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Search results 1 to 93 out of 93 for Tdp1

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Hits by Strain

Type Details Score
Gene
55775 | TDP1
Type: gene
Organism: human
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Gene
734106 | tdp1
Type: gene
Organism: frog, western clawed
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Gene
314380 | Tdp1
Type: gene
Organism: rat
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Gene
490828 | TDP1
Type: gene
Organism: dog, domestic
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Gene
453096 | TDP1
Type: gene
Organism: chimpanzee
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Gene
517053 | TDP1
Type: gene
Organism: cattle
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Gene
423403 | TDP1
Type: gene
Organism: chicken
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Gene
571485 | tdp1
Type: gene
Organism: zebrafish
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Gene
695338 | TDP1
Type: gene
Organism: macaque, rhesus
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Protein Coding Gene
MGI:1920036 | Tdp1
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Domain
IPR010347 | Tdp1
Type: Family
Description: Tyrosyl-DNA phosphodiesterase 1 (Tdp1) is a DNA repair enzyme that can remove a variety of covalent adducts from DNA through hydrolysis of a 3'-phosphodiester bond, giving rise to DNA with a free 3' phosphate [, ]. Mutations in human TDP1 gene cause spinocerebellar ataxia, autosomal recessive, with axonal neuropathy (SCAN1), which is a clinically and genetically heterogeneous group of cerebellar disorders [].
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Protein
Q6P1B8
Organism: Mus musculus/domesticus
Length: 609  
Fragment?: false
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Publication
16141202 | -
First Author: Interthal H
Year: 2005
Journal: J Biol Chem
Title: Human Tdp1 cleaves a broad spectrum of substrates, including phosphoamide linkages.
Volume: 280
Issue: 43
Pages: 36518-28
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Publication
17948061 | J:127602
First Author: Hirano R
Year: 2007
Journal: EMBO J
Title: Spinocerebellar ataxia with axonal neuropathy: consequence of a Tdp1 recessive neomorphic mutation?
Volume: 26
Issue: 22
Pages: 4732-43
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Publication
17914460 | J:127605
First Author: Katyal S
Year: 2007
Journal: EMBO J
Title: TDP1 facilitates chromosomal single-strand break repair in neurons and is neuroprotective in vivo.
Volume: 26
Issue: 22
Pages: 4720-31
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Publication
19303373 | J:148800
First Author: El-Khamisy SF
Year: 2009
Journal: DNA Repair (Amst)
Title: Synergistic decrease of DNA single-strand break repair rates in mouse neural cells lacking both Tdp1 and aprataxin.
Volume: 8
Issue: 6
Pages: 760-6
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Protein
Q8BJ37
Organism: Mus musculus/domesticus
Length: 609  
Fragment?: false
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Protein
B8JJC1
Organism: Mus musculus/domesticus
Length: 609  
Fragment?: false
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Publication
12023295 | -
First Author: Inamdar KV
Year: 2002
Journal: J Biol Chem
Title: Conversion of phosphoglycolate to phosphate termini on 3' overhangs of DNA double strand breaks by the human tyrosyl-DNA phosphodiesterase hTdp1.
Volume: 277
Issue: 30
Pages: 27162-8
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Publication
19505854 | -
First Author: Zhou T
Year: 2009
Journal: DNA Repair (Amst)
Title: Tyrosyl-DNA phosphodiesterase and the repair of 3'-phosphoglycolate-terminated DNA double-strand breaks.
Volume: 8
Issue: 8
Pages: 901-11
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Publication
21041670 | J:166601
First Author: Das BB
Year: 2010
Journal: Proc Natl Acad Sci U S A
Title: Role of tyrosyl-DNA phosphodiesterase (TDP1) in mitochondria.
Volume: 107
Issue: 46
Pages: 19790-5
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Publication
29523818 | J:262613
First Author: Fam HK
Year: 2018
Journal: Sci Rep
Title: Reactive oxygen species stress increases accumulation of tyrosyl-DNA phsosphodiesterase 1 within mitochondria.
Volume: 8
Issue: 1
Pages: 4304
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Publication
28508041 | J:258173
First Author: Chiang SC
Year: 2017
Journal: Sci Adv
Title: Mitochondrial protein-linked DNA breaks perturb mitochondrial gene transcription and trigger free radical-induced DNA damage.
Volume: 3
Issue: 4
Pages: e1602506
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Publication
22740648 | J:199691
First Author: Zeng Z
Year: 2012
Journal: Nucleic Acids Res
Title: TDP2 promotes repair of topoisomerase I-mediated DNA damage in the absence of TDP1.
Volume: 40
Issue: 17
Pages: 8371-80
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Publication
24637776 | J:215106
First Author: Yeo AJ
Year: 2014
Journal: PLoS One
Title: R-loops in proliferating cells but not in the brain: implications for AOA2 and other autosomal recessive ataxias.
Volume: 9
Issue: 3
Pages: e90219
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Protein Coding Gene
MGP_CAROLIEiJ_G0018017 | -
Type: protein_coding_gene
Organism: Mus caroli
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Protein Coding Gene
MGP_129S1SvImJ_G0020013 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AJ_G0019968 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AKRJ_G0019944 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_BALBcJ_G0019954 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C3HHeJ_G0019756 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI_C57BL6J_1920036 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C57BL6NJ_G0020403 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CASTEiJ_G0019302 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CBAJ_G0019728 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_DBA2J_G0019839 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_FVBNJ_G0019828 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_LPJ_G0019915 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NODShiLtJ_G0019870 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NZOHlLtJ_G0020432 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PWKPhJ_G0019066 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_WSBEiJ_G0019356 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PahariEiJ_G0029775 | -
Type: protein_coding_gene
Organism: Mus pahari
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Protein Coding Gene
MGP_SPRETEiJ_G0018862 | -
Type: protein_coding_gene
Organism: Mus spretus
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GXD Expression
GXD Expression
     
