-12
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689420
Stage: TS20
Assay Id: MGI:5648033
Age: embryonic day 12.0
Image: S1
Specimen Label: E12
Detected: true
Specimen Num: 1
GXD Expression    
Probe: MGI:7410947
Assay Type: Western blot
Annotation Date: 2022-12-20
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3284528
Stage: TS28
Assay Id: MGI:7410985
Age: postnatal adult
Image: 4
Specimen Label: ctr
Detected: true
Specimen Num: 1
GXD Expression    
Probe: MGI:7410947
Assay Type: Western blot
Annotation Date: 2022-12-20
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3284528
Stage: TS28
Assay Id: MGI:7410985
Age: postnatal adult
Image: 4
Specimen Label: ko
Detected: true
Specimen Num: 2
GXD Expression    
Probe: MGI:7493939
Assay Type: Western blot
Annotation Date: 2023-06-29
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1754428
Stage: TS28
Assay Id: MGI:7493979
Age: postnatal day 56
Image: S1
Specimen Label: Total
Detected: true
Specimen Num: 1
GXD Expression    
Probe: MGI:7493939
Assay Type: Western blot
Annotation Date: 2023-06-29
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1754428
Stage: TS28
Assay Id: MGI:7493981
Age: postnatal day 56
Image: 1
Specimen Label: Total
Detected: true
Specimen Num: 1
GXD Expression      
Probe: MGI:7495603
Assay Type: Western blot
Annotation Date: 2023-07-05
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3267826
Stage: TS26
Assay Id: MGI:7495677
Age: embryonic day 18.0
Specimen Label: +/+
Detected: true
Specimen Num: 1
GXD Expression      
Probe: MGI:7495603
Assay Type: Western blot
Annotation Date: 2023-07-05
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3267826
Stage: TS26
Assay Id: MGI:7495677
Age: embryonic day 18.0
Specimen Label: -/-
Detected: true
Specimen Num: 2
GXD Expression    
Probe: MGI:7493939
Assay Type: Western blot
Annotation Date: 2023-07-12
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1754428
Stage: TS28
Assay Id: MGI:7506643
Age: postnatal day 4
Image: 4
Specimen Label: Igsf21+/+ (1)
Detected: true
Specimen Num: 1
GXD Expression    
Probe: MGI:7493939
Assay Type: Western blot
Annotation Date: 2023-07-12
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1754428
Stage: TS28
Assay Id: MGI:7506643
Age: postnatal day 4
Image: 4
Specimen Label: Igsf21+/+ (2)
Detected: true
Specimen Num: 2
GXD Expression    
Probe: MGI:7493939
Assay Type: Western blot
Annotation Date: 2023-07-12
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1754428
Stage: TS28
Assay Id: MGI:7506643
Age: postnatal day 4
Image: 4
Specimen Label: Igsf21+/+ (3)
Detected: true
Specimen Num: 3
GXD Expression    
Probe: MGI:7493939
Assay Type: Western blot
Annotation Date: 2023-07-12
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1754428
Stage: TS28
Assay Id: MGI:7506643
Age: postnatal day 4
Image: 4
Specimen Label: Igsf21-/- (1)
Detected: true
Specimen Num: 4
GXD Expression    
Probe: MGI:7493939
Assay Type: Western blot
Annotation Date: 2023-07-12
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1754428
Stage: TS28
Assay Id: MGI:7506643
Age: postnatal day 4
Image: 4
Specimen Label: Igsf21-/- (2)
Detected: true
Specimen Num: 5
GXD Expression    
Probe: MGI:7493939
Assay Type: Western blot
Annotation Date: 2023-07-12
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1754428
Stage: TS28
Assay Id: MGI:7506643
Age: postnatal day 4
Image: 4
Specimen Label: Igsf21-/- (3)
Detected: true
Specimen Num: 6
GXD Expression    
Probe: MGI:7529843
Assay Type: Western blot
Annotation Date: 2023-09-25
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689426
Stage: TS26
Assay Id: MGI:7530020
Age: embryonic day 18.0
Image: 2
Specimen Label: INP
Detected: true
Specimen Num: 1
GXD Expression    
Probe: MGI:7529843
Assay Type: Western blot
Annotation Date: 2023-09-25
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689426
Stage: TS26
Assay Id: MGI:7530021
Age: embryonic day 18.0
Image: 2
Specimen Label: INP WT
Detected: true
Specimen Num: 1