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Search results 1 to 100 out of 120 for Taar1

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Hits by Pathway

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Type Details Score
Gene
134864 | TAAR1
Type: gene
Organism: human
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Gene
768536 | TAAR1
Type: gene
Organism: chicken
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Gene
708944 | TAAR1
Type: gene
Organism: macaque, rhesus
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Gene
100487786 | taar1
Type: gene
Organism: frog, western clawed
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Gene
104969593 | TAAR1
Type: gene
Organism: cattle
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Gene
113914 | Taar1
Type: gene
Organism: rat
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Gene
493908 | TAAR1
Type: gene
Organism: chimpanzee
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Protein Coding Gene
MGI:2148258 | Taar1
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Domain
IPR009133 | TAAR1
Type: Family
Description: Trace amines, such as tyramine, beta-phenylethylamine, tryptamine and octopamine are biogenic amines present in trace levels in mammalian nervous systems []. Although some "trace amines"have clearly defined roles as neurotransmitters in invertebrates, the extent to which they function as true neurotransmitters in vertebrates has remained speculative []. Recently, a novel family of G protein-coupled receptors that share sequence similarity with the classical amine receptors has been discovered []. These trace amine associated receptors (TAAR), also known as trace amine receptors (TAR or TA), are members of the rhodopsin-like G-protein coupled receptor (GPCR) family [, ]. Some members have been shown to act as receptors for tyramine and beta-phenylethylamine, supporting a role for trace amines as neurotransmitters in vertebrates []. However, not all members have a high affinity for trace amines, some for example are olfactory receptors, which is why they are classified as trace amine associated receptors [].Since trace amine associated receptors are putative endogenous receptors for trace amines, they are of interest the pharmaceutical industry, since they are metabolic derivatives of classical biogenic amines and the psychostimulants amphetamine and methamphetamine [, , ].Trace amine-associated receptors are found in a range of taxa, but not all the members are found in all taxa [, , , ]and act as different types of receptor. In mammals, for example, TAAR1 is probably a receptor for thyronamines, decarboxylated and deiodinated metabolites of the thyroid hormones []whilst in mouse TAAR2 to TAAR9 receptors are most probably olfactory receptors for volatile amines [, ].This entry represents trace amine receptor 1 (TAAR1), it is potently activated by tyramine and beta-phenylethylamine, and displays low affinity for tryptamine, octopamine and dopamine []. TAAR1 is believed to be a key regulator of common and trace brain monoamines, and may also play some role in immune system function []. It is expressed at low to moderate levels in peripheral tissues such as the stomach, kidney and lung, and within the central nervous system is restricted predominantly to the amygdala [].
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Publication
11459929 | J:70672
First Author: Borowsky B
Year: 2001
Journal: Proc Natl Acad Sci U S A
Title: Trace amines: identification of a family of mammalian G protein-coupled receptors.
Volume: 98
Issue: 16
Pages: 8966-71
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Publication
15718104 | J:95733
First Author: Lindemann L
Year: 2005
Journal: Genomics
Title: Trace amine-associated receptors form structurally and functionally distinct subfamilies of novel G protein-coupled receptors.
Volume: 85
Issue: 3
Pages: 372-85
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Publication
37963465 | J:343375
First Author: Shang P
Year: 2023
Journal: Cell
Title: Structural and signaling mechanisms of TAAR1 enabled preferential agonist design.
Volume: 186
Issue: 24
Pages: 5347-5362.e24
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Publication
21525407 | J:172791
First Author: Revel FG
Year: 2011
Journal: Proc Natl Acad Sci U S A
Title: TAAR1 activation modulates monoaminergic neurotransmission, preventing hyperdopaminergic and hypoglutamatergic activity.
Volume: 108
Issue: 20
Pages: 8485-90
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Publication
29403379 | J:265410
 
First Author: Reed C
Year: 2017
Journal: Front Pharmacol
Title: A Spontaneous Mutation in Taar1 Impacts Methamphetamine-Related Traits Exclusively in DBA/2 Mice from a Single Vendor.
Volume: 8
Pages: 993
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Publication
31274109 | J:282439
   
