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Search results 1 to 100 out of 120 for Sytl4

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Hits by Pathway

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Hits by Strain

Type Details Score
Gene
94121 | SYTL4
Type: gene
Organism: human
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Gene
100495134 | sytl4
Type: gene
Organism: frog, western clawed
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Gene
104003947 | SYTL4
Type: gene
Organism: chimpanzee
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Gene
119868467 | SYTL4
Type: gene
Organism: dog, domestic
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Gene
140594 | Sytl4
Type: gene
Organism: rat
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Gene
515978 | SYTL4
Type: gene
Organism: cattle
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Gene
422260 | SYTL4
Type: gene
Organism: chicken
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Gene
553322 | sytl4
Type: gene
Organism: zebrafish
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Gene
700889 | SYTL4
Type: gene
Organism: macaque, rhesus
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Protein Coding Gene
MGI:1351606 | Sytl4
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Domain
IPR028694 | SYTL4
Type: Family
Description: Synaptotagmin-like protein 4 (SYTL4, Slp4), also known as granuphilin or exophilin-2, belongs to the synaptotagmin-like protein family (Slp), which is a group of putative membrane trafficking proteins []. The characteristic feature of the Slp family is the N-terminal Slp homology domain (SHD), which functions as a Rab27-binding domain and C-terminal tandem C2 domains (known as the C2A domain and C2B domain), putative Ca2+-binding motifs [, ]. SHD consists of two conserved regions, designated SHD1 and SHD2, which may function as protein interaction sites. The SHD1 and SHD2 of Slp4 are separated by a putative FYVE zinc finger, which resembles a FYVE-related domain that is structurally similar to the canonical FYVE domains but lacks the three signature sequences: an N-terminal WxxD motif (x for any residue), the central basic R(R/K)HHCRxCG patch, and a C-terminal RVC motif.There are several alternatively spliced isoform of Slp4. Slp4-a (granuphilin-a) has two C2 domains, whereas Slp4-b (granuphilin-b) contains only the first C2 domain. Expression of Slp4-a inhibits regulated secretion in endocrine cells. Slp4-a binds to both the GTP- and GDP-bound forms of Rab27A and inhibits a specific GTP/GDP exchange cycle required for dense-core vesicle exocytosis []. Slp4 has been detected inthe pancreatic islet, in particular in insulin-positive beta cells, and in pituitary [].
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GXD Expression
GXD Expression
   
Probe: MGI:4416001
Assay Type: RNA in situ
Annotation Date: 2009-01-15
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1750322
Stage: TS22
Assay Id: MGI:3825766
Age: embryonic day 14.5
Image: Additional file 4 Sytl4
Specimen Label: Additional file 4 Sytl4
Detected: false
Specimen Num: 1
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Publication
10497219 | J:57922
First Author: Wang J
Year: 1999
Journal: J Biol Chem
Title: Novel rabphilin-3-like protein associates with insulin-containing granules in pancreatic beta cells.
Volume: 274
Issue: 40
Pages: 28542-8
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Publication
12590134 | J:83162
First Author: Fukuda M
Year: 2003
Journal: J Biol Chem
Title: Slp4-a/granuphilin-a inhibits dense-core vesicle exocytosis through interaction with the GDP-bound form of Rab27A in PC12 cells.
Volume: 278
Issue: 17
Pages: 15390-6
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Publication
12051743 | J:169802
First Author: Kuroda TS
Year: 2002
Journal: Biochem Biophys Res Commun
Title: Synaptotagmin-like protein 5: a novel Rab27A effector with C-terminal tandem C2 domains.
Volume: 293
Issue: 3
Pages: 899-906
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Protein
Q9R0Q1
Organism: Mus musculus/domesticus
Length: 673  
Fragment?: false
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Protein
G3UYC6
Organism: Mus musculus/domesticus
Length: 185  
Fragment?: true
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Protein
Q549X6
Organism: Mus musculus/domesticus
Length: 673  
Fragment?: false
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Publication
14745138 | -
First Author: Izumi T
Year: 2003
Journal: Cell Struct Funct
Title: The roles of Rab27 and its effectors in the regulated secretory pathways.
Volume: 28
Issue: 5
Pages: 465-74
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Publication
16481396 | -
First Author: Tsuboi T
Year: 2006
Journal: Mol Biol Cell
Title: The Slp4-a linker domain controls exocytosis through interaction with Munc18-1.syntaxin-1a complex.
Volume: 17
Issue: 5
Pages: 2101-12
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Protein Coding Gene
MGP_CAROLIEiJ_G0033382 | -
Type: protein_coding_gene
Organism: Mus caroli
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Protein Coding Gene
MGP_129S1SvImJ_G0036059 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AJ_G0036041 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AKRJ_G0035960 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_BALBcJ_G0036032 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C3HHeJ_G0035736 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI_C57BL6J_1351606 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C57BL6NJ_G0036554 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CASTEiJ_G0035023 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CBAJ_G0035713 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_DBA2J_G0035866 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_FVBNJ_G0035808 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_LPJ_G0035959 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NODShiLtJ_G0035836 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NZOHlLtJ_G0036583 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PWKPhJ_G0034715 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_WSBEiJ_G0035160 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PahariEiJ_G0031922 | -
Type: protein_coding_gene
Organism: Mus pahari
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Protein Coding Gene
MGP_SPRETEiJ_G0034547 | -
Type: protein_coding_gene
Organism: Mus spretus
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Publication
16216924 | J:102610
First Author: Gomi H
Year: 2005
Journal: J Cell Biol
Title: Granuphilin molecularly docks insulin granules to the fusion machinery.
Volume: 171
Issue: 1
Pages: 99-109
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GXD Expression
GXD Expression
   
