Type |
Details |
Score |
Gene |
Type: |
gene |
Organism: |
human |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
chimpanzee |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
dog, domestic |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
cattle |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
macaque, rhesus |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
frog, western clawed |
|
•
•
•
•
•
|
Gene |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
chicken |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
zebrafish |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
Mus caroli |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
Mus pahari |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
Mus spretus |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6430753 |
Assay Type: |
RT-PCR |
Annotation Date: |
2020-06-01 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1754426 |
|
Stage: |
TS26 |
Assay Id: |
MGI:6430765 |
Age: |
embryonic day 18.5 |
|
|
Specimen Label: |
Gm17296 |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
|
Assay Type: |
In situ reporter (knock in) |
Annotation Date: |
2021-04-16 |
Strength: |
Present |
Sex: |
Male |
Emaps: |
EMAPS:1706828 |
Pattern: |
Not Specified |
Stage: |
TS28 |
Assay Id: |
MGI:6692956 |
Age: |
postnatal adult |
Image: |
BCM_1287019 |
|
Specimen Label: |
BCM_1287019 |
Detected: |
true |
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
|
Assay Type: |
In situ reporter (knock in) |
Annotation Date: |
2021-04-16 |
Strength: |
Present |
Sex: |
Male |
Emaps: |
EMAPS:1868128 |
Pattern: |
Not Specified |
Stage: |
TS28 |
Assay Id: |
MGI:6692956 |
Age: |
postnatal adult |
Image: |
BCM_1287021 |
Note: |
vas deferens |
Specimen Label: |
BCM_1287021 |
Detected: |
true |
Specimen Num: |
3 |
|
•
•
•
•
•
|
GXD Expression |
|
Assay Type: |
In situ reporter (knock in) |
Annotation Date: |
2021-04-16 |
Strength: |
Present |
Sex: |
Male |
Emaps: |
EMAPS:1868128 |
Pattern: |
Not Specified |
Stage: |
TS28 |
Assay Id: |
MGI:6692956 |
Age: |
postnatal adult |
Image: |
BCM_1287023 |
Note: |
vas deferens |
Specimen Label: |
BCM_1287023 |
Detected: |
true |
Specimen Num: |
4 |
|
•
•
•
•
•
|
GXD Expression |
|
Assay Type: |
In situ reporter (knock in) |
Annotation Date: |
2021-04-16 |
Strength: |
Present |
Sex: |
Female |
Emaps: |
EMAPS:1898428 |
Pattern: |
Not Specified |
Stage: |
TS28 |
Assay Id: |
MGI:6692956 |
Age: |
postnatal adult |
Image: |
BCM_1287027 |
|
Specimen Label: |
BCM_1287027 |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
|
Assay Type: |
In situ reporter (knock in) |
Annotation Date: |
2021-04-16 |
Strength: |
Present |
Sex: |
Male |
Emaps: |
EMAPS:1610528 |
Pattern: |
Not Specified |
Stage: |
TS28 |
Assay Id: |
MGI:6692956 |
Age: |
postnatal adult |
Image: |
BCM_1287025 |
|
Specimen Label: |
BCM_1287025 |
Detected: |
true |
Specimen Num: |
5 |
|
•
•
•
•
•
|
GXD Expression |
|
Assay Type: |
In situ reporter (knock in) |
Annotation Date: |
2021-04-16 |
Strength: |
Present |
Sex: |
Male |
Emaps: |
EMAPS:1797228 |
Pattern: |
Not Specified |
Stage: |
TS28 |
Assay Id: |
MGI:6692956 |
Age: |
postnatal adult |
Image: |
BCM_1287021 |
|
Specimen Label: |
BCM_1287021 |
Detected: |
true |
Specimen Num: |
3 |
|
•
•
•
•
•
|
GXD Expression |
|
Assay Type: |
In situ reporter (knock in) |
Annotation Date: |
2021-04-16 |
Strength: |
Present |
Sex: |
Male |
Emaps: |
EMAPS:1928728 |
Pattern: |
Not Specified |
Stage: |
TS28 |
Assay Id: |
MGI:6692956 |
Age: |
postnatal adult |
Image: |
BCM_1287023 |
|
Specimen Label: |
BCM_1287023 |
Detected: |
true |
Specimen Num: |
4 |
|
•
•
•
•
•
|
GXD Expression |
|
Assay Type: |
In situ reporter (knock in) |
Annotation Date: |
2021-04-16 |
Strength: |
Present |
Sex: |
Female |
Emaps: |
EMAPS:2991528 |
Pattern: |
Not Specified |
Stage: |
TS28 |
Assay Id: |
MGI:6692956 |
Age: |
postnatal adult |
Image: |
BCM_1287027 |
|
Specimen Label: |
BCM_1287027 |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
