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Search results 1 to 100 out of 525 for Tbk1

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Type Details Score
Gene
Type: gene
Organism: Homo sapiens
Gene
Type: gene
Organism: Rattus norvegicus
Gene
Type: gene
Organism: Danio rerio
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Publication
First Author: Shu C
Year: 2013
Journal: Structure
Title: Structural insights into the functions of TBK1 in innate antimicrobial immunity.
Volume: 21
Issue: 7
Pages: 1137-48
Gene
Type: gene
Organism: Homo sapiens
Publication
First Author: Zhu L
Year: 2019
Journal: Nat Cell Biol
Title: TBKBP1 and TBK1 form a growth factor signalling axis mediating immunosuppression and tumourigenesis.
Volume: 21
Issue: 12
Pages: 1604-1614
GXD Expression  
Probe: MGI:3724900
Assay Type: RNA in situ
Annotation Date: 2009-01-15
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:3564522
Pattern: Not Specified
Stage: TS22
Assay Id: MGI:3826188
Age: embryonic day 14.5
Image: Additional file 4 Tbk1
Detected: true
Specimen Num: 1
Publication
First Author: Bonnard M
Year: 2000
Journal: EMBO J
Title: Deficiency of T2K leads to apoptotic liver degeneration and impaired NF-kappaB-dependent gene transcription.
Volume: 19
Issue: 18
Pages: 4976-85
Publication
First Author: McWhirter SM
Year: 2004
Journal: Proc Natl Acad Sci U S A
Title: IFN-regulatory factor 3-dependent gene expression is defective in Tbk1-deficient mouse embryonic fibroblasts.
Volume: 101
Issue: 1
Pages: 233-8
Publication
First Author: Pomerantz JL
Year: 1999
Journal: EMBO J
Title: NF-kappaB activation by a signaling complex containing TRAF2, TANK and TBK1, a novel IKK-related kinase.
Volume: 18
Issue: 23
Pages: 6694-704
Publication
First Author: O'Connell RM
Year: 2005
Journal: J Immunol
Title: Immune activation of type I IFNs by Listeria monocytogenes occurs independently of TLR4, TLR2, and receptor interacting protein 2 but involves TNFR-associated NF kappa B kinase-binding kinase 1.
Volume: 174
Issue: 3
Pages: 1602-7
Publication
First Author: Ou YH
Year: 2011
Journal: Mol Cell
Title: TBK1 directly engages Akt/PKB survival signaling to support oncogenic transformation.
Volume: 41
Issue: 4
Pages: 458-70
Publication
First Author: Hagan RS
Year: 2019
Journal: Am J Respir Cell Mol Biol
Title: Myeloid TBK1 Signaling Contributes to the Immune Response to Influenza.
Volume: 60
Issue: 3
Pages: 335-345
Publication
First Author: Lafont E
Year: 2018
Journal: Nat Cell Biol
Title: TBK1 and IKKε prevent TNF-induced cell death by RIPK1 phosphorylation.
Volume: 20
Issue: 12
Pages: 1389-1399
Publication  
First Author: Sieverding K
Year: 2021
Journal: Exp Neurol
Title: Hemizygous deletion of Tbk1 worsens neuromuscular junction pathology in TDP-43G298S transgenic mice.
Volume: 335
Pages: 113496
Publication
First Author: Zhao P
Year: 2018
Journal: Cell
Title: TBK1 at the Crossroads of Inflammation and Energy Homeostasis in Adipose Tissue.
Volume: 172
Issue: 4
Pages: 731-743.e12
Publication  
First Author: Yu J
Year: 2015
Journal: Nat Commun
Title: Regulation of T-cell activation and migration by the kinase TBK1 during neuroinflammation.
Volume: 6
Pages: 6074
Publication  
First Author: Uhm M
Year: 2017
Journal: Sci Signal
Title: Phosphorylation of the exocyst protein Exo84 by TBK1 promotes insulin-stimulated GLUT4 trafficking.
Volume: 10
Issue: 471
Publication
First Author: Duan W
Year: 2019
Journal: Aging (Albany NY)
Title: Deletion of Tbk1 disrupts autophagy and reproduces behavioral and locomotor symptoms of FTD-ALS in mice.
