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Search results 1 to 100 out of 735 for Tardbp

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Categories

Hits by Category

Hits by Strain

Type Details Score
Gene
23435 | TARDBP
Type: gene
Organism: human
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Gene
394651 | tardbp
Type: gene
Organism: frog, western clawed
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Gene
107974879 | TARDBP
Type: gene
Organism: chimpanzee
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Gene
298648 | Tardbp
Type: gene
Organism: rat
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Gene
478234 | TARDBP
Type: gene
Organism: dog, domestic
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Gene
540632 | TARDBP
Type: gene
Organism: cattle
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Gene
419453 | TARDBP
Type: gene
Organism: chicken
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Gene
100423163 | TARDBP
Type: gene
Organism: macaque, rhesus
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Protein Coding Gene
MGI:2387629 | Tardbp
Type: protein_coding_gene
Organism: mouse, laboratory
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GXD Expression
GXD Expression
Probe: MGI:4418852
Assay Type: Immunohistochemistry
Annotation Date: 2010-01-27
Strength: Present
Sex: Not Specified
Emaps: EMAPS:360354
Pattern: Regionally restricted
Stage: TS04
Assay Id: MGI:4418871
Age: embryonic day 3.5
Image: 3b Tardbp +/-
Note: Expression mainly in the nuclei.
Specimen Label: 3b Tardbp +/-
Detected: true
Specimen Num: 5
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Gene
440142 | TARDBPP2
Type: gene
Organism: human
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Gene
643387 | TARDBPP3
Type: gene
Organism: human
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Gene
643503 | TARDBPP1
Type: gene
Organism: human
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Gene
100128540 | TARDBPP4
Type: gene
Organism: human
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Gene
100996860 | TARDBPP5
Type: gene
Organism: human
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Publication
24740308 | J:215201
First Author: Dib S
Year: 2014
Journal: PLoS One
Title: Gene targeting of mouse Tardbp negatively affects Masp2 expression.
Volume: 9
Issue: 4
Pages: e95373
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Publication
30625319 | J:283769
First Author: Ebstein SY
Year: 2019
Journal: Cell Rep
Title: Mutant TDP-43 Causes Early-Stage Dose-Dependent Motor Neuron Degeneration in a TARDBP Knockin Mouse Model of ALS.
Volume: 26
Issue: 2
Pages: 364-373.e4
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Publication
34988393 | J:342505
First Author: Devoy A
Year: 2021
Journal: iScience
Title: Generation and analysis of innovative genomically humanized knockin SOD1, TARDBP (TDP-43), and FUS mouse models.
Volume: 24
Issue: 12
Pages: 103463
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Publication
29556029 | J:261673
First Author: White MA
Year: 2018
Journal: Nat Neurosci
Title: TDP-43 gains function due to perturbed autoregulation in a Tardbp knock-in mouse model of ALS-FTD.
Volume: 21
Issue: 4
Pages: 552-563
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Publication
25678563 | J:292536
First Author: Lauranzano E
Year: 2015
Journal: Brain
Title: Peptidylprolyl isomerase A governs TARDBP function and assembly in heterogeneous nuclear ribonucleoprotein complexes.
Volume: 138
Issue: Pt 4
Pages: 974-91
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Publication
24465814 | J:211620
First Author: Ricketts T
Year: 2014
Journal: PLoS One
Title: A nonsense mutation in mouse Tardbp affects TDP43 alternative splicing activity and causes limb-clasping and body tone defects.
Volume: 9
Issue: 1
Pages: e85962
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Publication
23798570 | J:201688
First Author: Dang TN
Year: 2013
Journal: Dis Model Mech
Title: Endogenous progesterone levels and frontotemporal dementia: modulation of TDP-43 and Tau levels in vitro and treatment of the A315T TARDBP mouse model.
Volume: 6
Issue: 5
Pages: 1198-204
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Protein
Q8R0B4
Organism: Mus musculus/domesticus
Length: 295  
Fragment?: false
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Protein
Q6VYI4
Organism: Mus musculus/domesticus
Length: 304  
Fragment?: false
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Protein
Q6VYI5
Organism: Mus musculus/domesticus
Length: 302  
Fragment?: false
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Protein
Q8BLD4
Organism: Mus musculus/domesticus
Length: 298  
Fragment?: false
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Publication
31959210 | J:285477
First Author: Watanabe S
Year: 2020
Journal: Mol Brain
Title: ALS-linked TDP-43M337V knock-in mice exhibit splicing deregulation without neurodegeneration.
Volume: 13
Issue: 1
Pages: 8
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Publication
34599968 | J:324061
First Author: Campbell KM
Year: 2021
Journal: J Biol Chem
Title: Loss of TDP-43 in male germ cells causes meiotic failure and impairs fertility in mice.
Volume: 297
Issue: 5
Pages: 101231
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Publication
32558887 | J:291709
First Author: Grønning AGB
Year: 2020
Journal: Nucleic Acids Res
Title: DeepCLIP: predicting the effect of mutations on protein-RNA binding with deep learning.
Volume: 48
Issue: 13
Pages: 7099-7118
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Publication
28129109 | J:277514
First Author: Wang W
Year: 2017
Journal: Mol Ther
Title: Motor-Coordinative and Cognitive Dysfunction Caused by Mutant TDP-43 Could Be Reversed by Inhibiting Its Mitochondrial Localization.
Volume: 25
Issue: 1
Pages: 127-139
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Publication
31242080 | J:313181
First Author: Donde A
Year: 2020
Journal: Autophagy
Title: Upregulation of ATG7 attenuates motor neuron dysfunction associated with depletion of TARDBP/TDP-43.
Volume: 16
Issue: 4
Pages: 672-682
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Publication
28669544 | J:241917
First Author: Paolicelli RC
Year: 2017
Journal: Neuron
Title: TDP-43 Depletion in Microglia Promotes Amyloid Clearance but Also Induces Synapse Loss.
Volume: 95
Issue: 2
Pages: 297-308.e6
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Publication
32187538 | J:287650
First Author: Sleigh JN
Year: 2020
Journal: Cell Rep
Title: Mice Carrying ALS Mutant TDP-43, but Not Mutant FUS, Display In Vivo Defects in Axonal Transport of Signaling Endosomes.
Volume: 30
Issue: 11
Pages: 3655-3662.e2
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Publication
20660762 | J:164406
First Author: Chiang PM
Year: 2010
Journal: Proc Natl Acad Sci U S A
Title: Deletion of TDP-43 down-regulates Tbc1d1, a gene linked to obesity, and alters body fat metabolism.
Volume: 107
Issue: 37
Pages: 16320-4
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Publication
26672899 | J:231836
 
