Type |
Details |
Score |
Gene |
Type: |
gene |
Organism: |
human |
|
•
•
•
•
•
|
Gene |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
chimpanzee |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
cattle |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
macaque, rhesus |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Publication |
First Author: |
Xu Z |
Year: |
2022 |
Journal: |
Sci Rep |
Title: |
Two entry tunnels in mouse TAAR9 suggest the possibility of multi-entry tunnels in olfactory receptors. |
Volume: |
12 |
Issue: |
1 |
Pages: |
2691 |
|
•
•
•
•
•
|
Publication |
First Author: |
Guo L |
Year: |
2023 |
Journal: |
Nature |
Title: |
Structural basis of amine odorant perception by a mammal olfactory receptor. |
Volume: |
618 |
Issue: |
7963 |
Pages: |
193-200 |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
Mus caroli |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
Mus pahari |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
Mus spretus |
|
•
•
•
•
•
|
Publication |
First Author: |
Jia L |
Year: |
2021 |
Journal: |
J Biol Chem |
Title: |
Convergent olfactory trace amine-associated receptors detect biogenic polyamines with distinct motifs via a conserved binding site. |
Volume: |
297 |
Issue: |
5 |
Pages: |
101268 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3807793 |
Assay Type: |
RT-PCR |
Annotation Date: |
2008-09-26 |
Strength: |
Absent |
Sex: |
Not Specified |
Emaps: |
EMAPS:3576528 |
|
Stage: |
TS28 |
Assay Id: |
MGI:3807900 |
Age: |
postnatal |
|
|
Specimen Label: |
GG |
Detected: |
false |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3807793 |
Assay Type: |
RT-PCR |
Annotation Date: |
2008-09-26 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1760628 |
|
Stage: |
TS28 |
Assay Id: |
MGI:3807900 |
Age: |
postnatal |
|
|
Specimen Label: |
MOE |
Detected: |
true |
Specimen Num: |
2 |
|
•
•
•
•
•
|
Publication |
First Author: |
Liberles SD |
Year: |
2006 |
Journal: |
Nature |
Title: |
A second class of chemosensory receptors in the olfactory epithelium. |
Volume: |
442 |
Issue: |
7103 |
Pages: |
645-50 |
|
•
•
•
•
•
|
Publication |
First Author: |
Lindemann L |
Year: |
2005 |
Journal: |
Genomics |
Title: |
Trace amine-associated receptors form structurally and functionally distinct subfamilies of novel G protein-coupled receptors. |
Volume: |
85 |
Issue: |
3 |
Pages: |
372-85 |
|
•
•
•
•
•
|
Publication |
First Author: |
Borowsky B |
Year: |
2001 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Trace amines: identification of a family of mammalian G protein-coupled receptors. |
Volume: |
98 |
Issue: |
16 |
Pages: |
8966-71 |
|
•
•
•
•
•
|
Publication |
First Author: |
Dewan A |
Year: |
2013 |
Journal: |
Nature |
Title: |
Non-redundant coding of aversive odours in the main olfactory pathway. |
Volume: |
497 |
Issue: |
7450 |
Pages: |
486-9 |
|
•
•
•
•
•
|
Publication |
First Author: |
Pacifico R |
Year: |
2012 |
Journal: |
Cell Rep |
Title: |
An olfactory subsystem that mediates high-sensitivity detection of volatile amines. |
Volume: |
2 |
Issue: |
1 |
Pages: |
76-88 |
|
•
•
•
•
•
|
Publication |
First Author: |
Vassilatis DK |
Year: |
2003 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
The G protein-coupled receptor repertoires of human and mouse. |
Volume: |
100 |
Issue: |
8 |
Pages: |
4903-8 |
|
•
•
•
•
•
|
Publication |
First Author: |
Fleischer J |
Year: |
2007 |
Journal: |
Chem Senses |
Title: |
Expression of trace amine-associated receptors in the Grueneberg ganglion. |
Volume: |
32 |
Issue: |
6 |
Pages: |
623-31 |
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Database and National Center for Biotechnology Information Editorial Staff Collaboration |
Year: |
2001 |
|
Title: |
LocusLink Collaboration |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2003 |
Journal: |
Database Download |
Title: |
Integrating Computational Gene Models into the Mouse Genome Informatics (MGI) Database |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Helmholtz Zentrum Muenchen GmbH |
Year: |
2010 |
Journal: |
MGI Direct Data Submission |
Title: |
Alleles produced for the EUCOMM and EUCOMMTools projects by the Helmholtz Zentrum Muenchen GmbH (Hmgu) |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Magdaleno S |
Year: |
2006 |
Journal: |
PLoS Biol |
Title: |
BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system. |
Volume: |
4 |
Issue: |
4 |
Pages: |
e86 |
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2003 |
|
Title: |
MGI Sequence Curation Reference |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Diez-Roux G |
Year: |
2011 |
Journal: |
PLoS Biol |
Title: |
A high-resolution anatomical atlas of the transcriptome in the mouse embryo. |
Volume: |
9 |
Issue: |
1 |
Pages: |
e1000582 |
|
•
•
•
•
•
|
Publication |
First Author: |
Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas |
Year: |
2010 |
|
Title: |
Annotation inferences using phylogenetic trees |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Database and National Center for Biotechnology Information |
