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Search results 1 to 100 out of 103 for Tasor

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Categories

Hits by Category

Hits by Strain

Type Details Score
Protein Domain
IPR046432 | TASOR
Type: Family
Description: TASOR is a key component of the HUSH complex, a vertebrate-specific multiprotein complex that mediates epigenetic repression of both exogenous and endogenous genetic elements [, , ]. The HUSH complex regulates H3K9me3 deposition by promoting recruitment of SETDB1 and also recruits MORC2 to compact chromatin [, , ]. The HUSH complex represses L1 retrotransposons and is also involved in the silencing of unintegrated retroviral DNA by being recruited by ZNF638: some part of the retroviral DNA formed immediately after infection remains unintegrated in the host genome and is transcriptionally repressed []. TASOR is crucial in early embryonic development [], and contains a catalytically-inactive PARP domain, necessary for epigenetic regulation of target elements.
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Gene
23272 | TASOR
Type: gene
Organism: human
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Gene
100145452 | tasor
Type: gene
Organism: frog, western clawed
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Gene
680155 | Tasor
Type: gene
Organism: rat
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Gene
747105 | TASOR
Type: gene
Organism: chimpanzee
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Gene
476580 | TASOR
Type: gene
Organism: dog, domestic
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Gene
510095 | TASOR
Type: gene
Organism: cattle
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Gene
708452 | TASOR
Type: gene
Organism: macaque, rhesus
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Protein Coding Gene
MGI:1921694 | Tasor
Type: protein_coding_gene
Organism: mouse, laboratory
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Publication
28839193 | J:254597
First Author: Bhargava S
Year: 2017
Journal: Sci Rep
Title: The epigenetic modifier Fam208a is required to maintain epiblast cell fitness.
Volume: 7
Issue: 1
Pages: 9322
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Protein
A0A286YDQ5
Organism: Mus musculus/domesticus
Length: 293  
Fragment?: true
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Protein
A0A1Y7VM81
Organism: Mus musculus/domesticus
Length: 51  
Fragment?: true
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Protein
Q69ZR9
Organism: Mus musculus/domesticus
Length: 1610  
Fragment?: false
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Protein
A0A1Y7VLA4
Organism: Mus musculus/domesticus
Length: 1701  
Fragment?: true
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Protein
Q3TNP4
Organism: Mus musculus/domesticus
Length: 745  
Fragment?: false
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Publication
33009411 | -
First Author: Douse CH
Year: 2020
Journal: Nat Commun
Title: TASOR is a pseudo-PARP that directs HUSH complex assembly and epigenetic transposon control.
Volume: 11
Issue: 1
Pages: 4940
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Protein
Q5DTT3
Organism: Mus musculus/domesticus
Length: 2382  
Fragment?: false
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Publication
28581500 | -
First Author: Tchasovnikarova IA
Year: 2017
Journal: Nat Genet
Title: Hyperactivation of HUSH complex function by Charcot-Marie-Tooth disease mutation in MORC2.
Volume: 49
Issue: 7
Pages: 1035-1044
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Publication
30487602 | -
First Author: Zhu Y
Year: 2018
Journal: Nature
Title: NP220 mediates silencing of unintegrated retroviral DNA.
Volume: 564
Issue: 7735
Pages: 278-282
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Publication
29211708 | -
First Author: Liu N
Year: 2018
Journal: Nature
Title: Selective silencing of euchromatic L1s revealed by genome-wide screens for L1 regulators.
Volume: 553
Issue: 7687
Pages: 228-232
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Publication
26022416 | -
First Author: Tchasovnikarova IA
Year: 2015
Journal: Science
Title: GENE SILENCING. Epigenetic silencing by the HUSH complex mediates position-effect variegation in human cells.
Volume: 348
Issue: 6242
Pages: 1481-1485
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Protein
Q3TAG2
Organism: Mus musculus/domesticus
Length: 163  
Fragment?: false
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Publication
24781204 | J:216844
First Author: Harten SK
Year: 2014
Journal: Mamm Genome
Title: The first mouse mutants of D14Abb1e (Fam208a) show that it is critical for early development.
Volume: 25
Issue: 7-8
Pages: 293-303
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Protein Coding Gene
MGP_CAROLIEiJ_G0019039 | -
Type: protein_coding_gene
Organism: Mus caroli
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Protein Coding Gene
MGP_129S1SvImJ_G0021092 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AJ_G0021040 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AKRJ_G0021017 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_BALBcJ_G0021044 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C3HHeJ_G0020827 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI_C57BL6J_1921694 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C57BL6NJ_G0021476 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CASTEiJ_G0020352 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CBAJ_G0020794 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_DBA2J_G0020916 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_FVBNJ_G0020900 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_LPJ_G0020985 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NODShiLtJ_G0020926 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NZOHlLtJ_G0021509 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PWKPhJ_G0020100 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_WSBEiJ_G0020407 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PahariEiJ_G0030056 | -
Type: protein_coding_gene
Organism: Mus pahari
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Protein Coding Gene
MGP_SPRETEiJ_G0019924 | -
Type: protein_coding_gene
Organism: Mus spretus
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GXD Expression
GXD Expression
 