First Author: Hasegawa M
Year: 2016
Journal: Neurosci Res
Title: Analysis of RNA metabolism in peripheral WBCs of TDP-43 KI mice identifies novel biomarkers of ALS.
Volume: 106
Pages: 12-22
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Publication
38300714 | J:361146
 
First Author: Arribas V
Year: 2024
Journal: JCI Insight
Title: Endothelial TDP-43 controls sprouting angiogenesis and vascular barrier integrity, and its deletion triggers neuroinflammation.
Volume: 9
Issue: 5
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Publication
30130494 | J:269757
 
First Author: Tawara N
Year: 2018
Journal: Exp Neurol
Title: Muscle-dominant wild-type TDP-43 expression induces myopathological changes featuring tubular aggregates and TDP-43-positive inclusions.
Volume: 309
Pages: 169-180
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Publication
37460529 | J:338266
First Author: Nie X
Year: 2023
Journal: Nat Commun
Title: Maternal TDP-43 interacts with RNA Pol II and regulates zygotic genome activation.
Volume: 14
Issue: 1
Pages: 4275
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Publication
30377984 | J:329603
First Author: Picher-Martel V
Year: 2019
Journal: Mol Neurobiol
Title: Neuronal Expression of UBQLN2P497H Exacerbates TDP-43 Pathology in TDP-43G348C Mice through Interaction with Ubiquitin.
Volume: 56
Issue: 7
Pages: 4680-4696
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Publication
35311646 | J:333154
   
