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Search results 1 to 100 out of 684 for Tardbp

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Type Details Score
Gene
Type: gene
Organism: human
Gene
Type: gene
Organism: rat
Gene
Type: gene
Organism: dog, domestic
Gene
Type: gene
Organism: cattle
Gene
Type: gene
Organism: chicken
Gene
Type: gene
Organism: macaque, rhesus
Gene
Type: gene
Organism: frog, western clawed
Gene
Type: gene
Organism: chimpanzee
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
GXD Expression
Probe: MGI:4418852
Assay Type: Immunohistochemistry
Annotation Date: 2010-01-27
Strength: Present
Sex: Not Specified
Emaps: EMAPS:360354
Pattern: Regionally restricted
Stage: TS04
Assay Id: MGI:4418871
Age: embryonic day 3.5
Image: 3b Tardbp +/-
Note: Expression mainly in the nuclei.
Specimen Label: 3b Tardbp +/-
Detected: true
Specimen Num: 5
Gene
Type: gene
Organism: human
Gene
Type: gene
Organism: human
Gene
Type: gene
Organism: human
Gene
Type: gene
Organism: human
Gene
Type: gene
Organism: human
Publication
First Author: Dib S
Year: 2014
Journal: PLoS One
Title: Gene targeting of mouse Tardbp negatively affects Masp2 expression.
Volume: 9
Issue: 4
Pages: e95373
Publication
First Author: Ebstein SY
Year: 2019
Journal: Cell Rep
Title: Mutant TDP-43 Causes Early-Stage Dose-Dependent Motor Neuron Degeneration in a TARDBP Knockin Mouse Model of ALS.
Volume: 26
Issue: 2
Pages: 364-373.e4
Publication
First Author: Devoy A
Year: 2021
Journal: iScience
Title: Generation and analysis of innovative genomically humanized knockin SOD1, TARDBP (TDP-43), and FUS mouse models.
Volume: 24
Issue: 12
Pages: 103463
Publication
First Author: White MA
Year: 2018
Journal: Nat Neurosci
Title: TDP-43 gains function due to perturbed autoregulation in a Tardbp knock-in mouse model of ALS-FTD.
Volume: 21
Issue: 4
Pages: 552-563
Publication
First Author: Lauranzano E
Year: 2015
Journal: Brain
Title: Peptidylprolyl isomerase A governs TARDBP function and assembly in heterogeneous nuclear ribonucleoprotein complexes.
Volume: 138
Issue: Pt 4
Pages: 974-91
Publication
First Author: Ricketts T
Year: 2014
Journal: PLoS One
Title: A nonsense mutation in mouse Tardbp affects TDP43 alternative splicing activity and causes limb-clasping and body tone defects.
Volume: 9
Issue: 1
Pages: e85962
Publication
First Author: Dang TN
Year: 2013
Journal: Dis Model Mech
Title: Endogenous progesterone levels and frontotemporal dementia: modulation of TDP-43 and Tau levels in vitro and treatment of the A315T TARDBP mouse model.
Volume: 6
Issue: 5
Pages: 1198-204
Protein
Organism: Mus musculus/domesticus
Length: 295  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 304  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 302  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 298  
Fragment?: false
Publication
First Author: Watanabe S
Year: 2020
Journal: Mol Brain
Title: ALS-linked TDP-43M337V knock-in mice exhibit splicing deregulation without neurodegeneration.
Volume: 13
Issue: 1
Pages: 8
Publication
First Author: Campbell KM
Year: 2021
Journal: J Biol Chem
Title: Loss of TDP-43 in male germ cells causes meiotic failure and impairs fertility in mice.
Volume: 297
Issue: 5
Pages: 101231
Publication
First Author: Wang W
Year: 2017
Journal: Mol Ther
Title: Motor-Coordinative and Cognitive Dysfunction Caused by Mutant TDP-43 Could Be Reversed by Inhibiting Its Mitochondrial Localization.
Volume: 25
Issue: 1
Pages: 127-139
Publication
First Author: Grønning AGB
Year: 2020
Journal: Nucleic Acids Res
Title: DeepCLIP: predicting the effect of mutations on protein-RNA binding with deep learning.
Volume: 48
Issue: 13
Pages: 7099-7118
Publication
First Author: Donde A
Year: 2020
Journal: Autophagy
Title: Upregulation of ATG7 attenuates motor neuron dysfunction associated with depletion of TARDBP/TDP-43.
