| Type | Details | Score | 
          
              | Gene | 
              
                | Type: | gene |  
                | Organism: | human |  | • • • • • | 
          
              | Gene | 
              
                | Type: | gene |  
                | Organism: | chimpanzee |  | • • • • • | 
          
              | Gene | 
              
                | Type: | gene |  
                | Organism: | dog, domestic |  | • • • • • | 
          
              | Gene | 
              
                | Type: | gene |  
                | Organism: | cattle |  | • • • • • | 
          
              | Gene | 
              
                | Type: | gene |  
                | Organism: | macaque, rhesus |  | • • • • • | 
          
              | Gene | 
              
                | Type: | gene |  
                | Organism: | frog, western clawed |  | • • • • • | 
          
              | Gene |  | • • • • • | 
          
              | Gene | 
              
                | Type: | gene |  
                | Organism: | chicken |  | • • • • • | 
          
              | Gene | 
              
                | Type: | gene |  
                | Organism: | zebrafish |  | • • • • • | 
          
              | Protein Coding Gene | 
              
                | Type: | protein_coding_gene |  
                | Organism: | mouse, laboratory |  | • • • • • | 
          
              | Protein Coding Gene | 
              
                | Type: | protein_coding_gene |  
                | Organism: | Mus caroli |  | • • • • • | 
          
              | Protein Coding Gene | 
              
                | Type: | protein_coding_gene |  
                | Organism: | mouse, laboratory |  | • • • • • | 
          
              | Protein Coding Gene | 
              
                | Type: | protein_coding_gene |  
                | Organism: | mouse, laboratory |  | • • • • • | 
          
              | Protein Coding Gene | 
              
                | Type: | protein_coding_gene |  
                | Organism: | mouse, laboratory |  | • • • • • | 
          
              | Protein Coding Gene | 
              
                | Type: | protein_coding_gene |  
                | Organism: | mouse, laboratory |  | • • • • • | 
          
              | Protein Coding Gene | 
              
                | Type: | protein_coding_gene |  
                | Organism: | mouse, laboratory |  | • • • • • | 
          
              | Protein Coding Gene | 
              
                | Type: | protein_coding_gene |  
                | Organism: | mouse, laboratory |  | • • • • • | 
          
              | Protein Coding Gene | 
              
                | Type: | protein_coding_gene |  
                | Organism: | mouse, laboratory |  | • • • • • | 
          
              | Protein Coding Gene | 
              
                | Type: | protein_coding_gene |  
                | Organism: | mouse, laboratory |  | • • • • • | 
          
              | Protein Coding Gene | 
              
                | Type: | protein_coding_gene |  
                | Organism: | mouse, laboratory |  | • • • • • | 
          
              | Protein Coding Gene | 
              
                | Type: | protein_coding_gene |  
                | Organism: | mouse, laboratory |  | • • • • • | 
          
              | Protein Coding Gene | 
              
                | Type: | protein_coding_gene |  
                | Organism: | mouse, laboratory |  | • • • • • | 
          
              | Protein Coding Gene | 
              
                | Type: | protein_coding_gene |  
                | Organism: | mouse, laboratory |  | • • • • • | 
          
              | Protein Coding Gene | 
              
                | Type: | protein_coding_gene |  
                | Organism: | mouse, laboratory |  | • • • • • | 
          
              | Protein Coding Gene | 
              
                | Type: | protein_coding_gene |  
                | Organism: | mouse, laboratory |  | • • • • • | 
          
              | Protein Coding Gene | 
              
                | Type: | protein_coding_gene |  
                | Organism: | mouse, laboratory |  | • • • • • | 
          
              | Protein Coding Gene | 
              
                | Type: | protein_coding_gene |  
                | Organism: | mouse, laboratory |  | • • • • • | 
          
              | Protein Coding Gene | 
              
                | Type: | protein_coding_gene |  
                | Organism: | Mus pahari |  | • • • • • | 
          
              | Protein Coding Gene | 
              
                | Type: | protein_coding_gene |  
                | Organism: | Mus spretus |  | • • • • • | 
          