First Author: Heo D
Year: 2022
Journal: Elife
Title: Stage-specific control of oligodendrocyte survival and morphogenesis by TDP-43.
Volume: 11
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Publication
23922830 | J:203274
First Author: Xu YF
Year: 2013
Journal: PLoS One
Title: The pathological phenotypes of human TDP-43 transgenic mouse models are independent of downregulation of mouse Tdp-43.
Volume: 8
Issue: 7
Pages: e69864
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Publication
32325033 | J:298772
First Author: Pourhaghighi R
Year: 2020
Journal: Cell Syst
Title: BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain.
Volume: 10
Issue: 4
Pages: 333-350.e14
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Publication
34347016 | J:328367
 
First Author: Ho WY
Year: 2021
Journal: J Cell Biol
Title: TDP-43 mediates SREBF2-regulated gene expression required for oligodendrocyte myelination.
Volume: 220
Issue: 9
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Publication
38287033 | J:351186
First Author: Kaye EG
Year: 2024
Journal: Nat Commun
Title: RNA polymerase II pausing is essential during spermatogenesis for appropriate gene expression and completion of meiosis.
Volume: 15
Issue: 1
Pages: 848
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Publication
34687812 | J:324271
 
First Author: Kao TJ
Year: 2022
Journal: Neurosci Res
Title: TDP-43 is essential for Eph receptor-class-specific spinal motor axon trajectory into the limb.
Volume: 176
Pages: 31-39
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Publication
28487370 | J:245965
First Author: Gu J
Year: 2017
Journal: J Biol Chem
Title: Transactive response DNA-binding protein 43 (TDP-43) regulates alternative splicing of tau exon 10: Implications for the pathogenesis of tauopathies.
Volume: 292
Issue: 25
Pages: 10600-10612
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Publication
20014337 | J:155958
First Author: Wu LS
Year: 2010
Journal: Genesis
Title: TDP-43, a neuro-pathosignature factor, is essential for early mouse embryogenesis.
Volume: 48
Issue: 1
Pages: 56-62
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Publication
20198480 | J:158641
First Author: Kraemer BC
Year: 2010
Journal: Acta Neuropathol
Title: Loss of murine TDP-43 disrupts motor function and plays an essential role in embryogenesis.
Volume: 119
Issue: 4
Pages: 409-19
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Publication
33127758 | J:299676
First Author: Peng AYT
Year: 2020
Journal: Proc Natl Acad Sci U S A
Title: Loss of TDP-43 in astrocytes leads to motor deficits by triggering A1-like reactive phenotype and triglial dysfunction.
Volume: 117
Issue: 46
Pages: 29101-29112
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Publication
39305312 | J:357803
First Author: Torres P
Year: 2024
Journal: Acta Neuropathol
Title: TDP-43 regulates LC3ylation in neural tissue through ATG4B cryptic splicing inhibition.
Volume: 148
Issue: 1
Pages: 45
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Publication
35986894 | J:340897
First Author: Zomer HD
Year: 2022
Journal: Biol Reprod
Title: Sertoli cells require TDP-43 to support spermatogenesis†.
Volume: 107
Issue: 5
Pages: 1345-1359
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Publication
23967244 | J:206353
First Author: Stallings NR
Year: 2013
Journal: PLoS One
Title: TDP-43, an ALS linked protein, regulates fat deposition and glucose homeostasis.
Volume: 8
Issue: 8
Pages: e71793
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Publication
20736350 | J:164382
First Author: Shan X
Year: 2010
Journal: Proc Natl Acad Sci U S A
Title: Altered distributions of Gemini of coiled bodies and mitochondria in motor neurons of TDP-43 transgenic mice.
Volume: 107
Issue: 37
Pages: 16325-30
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Publication
22084410 | J:178611
First Author: Swarup V
Year: 2011
Journal: J Exp Med
Title: Deregulation of TDP-43 in amyotrophic lateral sclerosis triggers nuclear factor κB-mediated pathogenic pathways.
Volume: 208
Issue: 12
Pages: 2429-47
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Publication
32371051 | J:294557
First Author: Chan G
Year: 2020
Journal: Am J Pathol
Title: Neurodegeneration and Motor Deficits in the Absence of Astrogliosis upon Transgenic Mutant TDP-43 Expression in Mature Mice.
Volume: 190
Issue: 8
Pages: 1713-1722
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Publication
29577934 | J:264748
First Author: van Hummel A
Year: 2018
Journal: Am J Pathol
Title: Selective Spatiotemporal Vulnerability of Central Nervous System Neurons to Pathologic TAR DNA-Binding Protein 43 in Aged Transgenic Mice.
Volume: 188
Issue: 6
Pages: 1447-1456
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Publication
33149110 | J:306979
First Author: Kim E
Year: 2020
Journal: Transl Psychiatry
Title: Coexistence of perseveration and apathy in the TDP-43Q331K knock-in mouse model of ALS-FTD.
Volume: 10
Issue: 1
Pages: 377
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Publication
31345270 | J:283597
First Author: Nishino K
Year: 2019
Journal: Acta Neuropathol Commun
Title: Mice deficient in the C-terminal domain of TAR DNA-binding protein 43 develop age-dependent motor dysfunction associated with impaired Notch1-Akt signaling pathway.
Volume: 7
Issue: 1
Pages: 118
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Publication
30464263 | J:268274
First Author: Vogler TO
Year: 2018
Journal: Nature
Title: TDP-43 and RNA form amyloid-like myo-granules in regenerating muscle.
Volume: 563
Issue: 7732
Pages: 508-513
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Publication
30373824 | J:267269
First Author: Wang J
Year: 2018
Journal: Proc Natl Acad Sci U S A
Title: Cell-autonomous requirement of TDP-43, an ALS/FTD signature protein, for oligodendrocyte survival and myelination.
Volume: 115
Issue: 46
Pages: E10941-E10950
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Publication
26525917 | J:346362
First Author: MacNair L
Year: 2016
Journal: Brain
Title: MTHFSD and DDX58 are novel RNA-binding proteins abnormally regulated in amyotrophic lateral sclerosis.
Volume: 139
Issue: Pt 1
Pages: 86-100
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Publication
31355778 | J:294122
First Author: Araki K
Year: 2019
Journal: J Clin Invest
Title: TDP-43 regulates early-phase insulin secretion via CaV1.2-mediated exocytosis in islets.
Volume: 129
Issue: 9
Pages: 3578-3593
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Publication
22718760 | J:190254
First Author: Wu LS
Year: 2012
Journal: J Biol Chem
Title: Targeted depletion of TDP-43 expression in the spinal cord motor neurons leads to the development of amyotrophic lateral sclerosis-like phenotypes in mice.
Volume: 287
Issue: 33
Pages: 27335-44
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Publication
24986919 | J:323507
First Author: Galloway JN
Year: 2014
Journal: Hum Mol Genet
Title: CGG repeats in RNA modulate expression of TDP-43 in mouse and fly models of fragile X tremor ataxia syndrome.
Volume: 23
Issue: 22
Pages: 5906-15
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Publication
30692134 | J:278313
 