Volume: 16
Issue: 4
Pages: 672-682
Publication
First Author: Paolicelli RC
Year: 2017
Journal: Neuron
Title: TDP-43 Depletion in Microglia Promotes Amyloid Clearance but Also Induces Synapse Loss.
Volume: 95
Issue: 2
Pages: 297-308.e6
Publication
First Author: Sleigh JN
Year: 2020
Journal: Cell Rep
Title: Mice Carrying ALS Mutant TDP-43, but Not Mutant FUS, Display In Vivo Defects in Axonal Transport of Signaling Endosomes.
Volume: 30
Issue: 11
Pages: 3655-3662.e2
Publication
First Author: Chiang PM
Year: 2010
Journal: Proc Natl Acad Sci U S A
Title: Deletion of TDP-43 down-regulates Tbc1d1, a gene linked to obesity, and alters body fat metabolism.
Volume: 107
Issue: 37
Pages: 16320-4
Publication  
First Author: Tawara N
Year: 2018
Journal: Exp Neurol
Title: Muscle-dominant wild-type TDP-43 expression induces myopathological changes featuring tubular aggregates and TDP-43-positive inclusions.
Volume: 309
Pages: 169-180
Publication  
First Author: Hasegawa M
Year: 2016
Journal: Neurosci Res
Title: Analysis of RNA metabolism in peripheral WBCs of TDP-43 KI mice identifies novel biomarkers of ALS.
Volume: 106
Pages: 12-22
Publication
First Author: Nie X
Year: 2023
Journal: Nat Commun
Title: Maternal TDP-43 interacts with RNA Pol II and regulates zygotic genome activation.
Volume: 14
Issue: 1
Pages: 4275
Publication
First Author: Picher-Martel V
Year: 2019
Journal: Mol Neurobiol
Title: Neuronal Expression of UBQLN2P497H Exacerbates TDP-43 Pathology in TDP-43G348C Mice through Interaction with Ubiquitin.
Volume: 56
Issue: 7
Pages: 4680-4696
Publication    
First Author: Heo D
Year: 2022
Journal: Elife
Title: Stage-specific control of oligodendrocyte survival and morphogenesis by TDP-43.
Volume: 11
Publication
First Author: Xu YF
Year: 2013
Journal: PLoS One
Title: The pathological phenotypes of human TDP-43 transgenic mouse models are independent of downregulation of mouse Tdp-43.
Volume: 8
Issue: 7
Pages: e69864
Publication  
First Author: Ho WY
Year: 2021
Journal: J Cell Biol
Title: TDP-43 mediates SREBF2-regulated gene expression required for oligodendrocyte myelination.
Volume: 220
Issue: 9
Publication
First Author: Pourhaghighi R
Year: 2020
Journal: Cell Syst
Title: BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain.
Volume: 10
Issue: 4
Pages: 333-350.e14
Publication  
First Author: Kao TJ
Year: 2022
Journal: Neurosci Res
Title: TDP-43 is essential for Eph receptor-class-specific spinal motor axon trajectory into the limb.
Volume: 176
Pages: 31-39
Publication
First Author: Gu J
Year: 2017
Journal: J Biol Chem
Title: Transactive response DNA-binding protein 43 (TDP-43) regulates alternative splicing of tau exon 10: Implications for the pathogenesis of tauopathies.
Volume: 292
Issue: 25
Pages: 10600-10612
Publication
First Author: Peng AYT
Year: 2020
Journal: Proc Natl Acad Sci U S A
Title: Loss of TDP-43 in astrocytes leads to motor deficits by triggering A1-like reactive phenotype and triglial dysfunction.
Volume: 117
Issue: 46
Pages: 29101-29112
Publication
First Author: Wu LS
Year: 2010
Journal: Genesis
Title: TDP-43, a neuro-pathosignature factor, is essential for early mouse embryogenesis.
Volume: 48
Issue: 1
Pages: 56-62
Publication
First Author: Kraemer BC
Year: 2010
Journal: Acta Neuropathol
Title: Loss of murine TDP-43 disrupts motor function and plays an essential role in embryogenesis.
Volume: 119
Issue: 4
Pages: 409-19
Publication
First Author: Swarup V
Year: 2011
Journal: J Exp Med
Title: Deregulation of TDP-43 in amyotrophic lateral sclerosis triggers nuclear factor κB-mediated pathogenic pathways.
