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Search results 1 to 100 out of 918 for Tbp

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Type Details Score
Gene
Type: gene
Organism: human
Gene
Type: gene
Organism: chimpanzee
Gene
Type: gene
Organism: cattle
Gene
Type: gene
Organism: chicken
Gene
Type: gene
Organism: zebrafish
Gene
Type: gene
Organism: macaque, rhesus
Gene
Type: gene
Organism: frog, western clawed
Gene
Type: gene
Organism: hamster, golden
Gene
Type: gene
Organism: rat
Gene
Type: gene
Organism: dog, domestic
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Domain
Type: Family
Description: The TATA-box binding protein (TBP) is required for the initiation of transcription by RNA polymerases I, II and III, from promoters with or without a TATA box [, ]. TBP associates with a host of factors, including the general transcription factors SL1, TFIIA, -B, -D, -E, and -H, to form huge multi-subunit pre-initiation complexes on the core promoter. Through its association with different transcription factors, TBP can initiate transcription from different RNA polymerases. There are several related TBPs, including TBP-like (TBPL) proteins []. TBP binds directly to the TATA box promoter element, where it nucleates polymerase assembly, thus defining the transcription start site.The C-terminal core of TBP (~180 residues) is highly conserved and contains two 77-amino acid repeats that produce a saddle-shaped structure that straddles the DNA; this region binds to the TATA box and interacts with transcription factors and regulatory proteins []. By contrast, the N-terminal region varies in both length and sequence.
GXD Expression  
Probe: MGI:3623381
Assay Type: RNA in situ
Annotation Date: 2006-05-26
Strength: Present
Sex: Female
Emaps: EMAPS:3102528
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:3623385
Age: postnatal adult
Image: 4B TBP
Specimen Label: 4B TBP
Detected: true
Specimen Num: 1
GXD Expression  
Probe: MGI:3623381
Assay Type: RNA in situ
Annotation Date: 2006-05-26
Strength: Present
Sex: Female
Emaps: EMAPS:3562728
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:3623385
Age: postnatal adult
Image: 4B TBP
Specimen Label: 4B TBP
Detected: true
Specimen Num: 1
GXD Expression    
Probe: MGI:5907637
Assay Type: RT-PCR
Annotation Date: 2017-08-29
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1716828
Stage: TS28
Assay Id: MGI:5907669
Age: postnatal adult
Image: 4
Specimen Label: TBP
Detected: true
Specimen Num: 1
Protein
Organism: Mus musculus/domesticus
Length: 316  
Fragment?: false
Publication
First Author: Davidson I
Year: 2003
Journal: Trends Biochem Sci
Title: The genetics of TBP and TBP-related factors.
Volume: 28
Issue: 7
Pages: 391-8
Protein
Organism: Mus musculus/domesticus
Length: 180  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 186  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 188  
Fragment?: false
Publication
First Author: Pugh BF
Year: 2000
Journal: Gene
Title: Control of gene expression through regulation of the TATA-binding protein.
Volume: 255
Issue: 1
Pages: 1-14
Publication
First Author: Hochheimer A
Year: 2003
Journal: Genes Dev
Title: Diversified transcription initiation complexes expand promoter selectivity and tissue-specific gene expression.
Volume: 17
Issue: 11
Pages: 1309-20
Protein
Organism: Mus musculus/domesticus
Length: 350  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 348  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 349  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 316  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 250  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 64  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 260  
Fragment?: false
Publication
First Author: Nikolov DB
Year: 1992
Journal: Nature
Title: Crystal structure of TFIID TATA-box binding protein.
Volume: 360
Issue: 6399
Pages: 40-6
Publication
First Author: Mittal V
Year: 1997
Journal: Science
Title: Role for the amino-terminal region of human TBP in U6 snRNA transcription.
Volume: 275
Issue: 5303
Pages: 1136-40
Publication
First Author: Sumita K
Year: 1993
Journal: Nucleic Acids Res
Title: Structure of a mammalian TBP (TATA-binding protein) gene: isolation of the mouse TBP genome.