First Author: Stafford AM
Year: 2019
Journal: Elife
Title: Taar1 gene variants have a causal role in methamphetamine intake and response and interact with Oprm1.
Volume: 8
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Publication
18083911 | J:279201
First Author: Lindemann L
Year: 2008
Journal: J Pharmacol Exp Ther
Title: Trace amine-associated receptor 1 modulates dopaminergic activity.
Volume: 324
Issue: 3
Pages: 948-56
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Publication
22038157 | -
First Author: Panas MW
Year: 2012
Journal: J Neuroimmune Pharmacol
Title: Trace amine associated receptor 1 signaling in activated lymphocytes.
Volume: 7
Issue: 4
Pages: 866-76
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Publication
16878137 | J:111708
First Author: Liberles SD
Year: 2006
Journal: Nature
Title: A second class of chemosensory receptors in the olfactory epithelium.
Volume: 442
Issue: 7103
Pages: 645-50
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Publication
17088868 | -
First Author: Zucchi R
Year: 2006
Journal: Br J Pharmacol
Title: Trace amine-associated receptors and their ligands.
Volume: 149
Issue: 8
Pages: 967-78
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Publication
19325074 | -
First Author: Maguire JJ
Year: 2009
Journal: Pharmacol Rev
Title: International Union of Pharmacology. LXXII. Recommendations for trace amine receptor nomenclature.
Volume: 61
Issue: 1
Pages: 1-8
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Publication
11723224 | -
First Author: Bunzow JR
Year: 2001
Journal: Mol Pharmacol
Title: Amphetamine, 3,4-methylenedioxymethamphetamine, lysergic acid diethylamide, and metabolites of the catecholamine neurotransmitters are agonists of a rat trace amine receptor.
Volume: 60
Issue: 6
Pages: 1181-8
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Publication
15860375 | -
First Author: Lindemann L
Year: 2005
Journal: Trends Pharmacol Sci
Title: A renaissance in trace amines inspired by a novel GPCR family.
Volume: 26
Issue: 5
Pages: 274-81
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Publication
16451074 | -
First Author: Hart ME
Year: 2006
Journal: J Med Chem
Title: Trace amine-associated receptor agonists: synthesis and evaluation of thyronamines and related analogues.
Volume: 49
Issue: 3
Pages: 1101-12
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Publication
19237578 | -
First Author: Hussain A
Year: 2009
Journal: Proc Natl Acad Sci U S A
Title: Positive Darwinian selection and the birth of an olfactory receptor clade in teleosts.
Volume: 106
Issue: 11
Pages: 4313-8
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Publication
15891052 | -
 
First Author: Gloriam DE
Year: 2005
Journal: Ann N Y Acad Sci
Title: High species variation within the repertoire of trace amine receptors.
Volume: 1040
Pages: 323-7
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Publication
14559210 | -
First Author: Vanti WB
Year: 2003
Journal: Genomics
Title: Discovery of a null mutation in a human trace amine receptor gene.
Volume: 82
Issue: 5
Pages: 531-6
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Publication
15146179 | -
First Author: Scanlan TS
Year: 2004
Journal: Nat Med
Title: 3-Iodothyronamine is an endogenous and rapid-acting derivative of thyroid hormone.
Volume: 10
Issue: 6
Pages: 638-42
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Publication
19686131 | -
 
First Author: Liberles SD
Year: 2009
Journal: Ann N Y Acad Sci
Title: Trace amine-associated receptors are olfactory receptors in vertebrates.
Volume: 1170
Pages: 168-72
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Protein
Q923Y8
Organism: Mus musculus/domesticus
Length: 332  
Fragment?: false
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Publication
27919403 | J:283845
First Author: Black SW
Year: 2017
Journal: Biol Psychiatry
Title: Trace Amine-Associated Receptor 1 Agonists as Narcolepsy Therapeutics.
Volume: 82
Issue: 9
Pages: 623-633
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Publication
21073468 | J:167622
First Author: Miller GM
Year: 2011
Journal: J Neurochem
Title: The emerging role of trace amine-associated receptor 1 in the functional regulation of monoamine transporters and dopaminergic activity.
Volume: 116
Issue: 2
Pages: 164-76
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Publication
19892733 | J:154753
First Author: Bradaia A
Year: 2009
Journal: Proc Natl Acad Sci U S A
Title: The selective antagonist EPPTB reveals TAAR1-mediated regulatory mechanisms in dopaminergic neurons of the mesolimbic system.
Volume: 106
Issue: 47
Pages: 20081-6
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Publication
34445611 | J:333682
 