Probe: MGI:3826415
Assay Type: RT-PCR
Annotation Date: 2009-01-15
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1706619
Stage: TS19
Assay Id: MGI:3826491
Age: embryonic day 11.5
Image: 4
Specimen Label: TS19
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
   
Probe: MGI:3826415
Assay Type: RT-PCR
Annotation Date: 2009-01-15
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1750321
Stage: TS21
Assay Id: MGI:3826491
Age: embryonic day 13.5
Image: 4
Specimen Label: TS21
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
   
Probe: MGI:3826415
Assay Type: RT-PCR
Annotation Date: 2009-01-15
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1750323
Stage: TS23
Assay Id: MGI:3826491
Age: embryonic day 15.5
Image: 4
Specimen Label: TS23
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
   
Probe: MGI:3826415
Assay Type: RT-PCR
Annotation Date: 2009-01-15
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1750326
Stage: TS26
Assay Id: MGI:3826491
Age: embryonic day 18.5
Image: 4
Specimen Label: TS26
Detected: true
Specimen Num: 4
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GXD Expression
GXD Expression
   
Probe: MGI:3826415
Assay Type: RT-PCR
Annotation Date: 2009-01-15
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3295228
Stage: TS28
Assay Id: MGI:3826491
Age: postnatal adult
Image: 4
Specimen Label: Ducts
Detected: true
Specimen Num: 5
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GXD Expression
GXD Expression
   
Probe: MGI:3826415
Assay Type: RT-PCR
Annotation Date: 2009-01-15
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3292728
Stage: TS28
Assay Id: MGI:3826491
Age: postnatal adult
Image: 4
Specimen Label: Islets
Detected: true
Specimen Num: 6
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GXD Expression
GXD Expression
 
Probe: MGI:4416001
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1843823
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4828577
Age: embryonic day 14.5
Image: euxassay_010462_07
Specimen Label: euxassay_010462_07
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
 
Probe: MGI:4416001
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1843823
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4828577
Age: embryonic day 14.5
Image: euxassay_010462_08
Specimen Label: euxassay_010462_08
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
 
Probe: MGI:4416001
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1843823
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4828577
Age: embryonic day 14.5
Image: euxassay_010462_16
Specimen Label: euxassay_010462_16
Detected: true
Specimen Num: 10
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GXD Expression
GXD Expression
 
Probe: MGI:4416001
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1843823
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4828577
Age: embryonic day 14.5
Image: euxassay_010462_17
Specimen Label: euxassay_010462_17
Detected: true
Specimen Num: 11
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GXD Expression
GXD Expression
 
Probe: MGI:4416001
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1822623
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4828577
Age: embryonic day 14.5
Image: euxassay_010462_08
Specimen Label: euxassay_010462_08
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
 
Probe: MGI:4416001
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1822623
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4828577
Age: embryonic day 14.5
Image: euxassay_010462_09
Specimen Label: euxassay_010462_09
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
 
Probe: MGI:4416001
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1822623
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4828577
Age: embryonic day 14.5
Image: euxassay_010462_10
Specimen Label: euxassay_010462_10
Detected: true
Specimen Num: 4
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GXD Expression
GXD Expression
 
Probe: MGI:4416001
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1822623
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4828577
Age: embryonic day 14.5
Image: euxassay_010462_14
Specimen Label: euxassay_010462_14
Detected: true
Specimen Num: 8
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GXD Expression
GXD Expression
 
Probe: MGI:4416001
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1822623
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4828577
Age: embryonic day 14.5
Image: euxassay_010462_15
Specimen Label: euxassay_010462_15
Detected: true
Specimen Num: 9
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GXD Expression
GXD Expression
 
Probe: MGI:4416001
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1842623
Pattern: Single cells
Stage: TS23
Assay Id: MGI:4828577
Age: embryonic day 14.5
Image: euxassay_010462_07
Specimen Label: euxassay_010462_07
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
 