Volume: 11
Issue: 8
Pages: 2457-2476
Publication
First Author: Yang JY
Year: 2020
Journal: Gastroenterology
Title: Intestinal Epithelial TBK1 Prevents Differentiation of T-helper 17 Cells and Tumorigenesis in Mice.
Volume: 159
Issue: 5
Pages: 1793-1806
Publication
First Author: Gu M
Year: 2016
Journal: EMBO J
Title: RKIP and TBK1 form a positive feedback loop to promote type I interferon production in innate immunity.
Volume: 35
Issue: 23
Pages: 2553-2565
Publication
First Author: Xiao Y
Year: 2017
Journal: J Exp Med
Title: The kinase TBK1 functions in dendritic cells to regulate T cell homeostasis, autoimmunity, and antitumor immunity.
Volume: 214
Issue: 5
Pages: 1493-1507
Publication  
First Author: Ozasa K
Year: 2019
Journal: Front Immunol
Title: Cyclic GMP-AMP Triggers Asthma in an IL-33-Dependent Manner That Is Blocked by Amlexanox, a TBK1 Inhibitor.
Volume: 10
Pages: 2212
Publication
First Author: Wang Y
Year: 2020
Journal: Immunity
Title: Decreased Expression of the Host Long-Noncoding RNA-GM Facilitates Viral Escape by Inhibiting the Kinase activity TBK1 via S-glutathionylation.
Volume: 53
Issue: 6
Pages: 1168-1181.e7
Publication
First Author: Jin J
Year: 2012
Journal: Nat Immunol
Title: The kinase TBK1 controls IgA class switching by negatively regulating noncanonical NF-κB signaling.
Volume: 13
Issue: 11
Pages: 1101-9
Publication
First Author: Marchlik E
Year: 2010
Journal: J Leukoc Biol
Title: Mice lacking Tbk1 activity exhibit immune cell infiltrates in multiple tissues and increased susceptibility to LPS-induced lethality.
Volume: 88
Issue: 6
Pages: 1171-80
Publication
First Author: Hasan M
Year: 2017
Journal: Proc Natl Acad Sci U S A
Title: Chronic innate immune activation of TBK1 suppresses mTORC1 activity and dysregulates cellular metabolism.
Volume: 114
Issue: 4
Pages: 746-751
Publication
First Author: Bakshi S
Year: 2017
Journal: Biochem J
Title: Identification of TBK1 complexes required for the phosphorylation of IRF3 and the production of interferon β.
Volume: 474
Issue: 7
Pages: 1163-1174
Publication
First Author: Smith H
Year: 2011
Journal: Biochem J
Title: The role of TBK1 and IKKε in the expression and activation of Pellino 1.
Volume: 434
Issue: 3
Pages: 537-48
Publication  
First Author: Li X
Year: 2017
Journal: Sci Signal
Title: The tyrosine kinase Src promotes phosphorylation of the kinase TBK1 to facilitate type I interferon production after viral infection.
Volume: 10
Issue: 460
Publication      
First Author: Gerbino V
Year: 2020
Journal: Neuron
Title: The Loss of TBK1 Kinase Activity in Motor Neurons or in All Cell Types Differentially Impacts ALS Disease Progression in SOD1 Mice.
Publication
First Author: Wang YY
Year: 2019
Journal: Biochem Biophys Res Commun
Title: Sting is a critical regulator of spinal cord injury by regulating microglial inflammation via interacting with TBK1 in mice.
Volume: 517
Issue: 4
Pages: 741-748
Publication
First Author: Ge M
Year: 2017
Journal: J Immunol
Title: HERP Binds TBK1 To Activate Innate Immunity and Repress Virus Replication in Response to Endoplasmic Reticulum Stress.
Volume: 199
Issue: 9
Pages: 3280-3292
Publication
First Author: Fukasaka M
Year: 2013
Journal: J Immunol
Title: Critical role of AZI2 in GM-CSF-induced dendritic cell differentiation.
