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Search results 1 to 92 out of 92 for Tespa1

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Categories

Hits by Category

Hits by Strain

Type Details Score
Gene
9840 | TESPA1
Type: gene
Organism: human
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Gene
100490993 | tespa1
Type: gene
Organism: frog, western clawed
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Gene
107055393 | TESPA1
Type: gene
Organism: chicken
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Protein Domain
IPR026647 | TESPA1
Type: Family
Description: TESPA1 (Thymocyte-expressed positive selection-associated protein 1) is required for the development and maturation of T-cells, its function being essential for the late stages of thymocyte development. It plays a role in T-cell antigen receptor (TCR)-mediated activation of the ERK and NFAT signaling pathways, possibly by serving as a scaffolding protein that promotes the assembly of the LAT signalosome in thymocytes [].
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Gene
486489 | TESPA1
Type: gene
Organism: dog, domestic
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Gene
451965 | TESPA1
Type: gene
Organism: chimpanzee
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Gene
538993 | TESPA1
Type: gene
Organism: cattle
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Gene
100332241 | tespa1
Type: gene
Organism: zebrafish
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Gene
704597 | TESPA1
Type: gene
Organism: macaque, rhesus
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Protein Coding Gene
MGI:1914846 | Tespa1
Type: protein_coding_gene
Organism: mouse, laboratory
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Publication
22561606 | J:186446
First Author: Wang D
Year: 2012
Journal: Nat Immunol
Title: Tespa1 is involved in late thymocyte development through the regulation of TCR-mediated signaling.
Volume: 13
Issue: 6
Pages: 560-8
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Protein
Q3U132
Organism: Mus musculus/domesticus
Length: 458  
Fragment?: false
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Publication
25422497 | J:284733
First Author: Wang D
Year: 2014
Journal: J Exp Med
Title: Tespa1 negatively regulates FcεRI-mediated signaling and the mast cell-mediated allergic response.
Volume: 211
Issue: 13
Pages: 2635-49
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Publication
28598420 | J:250573
 
First Author: Liang J
Year: 2017
Journal: Nat Commun
Title: Tespa1 regulates T cell receptor-induced calcium signals by recruiting inositol 1,4,5-trisphosphate receptors.
Volume: 8
Pages: 15732
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Publication
33228696 | J:340708
First Author: Yang R
Year: 2020
Journal: J Transl Med
Title: Tespa1 plays a role in the modulation of airway hyperreactivity through the IL-4/STAT6 pathway.
Volume: 18
Issue: 1
Pages: 444
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Publication
37660596 | J:340599
First Author: Yang R
Year: 2023
Journal: Int Immunopharmacol
Title: Tespa1 deficiency reduces the antitumour immune response by decreasing CD8(+)T cell activity in a mouse Lewis lung cancer model.
Volume: 124
Issue: Pt A
Pages: 110865
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Publication
29867947 | J:284732
 
First Author: Yao Y
Year: 2018
Journal: Front Immunol
Title: Tespa1 Deficiency Dampens Thymus-Dependent B-Cell Activation and Attenuates Collagen-Induced Arthritis in Mice.
Volume: 9
Pages: 965
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Publication
31316154 | J:284764
First Author: Lyu J
Year: 2019
Journal: Cell Mol Immunol
Title: Thymic-specific regulation of TCR signaling by Tespa1.
Volume: 16
Issue: 12
Pages: 897-907
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Protein Coding Gene
MGP_CAROLIEiJ_G0016003 | -
Type: protein_coding_gene
Organism: Mus caroli
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Protein Coding Gene
MGP_129S1SvImJ_G0017949 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AJ_G0017919 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AKRJ_G0017883 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_BALBcJ_G0017889 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C3HHeJ_G0017704 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI_C57BL6J_1914846 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C57BL6NJ_G0018344 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CASTEiJ_G0017267 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CBAJ_G0017677 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_DBA2J_G0017787 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_FVBNJ_G0017779 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_LPJ_G0017859 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NODShiLtJ_G0017808 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NZOHlLtJ_G0018380 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PWKPhJ_G0017047 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_WSBEiJ_G0017320 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PahariEiJ_G0031071 | -
Type: protein_coding_gene
Organism: Mus pahari
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Protein Coding Gene
MGP_SPRETEiJ_G0016841 | -
Type: protein_coding_gene
Organism: Mus spretus
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GXD Expression
GXD Expression
   
