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Search results 1 to 100 out of 122 for Tbca

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Hits by Category

Hits by Strain

Type Details Score
Gene
6902 | TBCA
Type: gene
Organism: human
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Gene
100038159 | tbca
Type: gene
Organism: frog, western clawed
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Gene
327683 | TBCA
Type: gene
Organism: cattle
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Gene
key_29950 | TBCA
Type: gene
Organism: rabbit, European
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Gene
366995 | Tbca
Type: gene
Organism: rat
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Gene
479173 | TBCA
Type: gene
Organism: dog, domestic
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Gene
737862 | TBCA
Type: gene
Organism: chimpanzee
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Gene
416367 | TBCA
Type: gene
Organism: chicken
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Gene
394029 | tbca
Type: gene
Organism: zebrafish
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Gene
708521 | TBCA
Type: gene
Organism: macaque, rhesus
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Protein Domain
IPR004226 | TBCA
Type: Family
Description: The tubulin heterodimer consists of one alpha- and one beta-tubulin polypeptide. In humans, five tubulin-specific chaperones termed TBCA/B/C/D/E are essential for bring the alpha- and beta-tubulin subunits together into a tightly associated heterodimer. Following the generation of quasi-native beta- and alpha-tubulin polypeptides (via multiple rounds of ATP-dependent interaction with the cytosolic chaperonin), TBCA and TBCB bind to and stabilise newly synthesised beta- and alpha-tubulin, respectively. The exchange of beta-tubulin between TBCA and TBCD, and of alpha-tubulin between TBCB and TBCE, resulting in the formation of TBCD/beta and TBCE/alpha. These two complexes then interact with each other and form a supercomplex (TBCE/alpha/TBCD/beta). Interaction of the supercomplex with TBCC causes the disassembly of the supercomplex and the release of E-site GDP-bound alpha/beta tubulin heterodimer, which becomes polymerization competent following spontaneous exchange with GTP [].This entry represents tubulin binding cofactor A (TBCA) from animal, plants and fungi. Human TBCA functions as a molecular chaperone for beta-tubulin []. Budding yeast TBCA, also known as Rbl2, may bind transiently to free beta-tubulin, which then passes into an aggregated form that is not toxic []. The sequence identity of Rbl2 and human TBCA is only 32%, they appear to be structurally distinct and may interact with beta-tubulin by different mechanisms [].
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Protein Coding Gene
MGI:107549 | Tbca
Type: protein_coding_gene
Organism: mouse, laboratory
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Publication
12054808 | J:76643
First Author: Guasch A
Year: 2002
Journal: J Mol Biol
Title: Three-dimensional structure of human tubulin chaperone cofactor A.
Volume: 318
Issue: 4
Pages: 1139-49
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Publication
22880023 | J:189827
First Author: Nolasco S
Year: 2012
Journal: PLoS One
Title: The expression of tubulin cofactor A (TBCA) is regulated by a noncoding antisense Tbca RNA during testis maturation.
Volume: 7
Issue: 8
Pages: e42536
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Protein
P48428
Organism: Mus musculus/domesticus
Length: 108  
Fragment?: false
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Protein
A0A1Y7VJ48
Organism: Mus musculus/domesticus
Length: 84  
Fragment?: false
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Protein
Q5I0U7
Organism: Mus musculus/domesticus
Length: 108  
Fragment?: false
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Publication
11739729 | -
First Author: Abruzzi KC
Year: 2002
Journal: Mol Cell Biol
Title: Protection from free beta-tubulin by the beta-tubulin binding protein Rbl2p.
Volume: 22
Issue: 1
Pages: 138-47
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Publication
15321725 | -
First Author: You L
Year: 2004
Journal: J Mol Biol
Title: Model for the yeast cofactor A-beta-tubulin complex based on computational docking and mutagensis.
Volume: 341
Issue: 5
Pages: 1343-54
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Publication
23973072 | -
 
