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Search results 1 to 100 out of 906 for Tcf7

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Hits by Pathway

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Hits by Strain

Type Details Score
Gene
6932 | TCF7
Type: gene
Organism: human
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Gene
395061 | tcf7
Type: gene
Organism: frog, western clawed
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Gene
363595 | Tcf7
Type: gene
Organism: rat
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Gene
745839 | TCF7
Type: gene
Organism: chimpanzee
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Gene
481506 | TCF7
Type: gene
Organism: dog, domestic
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Gene
782690 | TCF7
Type: gene
Organism: cattle
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Gene
395229 | TCF7
Type: gene
Organism: chicken
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Gene
497649 | tcf7
Type: gene
Organism: zebrafish
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Gene
710234 | TCF7
Type: gene
Organism: macaque, rhesus
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Protein Domain
IPR028785 | Tcf7
Type: Family
Description: Transcription factor 7 (Tcf7), also referred to by the symbol Tcf1, is a transcriptional activator involved in T-cell lymphocyte differentiation []. It is necessary for the survival of CD4+ CD8+ immature thymocytes []. Tcf7 has multiple isoforms, and there is functional differences between these isoforms [, ].
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Protein Coding Gene
MGI:98507 | Tcf7
Type: protein_coding_gene
Organism: mouse, laboratory
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GXD Expression
GXD Expression
Probe: MGI:7494317
Assay Type: RNA in situ
Annotation Date: 2023-07-03
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3821426
Pattern: Not Specified
Stage: TS26
Assay Id: MGI:7494350
Age: embryonic day 18.5
Image: 1F Tcf7
Note: Expression higher in osteogenic front.
Specimen Label: 1F Tcf7
Detected: true
Specimen Num: 1
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Protein
B7ZNN3
Organism: Mus musculus/domesticus
Length: 334  
Fragment?: false
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Publication
8622675 | J:35031
First Author: Van de Wetering M
Year: 1996
Journal: Mol Cell Biol
Title: Extensive alternative splicing and dual promoter usage generate Tcf-1 protein isoforms with differential transcription control properties.
Volume: 16
Issue: 3
Pages: 745-52
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Publication
11477404 | J:107212
First Author: Ioannidis V
Year: 2001
Journal: Nat Immunol
Title: The beta-catenin--TCF-1 pathway ensures CD4(+)CD8(+) thymocyte survival.
Volume: 2
Issue: 8
Pages: 691-7
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Publication
9462507 | J:110481
First Author: Okamura RM
Year: 1998
Journal: Immunity
Title: Redundant regulation of T cell differentiation and TCRalpha gene expression by the transcription factors LEF-1 and TCF-1.
Volume: 8
Issue: 1
Pages: 11-20
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Publication
33741532 | J:304447
 
First Author: Kaur KD
Year: 2021
Journal: Mol Metab
Title: TCF7 is not essential for glucose homeostasis in mice.
Volume: 48
Pages: 101213
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Publication
23212152 | J:199062
First Author: Huls G
Year: 2013
Journal: Leukemia
Title: Loss of Tcf7 diminishes hematopoietic stem/progenitor cell function.
Volume: 27
Issue: 7
Pages: 1613-4
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Publication
7640309 | -
First Author: Mayer K
Year: 1995
Journal: Biochim Biophys Acta
Title: The human high mobility group (HMG)-box transcription factor TCF-1: novel isoforms due to alternative splicing and usage of a new exon IXA.
Volume: 1263
Issue: 2
Pages: 169-72
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Protein
A0A5F8MPS9
Organism: Mus musculus/domesticus
Length: 192  
Fragment?: true
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Protein
Q00417
Organism: Mus musculus/domesticus
Length: 419  
Fragment?: false
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Protein
A0A5K1VVQ7
Organism: Mus musculus/domesticus
Length: 419  
Fragment?: false
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Protein
Q80UF1
Organism: Mus musculus/domesticus
Length: 303  
Fragment?: false
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Publication
32265924 | J:337301
 
First Author: Harly C
Year: 2020
Journal: Front Immunol
Title: A Shared Regulatory Element Controls the Initiation of Tcf7 Expression During Early T Cell and Innate Lymphoid Cell Developments.
Volume: 11
Pages: 470
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GXD Expression
GXD Expression
   