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Ambiguous
Sex: Male
Emaps: EMAPS:1868128
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6691759
Age: postnatal adult
Image: BCM_1467410
Note: vas deferens
Specimen Label: BCM_1467410
Specimen Num: 2
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GXD Expression
GXD Expression
 
Probe: MGI:459223
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1752323
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4822771
Age: embryonic day 14.5
Image: euxassay_007345_12
Specimen Label: euxassay_007345_12
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
 
Probe: MGI:459223
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1752323
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4822771
Age: embryonic day 14.5
Image: euxassay_007345_13
Specimen Label: euxassay_007345_13
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
 
Probe: MGI:459223
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1752323
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4822771
Age: embryonic day 14.5
Image: euxassay_007345_14
Specimen Label: euxassay_007345_14
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
 
Probe: MGI:459223
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1752323
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4822771
Age: embryonic day 14.5
Image: euxassay_007345_15
Specimen Label: euxassay_007345_15
Detected: true
Specimen Num: 4
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GXD Expression
GXD Expression
 
Probe: MGI:459223
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1752323
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4822771
Age: embryonic day 14.5
Image: euxassay_007345_16
Specimen Label: euxassay_007345_16
Detected: true
Specimen Num: 5
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GXD Expression
GXD Expression
   
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Male
Emaps: EMAPS:1797228
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6691759
Age: postnatal adult
Image: BCM_1467410
Specimen Label: BCM_1467410
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
   
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Male
Emaps: EMAPS:1876828
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6691759
Age: postnatal adult
Image: BCM_1467409
Specimen Label: BCM_1467409
Detected: true
Specimen Num: 1
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UniProt Feature
UniProt Feature
Begin: 1
Description: Protein TESPA1
Type: chain
End: 458
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Publication
16141072 | J:99680
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
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Publication
24194600 | J:228563
First Author: Koscielny G
Year: 2014
Journal: Nucleic Acids Res
Title: The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data.
Volume: 42
Issue: Database issue
Pages: D802-9
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Publication
- | J:80155
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations for FANTOM2 data
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Publication
- | J:204739
     
First Author: International Knockout Mouse Consortium
Year: 2014
Journal: Database Download
Title: MGI download of modified allele data from IKMC and creation of new knockout alleles
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Publication
- | J:157065
     
First Author: Helmholtz Zentrum Muenchen GmbH
Year: 2010
Journal: MGI Direct Data Submission
Title: Alleles produced for the EUCOMM and EUCOMMTools projects by the Helmholtz Zentrum Muenchen GmbH (Hmgu)
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Publication
- | J:342604
       
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
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Publication
- | J:72247
       
First Author: DDB, FB, MGI, GOA, ZFIN curators
Year: 2001
Title: Gene Ontology annotation through association of InterPro records with GO terms
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Publication
- | J:85000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Title: MGI Sequence Curation Reference
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Publication
11217851 | J:65060
First Author: Kawai J
Year: 2001
Journal: Nature
Title: Functional annotation of a full-length mouse cDNA collection.
Volume: 409
Issue: 6821
Pages: 685-90
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Publication
- | J:23000
       
First Author: MGD Nomenclature Committee
Year: 1995
Title: Nomenclature Committee Use
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Publication
- | J:293217
       
First Author: GemPharmatech
Year: 2020
Title: GemPharmatech Website.
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Publication
- | J:342587
       
First Author: AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators
Year: 2011
Title: Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
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Publication
- | J:342605
       
First Author: GOA curators
Year: 2016
Title: Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
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Publication
- | J:68900
     
First Author: The Jackson Laboratory Mouse Radiation Hybrid Database
Year: 2004
Journal: Database Release
Title: Mouse T31 Radiation Hybrid Data Load
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Publication
12466851 | J:80000
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
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Publication
- | J:164563
       
First Author: The Gene Ontology Consortium
Year: 2010
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs
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Publication
21267068 | J:153498
First Author: Diez-Roux G
Year: 2011
Journal: PLoS Biol
Title: A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Volume: 9
Issue: 1
Pages: e1000582
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Publication
- | J:75000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
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Publication
- | J:157972
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
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Publication
- | J:57747
     
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
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Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
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Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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Publication
23541577 | -
First Author: Fujimoto T
Year: 2013
Journal: Biochem Biophys Res Commun
Title: Tespa1 protein is phosphorylated in response to store-operated calcium entry.
Volume: 434
Issue: 1
Pages: 162-5
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Protein
Q3U132-2
Organism: Mus musculus/domesticus
Length: 238  
Fragment?: false
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Protein
Q3U132-3
Organism: Mus musculus/domesticus
Length: 318  
Fragment?: false
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Publication
23650607 | -
 
First Author: Matsuzaki H
Year: 2012
Journal: FEBS Open Bio
Title: Tespa1 is a novel inositol 1,4,5-trisphosphate receptor binding protein in T and B lymphocytes.
Volume: 2
Pages: 255-9
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Protein Domain
IPR029325 | ITPR-bd
Type: Domain
Description: This domain entry includes the N terminus of the actin-interacting protein sperm-specific antigen 2 (SSFA2), also known as Ki-ras-induced actin-interacting protein (KRAP) []. In this region are found the residues that interact with inositol 1,4,5-trisphosphate receptor (IP3R, also known as ITPR). SSFA2 was first localised as a membrane-bound form with extracellular regions suggesting it might be involved in the regulation of filamentous actin and signals from the outside of the cells []. It has now been shown to be critical for the proper subcellular localisation and function of IP3R. Inositol 1,4,5-trisphosphate receptor functions as the Ca2+ release channel on specialised endoplasmic reticulum membranes, so the subcellular localisation of IP3R is crucial for its proper function [].This entry also recognises a domain in Tespa1 and in uncharacterized coiled-coil protein CCDC129. Tespa1 (thymocyte-expressed positive selection-associated protein 1) is required for the development and maturation of T-cells []. Tespa1 shows sequence homology to SSFA2 and physically associates with IP3R in T and B lymphocytes [].
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Protein
Q14B48
Organism: Mus musculus/domesticus
Length: 1034  
Fragment?: false
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Publication
21501587 | -
First Author: Fujimoto T
Year: 2011
Journal: Biochem Biophys Res Commun
Title: Determination of the critical region of KRAS-induced actin-interacting protein for the interaction with inositol 1,4,5-trisphosphate receptor.
Volume: 408
Issue: 2
Pages: 282-6
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Publication
14673706 | -
First Author: Inokuchi J
Year: 2004
Journal: J Hum Genet
Title: Deregulated expression of KRAP, a novel gene encoding actin-interacting protein, in human colon cancer cells.
Volume: 49
Issue: 1
Pages: 46-52
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Protein
Q922B9
Organism: Mus musculus/domesticus
Length: 1252  
Fragment?: false
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Protein
A2AQD5
Organism: Mus musculus/domesticus
Length: 1230  
Fragment?: false
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Protein
A2AQD6
Organism: Mus musculus/domesticus
Length: 1219  
Fragment?: false
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Protein
Q3TEM8
Organism: Mus musculus/domesticus
Length: 943  
Fragment?: false
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Protein Domain
IPR043444 | TESPA1-like
Type: Family
Description: This entry includes TESPA1, ITPRID1 (also known CCDC129) and ITPRID2 (also known as SSFA2). SSFA2, also known as Ki-ras-induced actin-interacting protein (KRAP), interacts with inositol 1,4,5-trisphosphate receptor (IP3R, also known as ITPR) []. SSFA2 was first localised as a membrane-bound form with extracellular regions suggesting it might be involved in the regulation of filamentous actin and signals from the outside of the cells []. It has now been shown to be critical for the proper subcellular localisation and function of IP3R. Inositol 1,4,5-trisphosphate receptor functions as the Ca2+ release channel on specialised endoplasmic reticulum membranes, so the subcellular localisation of IP3R is crucial for its proper function [].TESPA1 (Thymocyte-expressed positive selection-associated protein 1) is required for the development and maturation of T-cells, its function being essential for the late stages of thymocyte development. It plays a role in T-cell antigen receptor (TCR)-mediated activation of the ERK and NFAT signaling pathways, possibly by serving as a scaffolding protein that promotes the assembly of the LAT signalosome in thymocytes []. TESPA1 shows sequence homology to SSFA2 and physically associates with IP3R in T and B lymphocytes [].The function of ITPRID1 is not clear.
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Publication
15489334 | -
First Author: Gerhard DS
Year: 2004
Journal: Genome Res
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Volume: 14
Issue: 10B
Pages: 2121-7
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Publication
21183079 | J:292518
First Author: Huttlin EL
Year: 2010
Journal: Cell
Title: A tissue-specific atlas of mouse protein phosphorylation and expression.
Volume: 143
Issue: 7
Pages: 1174-89
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