              | GXD Expression | 
              
                | Probe: | MGI:6430753 |  
                | Assay Type: | RT-PCR |  
                | Annotation Date: | 2020-06-01 |  
                | Strength: | Present |  
                | Sex: | Not Specified |  
                | Emaps: | EMAPS:1754426 |  
                |  |  
                | Stage: | TS26 |  
                | Assay Id: | MGI:6430765 |  
                | Age: | embryonic day 18.5 |  
                |  |  
                |  |  
                | Specimen Label: | Gm17296 |  
                | Detected: | true |  
                | Specimen Num: | 1 |  | • • • • • | 
          
              | GXD Expression | 
              
                |  |  
                | Assay Type: | In situ reporter (knock in) |  
                | Annotation Date: | 2021-04-16 |  
                | Strength: | Present |  
                | Sex: | Male |  
                | Emaps: | EMAPS:1706828 |  
                | Pattern: | Not Specified |  
                | Stage: | TS28 |  
                | Assay Id: | MGI:6692956 |  
                | Age: | postnatal adult |  
                | Image: | BCM_1287019 |  
                |  |  
                | Specimen Label: | BCM_1287019 |  
                | Detected: | true |  
                | Specimen Num: | 2 |  | • • • • • | 
          
              | GXD Expression | 
              
                |  |  
                | Assay Type: | In situ reporter (knock in) |  
                | Annotation Date: | 2021-04-16 |  
                | Strength: | Present |  
                | Sex: | Male |  
                | Emaps: | EMAPS:1868128 |  
                | Pattern: | Not Specified |  
                | Stage: | TS28 |  
                | Assay Id: | MGI:6692956 |  
                | Age: | postnatal adult |  
                | Image: | BCM_1287021 |  
                | Note: | vas deferens |  
                | Specimen Label: | BCM_1287021 |  
                | Detected: | true |  
                | Specimen Num: | 3 |  | • • • • • | 
          
              | GXD Expression | 
              
                |  |  
                | Assay Type: | In situ reporter (knock in) |  
                | Annotation Date: | 2021-04-16 |  
                | Strength: | Present |  
                | Sex: | Male |  
                | Emaps: | EMAPS:1868128 |  
                | Pattern: | Not Specified |  
                | Stage: | TS28 |  
                | Assay Id: | MGI:6692956 |  
                | Age: | postnatal adult |  
                | Image: | BCM_1287023 |  
                | Note: | vas deferens |  
                | Specimen Label: | BCM_1287023 |  
                | Detected: | true |  
                | Specimen Num: | 4 |  | • • • • • | 
          
              | GXD Expression | 
              
                |  |  
                | Assay Type: | In situ reporter (knock in) |  
                | Annotation Date: | 2021-04-16 |  
                | Strength: | Present |  
                | Sex: | Female |  
                | Emaps: | EMAPS:1898428 |  
                | Pattern: | Not Specified |  
                | Stage: | TS28 |  
                | Assay Id: | MGI:6692956 |  
                | Age: | postnatal adult |  
                | Image: | BCM_1287027 |  
                |  |  
                | Specimen Label: | BCM_1287027 |  
                | Detected: | true |  
                | Specimen Num: | 1 |  | • • • • • | 
          
              | GXD Expression | 
              
                |  |  
                | Assay Type: | In situ reporter (knock in) |  
                | Annotation Date: | 2021-04-16 |  
                | Strength: | Present |  
                | Sex: | Male |  
                | Emaps: | EMAPS:1610528 |  
                | Pattern: | Not Specified |  
                | Stage: | TS28 |  
                | Assay Id: | MGI:6692956 |  
                | Age: | postnatal adult |  
                | Image: | BCM_1287025 |  
                |  |  
                | Specimen Label: | BCM_1287025 |  
                | Detected: | true |  
                | Specimen Num: | 5 |  | • • • • • | 
          
              | GXD Expression | 
              
                |  |  
                | Assay Type: | In situ reporter (knock in) |  
                | Annotation Date: | 2021-04-16 |  
                | Strength: | Present |  
                | Sex: | Male |  
                | Emaps: | EMAPS:1797228 |  
                | Pattern: | Not Specified |  
                | Stage: | TS28 |  
                | Assay Id: | MGI:6692956 |  
                | Age: | postnatal adult |  
                | Image: | BCM_1287021 |  
                |  |  
                | Specimen Label: | BCM_1287021 |  
                | Detected: | true |  
                | Specimen Num: | 3 |  | • • • • • | 
          
