|  Help  |  About  |  Contact Us

Search our database by keyword

Examples

  • Search this entire website. Enter identifiers, names or keywords for genes, diseases, strains, ontology terms, etc. (e.g. Pax6, Parkinson, ataxia)
  • Use OR to search for either of two terms (e.g. OR mus) or quotation marks to search for phrases (e.g. "dna binding").
  • Boolean search syntax is supported: e.g. Balb* for partial matches or mus AND NOT embryo to exclude a term

Search results 1 to 95 out of 95 for Tex14

0.028s
Type Details Score
Gene
Type: gene
Organism: Homo sapiens
Gene
Type: gene
Organism: Danio rerio
Gene
Type: gene
Organism: Rattus norvegicus
Protein Domain
Type: Family
Description: TEX14 is an inactive serine/threonine-protein kinase because the active site aspartic acid residue has been replaced. It localizes to germ cell intercellular bridges during spermatogenesis. In germ cell cytokinesis a permanent intercellular bridge connecting the daughter cells through a large cytoplasmic channel forms, unlike in somatic cells. This bridge does not form in TEX14 deficient mice and male mice are sterile []; female knockout mice are fertile []. TEX14 binds to CEP55, which is a stable component of the intercellular bridge, via a GPPX3Y motif and preventing proteins with a similar motif (such as ALIX and TSG101) from binding to CEP55 []. During mitosis, TEX14 is recruited to kinetochores by Plk1 and without TEX14, kinetochores are unable to bind other essential components leading to chromosome instability. Phosphorylation of TEX14 by Plk1 leads to its degradation, which is essential for metaphase-to-anaphase transition and chromosome segregation []. TEX14 contains ankyrin repeat-containing domains and a protein kinase domain.
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Publication
First Author: Iwamori T
Year: 2010
Journal: Mol Cell Biol
Title: TEX14 interacts with CEP55 to block cell abscission.
Volume: 30
Issue: 9
Pages: 2280-92
Publication
First Author: Greenbaum MP
Year: 2006
Journal: Proc Natl Acad Sci U S A
Title: TEX14 is essential for intercellular bridges and fertility in male mice.
Volume: 103
Issue: 13
Pages: 4982-7
Publication
First Author: Greenbaum MP
Year: 2009
Journal: Biol Reprod
Title: Mouse TEX14 is required for embryonic germ cell intercellular bridges but not female fertility.
Volume: 80
Issue: 3
Pages: 449-57
Publication
First Author: Mondal G
Year: 2012
Journal: Mol Cell
Title: Tex14, a Plk1-regulated protein, is required for kinetochore-microtubule attachment and regulation of the spindle assembly checkpoint.
Volume: 45
Issue: 5
Pages: 680-95
Protein
Organism: Mus musculus
Length: 200  
Fragment?: true
Protein
Organism: Mus musculus
Length: 51  
Fragment?: true
Protein
Organism: Mus musculus
Length: 118  
Fragment?: true
Protein
Organism: Mus musculus
Length: 1450  
Fragment?: false
Protein
Organism: Mus musculus
Length: 294  
Fragment?: false
Publication
First Author: Wu MH
Year: 2003
Journal: Gene Expr Patterns
Title: Sequence and expression of testis-expressed gene 14 (Tex14): a gene encoding a protein kinase preferentially expressed during spermatogenesis.
Volume: 3
Issue: 2
Pages: 231-6
Publication
First Author: Greenbaum MP
Year: 2007
Journal: Dev Biol
Title: Conversion of midbodies into germ cell intercellular bridges.
Volume: 305
Issue: 2
Pages: 389-96
Publication
First Author: Iwamori T
Year: 2011
Journal: PLoS One
Title: Identification and characterization of RBM44 as a novel intercellular bridge protein.
Volume: 6
Issue: 2
Pages: e17066
Publication
First Author: Mork L
Year: 2012
Journal: Mech Dev
Title: Mouse germ cell clusters form by aggregation as well as clonal divisions.
Volume: 128
Issue: 11-12
Pages: 591-6
Publication
First Author: Iwamori N
Year: 2012
Journal: PLoS One
Title: Characterization of spermatogonial stem cells lacking intercellular bridges and genetic replacement of a mutation in spermatogonial stem cells.
Volume: 7
Issue: 6
Pages: e38914
Publication
First Author: Wang PJ
Year: 2001
Journal: Nat Genet
Title: An abundance of X-linked genes expressed in spermatogonia.
Volume: 27
Issue: 4
Pages: 422-6
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus caroli
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus pahari