Volume: 21
Issue: 11
Pages: 2769
Publication
First Author: Zhao DM
Year: 2019
Journal: Curr Med Sci
Title: Role of Mutant TBP in Regulation of Myogenesis on Muscle Satellite Cells.
Volume: 39
Issue: 5
Pages: 734-740
Publication    
First Author: Teves SS
Year: 2018
Journal: Elife
Title: A stable mode of bookmarking by TBP recruits RNA polymerase II to mitotic chromosomes.
Volume: 7
Publication
First Author: Hobbs NK
Year: 2002
Journal: Cell
Title: Removing the vertebrate-specific TBP N terminus disrupts placental beta2m-dependent interactions with the maternal immune system.
Volume: 110
Issue: 1
Pages: 43-54
Publication
First Author: Martianov I
Year: 2002
Journal: Development
Title: Distinct functions of TBP and TLF/TRF2 during spermatogenesis: requirement of TLF for heterochromatic chromocenter formation in haploid round spermatids.
Volume: 129
Issue: 4
Pages: 945-55
Protein
Organism: Mus musculus/domesticus
Length: 76  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 128  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 148  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 136  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 143  
Fragment?: false
Publication
First Author: Zhong S
Year: 2007
Journal: Mol Cell Biol
Title: TBP is differentially regulated by c-Jun N-terminal kinase 1 (JNK1) and JNK2 through Elk-1, controlling c-Jun expression and cell proliferation.
Volume: 27
Issue: 1
Pages: 54-64
Publication
First Author: Gazdag E
Year: 2007
Journal: Reproduction
Title: Analysis of TATA-binding protein 2 (TBP2) and TBP expression suggests different roles for the two proteins in regulation of gene expression during oogenesis and early mouse development.
Volume: 134
Issue: 1
Pages: 51-62
Gene
Type: gene
Organism: cattle
Publication  
First Author: Pitulescu ME
Year: 2009
Journal: BMC Biochem
Title: TIPT2 and geminin interact with basal transcription factors to synergize in transcriptional regulation.
Volume: 10
Pages: 16
Publication
First Author: Martianov I
Year: 2002
Journal: Science
Title: RNA polymerase II transcription in murine cells lacking the TATA binding protein.
Volume: 298
Issue: 5595
Pages: 1036-9
Publication
First Author: Ohbayashi T
Year: 1996
Journal: Biochem Biophys Res Commun
Title: Promoter structure of the mouse TATA-binding protein (TBP) gene.
Volume: 225
Issue: 1
Pages: 275-80
Publication
First Author: Oda T
Year: 2000
Journal: Mol Cell Biol
Title: A novel TATA-binding protein-binding protein, ABT1, activates basal transcription and has a yeast homolog that is essential for growth.
Volume: 20
Issue: 4
Pages: 1407-18
Publication
First Author: Liu Q
Year: 2020
Journal: Nat Commun
Title: Cerebellum-enriched protein INPP5A contributes to selective neuropathology in mouse model of spinocerebellar ataxias type 17.
Volume: 11
Issue: 1
Pages: 1101
Publication
First Author: Schmidt EE
Year: 1997
Journal: J Biol Chem
Title: Spermatid-specific overexpression of the TATA-binding protein gene involves recruitment of two potent testis-specific promoters.
Volume: 272
Issue: 8
Pages: 5326-34
Publication
First Author: Choukrallah MA
Year: 2012
Journal: Nucleic Acids Res
Title: Interconversion between active and inactive TATA-binding protein transcription complexes in the mouse genome.
Volume: 40
Issue: 4
Pages: 1446-59
Publication
First Author: Guo J
Year: 2018
Journal: Mol Neurodegener
Title: Piperine ameliorates SCA17 neuropathology by reducing ER stress.