|
Assay Type: |
In situ reporter (knock in) |
Annotation Date: |
2021-04-16 |
Strength: |
Present |
Sex: |
Female |
Emaps: |
EMAPS:1796228 |
Pattern: |
Not Specified |
Stage: |
TS28 |
Assay Id: |
MGI:6692956 |
Age: |
postnatal adult |
Image: |
BCM_1287027 |
|
Specimen Label: |
BCM_1287027 |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
Publication |
First Author: |
Wang YM |
Year: |
2019 |
Journal: |
Cell Death Differ |
Title: |
MicroRNA-197 controls ADAM10 expression to mediate MeCP2's role in the differentiation of neuronal progenitors. |
Volume: |
26 |
Issue: |
10 |
Pages: |
1863-1879 |
|
•
•
•
•
•
|
Publication |
First Author: |
Hansen J |
Year: |
2003 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome. |
Volume: |
100 |
Issue: |
17 |
Pages: |
9918-22 |
|
•
•
•
•
•
|
Publication |
First Author: |
Koscielny G |
Year: |
2014 |
Journal: |
Nucleic Acids Res |
Title: |
The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. |
Volume: |
42 |
Issue: |
Database issue |
Pages: |
D802-9 |
|
•
•
•
•
•
|
Publication |
First Author: |
Stryke D |
Year: |
2003 |
Journal: |
Nucleic Acids Res |
Title: |
BayGenomics: a resource of insertional mutations in mouse embryonic stem cells. |
Volume: |
31 |
Issue: |
1 |
Pages: |
278-81 |
|
•
•
•
•
•
|
Publication |
First Author: |
International Knockout Mouse Consortium |
Year: |
2014 |
Journal: |
Database Download |
Title: |
MGI download of modified allele data from IKMC and creation of new knockout alleles |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
International Mouse Strain Resource |
Year: |
2014 |
Journal: |
Database Download |
Title: |
MGI download of germline transmission data for alleles from IMSR strain data |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics and the International Mouse Phenotyping Consortium (IMPC) |
Year: |
2014 |
Journal: |
Database Release |
Title: |
Obtaining and Loading Phenotype Annotations from the International Mouse Phenotyping Consortium (IMPC) Database |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Helmholtz Zentrum Muenchen GmbH |
Year: |
2010 |
Journal: |
MGI Direct Data Submission |
Title: |
Alleles produced for the EUCOMM and EUCOMMTools projects by the Helmholtz Zentrum Muenchen GmbH (Hmgu) |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Adams DJ |
Year: |
2024 |
Journal: |
Nature |
Title: |
Genetic determinants of micronucleus formation in vivo. |
Volume: |
627 |
Issue: |
8002 |
Pages: |
130-136 |
|
•
•
•
•
•
|
Publication |
First Author: |
MGD Nomenclature Committee |
Year: |
1995 |
|
Title: |
Nomenclature Committee Use |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI) |
Year: |
2008 |
Journal: |
Database Download |
Title: |
Mouse Gene Trap Data Load from dbGSS |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas |
Year: |
2010 |
|
Title: |
Annotation inferences using phylogenetic trees |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Database and National Center for Biotechnology Information |
Year: |
2000 |
Journal: |
Database Release |
Title: |
Entrez Gene Load |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI) |
Year: |
2010 |
Journal: |
Database Download |
Title: |
Consensus CDS project |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Bairoch A |
Year: |
1999 |
Journal: |
Database Release |
Title: |
SWISS-PROT Annotated protein sequence database |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2005 |
|
Title: |
Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2005 |
|
Title: |
Obtaining and loading genome assembly coordinates from NCBI annotations |
|
|
|
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
zebrafish |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Family |
Description: |
This family includes TAR RNA-binding protein 1 (TARBP1), which is a probable S-adenosyl-L-methionine-dependent methyltransferase that methylates RNA molecules such as tRNAs. During infection by HIV-1, it binds to the loop region of TAR RNA, a region also bound by RNA polymerase II [, , ]. |