First Author: Tann JY
Year: 2019
Journal: EMBO J
Title: Abnormal TDP-43 function impairs activity-dependent BDNF secretion, synaptic plasticity, and cognitive behavior through altered Sortilin splicing.
Volume: 38
Issue: 5
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Publication
27785573 | J:319578
First Author: LaClair KD
Year: 2016
Journal: Acta Neuropathol
Title: Depletion of TDP-43 decreases fibril and plaque β-amyloid and exacerbates neurodegeneration in an Alzheimer's mouse model.
Volume: 132
Issue: 6
Pages: 859-873
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Publication
38157451 | J:352540
First Author: Yang X
Year: 2024
Journal: Proc Natl Acad Sci U S A
Title: Excessive nucleic acid R-loops induce mitochondria-dependent epithelial cell necroptosis and drive spontaneous intestinal inflammation.
Volume: 121
Issue: 1
Pages: e2307395120
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Publication
36536457 | J:338954
First Author: Kim DW
Year: 2022
Journal: Mol Neurodegener
Title: Amyloid-beta and tau pathologies act synergistically to induce novel disease stage-specific microglia subtypes.
Volume: 17
Issue: 1
Pages: 83
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Publication
22570411 | J:190257
First Author: Berkovits BD
Year: 2012
Journal: Nucleic Acids Res
Title: The testis-specific double bromodomain-containing protein BRDT forms a complex with multiple spliceosome components and is required for mRNA splicing and 3'-UTR truncation in round spermatids.
Volume: 40
Issue: 15
Pages: 7162-75
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Publication
29764981 | J:265666
 