Probe: MGI:7797798
Assay Type: RNA in situ
Annotation Date: 2025-01-06
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1606911
Pattern: Not Specified
Stage: TS11
Assay Id: MGI:7797996
Age: embryonic day 7.5
Image: S1C
Specimen Label: S1C
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
 
Probe: MGI:7797798
Assay Type: RNA in situ
Annotation Date: 2025-01-06
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1610911
Pattern: Not Specified
Stage: TS11
Assay Id: MGI:7797996
Age: embryonic day 7.5
Image: S1C
Specimen Label: S1C
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
Probe: MGI:7797798
Assay Type: RNA in situ
Annotation Date: 2025-01-06
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:160658
Pattern: Not Specified
Stage: TS08
Assay Id: MGI:7797996
Age: embryonic day 6.5
Image: S1B
Note: Lesser expression extends into extraembryonic ectoderm.
Specimen Label: S1B
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
 
Probe: MGI:7797798
Assay Type: RNA in situ
Annotation Date: 2025-01-06
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1611211
Pattern: Not Specified
Stage: TS11
Assay Id: MGI:7797996
Age: embryonic day 7.5
Image: S1C
Specimen Label: S1C
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
 
Probe: MGI:7797798
Assay Type: RNA in situ
Annotation Date: 2025-01-06
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1610711
Pattern: Not Specified
Stage: TS11
Assay Id: MGI:7797996
Age: embryonic day 7.5
Image: S1C
Specimen Label: S1C
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
Probe: MGI:7797798
Assay Type: RNA in situ
Annotation Date: 2025-01-06
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:160507
Pattern: Widespread
Stage: TS07
Assay Id: MGI:7797996
Age: embryonic day 5.5
Image: S1A
Note: Strong expression specifically in epiblast.
Specimen Label: S1A
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
 
Probe: MGI:7797798
Assay Type: RNA in situ
Annotation Date: 2025-01-06
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:160508
Pattern: Widespread
Stage: TS08
Assay Id: MGI:7797996
Age: embryonic day 6.5
Image: S1B
Specimen Label: S1B
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
 
Probe: MGI:7797798
Assay Type: RNA in situ
Annotation Date: 2025-01-06
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:3604013
Pattern: Ubiquitous
Stage: TS13
Assay Id: MGI:7797996
Age: embryonic day 8.5
Image: S1D
Specimen Label: S1D
Detected: true
Specimen Num: 4
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GXD Expression
GXD Expression
   
Probe: MGI:3609852
Assay Type: RNA in situ
Annotation Date: 2006-01-16
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689422
Pattern: Not Specified
Stage: TS22
Assay Id: MGI:3610072
Age: embryonic day 14.5
Specimen Label: None
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
   
Probe: MGI:3609852
Assay Type: RNA in situ
Annotation Date: 2006-01-16
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689424
Pattern: Not Specified
Stage: TS24
Assay Id: MGI:3610072
Age: embryonic day 16.5
Specimen Label: None
Detected: true
Specimen Num: 2
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Publication
19099580 | J:142335
First Author: Ashe A
Year: 2008
Journal: Genome Biol
Title: A genome-wide screen for modifiers of transgene variegation identifies genes with critical roles in development.
Volume: 9
Issue: 12
Pages: R182
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Publication
15890782 | J:99816
First Author: Blewitt ME
Year: 2005
Journal: Proc Natl Acad Sci U S A
Title: An N-ethyl-N-nitrosourea screen for genes involved in variegation in the mouse.
Volume: 102
Issue: 21
Pages: 7629-34
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Publication
34216590 | J:310903
First Author: Gresakova V
Year: 2021
Journal: Exp Cell Res
Title: Dual role of Fam208a during zygotic cleavage and early embryonic development.
Volume: 406
Issue: 2
Pages: 112723
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Publication
8858346 | J:34960
First Author: Chambers DM
Year: 1996
Journal: Genome Res
Title: Isolation and mapping of novel mouse brain cDNA clones containing trinucleotide repeats, and demonstration of novel alleles in recombinant inbred strains.
Volume: 6
Issue: 8
Pages: 715-23
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Publication
15582152 | J:102103
First Author: Jensen P
Year: 2004
Journal: Brain Res Mol Brain Res
Title: A neurogenomics approach to gene expression analysis in the developing brain.
Volume: 132
Issue: 2
Pages: 116-27
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Publication
- | J:29126
     
First Author: The Jackson Laboratory DNA Panel Mapping Resource
Year: 1999
Journal: Database Release
Title: JAX Interspecific Backcross BSS and BSB Public Mapping Data
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Publication
16141072 | J:99680
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
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Publication
12904583 | J:85162
First Author: Hansen J
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome.
Volume: 100
Issue: 17
Pages: 9918-22
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Publication
- | J:265051
     