Probe: MGI:6457050
Assay Type: RT-PCR
Annotation Date: 2020-09-24
Strength: Present
Sex: Female
Emaps: EMAPS:1796223
Stage: TS23
Assay Id: MGI:6457084
Age: embryonic day 15.5
Specimen Label: Ovary Fetal
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
       
Probe: MGI:6457050
Assay Type: RT-PCR
Annotation Date: 2020-09-24
Strength: Not Specified
Sex: Female
Emaps: EMAPS:1796228
Stage: TS28
Assay Id: MGI:6457084
Age: postnatal adult
Specimen Label: Ovary Adult
Specimen Num: 2
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GXD Expression
GXD Expression
     
Probe: MGI:6457050
Assay Type: RT-PCR
Annotation Date: 2020-09-24
Strength: Present
Sex: Male
Emaps: EMAPS:1797223
Stage: TS23
Assay Id: MGI:6457084
Age: embryonic day 15.5
Specimen Label: Testis Fetal
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
     
Probe: MGI:6457050
Assay Type: RT-PCR
Annotation Date: 2020-09-24
Strength: Present
Sex: Male
Emaps: EMAPS:1797228
Stage: TS28
Assay Id: MGI:6457084
Age: postnatal adult
Specimen Label: Testis Adult
Detected: true
Specimen Num: 4
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GXD Expression
GXD Expression
 
Probe: MGI:6457059
Assay Type: RNA in situ
Annotation Date: 2020-09-24
Strength: Present
Sex: Male
Emaps: EMAPS:1797228
Pattern: Ubiquitous
Stage: TS28
Assay Id: MGI:6457093
Age: postnatal adult
Note: Expression in all testicular tissue cells.
Specimen Label: 3 MLZ-501
Detected: true
Specimen Num: 1
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Publication
21390131 | J:170077
First Author: Gao Y
Year: 2011
Journal: Nature
Title: DNA ligase III is critical for mtDNA integrity but not Xrcc1-mediated nuclear DNA repair.
Volume: 471
Issue: 7337
Pages: 240-4
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Publication
23042675 | J:200260
First Author: Prasad R
Year: 2012
Journal: Nucleic Acids Res
Title: Pol β associated complex and base excision repair factors in mouse fibroblasts.
Volume: 40
Issue: 22
Pages: 11571-82
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Publication
20339383 | J:187568
First Author: Kogo H
Year: 2010
Journal: J Hum Genet
Title: Screening of genes involved in chromosome segregation during meiosis I: toward the identification of genes responsible for infertility in humans.
Volume: 55
Issue: 5
Pages: 293-9
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Publication
24793032 | J:212924
First Author: Katyal S
Year: 2014
Journal: Nat Neurosci
Title: Aberrant topoisomerase-1 DNA lesions are pathogenic in neurodegenerative genome instability syndromes.
Volume: 17
Issue: 6
Pages: 813-21
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Publication
- | J:193309
       
First Author: Mouse Genome Informatics Scientfic Curators
Year: 2013
Title: Curated associations of genes in MGI and UniProt sequence records
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Publication
- | J:94077
     