Volume: 208
Issue: 12
Pages: 2429-47
Publication
First Author: Shan X
Year: 2010
Journal: Proc Natl Acad Sci U S A
Title: Altered distributions of Gemini of coiled bodies and mitochondria in motor neurons of TDP-43 transgenic mice.
Volume: 107
Issue: 37
Pages: 16325-30
Publication
First Author: Stallings NR
Year: 2013
Journal: PLoS One
Title: TDP-43, an ALS linked protein, regulates fat deposition and glucose homeostasis.
Volume: 8
Issue: 8
Pages: e71793
Publication
First Author: Zomer HD
Year: 2022
Journal: Biol Reprod
Title: Sertoli cells require TDP-43 to support spermatogenesis†.
Volume: 107
Issue: 5
Pages: 1345-1359
Publication
First Author: van Hummel A
Year: 2018
Journal: Am J Pathol
Title: Selective Spatiotemporal Vulnerability of Central Nervous System Neurons to Pathologic TAR DNA-Binding Protein 43 in Aged Transgenic Mice.
Volume: 188
Issue: 6
Pages: 1447-1456
Publication
First Author: Chan G
Year: 2020
Journal: Am J Pathol
Title: Neurodegeneration and Motor Deficits in the Absence of Astrogliosis upon Transgenic Mutant TDP-43 Expression in Mature Mice.
Volume: 190
Issue: 8
Pages: 1713-1722
Publication
First Author: Nishino K
Year: 2019
Journal: Acta Neuropathol Commun
Title: Mice deficient in the C-terminal domain of TAR DNA-binding protein 43 develop age-dependent motor dysfunction associated with impaired Notch1-Akt signaling pathway.
Volume: 7
Issue: 1
Pages: 118
Publication
First Author: Kim E
Year: 2020
Journal: Transl Psychiatry
Title: Coexistence of perseveration and apathy in the TDP-43Q331K knock-in mouse model of ALS-FTD.
Volume: 10
Issue: 1
Pages: 377
Publication
First Author: Vogler TO
Year: 2018
Journal: Nature
Title: TDP-43 and RNA form amyloid-like myo-granules in regenerating muscle.
Volume: 563
Issue: 7732
Pages: 508-513
Publication
First Author: Wang J
Year: 2018
Journal: Proc Natl Acad Sci U S A
Title: Cell-autonomous requirement of TDP-43, an ALS/FTD signature protein, for oligodendrocyte survival and myelination.
Volume: 115
Issue: 46
Pages: E10941-E10950
Publication
First Author: Wu LS
Year: 2012
Journal: J Biol Chem
Title: Targeted depletion of TDP-43 expression in the spinal cord motor neurons leads to the development of amyotrophic lateral sclerosis-like phenotypes in mice.
Volume: 287
Issue: 33
Pages: 27335-44
Publication
First Author: Galloway JN
Year: 2014
Journal: Hum Mol Genet
Title: CGG repeats in RNA modulate expression of TDP-43 in mouse and fly models of fragile X tremor ataxia syndrome.
Volume: 23
Issue: 22
Pages: 5906-15
Publication
First Author: Araki K
Year: 2019
Journal: J Clin Invest
Title: TDP-43 regulates early-phase insulin secretion via CaV1.2-mediated exocytosis in islets.
Volume: 129
Issue: 9
Pages: 3578-3593
Publication  
First Author: Tann JY
Year: 2019
Journal: EMBO J
Title: Abnormal TDP-43 function impairs activity-dependent BDNF secretion, synaptic plasticity, and cognitive behavior through altered Sortilin splicing.
Volume: 38
Issue: 5
Publication
First Author: LaClair KD
Year: 2016
Journal: Acta Neuropathol
Title: Depletion of TDP-43 decreases fibril and plaque β-amyloid and exacerbates neurodegeneration in an Alzheimer's mouse model.
Volume: 132
Issue: 6
Pages: 859-873
Publication
First Author: Kim DW
Year: 2022
Journal: Mol Neurodegener
Title: Amyloid-beta and tau pathologies act synergistically to induce novel disease stage-specific microglia subtypes.
Volume: 17
Issue: 1
Pages: 83
Publication  
First Author: Haidet-Phillips AM
Year: 2013
Journal: Exp Neurol
Title: Altered astrocytic expression of TDP-43 does not influence motor neuron survival.