Probe: MGI:6184917
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689419
Pattern: Not Specified
Stage: TS19
Assay Id: MGI:6191438
Age: embryonic day 11.5
Specimen Label: Table S2 - E11.5 - Tcf7
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
   
Probe: MGI:6184917
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689421
Pattern: Not Specified
Stage: TS21
Assay Id: MGI:6191438
Age: embryonic day 13.5
Specimen Label: Table S2 - E13.5 - Tcf7
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
   
Probe: MGI:6184917
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689424
Pattern: Not Specified
Stage: TS24
Assay Id: MGI:6191438
Age: embryonic day 15.5
Specimen Label: Table S2 - E15.5 - Tcf7
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
   
Probe: MGI:6184917
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689426
Pattern: Not Specified
Stage: TS26
Assay Id: MGI:6191438
Age: embryonic day 18.5
Specimen Label: Table S2 - E18.5 - Tcf7
Detected: true
Specimen Num: 4
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GXD Expression
GXD Expression
   
Probe: MGI:6184917
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6191438
Age: postnatal day 4
Specimen Label: Table S2 - P4 - Tcf7
Detected: true
Specimen Num: 5
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GXD Expression
GXD Expression
     
Probe: MGI:6184917
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Absent
Sex: Male
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:6191438
Age: postnatal day 14
Specimen Label: Table S2 - P14 - Tcf7
Detected: false
Specimen Num: 6
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GXD Expression
GXD Expression
     
Probe: MGI:6184917
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Absent
Sex: Male
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:6191438
Age: postnatal day 28
Specimen Label: Table S2 - P28 - Tcf7
Detected: false
Specimen Num: 7
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Publication
36045674 | J:327921
 
First Author: Luo Y
Year: 2022
Journal: Front Immunol
Title: EZH2 restricts Tcf7 DNA methylation and promotes TFH differentiation during acute viral infection.
Volume: 13
Pages: 942465
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Publication
33128876 | J:305277
First Author: Pais Ferreira D
Year: 2020
Journal: Immunity
Title: Central memory CD8+ T cells derive from stem-like Tcf7hi effector cells in the absence of cytotoxic differentiation.
Volume: 53
Issue: 5
Pages: 985-1000.e11
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Publication
36239683 | J:330168
 
First Author: Du W
Year: 2023
Journal: J Exp Med
Title: WNT signaling in the tumor microenvironment promotes immunosuppression in murine pancreatic cancer.
Volume: 220
Issue: 1
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Publication
33535043 | J:304284
First Author: Fahl SP
Year: 2021
Journal: Cell Rep
Title: The E protein-TCF1 axis controls γδ T cell development and effector fate.
Volume: 34
Issue: 5
Pages: 108716
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Publication
31175159 | J:277838
First Author: Liu Z
Year: 2019
Journal: J Immunol
Title: Cutting Edge: Transcription Factor BCL6 Is Required for the Generation, but Not Maintenance, of Memory CD8+ T Cells in Acute Viral Infection.
Volume: 203
Issue: 2
Pages: 323-327
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Publication
25978037 | J:235318
First Author: Barra MM
Year: 2015
Journal: PLoS One
Title: Premature expression of Foxp3 in double-negative thymocytes.
Volume: 10
Issue: 5
Pages: e0127038
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Publication
27582468 | J:238279
First Author: Ladle BH
Year: 2016
Journal: Proc Natl Acad Sci U S A
Title: De novo DNA methylation by DNA methyltransferase 3a controls early effector CD8+ T-cell fate decisions following activation.
Volume: 113
Issue: 38
Pages: 10631-6
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Publication
33176163 | J:305779
First Author: van der Veeken J
Year: 2020
Journal: Immunity
Title: The Transcription Factor Foxp3 Shapes Regulatory T Cell Identity by Tuning the Activity of trans-Acting Intermediaries.
Volume: 53
Issue: 5
Pages: 971-984.e5
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Publication
29358218 | J:262883
     
First Author: Li Q
Year: 2018
Journal: Mol Cell Biol
Title: TCF7/TCF1 feedback controls osteocalcin signaling in brown adipocytes independent of canonical WNT/β-catenin pathway.
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Publication
34917097 | J:331246
 