Volume: 190
Issue: 11
Pages: 5702-11
Publication
First Author: Hemmi H
Year: 2004
Journal: J Exp Med
Title: The roles of two IkappaB kinase-related kinases in lipopolysaccharide and double stranded RNA signaling and viral infection.
Volume: 199
Issue: 12
Pages: 1641-50
Gene
Type: gene
Organism: Rattus norvegicus
Gene
Type: gene
Organism: Danio rerio
Publication
First Author: Brenner D
Year: 2019
Journal: J Exp Med
Title: Heterozygous Tbk1 loss has opposing effects in early and late stages of ALS in mice.
Volume: 216
Issue: 2
Pages: 267-278
Publication
First Author: Lin M
Year: 2016
Journal: Mol Cell
Title: USP38 Inhibits Type I Interferon Signaling by Editing TBK1 Ubiquitination through NLRP4 Signalosome.
Volume: 64
Issue: 2
Pages: 267-281
Publication
First Author: Soulat D
Year: 2008
Journal: EMBO J
Title: The DEAD-box helicase DDX3X is a critical component of the TANK-binding kinase 1-dependent innate immune response.
Volume: 27
Issue: 15
Pages: 2135-46
Publication
First Author: Fingert JH
Year: 2017
Journal: Hum Mol Genet
Title: Transgenic TBK1 mice have features of normal tension glaucoma.
Volume: 26
Issue: 1
Pages: 124-132
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Publication
First Author: Huh JY
Year: 2020
Journal: Cell Metab
Title: TANK-Binding Kinase 1 Regulates the Localization of Acyl-CoA Synthetase ACSL1 to Control Hepatic Fatty Acid Oxidation.
Volume: 32
Issue: 6
Pages: 1012-1027.e7
Publication
First Author: Wild P
Year: 2011
Journal: Science
Title: Phosphorylation of the autophagy receptor optineurin restricts Salmonella growth.
Volume: 333
Issue: 6039
Pages: 228-33
Publication
First Author: Tsuchida T
Year: 2010
Journal: Immunity
Title: The ubiquitin ligase TRIM56 regulates innate immune responses to intracellular double-stranded DNA.
Volume: 33
Issue: 5
Pages: 765-76
Publication
First Author: Huang L
Year: 2020
Journal: Cell Rep
Title: Ubiquitin-Conjugating Enzyme 2S Enhances Viral Replication by Inhibiting Type I IFN Production through Recruiting USP15 to Deubiquitinate TBK1.
Volume: 32
Issue: 7
Pages: 108044
Publication
First Author: Da Q
Year: 2011
Journal: J Immunol
Title: TANK-binding kinase 1 attenuates PTAP-dependent retroviral budding through targeting endosomal sorting complex required for transport-I.
Volume: 186
Issue: 5
Pages: 3023-30
Publication
First Author: Zhao T
Year: 2007
Journal: Nat Immunol
Title: The NEMO adaptor bridges the nuclear factor-kappaB and interferon regulatory factor signaling pathways.
Volume: 8
Issue: 6
Pages: 592-600
Ontology Term
Publication
First Author: Zhang M
Year: 2012
Journal: J Exp Med
Title: TRAF-interacting protein (TRIP) negatively regulates IFN-β production and antiviral response by promoting proteasomal degradation of TANK-binding kinase 1.
Volume: 209
Issue: 10
Pages: 1703-11
Publication
First Author: Matsui K
Year: 2006
Journal: J Immunol
Title: Cutting edge: Role of TANK-binding kinase 1 and inducible IkappaB kinase in IFN responses against viruses in innate immune cells.
Volume: 177
Issue: 9
Pages: 5785-9
Publication
First Author: Chen S
Year: 2020
Journal: Mol Cell
Title: TBK1-Mediated DRP1 Targeting Confers Nucleic Acid Sensing to Reprogram Mitochondrial Dynamics and Physiology.
Volume: 80
Issue: 5
Pages: 810-827.e7
Publication
First Author: Zhang L
Year: 2014
Journal: Immunity
Title: NLRC3, a member of the NLR family of proteins, is a negative regulator of innate immune signaling induced by the DNA sensor STING.