First Author: Mantas I
Year: 2021
Journal: Int J Mol Sci
Title: Trace Amine-Associated Receptor 1 Contributes to Diverse Functional Actions of O-Phenyl-Iodotyramine in Mice but Not to the Effects of Monoamine-Based Antidepressants.
Volume: 22
Issue: 16
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Publication
33579534 | J:311432
First Author: Mantas I
Year: 2021
Journal: Biol Psychiatry
Title: TAAR1-Dependent and -Independent Actions of Tyramine in Interaction With Glutamate Underlie Central Effects of Monoamine Oxidase Inhibition.
Volume: 90
Issue: 1
Pages: 16-27
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Publication
25740289 | J:224677
First Author: Harkness JH
Year: 2015
Journal: Neuropsychopharmacology
Title: Trace Amine-Associated Receptor 1 Regulation of Methamphetamine Intake and Related Traits.
Volume: 40
Issue: 9
Pages: 2175-84
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Publication
26601071 | J:236658
First Author: Szumska J
Year: 2015
Journal: Eur Thyroid J
Title: Trace Amine-Associated Receptor 1 Localization at the Apical Plasma Membrane Domain of Fisher Rat Thyroid Epithelial Cells Is Confined to Cilia.
Volume: 4
Issue: Suppl 1
Pages: 30-41
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Publication
28919515 | J:256441
 
First Author: Miner NB
Year: 2017
Journal: Neurotoxicology
Title: Trace amine-associated receptor 1 regulation of methamphetamine-induced neurotoxicity.
Volume: 63
Pages: 57-69
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Publication
27031617 | J:242619
First Author: Shi X
Year: 2016
Journal: PLoS One
Title: Genetic Polymorphisms Affect Mouse and Human Trace Amine-Associated Receptor 1 Function.
Volume: 11
Issue: 3
Pages: e0152581
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Publication
19725810 | J:157808
First Author: Hu LA
Year: 2009
Journal: Biochem J
Title: Human and mouse trace amine-associated receptor 1 have distinct pharmacology towards endogenous monoamines and imidazoline receptor ligands.
Volume: 424
Issue: 1
Pages: 39-45
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Publication
17218486 | J:158938
First Author: Reese EA
Year: 2007
Journal: J Pharmacol Exp Ther
Title: Trace amine-associated receptor 1 displays species-dependent stereoselectivity for isomers of methamphetamine, amphetamine, and para-hydroxyamphetamine.
Volume: 321
Issue: 1
Pages: 178-86
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Publication
22763617 | J:315905
First Author: Revel FG
Year: 2012
Journal: Neuropsychopharmacology
Title: Brain-specific overexpression of trace amine-associated receptor 1 alters monoaminergic neurotransmission and decreases sensitivity to amphetamine.
Volume: 37
Issue: 12
Pages: 2580-92
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Publication
31409621 | J:280692
First Author: Shi X
Year: 2019
Journal: Mol Pharmacol
Title: Activation of Trace Amine-Associated Receptor 1 Stimulates an Antiapoptotic Signal Cascade via Extracellular Signal-Regulated Kinase 1/2.
Volume: 96
Issue: 4
Pages: 493-504
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Publication
31320495 | J:284737
First Author: Miner NB
Year: 2019
Journal: J Pharmacol Exp Ther
Title: The Role of Biogenic Amine Transporters in Trace Amine-Associated Receptor 1 Regulation of Methamphetamine-Induced Neurotoxicity.
Volume: 371
Issue: 1
Pages: 36-44
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Publication
34512422 | J:310042
 