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus spretus
GXD Expression
Probe: MGI:5436417
Assay Type: Immunohistochemistry
Annotation Date: 2012-09-27
Strength: Present
Sex: Male
Emaps: EMAPS:1797521
Pattern: Not Specified
Stage: TS21
Assay Id: MGI:5436423
Age: embryonic day 13.5
Image: 3A E13.5 XY
Note: Expression is in intercellular bridges.
Detected: true
Specimen Num: 4
GXD Expression      
Probe: MGI:4845887
Assay Type: Immunohistochemistry
Annotation Date: 2010-12-16
Strength: Absent
Sex: Male
Emaps: EMAPS:1797528
Stage: TS28
Assay Id: MGI:4847558
Age: postnatal day 21
Detected: false
Specimen Num: 3
GXD Expression      
Probe: MGI:4845887
Assay Type: Immunohistochemistry
Annotation Date: 2010-12-16
Strength: Absent
Sex: Male
Emaps: EMAPS:1797528
Stage: TS28
Assay Id: MGI:4847558
Age: postnatal day 21
Detected: false
Specimen Num: 2
GXD Expression  
Probe: MGI:4845887
Assay Type: Immunohistochemistry
Annotation Date: 2010-12-16
Strength: Present
Sex: Male
Emaps: EMAPS:1797528
Pattern: Regionally restricted
Stage: TS28
Assay Id: MGI:4847558
Age: postnatal day 21
Note: Expression was detected in intercellular bridge structures in germ cells. Expression co-localized with Cep55.
Detected: true
Specimen Num: 1
GXD Expression  
Probe: MGI:4845887
Assay Type: Immunohistochemistry
Annotation Date: 2010-12-15
Strength: Present
Sex: Male
Emaps: EMAPS:1797528
Pattern: Regionally restricted
Stage: TS28
Assay Id: MGI:4845891
Age: postnatal week 6
Note: Expression was detected in ring-shaped intercellular bridge structures in germ cells throughout the seminiferous tubules.
Detected: true
Specimen Num: 3
GXD Expression  
Probe: MGI:4845887
Assay Type: Immunohistochemistry
Annotation Date: 2010-12-15
Strength: Present
Sex: Male
Emaps: EMAPS:1797528
Pattern: Regionally restricted
Stage: TS28
Assay Id: MGI:4845891
Age: postnatal week 6
Note: Expression was detected in ring-shaped intercellular bridge structures in germ cells throughout the seminiferous tubules. Expression co-localized with Cep55
Detected: true
Specimen Num: 2
GXD Expression  
Probe: MGI:4845887
Assay Type: Immunohistochemistry
Annotation Date: 2010-12-15
Strength: Present
Sex: Male
Emaps: EMAPS:1797528
Pattern: Regionally restricted
Stage: TS28
Assay Id: MGI:4845891
Age: postnatal day 15
Note: Expression was detected in ring-shaped intercellular bridge structures in germ cells throughout the seminiferous tubules. Expression co-localized with Cep55.
Detected: true
Specimen Num: 1
GXD Expression  
Probe: MGI:4845888
Assay Type: Immunohistochemistry
Annotation Date: 2010-12-15
Strength: Present
Sex: Female
Emaps: EMAPS:1796226
Pattern: Not Specified
Stage: TS26
Assay Id: MGI:4845892
Age: embryonic day 18.5
Note: Expression co-localized with Cep55.
Detected: true
Specimen Num: 1
GXD Expression
Probe: MGI:5436417
Assay Type: Immunohistochemistry
Annotation Date: 2012-09-27
Strength: Present
Sex: Female
Emaps: EMAPS:1796521
Pattern: Not Specified
Stage: TS21
Assay Id: MGI:5436423
Age: embryonic day 13.5
Image: 3A E13.5 XX
Note: Expression is in intercellular bridges.
Detected: true
Specimen Num: 3
GXD Expression
Probe: MGI:5436417
Assay Type: Immunohistochemistry
Annotation Date: 2012-09-27
Strength: Present
Sex: Male
Emaps: EMAPS:1657819
Pattern: Not Specified
Stage: TS19
Assay Id: MGI:5436423
Age: embryonic day 11.5
Image: 3A E11.5 XY
Note: Expression is in intercellular bridges.
Detected: true
Specimen Num: 2
GXD Expression
Probe: MGI:5436417
Assay Type: Immunohistochemistry
Annotation Date: 2012-09-27
Strength: Present
Sex: Female
Emaps: EMAPS:1657819
Pattern: Not Specified
Stage: TS19
Assay Id: MGI:5436423
Age: embryonic day 11.5
Image: 3A E11.5 XX
Note: Expression is in intercellular bridges.
Detected: true
Specimen Num: 1
Publication
First Author: Tarantino C
Year: 2010
Journal: FASEB J
Title: miRNA 34a, 100, and 137 modulate differentiation of mouse embryonic stem cells.
Volume: 24
Issue: 9
Pages: 3255-63
Publication
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
Publication
First Author: Ko MS
Year: 2000
Journal: Development
Title: Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development.
Volume: 127
Issue: 8
Pages: 1737-49
Publication
First Author: Friedel RH
Year: 2007