First Author: Liu J
Year: 2021
Journal: Front Immunol
Title: Tcf1 Sustains the Expression of Multiple Regulators in Promoting Early Natural Killer Cell Development.
Volume: 12
Pages: 791220
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Publication
26214741 | J:241194
First Author: Choi YS
Year: 2015
Journal: Nat Immunol
Title: LEF-1 and TCF-1 orchestrate T(FH) differentiation by regulating differentiation circuits upstream of the transcriptional repressor Bcl6.
Volume: 16
Issue: 9
Pages: 980-90
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Publication
30778251 | J:282505
First Author: Gautam S
Year: 2019
Journal: Nat Immunol
Title: The transcription factor c-Myb regulates CD8+ T cell stemness and antitumor immunity.
Volume: 20
Issue: 3
Pages: 337-349
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Publication
23932570 | J:208232
First Author: Kim MV
Year: 2013
Journal: Immunity
Title: The transcription factor Foxo1 controls central-memory CD8+ T cell responses to infection.
Volume: 39
Issue: 2
Pages: 286-97
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Publication
32268106 | J:303488
First Author: Wu J
Year: 2020
Journal: Cell Rep
Title: T Cell Factor 1 Suppresses CD103+ Lung Tissue-Resident Memory T Cell Development.
Volume: 31
Issue: 1
Pages: 107484
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Publication
39245681 | J:354290
First Author: Bao K
Year: 2024
Journal: Nat Commun
Title: TCF-1 and TOX regulate the memory formation of intestinal group 2 innate lymphoid cells in asthma.
Volume: 15
Issue: 1
Pages: 7850
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Publication
23103132 | J:190675
First Author: Yu S
Year: 2012
Journal: Immunity
Title: The TCF-1 and LEF-1 transcription factors have cooperative and opposing roles in T cell development and malignancy.
Volume: 37
Issue: 5
Pages: 813-26
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Publication
23601684 | J:196648
First Author: Yang Q
Year: 2013
Journal: Immunity
Title: T cell factor 1 is required for group 2 innate lymphoid cell generation.
Volume: 38
Issue: 4
Pages: 694-704
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Publication
28604718 | J:259951
First Author: Shan Q
Year: 2017
Journal: Nat Immunol
Title: The transcription factor Runx3 guards cytotoxic CD8+ effector T cells against deviation towards follicular helper T cell lineage.
Volume: 18
Issue: 8
Pages: 931-939
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Publication
37074193 | J:341394
First Author: Bélanger S
Year: 2023
Journal: J Immunol
Title: The Chromatin Regulator Mll1 Supports T Follicular Helper Cell Differentiation by Controlling Expression of Bcl6, LEF-1, and TCF-1.
Volume: 210
Issue: 11
Pages: 1752-1760
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Publication
36901757 | J:334973
 
First Author: Mammadli M
Year: 2023
Journal: Int J Mol Sci
Title: TCF-1 Is Required for CD4 T Cell Persistence Functions during AlloImmunity.
Volume: 24
Issue: 5
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Publication
27806296 | J:240894
First Author: Donnarumma T
Year: 2016
Journal: Cell Rep
Title: Opposing Development of Cytotoxic and Follicular Helper CD4 T Cells Controlled by the TCF-1-Bcl6 Nexus.
Volume: 17
Issue: 6
Pages: 1571-1583
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Publication
33104170 | J:307783
 
First Author: Kasal DN
Year: 2021
Journal: J Exp Med
Title: Multi-transcription factor reporter mice delineate early precursors to the ILC and LTi lineages.
Volume: 218
Issue: 2
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Publication
26193896 | J:247169
First Author: Kaur K
Year: 2015
Journal: Diabetes
Title: Elevated Hepatic miR-22-3p Expression Impairs Gluconeogenesis by Silencing the Wnt-Responsive Transcription Factor Tcf7.
Volume: 64
Issue: 11
Pages: 3659-69
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Publication
26324778 | J:329711
First Author: Barra MM
Year: 2015
Journal: J Immunol
Title: Transcription Factor 7 Limits Regulatory T Cell Generation in the Thymus.
Volume: 195
Issue: 7
Pages: 3058-70
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Publication
28930662 | J:258657
First Author: Xu L
Year: 2017
Journal: Immunity
Title: The Kinase mTORC1 Promotes the Generation and Suppressive Function of Follicular Regulatory T Cells.
Volume: 47
Issue: 3
Pages: 538-551.e5
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Publication
27941786 | J:260180
First Author: Herzig Y
Year: 2017
Journal: Nat Immunol
Title: Transcriptional programs that control expression of the autoimmune regulator gene Aire.
Volume: 18
Issue: 2
Pages: 161-172
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Publication
26642437 | J:233177
First Author: Campbell JE
Year: 2016
Journal: Nat Med
Title: TCF1 links GIPR signaling to the control of beta cell function and survival.
Volume: 22
Issue: 1
Pages: 84-90
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Publication
19563800 | J:154496
First Author: Railo A
Year: 2009
Journal: Exp Cell Res
Title: Genomic response to Wnt signalling is highly context-dependent--evidence from DNA microarray and chromatin immunoprecipitation screens of Wnt/TCF targets.
Volume: 315
Issue: 16
Pages: 2690-704
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HT Experiment
E-GEOD-65361 | Tcf7 biology in mouse beta-cells
Series Id: GSE65361
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: ArrayExpress
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Protein Coding Gene
MGP_CAROLIEiJ_G0016325 | -
Type: protein_coding_gene
Organism: Mus caroli
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Protein Coding Gene
MGP_129S1SvImJ_G0018283 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AJ_G0018252 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AKRJ_G0018222 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_BALBcJ_G0018223 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C3HHeJ_G0018034 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI_C57BL6J_98507 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C57BL6NJ_G0018675 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CASTEiJ_G0017599 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CBAJ_G0018009 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_DBA2J_G0018119 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_FVBNJ_G0018111 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_LPJ_G0018193 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NODShiLtJ_G0018135 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NZOHlLtJ_G0018717 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PWKPhJ_G0017374 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_WSBEiJ_G0017646 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PahariEiJ_G0017460 | -
Type: protein_coding_gene
Organism: Mus pahari
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Protein Coding Gene
MGP_SPRETEiJ_G0017169 | -
Type: protein_coding_gene
Organism: Mus spretus
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Publication
1827138 | J:11147
First Author: Oosterwegel M
Year: 1991
Journal: J Exp Med
Title: Cloning of murine TCF-1, a T cell-specific transcription factor interacting with functional motifs in the CD3-epsilon and T cell receptor alpha enhancers.
Volume: 173
Issue: 5
Pages: 1133-42
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Publication
7870176 | J:23255
First Author: Verbeek S
Year: 1995
Journal: Nature
Title: An HMG-box-containing T-cell factor required for thymocyte differentiation.
Volume: 374
Issue: 6517
Pages: 70-4
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Publication
10549625 | J:110534
First Author: Held W
Year: 1999
Journal: Immunity
Title: Clonal acquisition of the Ly49A NK cell receptor is dependent on the trans-acting factor TCF-1.
Volume: 11
Issue: 4
Pages: 433-42
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Publication
23185135 | J:193968
First Author: Tiemessen MM
Year: 2012
Journal: PLoS Biol
Title: The nuclear effector of Wnt-signaling, Tcf1, functions as a T-cell-specific tumor suppressor for development of lymphomas.
Volume: 10
Issue: 11
Pages: e1001430
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Publication