Volume: 40
Issue: 3
Pages: 329-41
Publication
First Author: Parvatiyar K
Year: 2012
Journal: Nat Immunol
Title: The helicase DDX41 recognizes the bacterial secondary messengers cyclic di-GMP and cyclic di-AMP to activate a type I interferon immune response.
Volume: 13
Issue: 12
Pages: 1155-61
Publication
First Author: Li Z
Year: 2015
Journal: PLoS Pathog
Title: PPM1A regulates antiviral signaling by antagonizing TBK1-mediated STING phosphorylation and aggregation.
Volume: 11
Issue: 3
Pages: e1004783
Publication
First Author: Pedros C
Year: 2016
Journal: Nat Immunol
Title: A TRAF-like motif of the inducible costimulator ICOS controls development of germinal center TFH cells via the kinase TBK1.
Volume: 17
Issue: 7
Pages: 825-33
Publication
First Author: Zhang M
Year: 2008
Journal: J Biol Chem
Title: Regulation of IkappaB kinase-related kinases and antiviral responses by tumor suppressor CYLD.
Volume: 283
Issue: 27
Pages: 18621-6
Publication
First Author: Perry AK
Year: 2004
Journal: J Exp Med
Title: Differential requirement for TANK-binding kinase-1 in type I interferon responses to toll-like receptor activation and viral infection.
Volume: 199
Issue: 12
Pages: 1651-8
Publication
First Author: Radtke AL
Year: 2008
Journal: Cell Microbiol
Title: Homeostatic maintenance of pathogen-containing vacuoles requires TBK1-dependent regulation of aquaporin-1.
Volume: 10
Issue: 11
Pages: 2197-207
Publication
First Author: Chen H
Year: 2011
Journal: Cell
Title: Activation of STAT6 by STING is critical for antiviral innate immunity.
Volume: 147
Issue: 2
Pages: 436-46
Publication
First Author: Hasan M
Year: 2013
Journal: Nat Immunol
Title: Trex1 regulates lysosomal biogenesis and interferon-independent activation of antiviral genes.
Volume: 14
Issue: 1
Pages: 61-71
Publication
First Author: Farlik M
Year: 2012
Journal: Mol Cell Biol
Title: Contribution of a TANK-binding kinase 1-interferon (IFN) regulatory factor 7 pathway to IFN-γ-induced gene expression.
Volume: 32
Issue: 6
Pages: 1032-43
Publication
First Author: Ishii KJ
Year: 2006
Journal: Nat Immunol
Title: A Toll-like receptor-independent antiviral response induced by double-stranded B-form DNA.
Volume: 7
Issue: 1
Pages: 40-8
Publication  
First Author: Ouali Alami N
Year: 2020
Journal: Life Sci Alliance
Title: Multiplexed chemogenetics in astrocytes and motoneurons restore blood-spinal cord barrier in ALS.
Volume: 3
Issue: 11
Publication
First Author: Bruni D
Year: 2013
Journal: J Immunol
Title: A novel IRAK1-IKKε signaling axis limits the activation of TAK1-IKKβ downstream of TLR3.
Volume: 190
Issue: 6
Pages: 2844-56
Publication
First Author: Zhang Y
Year: 2021
Journal: Nat Commun
Title: Cerebellar Kv3.3 potassium channels activate TANK-binding kinase 1 to regulate trafficking of the cell survival protein Hax-1.
Volume: 12
Issue: 1
Pages: 1731
Publication  
First Author: Deng KQ
Year: 2016
Journal: Nat Commun
Title: Suppressor of IKKɛ is an essential negative regulator of pathological cardiac hypertrophy.
Volume: 7
Pages: 11432
Publication
First Author: Wang C
Year: 2009
Journal: Nat Immunol
Title: The E3 ubiquitin ligase Nrdp1 'preferentially' promotes TLR-mediated production of type I interferon.
Volume: 10
Issue: 7
Pages: 744-52
Publication
First Author: Sharma S
Year: 2011
Journal: Immunity
Title: Innate immune recognition of an AT-rich stem-loop DNA motif in the Plasmodium falciparum genome.