First Author: Mutant Mouse Regional Resource Centers
Year: 2004
Journal: Unpublished
Title: Information obtained from the Mutant Mouse Regional Resource Centers (MMRRC)
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Publication
- | J:265051
     
First Author: MGI and IMPC
Year: 2018
Journal: Database Release
Title: MGI Load of Endonuclease-Mediated Alleles (CRISPR) from the International Mouse Phenotyping Consortium (IMPC)
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Publication
12520002 | J:91812
First Author: Stryke D
Year: 2003
Journal: Nucleic Acids Res
Title: BayGenomics: a resource of insertional mutations in mouse embryonic stem cells.
Volume: 31
Issue: 1
Pages: 278-81
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Publication
- | J:136110
     
First Author: Velocigene
Year: 2008
Journal: MGI Direct Data Submission
Title: Alleles produced for the KOMP project by Velocigene (Regeneron Pharmaceuticals)
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Publication
- | J:204812
     
First Author: International Mouse Strain Resource
Year: 2014
Journal: Database Download
Title: MGI download of germline transmission data for alleles from IMSR strain data
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Publication
- | J:211773
     
First Author: Mouse Genome Informatics and the International Mouse Phenotyping Consortium (IMPC)
Year: 2014
Journal: Database Release
Title: Obtaining and Loading Phenotype Annotations from the International Mouse Phenotyping Consortium (IMPC) Database
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Publication
- | J:157065
     
First Author: Helmholtz Zentrum Muenchen GmbH
Year: 2010
Journal: MGI Direct Data Submission
Title: Alleles produced for the EUCOMM and EUCOMMTools projects by the Helmholtz Zentrum Muenchen GmbH (Hmgu)
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Publication
- | J:85000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Title: MGI Sequence Curation Reference
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Publication
16141072 | J:99680
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
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Publication
11217851 | J:65060
First Author: Kawai J
Year: 2001
Journal: Nature
Title: Functional annotation of a full-length mouse cDNA collection.
Volume: 409
Issue: 6821
Pages: 685-90
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Publication
38355793 | J:345621
First Author: Adams DJ
Year: 2024
Journal: Nature
Title: Genetic determinants of micronucleus formation in vivo.
Volume: 627
Issue: 8002
Pages: 130-136
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Publication
14610273 | J:86696
First Author: Zambrowicz BP
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Volume: 100
Issue: 24
Pages: 14109-14
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Publication
- | J:293217
       
First Author: GemPharmatech
Year: 2020
Title: GemPharmatech Website.
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Publication
- | J:141210
     
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
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Publication
- | J:342587
       
First Author: AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators
Year: 2011
Title: Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
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Publication
- | J:60000
       
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
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Publication
- | J:68900
     
First Author: The Jackson Laboratory Mouse Radiation Hybrid Database
Year: 2004
Journal: Database Release
Title: Mouse T31 Radiation Hybrid Data Load
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Publication
12466851 | J:80000
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
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Publication
- | J:164563
       
First Author: The Gene Ontology Consortium
Year: 2010
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs
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Publication
21267068 | J:153498
First Author: Diez-Roux G
Year: 2011
Journal: PLoS Biol
Title: A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Volume: 9
Issue: 1
Pages: e1000582
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Publication
- | J:75000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
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Publication
- | J:157972
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
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Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
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Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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Strain
MGI:5575910 | B6.129P2-Tdp1<Gt1766Wcl>/Mmucd
Attribute String: congenic, mutant strain, gene trap
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Allele
Tdp1<Gt(XD105)Byg> | MGI:3818340
Name: tyrosyl-DNA phosphodiesterase 1; gene trap XD105, BayGenomics
Allele Type: Gene trapped
Attribute String: Null/knockout, Reporter
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Genotype
Genotype
Symbol: Tdp1/Tdp1
Background: involves: 129P2/OlaHsd * C57BL/6
Zygosity: hm
Has Mutant Allele: true
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DO Term
DOID:0090115 | spinocerebellar ataxia with axonal neuropathy 1
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Publication
32572188 | J:299298
First Author: Jing CB
Year: 2020
Journal: Leukemia
Title: Synthetic lethal targeting of TET2-mutant hematopoietic stem and progenitor cells (HSPCs) with TOP1-targeted drugs and PARP1 inhibitors.
Volume: 34
Issue: 11
Pages: 2992-3006
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Publication
15489334 | -
First Author: Gerhard DS
Year: 2004
Journal: Genome Res
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Volume: 14
Issue: 10B
Pages: 2121-7
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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