First Author: Phillips TJ
Year: 2021
Journal: Front Psychiatry
Title: Confirmation of a Causal Taar1 Allelic Variant in Addiction-Relevant Methamphetamine Behaviors.
Volume: 12
Pages: 725839
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Publication
20976142 | J:166223
First Author: Sotnikova TD
Year: 2010
Journal: PLoS One
Title: The dopamine metabolite 3-methoxytyramine is a neuromodulator.
Volume: 5
Issue: 10
Pages: e13452
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Publication
31925906 | J:310775
First Author: Mootz JRK
Year: 2020
Journal: Genes Brain Behav
Title: Differential genetic risk for methamphetamine intake confers differential sensitivity to the temperature-altering effects of other addictive drugs.
Volume: 19
Issue: 5
Pages: e12640
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Publication
26468205 | J:226689
First Author: Alvarsson A
Year: 2015
Journal: J Neurosci
Title: Modulation by Trace Amine-Associated Receptor 1 of Experimental Parkinsonism, L-DOPA Responsivity, and Glutamatergic Neurotransmission.
Volume: 35
Issue: 41
Pages: 14057-69
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Protein Coding Gene
MGP_CAROLIEiJ_G0015175 | -
Type: protein_coding_gene
Organism: Mus caroli
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Protein Coding Gene
MGP_129S1SvImJ_G0017076 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AJ_G0017054 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AKRJ_G0017016 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_BALBcJ_G0017016 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C3HHeJ_G0016836 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI_C57BL6J_2148258 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C57BL6NJ_G0017474 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CASTEiJ_G0016417 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CBAJ_G0016809 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_DBA2J_G0016915 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_FVBNJ_G0016911 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_LPJ_G0016991 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NODShiLtJ_G0016941 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NZOHlLtJ_G0017509 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PWKPhJ_G0016202 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_WSBEiJ_G0016480 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PahariEiJ_G0023795 | -
Type: protein_coding_gene
Organism: Mus pahari
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Protein Coding Gene
MGP_SPRETEiJ_G0015984 | -
Type: protein_coding_gene
Organism: Mus spretus
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Publication
22114263 | J:178061
First Author: Di Cara B
Year: 2011
Journal: J Neurosci
Title: Genetic deletion of trace amine 1 receptors reveals their role in auto-inhibiting the actions of ecstasy (MDMA).
Volume: 31
Issue: 47
Pages: 16928-40
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GXD Expression
GXD Expression
     
Probe: MGI:3807702
Assay Type: RT-PCR
Annotation Date: 2008-09-26
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:3576528
Stage: TS28
Assay Id: MGI:3807870
Age: postnatal
Specimen Label: GG
Detected: false
Specimen Num: 1
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GXD Expression
GXD Expression
     
Probe: MGI:3807702
Assay Type: RT-PCR
Annotation Date: 2008-09-26
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1760628
Stage: TS28
Assay Id: MGI:3807870
Age: postnatal
Specimen Label: MOE
Detected: false
Specimen Num: 2
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Publication
17212650 | J:141501
First Author: Wolinsky TD
Year: 2007
Journal: Genes Brain Behav
Title: The Trace Amine 1 receptor knockout mouse: an animal model with relevance to schizophrenia.
Volume: 6
Issue: 7
Pages: 628-39
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Publication
23624375 | J:197678
First Author: Dewan A
Year: 2013
Journal: Nature
Title: Non-redundant coding of aversive odours in the main olfactory pathway.
Volume: 497
Issue: 7450
Pages: 486-9
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Publication
22840399 | J:202086
First Author: Pacifico R
Year: 2012
Journal: Cell Rep
Title: An olfactory subsystem that mediates high-sensitivity detection of volatile amines.
Volume: 2
Issue: 1
Pages: 76-88
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Publication
17556730 | J:124221
First Author: Fleischer J
Year: 2007
Journal: Chem Senses
Title: Expression of trace amine-associated receptors in the Grueneberg ganglion.
Volume: 32
Issue: 6
Pages: 623-31
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Publication
- | J:136110
     
First Author: Velocigene
Year: 2008
Journal: MGI Direct Data Submission
Title: Alleles produced for the KOMP project by Velocigene (Regeneron Pharmaceuticals)
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Publication
- | J:204812
     