Year: |
2000 |
Journal: |
Database Release |
Title: |
Entrez Gene Load |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Allen Institute for Brain Science |
Year: |
2004 |
Journal: |
Allen Institute |
Title: |
Allen Brain Atlas: mouse riboprobes |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2009 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI) |
Year: |
2010 |
Journal: |
Database Download |
Title: |
Consensus CDS project |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Group |
Year: |
2003 |
Journal: |
Database Procedure |
Title: |
Automatic Encodes (AutoE) Reference |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Bairoch A |
Year: |
1999 |
Journal: |
Database Release |
Title: |
SWISS-PROT Annotated protein sequence database |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2005 |
|
Title: |
Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics |
Year: |
2010 |
Journal: |
Database Release |
Title: |
Protein Ontology Association Load. |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2005 |
|
Title: |
Obtaining and loading genome assembly coordinates from NCBI annotations |
|
|
|
|
•
•
•
•
•
|
Allele |
Name: |
deletion, Chr 10, Marius Hoener |
Allele Type: |
Targeted |
Attribute String: |
Null/knockout |
|
•
•
•
•
•
|
Publication |
First Author: |
Harmeier A |
Year: |
2018 |
Journal: |
Front Pharmacol |
Title: |
How Female Mice Attract Males: A Urinary Volatile Amine Activates a Trace Amine-Associated Receptor That Induces Male Sexual Interest. |
Volume: |
9 |
|
Pages: |
924 |
|
•
•
•
•
•
|
Publication |
First Author: |
Zucchi R |
Year: |
2006 |
Journal: |
Br J Pharmacol |
Title: |
Trace amine-associated receptors and their ligands. |
Volume: |
149 |
Issue: |
8 |
Pages: |
967-78 |
|
•
•
•
•
•
|
Publication |
First Author: |
Maguire JJ |
Year: |
2009 |
Journal: |
Pharmacol Rev |
Title: |
International Union of Pharmacology. LXXII. Recommendations for trace amine receptor nomenclature. |
Volume: |
61 |
Issue: |
1 |
Pages: |
1-8 |
|
•
•
•
•
•
|
Publication |
First Author: |
Bunzow JR |
Year: |
2001 |
Journal: |
Mol Pharmacol |
Title: |
Amphetamine, 3,4-methylenedioxymethamphetamine, lysergic acid diethylamide, and metabolites of the catecholamine neurotransmitters are agonists of a rat trace amine receptor. |
Volume: |
60 |
Issue: |
6 |
Pages: |
1181-8 |
|
•
•
•
•
•
|
Publication |
First Author: |
Lindemann L |
Year: |
2005 |
Journal: |
Trends Pharmacol Sci |
Title: |
A renaissance in trace amines inspired by a novel GPCR family. |
Volume: |
26 |
Issue: |
5 |
Pages: |
274-81 |
|
•
•
•
•
•
|
Publication |
First Author: |
Hart ME |
Year: |
2006 |
Journal: |
J Med Chem |
Title: |
Trace amine-associated receptor agonists: synthesis and evaluation of thyronamines and related analogues. |
Volume: |
49 |
Issue: |
3 |
Pages: |
1101-12 |
|
•
•
•
•
•
|
Publication |
First Author: |
Hussain A |
Year: |
2009 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Positive Darwinian selection and the birth of an olfactory receptor clade in teleosts. |
Volume: |
106 |
Issue: |
11 |
Pages: |
4313-8 |
|
•
•
•
•
•
|
Publication |
First Author: |
Gloriam DE |
Year: |
2005 |
Journal: |
Ann N Y Acad Sci |
Title: |
High species variation within the repertoire of trace amine receptors. |
Volume: |
1040 |
|
Pages: |
323-7 |
|
•
•
•
•
•
|
Publication |
First Author: |
Vanti WB |
Year: |
2003 |
Journal: |
Genomics |
Title: |
Discovery of a null mutation in a human trace amine receptor gene. |
Volume: |
82 |
Issue: |
5 |
Pages: |
531-6 |
|
•
•
•
•
•
|
Publication |
First Author: |
Scanlan TS |
Year: |
2004 |
Journal: |
Nat Med |
Title: |
3-Iodothyronamine is an endogenous and rapid-acting derivative of thyroid hormone. |
Volume: |
10 |
Issue: |
6 |
Pages: |
638-42 |
|
•
•
•
•
•
|
Publication |
First Author: |
Liberles SD |
Year: |
2009 |
Journal: |
Ann N Y Acad Sci |
Title: |
Trace amine-associated receptors are olfactory receptors in vertebrates. |
Volume: |
1170 |
|
Pages: |
168-72 |
|
•
•
•
•
•
|
Publication |
First Author: |
Panas MW |
Year: |
2012 |
Journal: |
J Neuroimmune Pharmacol |
Title: |
Trace amine associated receptor 1 signaling in activated lymphocytes. |
Volume: |
7 |
Issue: |
4 |
Pages: |
866-76 |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Family |
Description: |