|
•
•
•
•
•
|
Publication |
First Author: |
Wu-Baer F |
Year: |
1995 |
Journal: |
EMBO J |
Title: |
The cellular factor TRP-185 regulates RNA polymerase II binding to HIV-1 TAR RNA. |
Volume: |
14 |
Issue: |
23 |
Pages: |
5995-6009 |
|
•
•
•
•
•
|
Publication |
First Author: |
Wu-Baer F |
Year: |
1996 |
Journal: |
J Biol Chem |
Title: |
Identification of a group of cellular cofactors that stimulate the binding of RNA polymerase II and TRP-185 to human immunodeficiency virus 1 TAR RNA. |
Volume: |
271 |
Issue: |
8 |
Pages: |
4201-8 |
|
•
•
•
•
•
|
Publication |
First Author: |
Wu-Baer F |
Year: |
1995 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Specific binding of RNA polymerase II to the human immunodeficiency virus trans-activating region RNA is regulated by cellular cofactors and Tat. |
Volume: |
92 |
Issue: |
16 |
Pages: |
7153-7 |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
1579
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Publication |
First Author: |
Anantharaman V |
Year: |
2002 |
Journal: |
J Mol Microbiol Biotechnol |
Title: |
SPOUT: a class of methyltransferases that includes spoU and trmD RNA methylase superfamilies, and novel superfamilies of predicted prokaryotic RNA methylases. |
Volume: |
4 |
Issue: |
1 |
Pages: |
71-5 |
|
•
•
•
•
•
|
Publication |
First Author: |
Freund I |
Year: |
2019 |
Journal: |
RNA |
Title: |
2'-O-methylation within prokaryotic and eukaryotic tRNA inhibits innate immune activation by endosomal Toll-like receptors but does not affect recognition of whole organisms. |
Volume: |
25 |
Issue: |
7 |
Pages: |
869-880 |
|
•
•
•
•
•
|
Publication |
First Author: |
Endres L |
Year: |
2020 |
Journal: |
PLoS One |
Title: |
2'-O-ribose methylation of transfer RNA promotes recovery from oxidative stress in Saccharomyces cerevisiae. |
Volume: |
15 |
Issue: |
2 |
Pages: |
e0229103 |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Domain |
Description: |
This entry represents the C-terminal methyltransferase domain of TARBP1 and Trm3 [].Yeast tRNA (guanosine(18)-2'-O)-methyltransferase Trm3 catalyses the formation of 2'-O-methylguanosine at position 18 (Gm18) in various tRNAs []. Trm3 is similar to C-terminal domain of TAR (HIV-1) RNA binding protein 1 (TARBP1), a protein binding to TAR, which functions as a RNA regulatory signal by forming a stable stem-loop structure to which transactivator protein Tat binds. The role of TARBP1 is believed to be to disengage RNA polymerase II from TAR during transcriptional elongation [, ]. |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Family |
Description: |
This entry includes a group of putative methyltransferases, including TARBP1 from humans and Trm3 from Saccharomyces cerevisiae. TARBP1 (TAR RNA-binding protein 1) plays a role in HIV-1 infection by binding to the loop region of TAR RNA, a region also bound by RNA polymerase II [, , ]. Its dimerization may have a critical role in its activity []. Trm3 catalyses a specific methylation of the guanosine nucleotide at position 18 of the tRNAs. It is involved in the cellular response to oxidative stress, and its activity may play a role on innate response [, ]. |
|
•
•
•
•
•
|
Publication |
First Author: |
Wu H |
Year: |
2008 |
Journal: |
Proteins |
Title: |
Crystal structure of the methyltransferase domain of human TARBP1. |
Volume: |
72 |
Issue: |
1 |
Pages: |
519-25 |
|
•
•
•
•
•
|
Publication |
First Author: |
Cavaillé J |
Year: |
1999 |
Journal: |
RNA |
Title: |
The yeast Saccharomyces cerevisiae YDL112w ORF encodes the putative 2'-O-ribose methyltransferase catalyzing the formation of Gm18 in tRNAs. |
Volume: |
5 |
Issue: |
1 |
Pages: |
66-81 |
|
•
•
•
•
•
|
Publication |
First Author: |
Gatignol A |
Year: |
1991 |
Journal: |
Science |
Title: |
Characterization of a human TAR RNA-binding protein that activates the HIV-1 LTR. |
Volume: |
251 |
Issue: |
5001 |
Pages: |
1597-600 |
|
•
•
•
•
•
|