First Author: MGI and IMPC
Year: 2018
Journal: Database Release
Title: MGI Load of Endonuclease-Mediated Alleles (CRISPR) from the International Mouse Phenotyping Consortium (IMPC)
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Publication
- | J:73796
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Function or Process or Component Unknown following Literature Review
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Publication
12520002 | J:91812
First Author: Stryke D
Year: 2003
Journal: Nucleic Acids Res
Title: BayGenomics: a resource of insertional mutations in mouse embryonic stem cells.
Volume: 31
Issue: 1
Pages: 278-81
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Publication
- | J:211773
     
First Author: Mouse Genome Informatics and the International Mouse Phenotyping Consortium (IMPC)
Year: 2014
Journal: Database Release
Title: Obtaining and Loading Phenotype Annotations from the International Mouse Phenotyping Consortium (IMPC) Database
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Publication
18799693 | J:142754
First Author: Hansen GM
Year: 2008
Journal: Genome Res
Title: Large-scale gene trapping in C57BL/6N mouse embryonic stem cells.
Volume: 18
Issue: 10
Pages: 1670-9
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Publication
16602821 | J:162220
First Author: Magdaleno S
Year: 2006
Journal: PLoS Biol
Title: BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system.
Volume: 4
Issue: 4
Pages: e86
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Publication
- | J:85000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Title: MGI Sequence Curation Reference
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Publication
- | J:78475
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Chromosome assignment of mouse genes using the Mouse Genome Sequencing Consortium (MGSC) assembly and the ENSEMBL Database
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Publication
11217851 | J:65060
First Author: Kawai J
Year: 2001
Journal: Nature
Title: Functional annotation of a full-length mouse cDNA collection.
Volume: 409
Issue: 6821
Pages: 685-90
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Publication
38355793 | J:345621
First Author: Adams DJ
Year: 2024
Journal: Nature
Title: Genetic determinants of micronucleus formation in vivo.
Volume: 627
Issue: 8002
Pages: 130-136
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Publication
- | J:23000
       
First Author: MGD Nomenclature Committee
Year: 1995
Title: Nomenclature Committee Use
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Publication
14610273 | J:86696
First Author: Zambrowicz BP
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Volume: 100
Issue: 24
Pages: 14109-14
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Publication
- | J:293217
       
First Author: GemPharmatech
Year: 2020
Title: GemPharmatech Website.
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Publication
- | J:141210
     
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
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Publication
- | J:326541
       
First Author: Cyagen Biosciences Inc.
Year: 2022
Title: Cyagen Biosciences Website.
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Publication
- | J:342587
       
First Author: AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators
Year: 2011
Title: Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
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Publication
- | J:342605
       
First Author: GOA curators
Year: 2016
Title: Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
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Publication
12466851 | J:80000
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
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Publication
- | J:164563
       
First Author: The Gene Ontology Consortium
Year: 2010
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs
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Publication
- | J:75000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
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Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
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Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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UniProt Feature
UniProt Feature
Begin: 2
Description: Protein TASOR
Type: chain
End: 1610
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Protein
Q69ZR9-2
Organism: Mus musculus/domesticus
Length: 1498  
Fragment?: false
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UniProt Feature
UniProt Feature
Begin: 1
Description: Protein TASOR 2
Type: chain
End: 2382
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Publication
11731621 | J:77734
First Author: Li H
Year: 2001
Journal: Mol Endocrinol
Title: Identification, localization, and function in steroidogenesis of PAP7: a peripheral-type benzodiazepine receptor- and PKA (RIalpha)-associated protein.
Volume: 15
Issue: 12
Pages: 2211-28
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Protein Domain
IPR022188 | TASOR_DUF3715
Type: Domain
Description: This domain is found in eukaryotes, and is approximately 170 amino acids in length. Proteins containing this domain include TASOR and TASOR 2 (also known as FAM208A/B) proteins []. TASOR is a key component of the HUSH complex, a vertebrate-specific multiprotein complex that mediates epigenetic repression of both exogenous and endogenous genetic elements [, , ]. The HUSH complex regulates H3K9me3 deposition by promoting recruitment of SETDB1 and also recruits MORC2 to compact chromatin [, , ]. The HUSH complex represses L1 retrotransposons and is also involved in the silencing of unintegrated retroviral DNA by being recruited by ZNF638: some part of the retroviral DNA formed immediately after infection remains unintegrated in the host genome and is transcriptionally repressed []. TASOR is crucial in early embryonic development [], and contains a catalytically-inactive PARP domain, necessary for epigenetic regulation of target elements.
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Protein
E9PY31
Organism: Mus musculus/domesticus
Length: 1279  
Fragment?: true
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Protein
D3YVF5
Organism: Mus musculus/domesticus
Length: 148  
Fragment?: true
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Protein
M0QWY2
Organism: Mus musculus/domesticus
Length: 323  
Fragment?: false
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Publication
31112734 | J:282162
First Author: Gresakova V
Year: 2019
Journal: Exp Cell Res
Title: Fam208a orchestrates interaction protein network essential for early embryonic development and cell division.
Volume: 382
Issue: 1
Pages: 111437
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Publication
15368895 | J:92575
First Author: Okazaki N
Year: 2004
Journal: DNA Res
Title: Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.
Volume: 11
Issue: 3
Pages: 205-18
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

Copyright © 2017 by The Jackson Laboratory. All Rights Reserved

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