| Type |
Details |
Score |
| Gene |
| Type: |
gene |
| Organism: |
human |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
frog, western clawed |
|
•
•
•
•
•
|
| Gene |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
chimpanzee |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
cattle |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
dog, domestic |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
chicken |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
zebrafish |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
macaque, rhesus |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Tremblay MG |
| Year: |
2022 |
| Journal: |
PLoS Genet |
| Title: |
Ribosomal DNA promoter recognition is determined in vivo by cooperation between UBTF1 and SL1 and is compromised in the UBTF-E210K neuroregression syndrome. |
| Volume: |
18 |
| Issue: |
2 |
| Pages: |
e1009644 |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
Mus caroli |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
Mus pahari |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
Mus spretus |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:4844542 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2010-12-22 |
| Strength: |
Moderate |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1640519 |
| Pattern: |
Regionally restricted |
| Stage: |
TS19 |
| Assay Id: |
MGI:4848469 |
| Age: |
embryonic day 11.5 |
|
| Note: |
Staining is present in the interdigital region of the limb. |
| Specimen Label: |
Table S4 - E11.5 |
| Detected: |
true |
| Specimen Num: |
2 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:4844542 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2010-12-22 |
| Strength: |
Strong |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1610517 |
| Pattern: |
Not Specified |
| Stage: |
TS17 |
| Assay Id: |
MGI:4848469 |
| Age: |
embryonic day 10.5 |
|
|
| Specimen Label: |
Table S4 - E10.5 |
| Detected: |
true |
| Specimen Num: |
1 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Qiu H |
| Year: |
2011 |
| Journal: |
Biosci Biotechnol Biochem |
| Title: |
Identification of novel nuclear protein interactions with the N-terminal part of filamin A. |
| Volume: |
75 |
| Issue: |
1 |
| Pages: |
145-7 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Almendral JM |
| Year: |
1989 |
| Journal: |
Exp Cell Res |
| Title: |
Expression, cloning and cDNA sequence of a fibroblast serum-regulated gene encoding a putative actin-associated protein (p27). |
| Volume: |
181 |
| Issue: |
2 |
| Pages: |
518-30 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Wang Z |
| Year: |
2004 |
| Journal: |
Gene |
| Title: |
Gene structure and evolution of Tieg3, a new member of the Tieg family of proteins. |
| Volume: |
325 |
|
| Pages: |
25-34 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Eckey M |
| Year: |
2013 |
| Journal: |
FEBS J |
| Title: |
The corepressor activity of Alien is controlled by CREB-binding protein/p300. |
| Volume: |
280 |
| Issue: |
8 |
| Pages: |
1861-8 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Heix J |
| Year: |
1997 |
| Journal: |
Proc Natl Acad Sci U S A |
| Title: |
Cloning of murine RNA polymerase I-specific TAF factors: conserved interactions between the subunits of the species-specific transcription initiation factor TIF-IB/SL1. |
| Volume: |
94 |
| Issue: |
5 |
| Pages: |
1733-8 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Murano K |
| Year: |
2014 |
| Journal: |
J Cell Sci |
| Title: |
Reconstitution of human rRNA gene transcription in mouse cells by a complete SL1 complex. |
| Volume: |
127 |
| Issue: |
Pt 15 |
| Pages: |
3309-19 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Adolphe C |
| Year: |
2014 |
| Journal: |
J Invest Dermatol |
| Title: |
Patched 1 and patched 2 redundancy has a key role in regulating epidermal differentiation. |
| Volume: |
134 |
| Issue: |
7 |
| Pages: |
1981-1990 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Maga AM |
| Year: |
2015 |
| Journal: |
Front Physiol |
| Title: |
Quantitative trait loci affecting the 3D skull shape and size in mouse and prioritization of candidate genes in-silico. |
| Volume: |
6 |
|
| Pages: |
92 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Informatics Scientific Curators |
| Year: |
2001 |
|
| Title: |
RIKEN Data Curation in Mouse Genome Informatics |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Yokoyama S |
| Year: |
2009 |
| Journal: |
Dev Cell |
| Title: |
A systems approach reveals that the myogenesis genome network is regulated by the transcriptional repressor RP58. |
| Volume: |
17 |
| Issue: |
6 |
| Pages: |
836-48 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Informatics Scientific Curators |
| Year: |
2005 |
|
| Title: |