21339363 | J:170846
First Author: Yu Q
Year: 2011
Journal: J Immunol
Title: T cell factor-1 negatively regulates expression of IL-17 family of cytokines and protects mice from experimental autoimmune encephalomyelitis.
Volume: 186
Issue: 7
Pages: 3946-52
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Publication
21935461 | J:177880
First Author: Ma J
Year: 2011
Journal: PLoS One
Title: Critical role of TCF-1 in repression of the IL-17 gene.
Volume: 6
Issue: 9
Pages: e24768
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Publication
8617303 | J:31295
First Author: Ohteki T
Year: 1996
Journal: Eur J Immunol
Title: Selectively impaired development of intestinal T cell receptor gamma delta+ cells and liver CD4+ NK1+ T cell receptor alpha beta+ cells in T cell factor-1-deficient mice.
Volume: 26
Issue: 2
Pages: 351-5
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Publication
9780167 | J:112142
First Author: Schilham MW
Year: 1998
Journal: J Immunol
Title: Critical involvement of Tcf-1 in expansion of thymocytes.
Volume: 161
Issue: 8
Pages: 3984-91
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Publication
23954131 | J:208228
First Author: van Loosdregt J
Year: 2013
Journal: Immunity
Title: Canonical Wnt signaling negatively modulates regulatory T cell function.
Volume: 39
Issue: 2
Pages: 298-310
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Publication
23660861 | J:200960
First Author: Yu S
Year: 2013
Journal: Blood
Title: TCF-1 mediates repression of Notch pathway in T lineage-committed early thymocytes.
Volume: 121
Issue: 19
Pages: 4008-9
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Publication
29466756 | J:272352
First Author: Johnson JL
Year: 2018
Journal: Immunity
Title: Lineage-Determining Transcription Factor TCF-1 Initiates the Epigenetic Identity of T Cells.
Volume: 48
Issue: 2
Pages: 243-257.e10
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Publication
12847244 | J:84290
First Author: Ioannidis V
Year: 2003
Journal: J Immunol
Title: Initiation and limitation of Ly-49A NK cell receptor acquisition by T cell factor-1.
Volume: 171
Issue: 2
Pages: 769-75
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Publication
20457902 | J:160546
First Author: Jeannet G
Year: 2010
Journal: Proc Natl Acad Sci U S A
Title: Essential role of the Wnt pathway effector Tcf-1 for the establishment of functional CD8 T cell memory.
Volume: 107
Issue: 21
Pages: 9777-82
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Publication
27533016 | J:259220
First Author: Utzschneider DT
Year: 2016
Journal: Immunity
Title: T Cell Factor 1-Expressing Memory-like CD8(+) T Cells Sustain the Immune Response to Chronic Viral Infections.
Volume: 45
Issue: 2
Pages: 415-27
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Publication
30635237 | J:282507
First Author: Siddiqui I
Year: 2019
Journal: Immunity
Title: Intratumoral Tcf1+PD-1+CD8+ T Cells with Stem-like Properties Promote Tumor Control in Response to Vaccination and Checkpoint Blockade Immunotherapy.
Volume: 50
Issue: 1
Pages: 195-211.e10
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Publication
20727791 | J:163912
First Author: Zhou X
Year: 2010
Journal: Immunity
Title: Differentiation and persistence of memory CD8(+) T cells depend on T cell factor 1.
Volume: 33
Issue: 2
Pages: 229-40
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Publication
27501248 | J:236613
First Author: Im SJ
Year: 2016
Journal: Nature
Title: Defining CD8+ T cells that provide the proliferative burst after PD-1 therapy.
Volume: 537
Issue: 7620
Pages: 417-421
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Publication
30814995 | J:291250
 
First Author: Wang Y
Year: 2019
Journal: Front Immunol
Title: The Transcription Factor TCF1 Preserves the Effector Function of Exhausted CD8 T Cells During Chronic Viral Infection.
Volume: 10
Pages: 169
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Publication
28652395 | J:250822
First Author: Gullicksrud JA
Year: 2017
Journal: J Immunol
Title: Differential Requirements for Tcf1 Long Isoforms in CD8+ and CD4+ T Cell Responses to Acute Viral Infection.
Volume: 199
Issue: 3
Pages: 911-919
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Publication
28348272 | J:247679
First Author: Xu Z
Year: 2017
Journal: J Immunol
Title: Cutting Edge: β-Catenin-Interacting Tcf1 Isoforms Are Essential for Thymocyte Survival but Dispensable for Thymic Maturation Transitions.
Volume: 198
Issue: 9
Pages: 3404-3409
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Publication
1569101 | J:838
First Author: van de Wetering M
Year: 1992
Journal: J Biol Chem
Title: The human T cell transcription factor-1 gene. Structure, localization, and promoter characterization.
Volume: 267
Issue: 12
Pages: 8530-6
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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