First Author: Tian G
Year: 2013
Journal: Methods Cell Biol
Title: Tubulin-specific chaperones: components of a molecular machine that assembles the α/β heterodimer.
Volume: 115
Pages: 155-71
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Protein Coding Gene
MGP_CAROLIEiJ_G0018790 | -
Type: protein_coding_gene
Organism: Mus caroli
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Protein Coding Gene
MGP_129S1SvImJ_G0020834 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AJ_G0020788 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AKRJ_G0020762 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_BALBcJ_G0020785 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C3HHeJ_G0020578 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI_C57BL6J_107549 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C57BL6NJ_G0021221 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CASTEiJ_G0020097 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CBAJ_G0020537 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_DBA2J_G0020662 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_FVBNJ_G0020643 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_LPJ_G0020737 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NODShiLtJ_G0020671 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NZOHlLtJ_G0021261 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PWKPhJ_G0019849 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_WSBEiJ_G0020154 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PahariEiJ_G0015867 | -
Type: protein_coding_gene
Organism: Mus pahari
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Protein Coding Gene
MGP_SPRETEiJ_G0019673 | -
Type: protein_coding_gene
Organism: Mus spretus
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Publication
7910827 | J:34881
First Author: Gao Y
Year: 1994
Journal: J Cell Biol
Title: A novel cochaperonin that modulates the ATPase activity of cytoplasmic chaperonin.
Volume: 125
Issue: 5
Pages: 989-96
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Publication
8756698 | J:34803
First Author: Melki R
Year: 1996
Journal: Biochemistry
Title: Cofactor A is a molecular chaperone required for beta-tubulin folding: functional and structural characterization.
Volume: 35
Issue: 32
Pages: 10422-35
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GXD Expression
GXD Expression
 
Probe: MGI:4416327
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1756423
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4828610
Age: embryonic day 14.5
Image: euxassay_009814_08
Specimen Label: euxassay_009814_08
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
 
Probe: MGI:4416327
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1756423
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4828610
Age: embryonic day 14.5
Image: euxassay_009814_09
Specimen Label: euxassay_009814_09
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
 
Probe: MGI:4416327
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1756423
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4828610
Age: embryonic day 14.5
Image: euxassay_009814_11
Specimen Label: euxassay_009814_11
Detected: true
Specimen Num: 4
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GXD Expression
GXD Expression
 
Probe: MGI:4416327
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1756423
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4828610
Age: embryonic day 14.5
Image: euxassay_009814_14
Specimen Label: euxassay_009814_14
Detected: true
Specimen Num: 7
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GXD Expression
GXD Expression
 
Probe: MGI:4416327
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1756423
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4828610
Age: embryonic day 14.5
Image: euxassay_009814_17
Specimen Label: euxassay_009814_17
Detected: true
Specimen Num: 10
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GXD Expression
GXD Expression
 
Probe: MGI:4416327
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1756423
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4828610
Age: embryonic day 14.5
Image: euxassay_009814_18
Specimen Label: euxassay_009814_18
Detected: true
Specimen Num: 11
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GXD Expression
GXD Expression
 
Probe: MGI:4416327
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1758523
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4828610
Age: embryonic day 14.5
Image: euxassay_009814_11
Specimen Label: euxassay_009814_11
Detected: true
Specimen Num: 4
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GXD Expression
GXD Expression
 
Probe: MGI:4416327
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1758523
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4828610
Age: embryonic day 14.5
Image: euxassay_009814_12
Specimen Label: euxassay_009814_12
Detected: true
Specimen Num: 5
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GXD Expression
GXD Expression
 
Probe: MGI:4416327
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1758523
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4828610
Age: embryonic day 14.5
Image: euxassay_009814_13
Specimen Label: euxassay_009814_13
Detected: true
Specimen Num: 6
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GXD Expression
GXD Expression
 
Probe: MGI:4416327
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1753723
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4828610
Age: embryonic day 14.5
Image: euxassay_009814_08
Specimen Label: euxassay_009814_08
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
 