Volume: 13
Issue: 1
Pages: 4
Publication
First Author: Friedman MJ
Year: 2008
Journal: J Biol Chem
Title: Polyglutamine expansion reduces the association of TATA-binding protein with DNA and induces DNA binding-independent neurotoxicity.
Volume: 283
Issue: 13
Pages: 8283-90
Publication
First Author: Mohan WS Jr
Year: 2003
Journal: Mol Cell Biol
Title: TAF10 (TAF(II)30) is necessary for TFIID stability and early embryogenesis in mice.
Volume: 23
Issue: 12
Pages: 4307-18
Publication
First Author: Yang S
Year: 2014
Journal: Neuron
Title: Age-dependent decrease in chaperone activity impairs MANF expression, leading to Purkinje cell degeneration in inducible SCA17 mice.
Volume: 81
Issue: 2
Pages: 349-65
Publication
First Author: Trachtulec Z
Year: 1997
Journal: Mamm Genome
Title: Isolation of candidate hybrid sterility 1 genes by cDNA selection in a 1.1 megabase pair region on mouse chromosome 17.
Volume: 8
Issue: 5
Pages: 312-6
Publication
First Author: Wansleeben C
Year: 2011
Journal: Mech Dev
Title: An ENU-induced point mutation in the mouse Btaf1 gene causes post-gastrulation embryonic lethality and protein instability.
Volume: 128
Issue: 5-6
Pages: 279-88
Publication
First Author: Huang S
Year: 2015
Journal: Cell Rep
Title: Large Polyglutamine Repeats Cause Muscle Degeneration in SCA17 Mice.
Volume: 13
Issue: 1
Pages: 196-208
Publication    
First Author: Malecova B
Year: 2016
Journal: Elife
Title: TBP/TFIID-dependent activation of MyoD target genes in skeletal muscle cells.
Volume: 5
Publication
First Author: Huang H
Year: 2002
Journal: Exp Cell Res
Title: Repression of transcription and interference with DNA binding of TATA-binding protein by C-terminal alternatively spliced p53.
Volume: 279
Issue: 2
Pages: 248-59
Publication
First Author: Yang Y
Year: 2017
Journal: J Neurosci
Title: Synergistic Toxicity of Polyglutamine-Expanded TATA-Binding Protein in Glia and Neuronal Cells: Therapeutic Implications for Spinocerebellar Ataxia 17.
Volume: 37
Issue: 38
Pages: 9101-9115
Publication
First Author: Trachtulec Z
Year: 1997
Journal: Genomics
Title: Linkage of TATA-binding protein and proteasome subunit C5 genes in mice and humans reveals synteny conserved between mammals and invertebrates.
Volume: 44
Issue: 1
Pages: 1-7
Publication
First Author: Aoki T
Year: 1999
Journal: Biochem Biophys Res Commun
Title: TIP120B: a novel TIP120-family protein that is expressed specifically in muscle tissues.
Volume: 261
Issue: 3
Pages: 911-6
Publication
First Author: Zhang H
Year: 1996
Journal: Proc Natl Acad Sci U S A
Title: A role for the Msx-1 homeodomain in transcriptional regulation: residues in the N-terminal arm mediate TATA binding protein interaction and transcriptional repression.
Volume: 93
Issue: 5
Pages: 1764-9
Publication
First Author: Gregorová S
Year: 1996
Journal: Mamm Genome
Title: Sub-milliMorgan map of the proximal part of mouse Chromosome 17 including the hybrid sterility 1 gene.
Volume: 7
Issue: 2
Pages: 107-13
Publication
First Author: Heix J
Year: 1997
Journal: Proc Natl Acad Sci U S A
Title: Cloning of murine RNA polymerase I-specific TAF factors: conserved interactions between the subunits of the species-specific transcription initiation factor TIF-IB/SL1.
Volume: 94
Issue: 5
Pages: 1733-8
Publication
First Author: Freiman RN
Year: 2001
Journal: Science
Title: Requirement of tissue-selective TBP-associated factor TAFII105 in ovarian development.
