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Search results 1 to 100 out of 108 for Tex14

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Type Details Score
Gene
56155 | TEX14
Type: gene
Organism: human
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Gene
455161 | TEX14
Type: gene
Organism: chimpanzee
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Gene
522810 | TEX14
Type: gene
Organism: cattle
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Gene
417625 | TEX14
Type: gene
Organism: chicken
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Gene
100332421 | tex14
Type: gene
Organism: zebrafish
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Gene
714776 | TEX14
Type: gene
Organism: macaque, rhesus
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Gene
779474 | tex14
Type: gene
Organism: frog, western clawed
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Protein Domain
IPR039339 | Tex14
Type: Family
Description: TEX14 is an inactive serine/threonine-protein kinase because the active site aspartic acid residue has been replaced. It localizes to germ cell intercellular bridges during spermatogenesis. In germ cell cytokinesis a permanent intercellular bridge connecting the daughter cells through a large cytoplasmic channel forms, unlike in somatic cells. This bridge does not form in TEX14 deficient mice and male mice are sterile []; female knockout mice are fertile []. TEX14 binds to CEP55, which is a stable component of the intercellular bridge, via a GPPX3Y motif and preventing proteins with a similar motif (such as ALIX and TSG101) from binding to CEP55 []. During mitosis, TEX14 is recruited to kinetochores by Plk1 and without TEX14, kinetochores are unable to bind other essential components leading to chromosome instability. Phosphorylation of TEX14 by Plk1 leads to its degradation, which is essential for metaphase-to-anaphase transition and chromosome segregation []. TEX14 contains ankyrin repeat-containing domains and a protein kinase domain.
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Gene
287603 | Tex14
Type: gene
Organism: rat
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Gene
480572 | TEX14
Type: gene
Organism: dog, domestic
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Protein Coding Gene
MGI:1933227 | Tex14
Type: protein_coding_gene
Organism: mouse, laboratory
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Publication
20176808 | J:161709
First Author: Iwamori T
Year: 2010
Journal: Mol Cell Biol
Title: TEX14 interacts with CEP55 to block cell abscission.
Volume: 30
Issue: 9
Pages: 2280-92
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Publication
16549803 | J:107660
First Author: Greenbaum MP
Year: 2006
Journal: Proc Natl Acad Sci U S A
Title: TEX14 is essential for intercellular bridges and fertility in male mice.
Volume: 103
Issue: 13
Pages: 4982-7
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Publication
19020301 | J:145878
First Author: Greenbaum MP
Year: 2009
Journal: Biol Reprod
Title: Mouse TEX14 is required for embryonic germ cell intercellular bridges but not female fertility.
Volume: 80
Issue: 3
Pages: 449-57
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Publication
22405274 | J:183245
First Author: Mondal G
Year: 2012
Journal: Mol Cell
Title: Tex14, a Plk1-regulated protein, is required for kinetochore-microtubule attachment and regulation of the spindle assembly checkpoint.
Volume: 45
Issue: 5
Pages: 680-95
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Protein
B2KGK9
Organism: Mus musculus/domesticus
Length: 118  
Fragment?: true
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Protein
Q7M6U3
Organism: Mus musculus/domesticus
Length: 1450  
Fragment?: false
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Publication
32438343 | J:302235
First Author: Rezende-Melo CA
Year: 2020
Journal: Reproduction
Title: Spermatogonial asynchrony in Tex14 mutant mice lacking intercellular bridges.
Volume: 160
Issue: 2
Pages: 205-215
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Protein
I6L9F2
Organism: Mus musculus/domesticus
Length: 294  
Fragment?: false
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Protein
A0A571BD42
Organism: Mus musculus/domesticus
Length: 667  
Fragment?: false
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Publication
12711554 | J:83320
First Author: Wu MH
Year: 2003
Journal: Gene Expr Patterns
Title: Sequence and expression of testis-expressed gene 14 (Tex14): a gene encoding a protein kinase preferentially expressed during spermatogenesis.
Volume: 3
Issue: 2
Pages: 231-6
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Publication
17383626 | J:183221
First Author: Greenbaum MP
Year: 2007
Journal: Dev Biol
Title: Conversion of midbodies into germ cell intercellular bridges.
Volume: 305
Issue: 2
Pages: 389-96
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Publication
21364893 | J:171073
First Author: Iwamori T
Year: 2011
Journal: PLoS One
Title: Identification and characterization of RBM44 as a novel intercellular bridge protein.
Volume: 6
Issue: 2
Pages: e17066
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Publication
22245112 | J:182765
First Author: Mork L
Year: 2012
Journal: Mech Dev
Title: Mouse germ cell clusters form by aggregation as well as clonal divisions.
Volume: 128
Issue: 11-12
Pages: 591-6
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Gene
108708317 | LOC108708317
Type: gene
Organism: frog, African clawed
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Publication
22719986 | J:187829
First Author: Iwamori N
Year: 2012
Journal: PLoS One
Title: Characterization of spermatogonial stem cells lacking intercellular bridges and genetic replacement of a mutation in spermatogonial stem cells.
Volume: 7
Issue: 6
Pages: e38914
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Publication
33827806 | J:313675
 
First Author: Soygur B
Year: 2021
Journal: Sci Adv
Title: Intercellular bridges coordinate the transition from pluripotency to meiosis in mouse fetal oocytes.
Volume: 7
Issue: 15
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Publication
11279525 | J:68614
First Author: Wang PJ
Year: 2001
Journal: Nat Genet
Title: An abundance of X-linked genes expressed in spermatogonia.
Volume: 27
Issue: 4
Pages: 422-6
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Protein Coding Gene
MGP_CAROLIEiJ_G0016929 | -
Type: protein_coding_gene
Organism: Mus caroli
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Protein Coding Gene
MGP_129S1SvImJ_G0018904 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AJ_G0018871 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AKRJ_G0018841 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_BALBcJ_G0018844 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C3HHeJ_G0018658 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI_C57BL6J_1933227 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C57BL6NJ_G0019296 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CASTEiJ_G0018213 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CBAJ_G0018629 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_DBA2J_G0018737 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_FVBNJ_G0018726 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_LPJ_G0018807 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NODShiLtJ_G0018753 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NZOHlLtJ_G0019336 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PWKPhJ_G0017983 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_WSBEiJ_G0018264 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PahariEiJ_G0018058 | -
Type: protein_coding_gene
Organism: Mus pahari
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Protein Coding Gene
MGP_SPRETEiJ_G0017775 | -
Type: protein_coding_gene
Organism: Mus spretus
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Publication
33596419 | J:324658
First Author: Suzuki S
Year: 2021
Journal: Cell Rep
Title: An mTORC1-dependent switch orchestrates the transition between mouse spermatogonial stem cells and clones of progenitor spermatogonia.
Volume: 34
Issue: 7
Pages: 108752
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GXD Expression
GXD Expression
Probe: MGI:5436417
Assay Type: Immunohistochemistry
Annotation Date: 2012-09-27
Strength: Present
Sex: Female
Emaps: EMAPS:1796521
Pattern: Not Specified
Stage: TS21
Assay Id: MGI:5436423
Age: embryonic day 13.5
Image: 3A E13.5 XX
Note: Expression is in intercellular bridges.
Specimen Label: 3A E13.5 XX
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
Probe: MGI:5436417
Assay Type: Immunohistochemistry
Annotation Date: 2012-09-27
Strength: Present
Sex: Female
Emaps: EMAPS:1657819
Pattern: Not Specified
Stage: TS19
Assay Id: MGI:5436423
Age: embryonic day 11.5
Image: 3A E11.5 XX
Note: Expression is in intercellular bridges.
Specimen Label: 3A E11.5 XX
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
Probe: MGI:5436417
Assay Type: Immunohistochemistry
Annotation Date: 2012-09-27
Strength: Present
Sex: Male
Emaps: EMAPS:1657819
Pattern: Not Specified
Stage: TS19
Assay Id: MGI:5436423
Age: embryonic day 11.5
Image: 3A E11.5 XY
Note: Expression is in intercellular bridges.
Specimen Label: 3A E11.5 XY
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
 
Probe: MGI:4845887
Assay Type: Immunohistochemistry
Annotation Date: 2010-12-15
Strength: Present
Sex: Male
Emaps: EMAPS:1797528
Pattern: Regionally restricted
Stage: TS28
Assay Id: MGI:4845891
Age: postnatal day 15
Note: Expression was detected in ring-shaped intercellular bridge structures in germ cells throughout the seminiferous tubules. Expression co-localized with Cep55.
Specimen Label: 2A, 2D, 2E
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
 
Probe: MGI:4845887
Assay Type: Immunohistochemistry
Annotation Date: 2010-12-15
Strength: Present
Sex: Male
Emaps: EMAPS:1797528
Pattern: Regionally restricted
Stage: TS28
Assay Id: MGI:4845891
Age: postnatal week 6
Note: Expression was detected in ring-shaped intercellular bridge structures in germ cells throughout the seminiferous tubules. Expression co-localized with Cep55
Specimen Label: 2F, 2I, 2J
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
 
Probe: MGI:4845887
Assay Type: Immunohistochemistry
Annotation Date: 2010-12-15
Strength: Present
Sex: Male
Emaps: EMAPS:1797528
Pattern: Regionally restricted
Stage: TS28
Assay Id: MGI:4845891
Age: postnatal week 6
Note: Expression was detected in ring-shaped intercellular bridge structures in germ cells throughout the seminiferous tubules.
Specimen Label: 2K
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
 
Probe: MGI:4845887
Assay Type: Immunohistochemistry
Annotation Date: 2010-12-16
Strength: Present
Sex: Male
Emaps: EMAPS:1797528
Pattern: Regionally restricted
Stage: TS28
Assay Id: MGI:4847558
Age: postnatal day 21
Note: Expression was detected in intercellular bridge structures in germ cells. Expression co-localized with Cep55.
Specimen Label: 10A, 10D
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
     
Probe: MGI:4845887
Assay Type: Immunohistochemistry
Annotation Date: 2010-12-16
Strength: Absent
Sex: Male
Emaps: EMAPS:1797528
Stage: TS28
Assay Id: MGI:4847558
Age: postnatal day 21
Specimen Label: 10E, 10H
Detected: false
Specimen Num: 2
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GXD Expression
GXD Expression
     
Probe: MGI:4845887
Assay Type: Immunohistochemistry
Annotation Date: 2010-12-16
Strength: Absent
Sex: Male
Emaps: EMAPS:1797528
Stage: TS28
Assay Id: MGI:4847558
Age: postnatal day 21
Specimen Label: 10I, 10L
Detected: false
Specimen Num: 3
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GXD Expression
GXD Expression
Probe: MGI:5436417
Assay Type: Immunohistochemistry
Annotation Date: 2012-09-27
Strength: Present
Sex: Male
Emaps: EMAPS:1797521
Pattern: Not Specified
Stage: TS21
Assay Id: MGI:5436423
Age: embryonic day 13.5
Image: 3A E13.5 XY
Note: Expression is in intercellular bridges.
Specimen Label: 3A E13.5 XY
Detected: true
Specimen Num: 4
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GXD Expression
GXD Expression
 
Probe: MGI:4845888
Assay Type: Immunohistochemistry
Annotation Date: 2010-12-15
Strength: Present
Sex: Female
Emaps: EMAPS:1796226
Pattern: Not Specified
Stage: TS26
Assay Id: MGI:4845892
Age: embryonic day 18.5
Note: Expression co-localized with Cep55.
Specimen Label: 3A, 3D, 3E, 3H
Detected: true
Specimen Num: 1
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Publication
33199844 | J:306151
First Author: Nguyen DH
Year: 2020
Journal: Nat Cell Biol
Title: Apoptosis in the fetal testis eliminates developmentally defective germ cell clones.
Volume: 22
Issue: 12
Pages: 1423-1435
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Publication
33913480 | J:305434
 
First Author: Scovell JM
Year: 2021
Journal: Development
Title: PRSS50 is a testis protease responsible for proper sperm tail formation and function.
Volume: 148
Issue: 8
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Publication
31657143 | J:282136
First Author: Kato Y
Year: 2019
Journal: EMBO Rep
Title: ELAVL2-directed RNA regulatory network drives the formation of quiescent primordial follicles.
Volume: 20
Issue: 12
Pages: e48251
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Publication
38485951 | J:346053
First Author: Zhang J
Year: 2024
Journal: Nat Commun
Title: Regulation of meiotic telomere dynamics through membrane fluidity promoted by AdipoR2-ELOVL2.
Volume: 15
Issue: 1
Pages: 2315
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Publication
20439489 | J:163558
First Author: Tarantino C
Year: 2010
Journal: FASEB J
Title: miRNA 34a, 100, and 137 modulate differentiation of mouse embryonic stem cells.
Volume: 24
Issue: 9
Pages: 3255-63
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Publication
16141072 | J:99680
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
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Publication
10725249 | J:60984
First Author: Ko MS
Year: 2000
Journal: Development
Title: Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development.
Volume: 127
Issue: 8
Pages: 1737-49
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Publication
12904583 | J:85162
First Author: Hansen J
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome.
Volume: 100
Issue: 17
Pages: 9918-22
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Publication
17967808 | J:152068
First Author: Friedel RH
Year: 2007
Journal: Brief Funct Genomic Proteomic
Title: EUCOMM--the European conditional mouse mutagenesis program.
Volume: 6
Issue: 3
Pages: 180-5
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Publication
- | J:80155
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations for FANTOM2 data
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Publication
- | J:155845
     
First Author: Wellcome Trust Sanger Institute
Year: 2010
Journal: MGI Direct Data Submission
Title: Alleles produced for the EUCOMM and EUCOMMTools projects by the Wellcome Trust Sanger Institute
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Publication
- | J:157065
     
First Author: Helmholtz Zentrum Muenchen GmbH
Year: 2010
Journal: MGI Direct Data Submission
Title: Alleles produced for the EUCOMM and EUCOMMTools projects by the Helmholtz Zentrum Muenchen GmbH (Hmgu)
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Publication
- | J:72247
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2001
Title: Gene Ontology Annotation by the MGI Curatorial Staff
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Publication
18799693 | J:142754
First Author: Hansen GM
Year: 2008
Journal: Genome Res
Title: Large-scale gene trapping in C57BL/6N mouse embryonic stem cells.
Volume: 18
Issue: 10
Pages: 1670-9
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Publication
- | J:342605
       
First Author: GOA curators
Year: 2016
Title: Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
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Publication
- | J:342604
       
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
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Publication
- | J:85000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Title: MGI Sequence Curation Reference
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Publication
- | J:141210
     
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
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Publication
14610273 | J:86696
First Author: Zambrowicz BP
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Volume: 100
Issue: 24
Pages: 14109-14
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Publication
21677750 | J:173534
First Author: Skarnes WC
Year: 2011
Journal: Nature
Title: A conditional knockout resource for the genome-wide study of mouse gene function.
Volume: 474
Issue: 7351
Pages: 337-42
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Publication
- | J:293217
       
First Author: GemPharmatech
Year: 2020
Title: GemPharmatech Website.
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Publication
- | J:60000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2000
Title: Gene Ontology Annotation by electronic association of SwissProt Keywords with GO terms
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Publication
- | J:68900
     
First Author: The Jackson Laboratory Mouse Radiation Hybrid Database
Year: 2004
Journal: Database Release
Title: Mouse T31 Radiation Hybrid Data Load
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Publication
12466851 | J:80000
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
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Publication
- | J:164563
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Title: Human to Mouse ISO GO annotation transfer
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Publication
21267068 | J:153498
First Author: Diez-Roux G
Year: 2011
Journal: PLoS Biol
Title: A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Volume: 9
Issue: 1
Pages: e1000582
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Publication
- | J:57747
     
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
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Publication
- | J:75000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
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Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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UniProt Feature
UniProt Feature
Begin: 1
Description: Inactive serine/threonine-protein kinase TEX14
Type: chain
End: 1450
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Protein
Q7M6U3-2
Organism: Mus musculus/domesticus
Length: 1232  
Fragment?: false
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

Copyright © 2017 by The Jackson Laboratory. All Rights Reserved

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