Probe: MGI:4416327
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1753723
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4828610
Age: embryonic day 14.5
Image: euxassay_009814_09
Specimen Label: euxassay_009814_09
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
 
Probe: MGI:4416327
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1753723
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4828610
Age: embryonic day 14.5
Image: euxassay_009814_10
Specimen Label: euxassay_009814_10
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
 
Probe: MGI:4416327
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1753723
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4828610
Age: embryonic day 14.5
Image: euxassay_009814_11
Specimen Label: euxassay_009814_11
Detected: true
Specimen Num: 4
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GXD Expression
GXD Expression
 
Probe: MGI:4416327
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1753723
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4828610
Age: embryonic day 14.5
Image: euxassay_009814_14
Specimen Label: euxassay_009814_14
Detected: true
Specimen Num: 7
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GXD Expression
GXD Expression
 
Probe: MGI:4416327
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1753723
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4828610
Age: embryonic day 14.5
Image: euxassay_009814_15
Specimen Label: euxassay_009814_15
Detected: true
Specimen Num: 8
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GXD Expression
GXD Expression
 
Probe: MGI:4416327
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1753723
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4828610
Age: embryonic day 14.5
Image: euxassay_009814_16
Specimen Label: euxassay_009814_16
Detected: true
Specimen Num: 9
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GXD Expression
GXD Expression
 
Probe: MGI:4416327
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1690623
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4828610
Age: embryonic day 14.5
Image: euxassay_009814_11
Specimen Label: euxassay_009814_11
Detected: true
Specimen Num: 4
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GXD Expression
GXD Expression
 
Probe: MGI:4416327
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1690623
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4828610
Age: embryonic day 14.5
Image: euxassay_009814_12
Specimen Label: euxassay_009814_12
Detected: true
Specimen Num: 5
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GXD Expression
GXD Expression
 
Probe: MGI:4416327
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1690623
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4828610
Age: embryonic day 14.5
Image: euxassay_009814_14
Specimen Label: euxassay_009814_14
Detected: true
Specimen Num: 7
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GXD Expression
GXD Expression
 
Probe: MGI:4416327
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1755823
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4828610
Age: embryonic day 14.5
Image: euxassay_009814_09
Specimen Label: euxassay_009814_09
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
 
Probe: MGI:4416327
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1755823
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4828610
Age: embryonic day 14.5
Image: euxassay_009814_10
Specimen Label: euxassay_009814_10
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
 
Probe: MGI:4416327
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1755823
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4828610
Age: embryonic day 14.5
Image: euxassay_009814_17
Specimen Label: euxassay_009814_17
Detected: true
Specimen Num: 10
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Publication
20176735 | J:158711
First Author: Wen HL
Year: 2010
Journal: Hum Mol Genet
Title: Stathmin, a microtubule-destabilizing protein, is dysregulated in spinal muscular atrophy.
Volume: 19
Issue: 9
Pages: 1766-78
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Publication
15741512 | J:97506
First Author: Osipovich AB
Year: 2005
Journal: Genome Res
Title: Post-entrapment genome engineering: first exon size does not affect the expression of fusion transcripts generated by gene entrapment.
Volume: 15
Issue: 3
Pages: 428-35
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Publication
9507200 | J:46507
First Author: Takenaka M
Year: 1998
Journal: Kidney Int
Title: Isolation of genes identified in mouse renal proximal tubule by comparing different gene expression profiles.
Volume: 53
Issue: 3
Pages: 562-72
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Publication
11172053 | J:67552
First Author: Jiang CH
Year: 2001
Journal: Proc Natl Acad Sci U S A
Title: The effects of aging on gene expression in the hypothalamus and cortex of mice.
Volume: 98
Issue: 4
Pages: 1930-4
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Publication
- | J:157064
     
First Author: University of California, Davis
Year: 2010
Journal: MGI Direct Data Submission
Title: Alleles produced for the KOMP project by the University of California, Davis
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Publication
- | J:94790
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Mouse Synonym Curation
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Publication
18799693 | J:142754
First Author: Hansen GM
Year: 2008
Journal: Genome Res
Title: Large-scale gene trapping in C57BL/6N mouse embryonic stem cells.
Volume: 18
Issue: 10
Pages: 1670-9
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Publication
- | J:157065
     
First Author: Helmholtz Zentrum Muenchen GmbH
Year: 2010
Journal: MGI Direct Data Submission
Title: Alleles produced for the EUCOMM and EUCOMMTools projects by the Helmholtz Zentrum Muenchen GmbH (Hmgu)
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Publication
- | J:72247
       
First Author: DDB, FB, MGI, GOA, ZFIN curators
Year: 2001
Title: Gene Ontology annotation through association of InterPro records with GO terms
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Publication
- | J:78475
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Chromosome assignment of mouse genes using the Mouse Genome Sequencing Consortium (MGSC) assembly and the ENSEMBL Database
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Publication
16141072 | J:99680
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
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Publication
11217851 | J:65060
First Author: Kawai J
Year: 2001
Journal: Nature
Title: Functional annotation of a full-length mouse cDNA collection.
Volume: 409
Issue: 6821
Pages: 685-90
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Publication
14610273 | J:86696
First Author: Zambrowicz BP
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Volume: 100
Issue: 24
Pages: 14109-14
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Publication
- | J:293217
       
First Author: GemPharmatech
Year: 2020
Title: GemPharmatech Website.
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Publication
- | J:141210
     
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
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Publication
- | J:60000
       
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
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Publication
- | J:342605
       
First Author: GOA curators
Year: 2016
Title: Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
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Publication
12466851 | J:80000
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
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Publication
- | J:164563
       
First Author: The Gene Ontology Consortium
Year: 2010
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs
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Publication
21267068 | J:153498
First Author: Diez-Roux G
Year: 2011
Journal: PLoS Biol
Title: A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Volume: 9
Issue: 1
Pages: e1000582
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Publication
- | J:75000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
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Publication
- | J:157972
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
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Publication
- | J:57747
     
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
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Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
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Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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Allele
Tg(Otp-cre)1Hzo | MGI:5897831
Name: transgene insertion 1, Huda Y Zoghbi
Allele Type: Transgenic
Attribute String: Recombinase
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Strain
MGI:5903089 | B6.FVB-Tg(Otp-cre)1Hzo/J
Attribute String: mutant strain, transgenic, congenic
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Protein Domain
IPR036126 | TBCA_sf
Type: Homologous_superfamily
Description: The tubulin heterodimer consists of one alpha- and one beta-tubulin polypeptide. In humans, five tubulin-specific chaperones termed TBCA/B/C/D/E are essential for bring the alpha- and beta-tubulin subunits together into a tightly associated heterodimer. Following the generation of quasi-native beta- and alpha-tubulin polypeptides (via multiple rounds of ATP-dependent interaction with the cytosolic chaperonin), TBCA and TBCB bind to and stabilise newly synthesised beta- and alpha-tubulin, respectively. The exchange of beta-tubulin between TBCA and TBCD, and of alpha-tubulin between TBCB and TBCE, resulting in the formation of TBCD/beta and TBCE/alpha. These two complexes then interact with each other and form a supercomplex (TBCE/alpha/TBCD/beta). Interaction of the supercomplex with TBCC causes the disassembly of the supercomplex and the release of E-site GDP-bound alpha/beta tubulin heterodimer, which becomes polymerization competent following spontaneous exchange with GTP [].This entry represents tubulin binding cofactor A (TBCA) from animal, plants and fungi. Human TBCA functions as a molecular chaperone for beta-tubulin []. Budding yeast TBCA, also known as Rbl2, may bind transiently to free beta-tubulin, which then passes into an aggregated form that is not toxic []. The sequence identity of Rbl2 and human TBCA is only 32%, they appear to be structurally distinct and may interact with beta-tubulin by different mechanisms []. The structure of TBCA has three helices forming a bundle closed fold with left-handed twist topology going up-and-down.
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