Probe: MGI:4416001
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1842623
Pattern: Single cells
Stage: TS23
Assay Id: MGI:4828577
Age: embryonic day 14.5
Image: euxassay_010462_08
Specimen Label: euxassay_010462_08
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
 
Probe: MGI:4416001
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1842623
Pattern: Single cells
Stage: TS23
Assay Id: MGI:4828577
Age: embryonic day 14.5
Image: euxassay_010462_09
Specimen Label: euxassay_010462_09
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
 
Probe: MGI:4416001
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1842623
Pattern: Single cells
Stage: TS23
Assay Id: MGI:4828577
Age: embryonic day 14.5
Image: euxassay_010462_16
Specimen Label: euxassay_010462_16
Detected: true
Specimen Num: 10
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GXD Expression
GXD Expression
 
Probe: MGI:4416001
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1842623
Pattern: Single cells
Stage: TS23
Assay Id: MGI:4828577
Age: embryonic day 14.5
Image: euxassay_010462_17
Specimen Label: euxassay_010462_17
Detected: true
Specimen Num: 11
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GXD Expression
GXD Expression
 
Probe: MGI:4416001
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1690823
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4828577
Age: embryonic day 14.5
Image: euxassay_010462_12
Specimen Label: euxassay_010462_12
Detected: true
Specimen Num: 6
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GXD Expression
GXD Expression
 
Probe: MGI:4416001
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1690823
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4828577
Age: embryonic day 14.5
Image: euxassay_010462_13
Specimen Label: euxassay_010462_13
Detected: true
Specimen Num: 7
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GXD Expression
GXD Expression
 
Probe: MGI:4416001
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1690823
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4828577
Age: embryonic day 14.5
Image: euxassay_010462_14
Specimen Label: euxassay_010462_14
Detected: true
Specimen Num: 8
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GXD Expression
GXD Expression
 
Probe: MGI:4416001
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1715823
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4828577
Age: embryonic day 14.5
Image: euxassay_010462_11
Specimen Label: euxassay_010462_11
Detected: true
Specimen Num: 5
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GXD Expression
GXD Expression
 
Probe: MGI:4416001
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1715823
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4828577
Age: embryonic day 14.5
Image: euxassay_010462_12
Specimen Label: euxassay_010462_12
Detected: true
Specimen Num: 6
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GXD Expression
GXD Expression
 
Probe: MGI:4416001
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1715823
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4828577
Age: embryonic day 14.5
Image: euxassay_010462_13
Specimen Label: euxassay_010462_13
Detected: true
Specimen Num: 7
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GXD Expression
GXD Expression
 
Probe: MGI:4416001
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1715823
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4828577
Age: embryonic day 14.5
Image: euxassay_010462_14
Specimen Label: euxassay_010462_14
Detected: true
Specimen Num: 8
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GXD Expression
GXD Expression
 
Probe: MGI:4416001
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:3599823
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4828577
Age: embryonic day 14.5
Image: euxassay_010462_10
Specimen Label: euxassay_010462_10
Detected: true
Specimen Num: 4
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GXD Expression
GXD Expression
 
Probe: MGI:4416001
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:3599823
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4828577
Age: embryonic day 14.5
Image: euxassay_010462_11
Specimen Label: euxassay_010462_11
Detected: true
Specimen Num: 5
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GXD Expression
GXD Expression
 
Probe: MGI:4416001
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:3599823
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4828577
Age: embryonic day 14.5
Image: euxassay_010462_12
Specimen Label: euxassay_010462_12
Detected: true
Specimen Num: 6
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•
GXD Expression
GXD Expression
 
Probe: MGI:4416001
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:3599823
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4828577
Age: embryonic day 14.5
Image: euxassay_010462_13
Specimen Label: euxassay_010462_13
Detected: true
Specimen Num: 7
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•
GXD Expression
GXD Expression
 
Probe: MGI:4416001
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:3599823
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4828577
Age: embryonic day 14.5
Image: euxassay_010462_14
Specimen Label: euxassay_010462_14
Detected: true
Specimen Num: 8
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GXD Expression
GXD Expression
 
Probe: MGI:4416001
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:3599823
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4828577
Age: embryonic day 14.5
Image: euxassay_010462_15
Specimen Label: euxassay_010462_15
Detected: true
Specimen Num: 9
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Publication
11956164 | J:76325
First Author: Zhao S
Year: 2002
Journal: Endocrinology
Title: Involvement of Rab27b in the regulated secretion of pituitary hormones.
Volume: 143
Issue: 5
Pages: 1817-24
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Publication
23223571 | J:200233
First Author: Wang H
Year: 2013
Journal: Mol Biol Cell
Title: The Rab27a effector exophilin7 promotes fusion of secretory granules that have not been docked to the plasma membrane.
Volume: 24
Issue: 3
Pages: 319-30
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Publication
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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