First Author: Fratta P
Year: 2018
Journal: EMBO J
Title: Mice with endogenous TDP-43 mutations exhibit gain of splicing function and characteristics of amyotrophic lateral sclerosis.
Volume: 37
Issue: 11
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Publication
33689679 | J:303815
   
First Author: Chang KJ
Year: 2021
Journal: Elife
Title: TDP-43 maximizes nerve conduction velocity by repressing a cryptic exon for paranodal junction assembly in Schwann cells.
Volume: 10
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Publication
24120466 | J:206607
 
First Author: Haidet-Phillips AM
Year: 2013
Journal: Exp Neurol
Title: Altered astrocytic expression of TDP-43 does not influence motor neuron survival.
Volume: 250
Pages: 250-9
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Publication
38367882 | J:346070
 
First Author: Godoy-Corchuelo JM
Year: 2024
Journal: Neurobiol Dis
Title: TDP-43-M323K causes abnormal brain development and progressive cognitive and motor deficits associated with mislocalised and increased levels of TDP-43.
Volume: 193
Pages: 106437
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Publication
38343132 | J:347607
First Author: Benzow K
Year: 2024
Journal: Alzheimers Dement
Title: Gene replacement-Alzheimer's disease (GR-AD): Modeling the genetics of human dementias in mice.
Volume: 20
Issue: 4
Pages: 3080-3087
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Protein Coding Gene
MGP_CAROLIEiJ_G0026805 | -
Type: protein_coding_gene
Organism: Mus caroli
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Protein Coding Gene
MGP_129S1SvImJ_G0029129 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AJ_G0029094 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AKRJ_G0029042 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_BALBcJ_G0029110 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C3HHeJ_G0028831 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI_C57BL6J_2387629 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C57BL6NJ_G0029559 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CASTEiJ_G0028244 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CBAJ_G0028793 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_DBA2J_G0028942 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_FVBNJ_G0028906 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_LPJ_G0029032 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NODShiLtJ_G0028933 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NZOHlLtJ_G0029591 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PWKPhJ_G0027964 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_WSBEiJ_G0028324 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PahariEiJ_G0029153 | -
Type: protein_coding_gene
Organism: Mus pahari
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Protein Coding Gene
MGP_SPRETEiJ_G0027798 | -
Type: protein_coding_gene
Organism: Mus spretus
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Publication
23449777 | J:324570
First Author: Iguchi Y
Year: 2013
Journal: Brain
Title: Loss of TDP-43 causes age-dependent progressive motor neuron degeneration.
Volume: 136
Issue: Pt 5
Pages: 1371-82
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Publication
31964415 | J:285792
First Author: Huang SL
Year: 2020
Journal: Acta Neuropathol Commun
Title: A robust TDP-43 knock-in mouse model of ALS.
Volume: 8
Issue: 1
Pages: 3
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Publication
31953403 | J:285640
First Author: Zhao L
Year: 2020
Journal: Nat Commun
Title: TDP-43 facilitates milk lipid secretion by post-transcriptional regulation of Btn1a1 and Xdh.
Volume: 11
Issue: 1
Pages: 341
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Publication
24616503 | J:207750
First Author: Yang C
Year: 2014
Journal: Proc Natl Acad Sci U S A
Title: Partial loss of TDP-43 function causes phenotypes of amyotrophic lateral sclerosis.
Volume: 111
Issue: 12
Pages: E1121-9
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Publication
30922385 | J:290614
First Author: Wu LS
Year: 2019
Journal: Acta Neuropathol Commun
Title: Transcriptomopathies of pre- and post-symptomatic frontotemporal dementia-like mice with TDP-43 depletion in forebrain neurons.
Volume: 7
Issue: 1
Pages: 50
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Publication
22539017 | J:265381
First Author: Cannon A
Year: 2012
Journal: Acta Neuropathol
Title: Neuronal sensitivity to TDP-43 overexpression is dependent on timing of induction.
Volume: 123
Issue: 6
Pages: 807-23
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Publication
25392493 | J:217404
First Author: Alfieri JA
Year: 2014
Journal: J Neurosci
Title: Reversible behavioral phenotypes in a conditional mouse model of TDP-43 proteinopathies.
Volume: 34
Issue: 46
Pages: 15244-59
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

Copyright © 2017 by The Jackson Laboratory. All Rights Reserved

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