Journal: Brief Funct Genomic Proteomic
Title: EUCOMM--the European conditional mouse mutagenesis program.
Volume: 6
Issue: 3
Pages: 180-5
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations for FANTOM2 data
Publication
First Author: Hansen J
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome.
Volume: 100
Issue: 17
Pages: 9918-22
Publication      
First Author: Wellcome Trust Sanger Institute
Year: 2010
Journal: MGI Direct Data Submission
Title: Alleles produced for the EUCOMM and EUCOMMTools projects by the Wellcome Trust Sanger Institute
Publication
First Author: Hansen GM
Year: 2008
Journal: Genome Res
Title: Large-scale gene trapping in C57BL/6N mouse embryonic stem cells.
Volume: 18
Issue: 10
Pages: 1670-9
Publication      
First Author: Helmholtz Zentrum Muenchen GmbH
Year: 2010
Journal: MGI Direct Data Submission
Title: Alleles produced for the EUCOMM and EUCOMMTools projects by the Helmholtz Zentrum Muenchen GmbH (Hmgu)
Publication
First Author: Zambrowicz BP
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Volume: 100
Issue: 24
Pages: 14109-14
Publication
First Author: Skarnes WC
Year: 2011
Journal: Nature
Title: A conditional knockout resource for the genome-wide study of mouse gene function.
Volume: 474
Issue: 7351
Pages: 337-42
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Title: MGI Sequence Curation Reference
Publication
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
Publication      
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
Publication
First Author: Gaudet P
Year: 2011
Journal: Brief Bioinform
Title: Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.
Volume: 12
Issue: 5
Pages: 449-62
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Title: Human to Mouse ISO GO annotation transfer
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2001
Title: Gene Ontology Annotation by the MGI Curatorial Staff
Publication
First Author: Diez-Roux G
Year: 2011
Journal: PLoS Biol
Title: A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Volume: 9
Issue: 1
Pages: e1000582
Publication      
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
Publication      
First Author: The Jackson Laboratory Mouse Radiation Hybrid Database
Year: 2004
Journal: Database Release
Title: Mouse T31 Radiation Hybrid Data Load
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2000
Title: Gene Ontology Annotation by electronic association of SwissProt Keywords with GO terms
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
Publication      
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
Publication      
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
Publication      
First Author: Mouse Genome Informatics, the Protein Information Resource and the Protein Ontology Consortium
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
Publication      
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
Publication      
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
Publication      
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
UniProt Feature
Begin: 1
Description: Inactive serine/threonine-protein kinase TEX14
Type: chain
End: 1450
Protein
Organism: Mus musculus
Length: 1232  
Fragment?: false
Interaction Experiment
Description: TEX14 interacts with CEP55 to block cell abscission.
Interaction Experiment
Description: TEX14 interacts with CEP55 to block cell abscission.
Interaction Experiment
Description: TEX14 interacts with CEP55 to block cell abscission.
Interaction Experiment
Description: TEX14 interacts with CEP55 to block cell abscission.
Interaction Experiment
Description: TEX14 interacts with CEP55 to block cell abscission.
Interaction Experiment
Description: TEX14 interacts with CEP55 to block cell abscission.
Interaction Experiment
Description: TEX14 interacts with CEP55 to block cell abscission.
Interaction Experiment
Description: TEX14 interacts with CEP55 to block cell abscission.
DO Term
Publication
First Author: Huttlin EL
Year: 2010
Journal: Cell
Title: A tissue-specific atlas of mouse protein phosphorylation and expression.
Volume: 143
Issue: 7
Pages: 1174-89
Publication
First Author: Church DM
Year: 2009
Journal: PLoS Biol
Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.
Volume: 7
Issue: 5
Pages: e1000112