              | GXD Expression | 
              
                |  |  
                | Assay Type: | In situ reporter (knock in) |  
                | Annotation Date: | 2021-04-16 |  
                | Strength: | Present |  
                | Sex: | Male |  
                | Emaps: | EMAPS:1928728 |  
                | Pattern: | Not Specified |  
                | Stage: | TS28 |  
                | Assay Id: | MGI:6692956 |  
                | Age: | postnatal adult |  
                | Image: | BCM_1287023 |  
                |  |  
                | Specimen Label: | BCM_1287023 |  
                | Detected: | true |  
                | Specimen Num: | 4 |  | • • • • • | 
          
              | GXD Expression | 
              
                |  |  
                | Assay Type: | In situ reporter (knock in) |  
                | Annotation Date: | 2021-04-16 |  
                | Strength: | Present |  
                | Sex: | Female |  
                | Emaps: | EMAPS:2991528 |  
                | Pattern: | Not Specified |  
                | Stage: | TS28 |  
                | Assay Id: | MGI:6692956 |  
                | Age: | postnatal adult |  
                | Image: | BCM_1287027 |  
                |  |  
                | Specimen Label: | BCM_1287027 |  
                | Detected: | true |  
                | Specimen Num: | 1 |  | • • • • • | 
          
              | GXD Expression | 
              
                |  |  
                | Assay Type: | In situ reporter (knock in) |  
                | Annotation Date: | 2021-04-16 |  
                | Strength: | Present |  
                | Sex: | Female |  
                | Emaps: | EMAPS:1796228 |  
                | Pattern: | Not Specified |  
                | Stage: | TS28 |  
                | Assay Id: | MGI:6692956 |  
                | Age: | postnatal adult |  
                | Image: | BCM_1287027 |  
                |  |  
                | Specimen Label: | BCM_1287027 |  
                | Detected: | true |  
                | Specimen Num: | 1 |  | • • • • • | 
          
              | Publication | 
              
                | First Author: | Wang YM |  
                | Year: | 2019 |  
                | Journal: | Cell Death Differ |  
                | Title: | MicroRNA-197 controls ADAM10 expression to mediate MeCP2's role in the differentiation of neuronal progenitors. |  
                | Volume: | 26 |  
                | Issue: | 10 |  
                | Pages: | 1863-1879 |  | • • • • • | 
          
              | Publication | 
              
                | First Author: | Hansen J |  
                | Year: | 2003 |  
                | Journal: | Proc Natl Acad Sci U S A |  
                | Title: | A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome. |  
                | Volume: | 100 |  
                | Issue: | 17 |  
                | Pages: | 9918-22 |  | • • • • • | 
          
              | Publication | 
              
                | First Author: | Koscielny G |  
                | Year: | 2014 |  
                | Journal: | Nucleic Acids Res |  
                | Title: | The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. |  
                | Volume: | 42 |  
                | Issue: | Database issue |  
                | Pages: | D802-9 |  | • • • • • | 
          
              | Publication | 
              
                | First Author: | Stryke D |  
                | Year: | 2003 |  
                | Journal: | Nucleic Acids Res |  
                | Title: | BayGenomics: a resource of insertional mutations in mouse embryonic stem cells. |  
                | Volume: | 31 |  
                | Issue: | 1 |  
                | Pages: | 278-81 |  | • • • • • | 
          
              | Publication | 
              
                | First Author: | International Knockout Mouse Consortium |  
                | Year: | 2014 |  
                | Journal: | Database Download |  
                | Title: | MGI download of modified allele data from IKMC and creation of new knockout alleles |  
                |  |  
                |  |  
                |  |  | • • • • • | 
          
              | Publication | 
              
                | First Author: | International Mouse Strain Resource |  
                | Year: | 2014 |  
                | Journal: | Database Download |  
                | Title: | MGI download of germline transmission data for alleles from IMSR strain data |  
                |  |  
                |  |  
                |  |  | • • • • • | 
          
              | Publication | 
              
                | First Author: | Mouse Genome Informatics and the International Mouse Phenotyping Consortium (IMPC) |  
                | Year: | 2014 |  
                | Journal: | Database Release |  
                | Title: | Obtaining and Loading Phenotype Annotations from the International Mouse Phenotyping Consortium (IMPC) Database |  
                |  |  
                |  |  
                |  |  | • • • • • | 
          
              | Publication | 
              
                | First Author: | Helmholtz Zentrum Muenchen GmbH |  
                | Year: | 2010 |  
                | Journal: | MGI Direct Data Submission |  
                | Title: | Alleles produced for the EUCOMM and EUCOMMTools projects by the Helmholtz Zentrum Muenchen GmbH (Hmgu) |  
                |  |  
                |  |  
                |  |  | • • • • • | 
          
              | Publication | 
              
                | First Author: | Adams DJ |  
                | Year: | 2024 |  
                | Journal: | Nature |  
                | Title: | Genetic determinants of micronucleus formation in vivo. |  
                | Volume: | 627 |  
                | Issue: | 8002 |  
                | Pages: | 130-136 |  | • • • • • | 
          
              | Publication | 
              
                | First Author: | MGD Nomenclature Committee |  
                | Year: | 1995 |  
                |  |  
                | Title: | Nomenclature Committee Use |  
                |  |  
                |  |  
                |  |  | • • • • • | 
          
              | Publication | 
              
                | First Author: | Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI) |  
                | Year: | 2008 |  
                | Journal: | Database Download |  
                | Title: | Mouse Gene Trap Data Load from dbGSS |  
                |  |  
                |  |  
                |  |  | • • • • • | 
          
              | Publication | 
              
                | First Author: | Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas |  
                | Year: | 2010 |  
                |  |  
                | Title: | Annotation inferences using phylogenetic trees |  
                |  |  
                |  |  
                |  |  | • • • • • | 
          
              | Publication | 
              
                | First Author: | Mouse Genome Database and National Center for Biotechnology Information |  
                | Year: | 2000 |  
                | Journal: | Database Release |  
                | Title: | Entrez Gene Load |  
                |  |  
                |  |  
                |  |  | • • • • • | 
          
              | Publication | 
              
                | First Author: | Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI) |  
                | Year: | 2010 |  
                | Journal: | Database Download |  
                | Title: | Consensus CDS project |  
                |  |  
                |  |  
                |  |  | • • • • • | 
          
              | Publication | 
              
                | First Author: | Bairoch A |  
                | Year: | 1999 |  
                | Journal: | Database Release |  
                | Title: | SWISS-PROT Annotated protein sequence database |  
                |  |  
                |  |  
                |  |  | • • • • • | 
          
              | Publication | 
              
                | First Author: | Mouse Genome Informatics Scientific Curators |  
                | Year: | 2005 |  
                |  |  
                | Title: | Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations |  
                |  |  
                |  |  
                |  |  | • • • • • | 
          
              | Publication | 
              
                | First Author: | Mouse Genome Informatics Scientific Curators |  
                | Year: | 2005 |  
                |  |  
                | Title: | Obtaining and loading genome assembly coordinates from NCBI annotations |  
                |  |  
                |  |  
                |  |  | • • • • • | 
          
              | Gene | 
              
                | Type: | gene |  
                | Organism: | zebrafish |  | • • • • • | 
          
              | Protein Domain | 
              
                | Type: | Family |  
                | Description: | This family includes TAR RNA-binding protein 1 (TARBP1), which is a probable S-adenosyl-L-methionine-dependent methyltransferase that methylates RNA molecules such as tRNAs. During infection by HIV-1, it binds to the loop region of TAR RNA, a region also bound by RNA polymerase II [, , ]. |  | • • • • • | 
          
              | Publication | 
              
                | First Author: | Wu-Baer F |  
                | Year: | 1995 |  
                | Journal: | EMBO J |  
                | Title: | The cellular factor TRP-185 regulates RNA polymerase II binding to HIV-1 TAR RNA. |  
                | Volume: | 14 |  
                | Issue: | 23 |  
                | Pages: | 5995-6009 |  | • • • • • | 
          
              | Publication | 
              
                | First Author: | Wu-Baer F |  
                | Year: | 1996 |  
                | Journal: | J Biol Chem |  
                | Title: | Identification of a group of cellular cofactors that stimulate the binding of RNA polymerase II and TRP-185 to human immunodeficiency virus 1 TAR RNA. |  
                | Volume: | 271 |  
                | Issue: | 8 |  
                | Pages: | 4201-8 |  | • • • • • | 
          