Volume: 293
Issue: 5537
Pages: 2084-7
Publication
First Author: Xiao L
Year: 2006
Journal: Gene Expr Patterns
Title: Developmental and cell type-specific regulation of core promoter transcription factors in germ cells of frogs and mice.
Volume: 6
Issue: 4
Pages: 409-19
Publication
First Author: Schmidt EE
Year: 2003
Journal: J Biol Chem
Title: Fundamental cellular processes do not require vertebrate-specific sequences within the TATA-binding protein.
Volume: 278
Issue: 8
Pages: 6168-74
Publication  
First Author: Moysés-Oliveira M
Year: 2019
Journal: Gene
Title: Search for appropriate reference genes for quantitative reverse transcription PCR studies in somite, prosencephalon and heart of early mouse embryo.
Volume: 710
Pages: 148-155
Publication
First Author: Pointud JC
Year: 2003
Journal: J Cell Sci
Title: The intracellular localisation of TAF7L, a paralogue of transcription factor TFIID subunit TAF7, is developmentally regulated during male germ-cell differentiation.
Volume: 116
Issue: Pt 9
Pages: 1847-58
Publication
First Author: Prigge JR
Year: 2006
Journal: J Biol Chem
Title: Interaction of protein inhibitor of activated STAT (PIAS) proteins with the TATA-binding protein, TBP.
Volume: 281
Issue: 18
Pages: 12260-9
Publication
First Author: Svingen T
Year: 2009
Journal: Sex Dev
Title: Identification of suitable normalizing genes for quantitative real-time RT-PCR analysis of gene expression in fetal mouse gonads.
Volume: 3
Issue: 4
Pages: 194-204
Publication
First Author: Bottardi S
Year: 2011
Journal: Nucleic Acids Res
Title: Ikaros interacts with P-TEFb and cooperates with GATA-1 to enhance transcription elongation.
Volume: 39
Issue: 9
Pages: 3505-19
Publication
First Author: Barratt KS
Year: 2018
Journal: Mamm Genome
Title: Identification of reference genes suitable for RT-qPCR studies of murine gastrulation and patterning.
Volume: 29
Issue: 9-10
Pages: 656-662
Publication
First Author: Guermah M
Year: 2003
Journal: Mol Cell
Title: The TBN protein, which is essential for early embryonic mouse development, is an inducible TAFII implicated in adipogenesis.
Volume: 12
Issue: 4
Pages: 991-1001
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus caroli
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus pahari
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus spretus
Publication
First Author: Tamura T
Year: 1991
Journal: Nucleic Acids Res
Title: Striking homology of the 'variable' N-terminal as well as the 'conserved core' domains of the mouse and human TATA-factors (TFIID).
Volume: 19
Issue: 14
Pages: 3861-5
Publication  
First Author: Portal E
Year: 2013
Journal: Behav Brain Res
Title: Automated home cage assessment shows behavioral changes in a transgenic mouse model of spinocerebellar ataxia type 17.
Volume: 250
Pages: 157-65
Publication
First Author: Danciger M
Year: 1993
Journal: Gene
Title: Transcription factor IID probes localize a single gene to the proximal region of mouse chromosome 17.
Volume: 130
Issue: 2
Pages: 283-6
GXD Expression    
Probe: MGI:2660600
Assay Type: RT-PCR
Annotation Date: 2003-05-22
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603913
Stage: TS13
Assay Id: MGI:2660663
Age: embryonic day 8.5
Image: 4
Specimen Label: 8.5E +
Detected: true
Specimen Num: 1
GXD Expression    
Probe: MGI:2660600
Assay Type: RT-PCR
Annotation Date: 2003-05-22
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3568928
Stage: TS28
Assay Id: MGI:2660663
Age: postnatal adult
Image: 4
Specimen Label: 8.5d/p +
Detected: true
Specimen Num: 3