First Author: International Mouse Strain Resource
Year: 2014
Journal: Database Download
Title: MGI download of germline transmission data for alleles from IMSR strain data
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Publication
- | J:157065
     
First Author: Helmholtz Zentrum Muenchen GmbH
Year: 2010
Journal: MGI Direct Data Submission
Title: Alleles produced for the EUCOMM and EUCOMMTools projects by the Helmholtz Zentrum Muenchen GmbH (Hmgu)
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Publication
- | J:326541
       
First Author: Cyagen Biosciences Inc.
Year: 2022
Title: Cyagen Biosciences Website.
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Publication
- | J:342604
       
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
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Publication
- | J:155856
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Title: Rat to Mouse ISO GO annotation transfer
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Publication
16602821 | J:162220
First Author: Magdaleno S
Year: 2006
Journal: PLoS Biol
Title: BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system.
Volume: 4
Issue: 4
Pages: e86
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Publication
- | J:78475
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Chromosome assignment of mouse genes using the Mouse Genome Sequencing Consortium (MGSC) assembly and the ENSEMBL Database
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Publication
- | J:23000
       
First Author: MGD Nomenclature Committee
Year: 1995
Title: Nomenclature Committee Use
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Publication
- | J:164563
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Title: Human to Mouse ISO GO annotation transfer
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Publication
21267068 | J:153498
First Author: Diez-Roux G
Year: 2011
Journal: PLoS Biol
Title: A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Volume: 9
Issue: 1
Pages: e1000582
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Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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Allele
Taar1<tm1Blt> | MGI:7428315
Name: trace amine-associated receptor 1; targeted mutation 1, Horst Bluethmann
Allele Type: Targeted
Attribute String: Null/knockout, Reporter
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Publication
25391046 | J:345351
First Author: Mühlhaus J
Year: 2014
Journal: Int J Mol Sci
Title: Analysis of human TAAR8 and murine Taar8b mediated signaling pathways and expression profile.
Volume: 15
Issue: 11
Pages: 20638-55
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Publication
32194374 | J:287282
 
First Author: Espinoza S
Year: 2020
Journal: Front Mol Neurosci
Title: Trace Amine-Associated Receptor 5 Provides Olfactory Input Into Limbic Brain Areas and Modulates Emotional Behaviors and Serotonin Transmission.
Volume: 13
Pages: 18
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Protein Domain
IPR009132 | TAAR_fam
Type: Family
Description: Trace amines, such as tyramine, beta-phenylethylamine, tryptamine and octopamine are biogenic amines present in trace levels in mammalian nervous systems []. Although some "trace amines"have clearly defined roles as neurotransmitters in invertebrates, the extent to which they function as true neurotransmitters in vertebrates has remained speculative []. Recently, a novel family of G protein-coupled receptors that share sequence similarity with the classical amine receptors has been discovered []. These trace amine associated receptors (TAAR), also known as trace amine receptors (TAR or TA), are members of the rhodopsin-like G-protein coupled receptor (GPCR) family [, ]. Some members have been shown to act as receptors for tyramine and beta-phenylethylamine, supporting a role for trace amines as neurotransmitters in vertebrates []. However, not all members have a high affinity for trace amines, some for example are olfactory receptors, which is why they are classified as trace amine associated receptors [].Since trace amine associated receptors are putative endogenous receptors for trace amines, they are of interest the pharmaceutical industry, since they are metabolic derivatives of classical biogenic amines and the psychostimulants amphetamine and methamphetamine [, , ].Trace amine-associated receptors are found in a range of taxa, but not all the members are found in all taxa [, , , ]and act as different types of receptor. In mammals, for example, TAAR1 is probably a receptor for thyronamines, decarboxylated and deiodinated metabolites of the thyroid hormones []whilst in mouse TAAR2 to TAAR9 receptors are most probably olfactory receptors for volatile amines [, ].This entry represents the trace amine associated receptor family.
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Protein
Q5QD06
Organism: Mus musculus/domesticus
Length: 344  
Fragment?: false
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