              | Publication | 
              
                | First Author: | Wu-Baer F |  
                | Year: | 1995 |  
                | Journal: | Proc Natl Acad Sci U S A |  
                | Title: | Specific binding of RNA polymerase II to the human immunodeficiency virus trans-activating region RNA is regulated by cellular cofactors and Tat. |  
                | Volume: | 92 |  
                | Issue: | 16 |  
                | Pages: | 7153-7 |  | • • • • • | 
          
              | Protein | 
              
                | Organism: | Mus musculus/domesticus |  
                | Length: | 1579  |  
                | Fragment?: | false |  | • • • • • | 
          
              | Publication | 
              
                | First Author: | Anantharaman V |  
                | Year: | 2002 |  
                | Journal: | J Mol Microbiol Biotechnol |  
                | Title: | SPOUT: a class of methyltransferases that includes spoU and trmD RNA methylase superfamilies, and novel superfamilies of predicted prokaryotic RNA methylases. |  
                | Volume: | 4 |  
                | Issue: | 1 |  
                | Pages: | 71-5 |  | • • • • • | 
          
              | Publication | 
              
                | First Author: | Freund I |  
                | Year: | 2019 |  
                | Journal: | RNA |  
                | Title: | 2'-O-methylation within prokaryotic and eukaryotic tRNA inhibits innate immune activation by endosomal Toll-like receptors but does not affect recognition of whole organisms. |  
                | Volume: | 25 |  
                | Issue: | 7 |  
                | Pages: | 869-880 |  | • • • • • | 
          
              | Publication | 
              
                | First Author: | Endres L |  
                | Year: | 2020 |  
                | Journal: | PLoS One |  
                | Title: | 2'-O-ribose methylation of transfer RNA promotes recovery from oxidative stress in Saccharomyces cerevisiae. |  
                | Volume: | 15 |  
                | Issue: | 2 |  
                | Pages: | e0229103 |  | • • • • • | 
          
              | Protein Domain | 
              
                | Type: | Domain |  
                | Description: | This entry represents the C-terminal methyltransferase domain of TARBP1 and Trm3 [].Yeast tRNA (guanosine(18)-2'-O)-methyltransferase Trm3 catalyses the formation of 2'-O-methylguanosine at position 18 (Gm18) in various tRNAs []. Trm3 is similar to C-terminal domain of TAR (HIV-1) RNA binding protein 1 (TARBP1), a protein binding to TAR, which functions as a RNA regulatory signal by forming a stable stem-loop structure to which transactivator protein Tat binds. The role of TARBP1 is believed to be to disengage RNA polymerase II from TAR during transcriptional elongation  [, ]. |  | • • • • • | 
          
              | Protein Domain | 
              
                | Type: | Family |  
                | Description: | This entry includes a group of putative methyltransferases, including TARBP1 from humans and Trm3 from Saccharomyces cerevisiae. TARBP1 (TAR RNA-binding protein 1) plays a role in HIV-1 infection by binding to the loop region of TAR RNA, a region also bound by RNA polymerase II [, , ]. Its dimerization may have a critical role in its activity []. Trm3 catalyses a specific methylation of the guanosine nucleotide at position 18 of the tRNAs. It is involved in the cellular response to oxidative stress, and its activity may play a role on innate response [, ]. |  | • • • • • | 
          
              | Publication | 
              
                | First Author: | Wu H |  
                | Year: | 2008 |  
                | Journal: | Proteins |  
                | Title: | Crystal structure of the methyltransferase domain of human TARBP1. |  
                | Volume: | 72 |  
                | Issue: | 1 |  
                | Pages: | 519-25 |  | • • • • • | 
          
              | Publication | 
              
                | First Author: | Cavaillé J |  
                | Year: | 1999 |  
                | Journal: | RNA |  
                | Title: | The yeast Saccharomyces cerevisiae YDL112w ORF encodes the putative 2'-O-ribose methyltransferase catalyzing the formation of Gm18 in tRNAs. |  
                | Volume: | 5 |  
                | Issue: | 1 |  
                | Pages: | 66-81 |  | • • • • • | 
          
              | Publication | 
              
                | First Author: | Gatignol A |  
                | Year: | 1991 |  
                | Journal: | Science |  
                | Title: | Characterization of a human TAR RNA-binding protein that activates the HIV-1 LTR. |  
                | Volume: | 251 |  
                | Issue: | 5001 |  
                | Pages: | 1597-600 |  | • • • • • |