Mouse Synonym Curation |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Friedel RH |
| Year: |
2007 |
| Journal: |
Brief Funct Genomic Proteomic |
| Title: |
EUCOMM--the European conditional mouse mutagenesis program. |
| Volume: |
6 |
| Issue: |
3 |
| Pages: |
180-5 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Helmholtz Zentrum Muenchen GmbH |
| Year: |
2010 |
| Journal: |
MGI Direct Data Submission |
| Title: |
Alleles produced for the EUCOMM and EUCOMMTools projects by the Helmholtz Zentrum Muenchen GmbH (Hmgu) |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Informatics Scientific Curators |
| Year: |
2003 |
|
| Title: |
MGI Sequence Curation Reference |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Informatics Scientific Curators |
| Year: |
2002 |
|
| Title: |
Chromosome assignment of mouse genes using the Mouse Genome Sequencing Consortium (MGSC) assembly and the ENSEMBL Database |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Carninci P |
| Year: |
2005 |
| Journal: |
Science |
| Title: |
The transcriptional landscape of the mammalian genome. |
| Volume: |
309 |
| Issue: |
5740 |
| Pages: |
1559-63 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Kawai J |
| Year: |
2001 |
| Journal: |
Nature |
| Title: |
Functional annotation of a full-length mouse cDNA collection. |
| Volume: |
409 |
| Issue: |
6821 |
| Pages: |
685-90 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Zambrowicz BP |
| Year: |
2003 |
| Journal: |
Proc Natl Acad Sci U S A |
| Title: |
Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. |
| Volume: |
100 |
| Issue: |
24 |
| Pages: |
14109-14 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
GemPharmatech |
| Year: |
2020 |
|
| Title: |
GemPharmatech Website. |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI) |
| Year: |
2008 |
| Journal: |
Database Download |
| Title: |
Mouse Gene Trap Data Load from dbGSS |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators |
| Year: |
2011 |
|
| Title: |
Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
UniProt-GOA |
| Year: |
2012 |
|
| Title: |
Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
GOA curators |
| Year: |
2016 |
|
| Title: |
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Okazaki Y |
| Year: |
2002 |
| Journal: |
Nature |
| Title: |
Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. |
| Volume: |
420 |
| Issue: |
6915 |
| Pages: |
563-73 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
The Gene Ontology Consortium |
| Year: |
2010 |
|
| Title: |
Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Diez-Roux G |
| Year: |
2011 |
| Journal: |
PLoS Biol |
| Title: |
A high-resolution anatomical atlas of the transcriptome in the mouse embryo. |
| Volume: |
9 |
| Issue: |
1 |
| Pages: |
e1000582 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Informatics Scientific Curators |
| Year: |
2002 |
|
| Title: |
Mouse Genome Informatics Computational Sequence to Gene Associations |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Informatics Scientific Curators |
| Year: |
2010 |
| Journal: |
Database Download |
| Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2). |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas |
| Year: |
2010 |
|
| Title: |
Annotation inferences using phylogenetic trees |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Database and National Center for Biotechnology Information |
| Year: |
2000 |
| Journal: |
Database Release |
| Title: |
Entrez Gene Load |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Allen Institute for Brain Science |
| Year: |
2004 |
| Journal: |
Allen Institute |
| Title: |
Allen Brain Atlas: mouse riboprobes |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Informatics Scientific Curators |
| Year: |
2009 |
| Journal: |
Database Download |
| Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI) |
| Year: |
2010 |
| Journal: |
Database Download |
| Title: |
Consensus CDS project |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Informatics Group |
| Year: |
2003 |
| Journal: |
Database Procedure |
| Title: |
Automatic Encodes (AutoE) Reference |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Bairoch A |
| Year: |
1999 |
| Journal: |
Database Release |
| Title: |
SWISS-PROT Annotated protein sequence database |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Informatics Scientific Curators |
| Year: |
2005 |
|
| Title: |
Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Informatics |
| Year: |
2010 |
| Journal: |
Database Release |
| Title: |
Protein Ontology Association Load. |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Informatics Scientific Curators |
| Year: |
2005 |
|
| Title: |