Volume: 250
Pages: 250-9
Publication
First Author: Berkovits BD
Year: 2012
Journal: Nucleic Acids Res
Title: The testis-specific double bromodomain-containing protein BRDT forms a complex with multiple spliceosome components and is required for mRNA splicing and 3'-UTR truncation in round spermatids.
Volume: 40
Issue: 15
Pages: 7162-75
Publication  
First Author: Fratta P
Year: 2018
Journal: EMBO J
Title: Mice with endogenous TDP-43 mutations exhibit gain of splicing function and characteristics of amyotrophic lateral sclerosis.
Volume: 37
Issue: 11
Publication    
First Author: Chang KJ
Year: 2021
Journal: Elife
Title: TDP-43 maximizes nerve conduction velocity by repressing a cryptic exon for paranodal junction assembly in Schwann cells.
Volume: 10
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus caroli
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus pahari
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus spretus
Publication
First Author: Iguchi Y
Year: 2013
Journal: Brain
Title: Loss of TDP-43 causes age-dependent progressive motor neuron degeneration.
Volume: 136
Issue: Pt 5
Pages: 1371-82
Publication
First Author: Cannon A
Year: 2012
Journal: Acta Neuropathol
Title: Neuronal sensitivity to TDP-43 overexpression is dependent on timing of induction.
Volume: 123
Issue: 6
Pages: 807-23
Publication
First Author: Alfieri JA
Year: 2014
Journal: J Neurosci
Title: Reversible behavioral phenotypes in a conditional mouse model of TDP-43 proteinopathies.
Volume: 34
Issue: 46
Pages: 15244-59
Publication
First Author: Igaz LM
Year: 2011
Journal: J Clin Invest
Title: Dysregulation of the ALS-associated gene TDP-43 leads to neuronal death and degeneration in mice.
Volume: 121
Issue: 2
Pages: 726-38
Publication  
First Author: Davis SA
Year: 2017
Journal: Neurobiol Dis
Title: TDP-43 expression influences amyloidβ plaque deposition and tau aggregation.
Volume: 103
Pages: 154-162
Publication
First Author: Arnold ES
Year: 2013
Journal: Proc Natl Acad Sci U S A
Title: ALS-linked TDP-43 mutations produce aberrant RNA splicing and adult-onset motor neuron disease without aggregation or loss of nuclear TDP-43.
Volume: 110
Issue: 8
Pages: E736-45
Publication
First Author: Chand KK
Year: 2018
Journal: FASEB J
Title: Defects in synaptic transmission at the neuromuscular junction precede motor deficits in a TDP-43Q331K transgenic mouse model of amyotrophic lateral sclerosis.
Volume: 32
Issue: 5
Pages: 2676-2689
Publication
First Author: Huang SL
Year: 2020
Journal: Acta Neuropathol Commun
Title: A robust TDP-43 knock-in mouse model of ALS.
Volume: 8
Issue: 1
Pages: 3
Publication
First Author: Gao J
Year: 2020
Journal: Biochim Biophys Acta Mol Basis Dis
Title: TDP-43 inhibitory peptide alleviates neurodegeneration and memory loss in an APP transgenic mouse model for Alzheimer's disease.
Volume: 1866
Issue: 1
Pages: 165580
Publication
First Author: Perera ND
Year: 2016
Journal: Hum Mol Genet
Title: Enhancing survival motor neuron expression extends lifespan and attenuates neurodegeneration in mutant TDP-43 mice.
Volume: 25
Issue: 18
Pages: 4080-4093
Publication
First Author: Wang W
Year: 2016
Journal: Nat Med
Title: The inhibition of TDP-43 mitochondrial localization blocks its neuronal toxicity.
Volume: 22
Issue: 8
Pages: 869-78
Publication  
First Author: Herdewyn S
Year: 2014
Journal: Mol Neurodegener
Title: Prevention of intestinal obstruction reveals progressive neurodegeneration in mutant TDP-43 (A315T) mice.
Volume: 9
Pages: 24
Publication
First Author: Martínez-González L
Year: 2020
Journal: Sci Rep
Title: Motor neuron preservation and decrease of in vivo TDP-43 phosphorylation by protein CK-1δ kinase inhibitor treatment.
Volume: 10
Issue: 1
Pages: 4449
Publication
First Author: Gautam M
Year: 2019
Journal: Acta Neuropathol
Title: Mitochondria, ER, and nuclear membrane defects reveal early mechanisms for upper motor neuron vulnerability with respect to TDP-43 pathology.
Volume: 137
Issue: 1
Pages: 47-69