Volume: 35
Issue: 2
Pages: 194-207
Publication
First Author: Wang F
Year: 2016
Journal: Nat Immunol
Title: S6K-STING interaction regulates cytosolic DNA-mediated activation of the transcription factor IRF3.
Volume: 17
Issue: 5
Pages: 514-522
Publication
First Author: Goh ET
Year: 2012
Journal: Biochem J
Title: Identification of the protein kinases that activate the E3 ubiquitin ligase Pellino 1 in the innate immune system.
Volume: 441
Issue: 1
Pages: 339-46
Publication
First Author: Gabhann JN
Year: 2010
Journal: J Immunol
Title: Absence of SHIP-1 results in constitutive phosphorylation of tank-binding kinase 1 and enhanced TLR3-dependent IFN-beta production.
Volume: 184
Issue: 5
Pages: 2314-20
Publication
First Author: Kang HR
Year: 2014
Journal: J Virol
Title: Murine gammaherpesvirus 68 encoding open reading frame 11 targets TANK binding kinase 1 to negatively regulate the host type I interferon response.
Volume: 88
Issue: 12
Pages: 6832-46
Publication
First Author: Miyahira AK
Year: 2009
Journal: J Immunol
Title: TANK-binding kinase-1 plays an important role during in vitro and in vivo type I IFN responses to DNA virus infections.
Volume: 182
Issue: 4
Pages: 2248-57
Publication
First Author: Lin YC
Year: 2013
Journal: Sci Signal
Title: The tyrosine kinase Syk differentially regulates Toll-like receptor signaling downstream of the adaptor molecules TRAF6 and TRAF3.
Volume: 6
Issue: 289
Pages: ra71
Publication
First Author: Delhase M
Year: 2012
Journal: Proc Natl Acad Sci U S A
Title: TANK-binding kinase 1 (TBK1) controls cell survival through PAI-2/serpinB2 and transglutaminase 2.
Volume: 109
Issue: 4
Pages: E177-86
Publication
First Author: Xie X
Year: 2011
Journal: Proc Natl Acad Sci U S A
Title: IkappaB kinase epsilon and TANK-binding kinase 1 activate AKT by direct phosphorylation.
Volume: 108
Issue: 16
Pages: 6474-9
Publication
First Author: Gleason CE
Year: 2011
Journal: J Biol Chem
Title: Polyubiquitin binding to optineurin is required for optimal activation of TANK-binding kinase 1 and production of interferon β.
Volume: 286
Issue: 41
Pages: 35663-74
Publication
First Author: Joung SM
Year: 2011
Journal: J Immunol
Title: Akt contributes to activation of the TRIF-dependent signaling pathways of TLRs by interacting with TANK-binding kinase 1.
Volume: 186
Issue: 1
Pages: 499-507
Publication
First Author: Qu F
Year: 2012
Journal: Mol Cell Biol
Title: TRAF6-dependent Act1 phosphorylation by the IκB kinase-related kinases suppresses interleukin-17-induced NF-κB activation.
Volume: 32
Issue: 19
Pages: 3925-37
Publication
First Author: Oshiumi H
Year: 2013
Journal: PLoS Pathog
Title: A distinct role of Riplet-mediated K63-Linked polyubiquitination of the RIG-I repressor domain in human antiviral innate immune responses.
Volume: 9
Issue: 8
Pages: e1003533
Publication
First Author: Chessler AD
Year: 2008
Journal: J Immunol
Title: A novel IFN regulatory factor 3-dependent pathway activated by trypanosomes triggers IFN-beta in macrophages and fibroblasts.
Volume: 181
Issue: 11
Pages: 7917-24
Publication
First Author: Ishii KJ
Year: 2008
Journal: Nature
Title: TANK-binding kinase-1 delineates innate and adaptive immune responses to DNA vaccines.
Volume: 451
Issue: 7179
Pages: 725-9
Publication  
First Author: Hayashi T
Year: 2018
Journal: Front Immunol
Title: DAMP-Inducing Adjuvant and PAMP Adjuvants Parallelly Enhance Protective Type-2 and Type-1 Immune Responses to Influenza Split Vaccination.
Volume: 9
Pages: 2619
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus caroli
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus