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Search results 1 to 100 out of 257 for Terf2

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Type Details Score
Gene
7014 | TERF2
Type: gene
Organism: human
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Gene
489736 | TERF2
Type: gene
Organism: dog, domestic
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Gene
506501 | TERF2
Type: gene
Organism: cattle
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Gene
395598 | TERF2
Type: gene
Organism: chicken
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Gene
704879 | TERF2
Type: gene
Organism: macaque, rhesus
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Gene
100233217 | terf2
Type: gene
Organism: frog, western clawed
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Gene
361403 | Terf2
Type: gene
Organism: rat
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Gene
454201 | TERF2
Type: gene
Organism: chimpanzee
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Protein Coding Gene
MGI:1195972 | Terf2
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Domain
IPR030657 | TERF2
Type: Family
Description: This entry represents telomeric repeat-binding factor 2 (TERF2, also known as TRF2).Telomeres function to shield chromosome ends from degradation and end-to-end fusions, as well as preventing the activation of DNA damage checkpoints. Telomeric repeat binding factor (TRF) proteins TRF1 and TRF2 are major components of vertebrate telomeres required for regulation of telomere stability. TRF1 and TRF2 bind to telomeric DNA as homodimers. Dimerisation involves the TRF homology (TRFH) subdomain contained within the dimerisation domain. The TRFH subdomain is important not only for dimerisation, but for DNA binding, telomere localisation, and interactions with other telomeric proteins. The dimerisation domains of TRF1 and TRF2 show the same multi-helical structure, arranged in a solenoid conformation similar to TPR repeats, which can be divided into an α-α superhelix and a long alpha hairpin [].The two related human TRF proteins hTRF1 and hTRF2 form homodimers and bind directly to telomeric TTAGGG repeats via the myb DNA binding domain at the carboxy terminus []. TRF1 is implicated in telomere length regulation and TRF2 in telomere protection []. Other telomere complex associated proteins are recruited through their interaction with either TRF1 or TRF2. The fission yeast protein Taz1p (telomere-associated in Schizosaccharomyces pombe (Fission yeast) has similarity to both hTRF1 and hTRF2 and may perform the dual functions of TRF1 and TRF2 at fission yeast telomeres [].
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Gene
54386 | TERF2IP
Type: gene
Organism: human
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Gene
100128762 | LOC100128762
Type: gene
Organism: human
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Publication
28620865 | J:309383
First Author: Kim J
Year: 2017
Journal: Histochem Cell Biol
Title: Involvement of Atm and Trp53 in neural cell loss due to Terf2 inactivation during mouse brain development.
Volume: 148
Issue: 5
Pages: 489-501
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Gene
644899 | TERF2IPP1
Type: gene
Organism: human
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Protein
O35144
Organism: Mus musculus/domesticus
Length: 541  
Fragment?: false
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Protein
Q8C9B6
Organism: Mus musculus/domesticus
Length: 194  
Fragment?: false
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Protein
Q8C806
Organism: Mus musculus/domesticus
Length: 142  
Fragment?: true
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Protein
D3YZ08
Organism: Mus musculus/domesticus
Length: 540  
Fragment?: false
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Protein
E9QM06
Organism: Mus musculus/domesticus
Length: 476  
Fragment?: false
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Protein
F6VIR4
Organism: Mus musculus/domesticus
Length: 179  
Fragment?: true
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Publication
11545737 | -
First Author: Fairall L
Year: 2001
Journal: Mol Cell
Title: Structure of the TRFH dimerization domain of the human telomeric proteins TRF1 and TRF2.
Volume: 8
Issue: 2
Pages: 351-61
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Publication
15316005 | -
First Author: Ye JZ
Year: 2004
Journal: J Biol Chem
Title: TIN2 binds TRF1 and TRF2 simultaneously and stabilizes the TRF2 complex on telomeres.
Volume: 279
Issue: 45
Pages: 47264-71
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Publication
9034194 | -
First Author: Cooper JP
Year: 1997
Journal: Nature
Title: Regulation of telomere length and function by a Myb-domain protein in fission yeast.
Volume: 385
Issue: 6618
Pages: 744-7
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Publication
31991048 | J:286179
First Author: Robin JD
Year: 2020
Journal: Aging Cell
Title: Mitochondrial function in skeletal myofibers is controlled by a TRF2-SIRT3 axis over lifetime.
Volume: 19
Issue: 3
Pages: e13097
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Publication
10226653 | J:54708
First Author: Sakaguchi AY
Year: 1998
Journal: Somat Cell Mol Genet
Title: Chromosomal sublocalization of the transcribed human telomere repeat binding factor 2 gene and comparative mapping in the mouse.
Volume: 24
Issue: 3
Pages: 157-63
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Gene
307861 | Terf2ip
Type: gene
Organism: rat
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Gene
479643 | TERF2IP
Type: gene
Organism: dog, domestic
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Gene
454253 | TERF2IP
Type: gene
Organism: chimpanzee
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Gene
509625 | TERF2IP
Type: gene
Organism: cattle
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Gene
395122 | TERF2IP
Type: gene
Organism: chicken
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Gene
712149 | TERF2IP
Type: gene
Organism: macaque, rhesus
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Gene
779476 | terf2ip
Type: gene
Organism: frog, western clawed
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Publication
16142233 | J:102653
First Author: Muñoz P
Year: 2005
Journal: Nat Genet
Title: XPF nuclease-dependent telomere loss and increased DNA damage in mice overexpressing TRF2 result in premature aging and cancer.
Volume: 37
Issue: 10
Pages: 1063-71
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Protein Coding Gene
MGP_CAROLIEiJ_G0031532 | -
Type: protein_coding_gene
Organism: Mus caroli
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Protein Coding Gene
MGP_129S1SvImJ_G0034097 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AJ_G0034077 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AKRJ_G0034003 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_BALBcJ_G0034070 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C3HHeJ_G0033782 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI_C57BL6J_1195972 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C57BL6NJ_G0034590 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CASTEiJ_G0033109 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CBAJ_G0033755 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_DBA2J_G0033910 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_FVBNJ_G0033855 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_LPJ_G0034001 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NODShiLtJ_G0033900 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NZOHlLtJ_G0034608 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PWKPhJ_G0032810 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_WSBEiJ_G0033224 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PahariEiJ_G0023132 | -
Type: protein_coding_gene
Organism: Mus pahari
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Protein Coding Gene
MGP_SPRETEiJ_G0032650 | -
Type: protein_coding_gene
Organism: Mus spretus
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Publication
25620558 | J:219962
First Author: Sarek G
Year: 2015
Journal: Mol Cell
Title: TRF2 recruits RTEL1 to telomeres in S phase to promote t-loop unwinding.
Volume: 57
Issue: 4
Pages: 622-35
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Publication
30502348 | J:270073
 
First Author: Morgan RG
Year: 2019
Journal: J Mol Cell Cardiol
Title: Induced Trf2 deletion leads to aging vascular phenotype in mice associated with arterial telomere uncapping, senescence signaling, and oxidative stress.
Volume: 127
Pages: 74-82
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Publication
17015429 | J:112957
First Author: Lazzerini Denchi E
Year: 2006
Journal: Genes Dev
Title: Hepatocytes with extensive telomere deprotection and fusion remain viable and regenerate liver mass through endoreduplication.
Volume: 20
Issue: 19
Pages: 2648-53
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Publication
37688329 | J:342060
First Author: Sullivan DI
Year: 2023
Journal: Aging Cell
Title: Intact mitochondrial function in the setting of telomere-induced senescence.
Volume: 22
Issue: 10
Pages: e13941
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Publication
24210823 | J:205527
First Author: Békés M
Year: 2013
Journal: Cell Rep
Title: DUB-resistant ubiquitin to survey ubiquitination switches in mammalian cells.
Volume: 5
Issue: 3
Pages: 826-38
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Publication
23178498 | J:203237
First Author: Bojovic B
Year: 2013
Journal: Oncogene
Title: Stem cell expansion during carcinogenesis in stem cell-depleted conditional telomeric repeat factor 2 null mutant mice.
Volume: 32
Issue: 43
Pages: 5156-66
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Publication
12169636 | J:78543
First Author: Smogorzewska A
Year: 2002
Journal: EMBO J
Title: Different telomere damage signaling pathways in human and mouse cells.
Volume: 21
Issue: 16
Pages: 4338-48
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Publication
19259387 | J:146212
First Author: Stout GJ
Year: 2009
Journal: Dis Model Mech
Title: Genetic dissection of the mechanisms underlying telomere-associated diseases: impact of the TRF2 telomeric protein on mouse epidermal stem cells.
Volume: 2
Issue: 3-4
Pages: 139-56
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Publication
21903926 | J:176661
First Author: Zhang P
Year: 2011
Journal: Proc Natl Acad Sci U S A
Title: Nontelomeric splice variant of telomere repeat-binding factor 2 maintains neuronal traits by sequestering repressor element 1-silencing transcription factor.
Volume: 108
Issue: 39
Pages: 16434-9
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Publication
23792691 | J:201529
First Author: Biroccio A
Year: 2013
Journal: Nat Cell Biol
Title: TRF2 inhibits a cell-extrinsic pathway through which natural killer cells eliminate cancer cells.
Volume: 15
Issue: 7
Pages: 818-28
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Publication
28805810 | J:318438
First Author: Schmutz I
Year: 2017
Journal: Nat Struct Mol Biol
Title: TRF2 binds branched DNA to safeguard telomere integrity.
Volume: 24
Issue: 9
Pages: 734-742
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GXD Expression
GXD Expression
   
Probe: MGI:5647910
Assay Type: Western blot
Annotation Date: 2015-08-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1754420
Stage: TS20
Assay Id: MGI:5647916
Age: embryonic day 12.0
Image: 1
Specimen Label: E12
Detected: false
Specimen Num: 1
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GXD Expression
GXD Expression
   
Probe: MGI:5647910
Assay Type: Western blot
Annotation Date: 2015-08-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1754422
Stage: TS22
Assay Id: MGI:5647916
Age: embryonic day 14.0
Image: 1
Specimen Label: E14
Detected: false
Specimen Num: 2
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GXD Expression
GXD Expression
   
Probe: MGI:5647910
Assay Type: Western blot
Annotation Date: 2015-08-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1754424
Stage: TS24
Assay Id: MGI:5647916
Age: embryonic day 16.0
Image: 1
Specimen Label: E16
Detected: false
Specimen Num: 3
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GXD Expression
GXD Expression
   
Probe: MGI:5647910
Assay Type: Western blot
Annotation Date: 2015-08-12
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1754426
Stage: TS26
Assay Id: MGI:5647916
Age: embryonic day 18.5
Image: 1
Specimen Label: E18
Detected: true
Specimen Num: 4
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GXD Expression
GXD Expression
   
Probe: MGI:5647910
Assay Type: Western blot
Annotation Date: 2015-08-12
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1754427
Stage: TS27
Assay Id: MGI:5647916
Age: postnatal day 0
Image: 1
Specimen Label: P0
Detected: true
Specimen Num: 5
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GXD Expression
GXD Expression
   
Probe: MGI:5647910
Assay Type: Western blot
Annotation Date: 2015-08-12
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1754428
Stage: TS28
Assay Id: MGI:5647916
Age: postnatal day 5
Image: 1
Specimen Label: P5
Detected: true
Specimen Num: 6
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GXD Expression
GXD Expression
   
Probe: MGI:5647910
Assay Type: Western blot
Annotation Date: 2015-08-12
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1754428
Stage: TS28
Assay Id: MGI:5647916
Age: postnatal day 15
Image: 1
Specimen Label: P15
Detected: true
Specimen Num: 7
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GXD Expression
GXD Expression
   
Probe: MGI:5647910
Assay Type: Western blot
Annotation Date: 2015-08-12
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1754428
Stage: TS28
Assay Id: MGI:5647916
Age: postnatal adult
Image: 1
Specimen Label: Ad
Detected: true
Specimen Num: 8
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GXD Expression
GXD Expression
     
Probe: MGI:7266328
Assay Type: RT-PCR
Annotation Date: 2022-05-04
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1691016
Stage: TS16
Assay Id: MGI:7266387
Age: embryonic day 10.0
Specimen Label: E10
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
     
Probe: MGI:7266328
Assay Type: RT-PCR
Annotation Date: 2022-05-04
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1754420
Stage: TS20
Assay Id: MGI:7266387
Age: embryonic day 12.0
Specimen Label: E12
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
     
Probe: MGI:7266328
Assay Type: RT-PCR
Annotation Date: 2022-05-04
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1754422
Stage: TS22
Assay Id: MGI:7266387
Age: embryonic day 14.0
Specimen Label: E14
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
     
Probe: MGI:7266328
Assay Type: RT-PCR
Annotation Date: 2022-05-04
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1754424
Stage: TS24
Assay Id: MGI:7266387
Age: embryonic day 16.0
Specimen Label: E16
Detected: true
Specimen Num: 4
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GXD Expression
GXD Expression
     
Probe: MGI:7266328
Assay Type: RT-PCR
Annotation Date: 2022-05-04
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1754426
Stage: TS26
Assay Id: MGI:7266387
Age: embryonic day 18.0
Specimen Label: E18
Detected: true
Specimen Num: 5
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GXD Expression
GXD Expression
     
Probe: MGI:7266328
Assay Type: RT-PCR
Annotation Date: 2022-05-04
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1754427
Stage: TS27
Assay Id: MGI:7266387
Age: postnatal day 1
Specimen Label: P1
Detected: true
Specimen Num: 6
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GXD Expression
GXD Expression
     
Probe: MGI:7266328
Assay Type: RT-PCR
Annotation Date: 2022-05-04
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1754428
Stage: TS28
Assay Id: MGI:7266387
Age: postnatal day 7
Specimen Label: P7
Detected: true
Specimen Num: 7
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GXD Expression
GXD Expression
     
Probe: MGI:7266328
Assay Type: RT-PCR
Annotation Date: 2022-05-04
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1754428
Stage: TS28
Assay Id: MGI:7266387
Age: postnatal day 21
Specimen Label: P21
Detected: true
Specimen Num: 8
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GXD Expression
GXD Expression
     
Probe: MGI:7266328
Assay Type: RT-PCR
Annotation Date: 2022-05-04
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1754428
Stage: TS28
Assay Id: MGI:7266387
Age: postnatal day 100
Specimen Label: P100
Detected: true
Specimen Num: 9
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GXD Expression
GXD Expression
     
Probe: MGI:7266328
Assay Type: RT-PCR
Annotation Date: 2022-05-04
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1610516
Stage: TS16
Assay Id: MGI:7266395
Age: embryonic day 10.0
Specimen Label: E10
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
     
Probe: MGI:7266328
Assay Type: RT-PCR
Annotation Date: 2022-05-04
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1610520
Stage: TS20
Assay Id: MGI:7266395
Age: embryonic day 12.0
Specimen Label: E12
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
     
Probe: MGI:7266328
Assay Type: RT-PCR
Annotation Date: 2022-05-04
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1610522
Stage: TS22
Assay Id: MGI:7266395
Age: embryonic day 14.0
Specimen Label: E14
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
     
Probe: MGI:7266328
Assay Type: RT-PCR
Annotation Date: 2022-05-04
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1610524
Stage: TS24
Assay Id: MGI:7266395
Age: embryonic day 16.0
Specimen Label: E16
Detected: true
Specimen Num: 4
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GXD Expression
GXD Expression
     
Probe: MGI:7266328
Assay Type: RT-PCR
Annotation Date: 2022-05-04
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1610526
Stage: TS26
Assay Id: MGI:7266395
Age: embryonic day 18.0
Specimen Label: E18
Detected: true
Specimen Num: 5
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GXD Expression
GXD Expression
     
Probe: MGI:7266328
Assay Type: RT-PCR
Annotation Date: 2022-05-04
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1610527
Stage: TS27
Assay Id: MGI:7266395
Age: postnatal day 1
Specimen Label: P1
Detected: true
Specimen Num: 6
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GXD Expression
GXD Expression
     
Probe: MGI:7266328
Assay Type: RT-PCR
Annotation Date: 2022-05-04
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1610528
Stage: TS28
Assay Id: MGI:7266395
Age: postnatal day 7
Specimen Label: P7
Detected: true
Specimen Num: 7
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•
GXD Expression
GXD Expression
     
Probe: MGI:7266328
Assay Type: RT-PCR
Annotation Date: 2022-05-04
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1610528
Stage: TS28
Assay Id: MGI:7266395
Age: postnatal day 21
Specimen Label: P21
Detected: true
Specimen Num: 8
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•
GXD Expression
GXD Expression
     
Probe: MGI:7266328
Assay Type: RT-PCR
Annotation Date: 2022-05-04
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1610528
Stage: TS28
Assay Id: MGI:7266395
Age: postnatal day 100
Specimen Label: P100
Detected: true
Specimen Num: 9
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•
GXD Expression
GXD Expression
     
Probe: MGI:7266328
Assay Type: RT-PCR
Annotation Date: 2022-05-04
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1636716
Stage: TS16
Assay Id: MGI:7266412
Age: embryonic day 10.0
Specimen Label: E10
Detected: true
Specimen Num: 1
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•
GXD Expression
GXD Expression
     
Probe: MGI:7266328
Assay Type: RT-PCR
Annotation Date: 2022-05-04
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1737320
Stage: TS20
Assay Id: MGI:7266412
Age: embryonic day 12.0
Specimen Label: E12
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
     
Probe: MGI:7266328
Assay Type: RT-PCR
Annotation Date: 2022-05-04
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1737322
Stage: TS22
Assay Id: MGI:7266412
Age: embryonic day 14.0
Specimen Label: E14
Detected: true
Specimen Num: 3
•
•
•
•
•
GXD Expression
GXD Expression
     
Probe: MGI:7266328
Assay Type: RT-PCR
Annotation Date: 2022-05-04
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1737324
Stage: TS24
Assay Id: MGI:7266412
Age: embryonic day 16.0
Specimen Label: E16
Detected: true
Specimen Num: 4
•
•
•
•
•
GXD Expression
GXD Expression
     
Probe: MGI:7266328
Assay Type: RT-PCR
Annotation Date: 2022-05-04
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1737326
Stage: TS26
Assay Id: MGI:7266412
Age: embryonic day 18.0
Specimen Label: E18
Detected: true
Specimen Num: 5
•
•
•
•
•
GXD Expression
GXD Expression
     
Probe: MGI:7266328
Assay Type: RT-PCR
Annotation Date: 2022-05-04
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1737327
Stage: TS27
Assay Id: MGI:7266412
Age: postnatal day 1
Specimen Label: P1
Detected: true
Specimen Num: 6
•
•
•
•
•
GXD Expression
GXD Expression
     
Probe: MGI:7266328
Assay Type: RT-PCR
Annotation Date: 2022-05-04
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1737328
Stage: TS28
Assay Id: MGI:7266412
Age: postnatal day 7
Specimen Label: P7
Detected: true
Specimen Num: 7
•
•
•
•
•
GXD Expression
GXD Expression
     
Probe: MGI:7266328
Assay Type: RT-PCR
Annotation Date: 2022-05-04
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1737328
Stage: TS28
Assay Id: MGI:7266412
Age: postnatal day 21
Specimen Label: P21
Detected: true
Specimen Num: 8
•
•
•
•
•
GXD Expression
GXD Expression
     
Probe: MGI:7266328
Assay Type: RT-PCR
Annotation Date: 2022-05-04
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1737328
Stage: TS28
Assay Id: MGI:7266412
Age: postnatal day 100
Specimen Label: P100
Detected: true
Specimen Num: 9
•
•
•
•
•
GXD Expression
GXD Expression
     
Probe: MGI:7266328
Assay Type: RT-PCR
Annotation Date: 2022-05-04
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1684616
Stage: TS16
Assay Id: MGI:7266404
Age: embryonic day 10.0
Specimen Label: E10
Detected: true
Specimen Num: 1
•
•
•
•
•
GXD Expression
GXD Expression
     
Probe: MGI:7266328
Assay Type: RT-PCR
Annotation Date: 2022-05-04
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1684620
Stage: TS20
Assay Id: MGI:7266404
Age: embryonic day 12.0
Specimen Label: E12
Detected: true
Specimen Num: 2
•
•
•
•
•




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