Obtaining and loading genome assembly coordinates from NCBI annotations |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Informatics Scientific Curators |
| Year: |
2009 |
| Journal: |
Database Download |
| Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Knutson BA |
| Year: |
2011 |
| Journal: |
Science |
| Title: |
Yeast Rrn7 and human TAF1B are TFIIB-related RNA polymerase I general transcription factors. |
| Volume: |
333 |
| Issue: |
6049 |
| Pages: |
1637-40 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Naidu S |
| Year: |
2011 |
| Journal: |
Science |
| Title: |
TAF1B is a TFIIB-like component of the basal transcription machinery for RNA polymerase I. |
| Volume: |
333 |
| Issue: |
6049 |
| Pages: |
1640-2 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Agger K |
| Year: |
2019 |
| Journal: |
Blood |
| Title: |
The KDM4/JMJD2 histone demethylases are required for hematopoietic stem cell maintenance. |
| Volume: |
134 |
| Issue: |
14 |
| Pages: |
1154-1158 |
|
•
•
•
•
•
|
| Protein Domain |
| Type: |
Family |
| Description: |
Rrn7 is a subunit of the yeast Pol I core factor. It associates strongly with both Rrn6 and Rrn11 to form a complex which itself binds the TATA-binding protein, and is required for transcription by the core domain of the RNA Pol I promoter [, , ].Rrn7 human orthologue, TATA box-binding protein-associated factor RNA polymerase I subunit B (TAF1B), is also a component of RNA polymerase I core factor complex. It acts as a GTF2B/TFIIB-like factor and plays a key role in multiple steps during transcription initiation []. Both Rrn7 and TAF1B are TFIIB-like factors. Although distantly related, they share many activities associated with TFIIB-like factors []. |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
586
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Beckmann H |
| Year: |
1995 |
| Journal: |
Science |
| Title: |
Coactivator and promoter-selective properties of RNA polymerase I TAFs. |
| Volume: |
270 |
| Issue: |
5241 |
| Pages: |
1506-9 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Lin CW |
| Year: |
1996 |
| Journal: |
Mol Cell Biol |
| Title: |
A novel 66-kilodalton protein complexes with Rrn6, Rrn7, and TATA-binding protein to promote polymerase I transcription initiation in Saccharomyces cerevisiae. |
| Volume: |
16 |
| Issue: |
11 |
| Pages: |
6436-43 |
|
•
•
•
•
•
|
| Protein Domain |
| Type: |
Family |
| Description: |
This entry represents subunit A (TATA-binding protein-associated factor TAFI48 or TAF1A) of RNA polymerase I. It is a component of the transcription factor SL1/TIFIB complex involved in the assembly of the pre-initiation complex (PIC). The SL1/TIFIB complex is composed of TBP (TATA-binding protein) and TAF1A (TAFI48), TAF1B (TAFI63) and TAF1C (TAFI110) []. Human ribosomal RNA synthesis by RNA polymerase I requires the activator UBF and the promoter selectivity factor SL1/TIFIB. Both TAF1B/TAFI63 and TAF1C/TAFI110 contact the promoter, whereas TAF1A/TAFI48 serves as a target for interaction with UBF and is required to form a transcriptionally active SL1/TIFIB complex responsive to UBF []. Interaction of the SL1/TIFIB subunits with TBP excluded interaction with the transcription factor IID (TFIID) subunits []. This mutually exclusive binding directs the formation of promoter- and RNA polymerase-selective TBP-TAF complexes. Therefore, TAF1A/TAFI48 may function both as a target to mediate UBF activation and as a class-specific promoter selectivity factor. |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
453
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
456
 |
| Fragment?: |
true |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
440
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Keys DA |
| Year: |
1994 |
| Journal: |
Genes Dev |
| Title: |
RRN6 and RRN7 encode subunits of a multiprotein complex essential for the initiation of rDNA transcription by RNA polymerase I in Saccharomyces cerevisiae. |
| Volume: |
8 |
| Issue: |
19 |
| Pages: |
2349-62 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Gorski JJ |
| Year: |
2007 |
| Journal: |
EMBO J |
| Title: |
A novel TBP-associated factor of SL1 functions in RNA polymerase I transcription. |
| Volume: |
26 |
| Issue: |
6 |
| Pages: |
1560-8 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Friedrich JK |
| Year: |
2005 |
| Journal: |
J Biol Chem |
| Title: |
TBP-TAF complex SL1 directs RNA polymerase I pre-initiation complex formation and stabilizes upstream binding factor at the rDNA promoter. |
| Volume: |
280 |
| Issue: |
33 |
| Pages: |
29551-8 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Engel C |
| Year: |
2017 |
| Journal: |
Cell |
| Title: |
Structural Basis of RNA Polymerase I Transcription Initiation. |
| Volume: |
169 |
| Issue: |
1 |
| Pages: |
120-131.e22 |
|
•
•
•
•
•
|