Trace amines, such as tyramine, beta-phenylethylamine, tryptamine and octopamine are biogenic amines present in trace levels in mammalian nervous systems []. Although some "trace amines"have clearly defined roles as neurotransmitters in invertebrates, the extent to which they function as true neurotransmitters in vertebrates has remained speculative []. Recently, a novel family of G protein-coupled receptors that share sequence similarity with the classical amine receptors has been discovered []. These trace amine associated receptors (TAAR), also known as trace amine receptors (TAR or TA), are members of the rhodopsin-like G-protein coupled receptor (GPCR) family [, ]. Some members have been shown to act as receptors for tyramine and beta-phenylethylamine, supporting a role for trace amines as neurotransmitters in vertebrates []. However, not all members have a high affinity for trace amines, some for example are olfactory receptors, which is why they are classified as trace amine associated receptors [].Since trace amine associated receptors are putative endogenous receptors for trace amines, they are of interest the pharmaceutical industry, since they are metabolic derivatives of classical biogenic amines and the psychostimulants amphetamine and methamphetamine [, , ].Trace amine-associated receptors are found in a range of taxa, but not all the members are found in all taxa [, , , ]and act as different types of receptor. In mammals, for example, TAAR1 is probably a receptor for thyronamines, decarboxylated and deiodinated metabolites of the thyroid hormones []whilst in mouse TAAR2 to TAAR9 receptors are most probably olfactory receptors for volatile amines [, ].This entry represents the trace amine associated receptor family. |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Family |
Description: |
Trace amines, such as tyramine, beta-phenylethylamine, tryptamine and octopamine are biogenic amines present in trace levels in mammalian nervous systems []. Although some "trace amines"have clearly defined roles as neurotransmitters in invertebrates, the extent to which they function as true neurotransmitters in vertebrates has remained speculative []. Recently, a novel family of G protein-coupled receptors that share sequence similarity with the classical amine receptors has been discovered []. These trace amine associated receptors (TAAR), also known as trace amine receptors (TAR or TA), are members of the rhodopsin-like G-protein coupled receptor (GPCR) family [, ]. Some members have been shown to act as receptors for tyramine and beta-phenylethylamine, supporting a role for trace amines as neurotransmitters in vertebrates []. However, not all members have a high affinity for trace amines, some for example are olfactory receptors, which is why they are classified as trace amine associated receptors [].Since trace amine associated receptors are putative endogenous receptors for trace amines, they are of interest the pharmaceutical industry, since they are metabolic derivatives of classical biogenic amines and the psychostimulants amphetamine and methamphetamine [, , ].Trace amine-associated receptors are found in a range of taxa, but not all the members are found in all taxa [, , , ]and act as different types of receptor. In mammals, for example, TAAR1 is probably a receptor for thyronamines, decarboxylated and deiodinated metabolites of the thyroid hormones []whilst in mouse TAAR2 to TAAR9 receptors are most probably olfactory receptors for volatile amines [, ].This entry represents trace amine receptor 1 (TAAR1), it is potently activated by tyramine and beta-phenylethylamine, and displays low affinity for tryptamine, octopamine and dopamine []. TAAR1 is believed to be a key regulator of common and trace brain monoamines, and may also play some role in immune system function []. It is expressed at low to moderate levels in peripheral tissues such as the stomach, kidney and lung, and within the central nervous system is restricted predominantly to the amygdala []. |
|
•
•
•
•
•
|
Publication |
First Author: |
Fei A |
Year: |
2021 |
Journal: |
Nat Commun |
Title: |
Coordination of two enhancers drives expression of olfactory trace amine-associated receptors. |
Volume: |
12 |
Issue: |
1 |
Pages: |
3798 |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
332
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
344
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
344
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
344
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
358
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
345
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
348
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
358
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
343
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
347
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
339
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
358
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
358
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
358
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
358
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
343
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
343
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
110
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
346
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
291
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
337
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
337
 |
Fragment?: |
false |
|
•
•
•
•
•
|