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Search results 1 to 100 out of 429 for Tfe3

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0.057s
Type Details Score
Gene
Type: gene
Organism: human
Gene
Type: gene
Organism: chimpanzee
Gene
Type: gene
Organism: dog, domestic
Gene
Type: gene
Organism: cattle
Gene
Type: gene
Organism: macaque, rhesus
Gene
Type: gene
Organism: frog, western clawed
Gene
Type: gene
Organism: rat
Protein Domain
Type: Family
Description: The MiT/TFE family of basic helix-loop-helix leucine zipper transcription factors includes MITF (microphthalmia-associated transcription factor) and related family members TFE3, TFEB and TFEC []. The transcription factors heterodimerize with each other and recognise the same DNA sequences []. They recognise and bind E-box sequences (3'-CANNTG-5').This entry represents the transcription factor E3 (TFE3). In association with TFEB, TFE3 activates the expression of CD40L in T-cells, thereby playing a role in T-cell-dependent antibody responses in activated CD4+ T-cells and thymus-dependent humoral immunity. It also has also a role in osteoclast development []. TFE3 specifically recognises the MUE3 box, a subset of E-boxes, present in the immunoglobulin enhancer []. For efficient DNA-binding, TFE3 requires dimerisation with itself or with another MiT/TFE family member, such as TFEB or MITF.
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Publication
First Author: Huan C
Year: 2006
Journal: Nat Immunol
Title: Transcription factors TFE3 and TFEB are critical for CD40 ligand expression and thymus-dependent humoral immunity.
Volume: 7
Issue: 10
Pages: 1082-91
Publication
First Author: Steingrimsson E
Year: 2002
Journal: Proc Natl Acad Sci U S A
Title: Mitf and Tfe3, two members of the Mitf-Tfe family of bHLH-Zip transcription factors, have important but functionally redundant roles in osteoclast development.
Volume: 99
Issue: 7
Pages: 4477-82
Publication
First Author: Miller AJ
Year: 2005
Journal: J Biol Chem
Title: Sumoylation of MITF and its related family members TFE3 and TFEB.
Volume: 280
Issue: 1
Pages: 146-55
Publication
First Author: Di Malta C
Year: 2023
Journal: EMBO Mol Med
Title: TFEB and TFE3 drive kidney cystogenesis and tumorigenesis.
Volume: 15
Issue: 5
Pages: e16877
Publication
First Author: Pastore N
Year: 2017
Journal: EMBO Mol Med
Title: TFE3 regulates whole-body energy metabolism in cooperation with TFEB.
Volume: 9
Issue: 5
Pages: 605-621
Protein
Organism: Mus musculus/domesticus
Length: 136  
Fragment?: true
Publication
First Author: Blair HJ
Year: 1994
Journal: Mouse Genome
Title: Tfe3 maps close to Gata1 on the mouse X Chromosome
Volume: 92
Issue: 3
Pages: 511-12
Publication
First Author: Sun ZJ
Year: 2016
Journal: Oncotarget
Title: Hypoxia induces TFE3 expression in head and neck squamous cell carcinoma.
Volume: 7
Issue: 10
Pages: 11651-63
Publication
First Author: Martina JA
Year: 2016
Journal: EMBO J
Title: TFEB and TFE3 are novel components of the integrated stress response.
Volume: 35
Issue: 5
Pages: 479-95
Protein
Organism: Mus musculus/domesticus
Length: 145  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 136  
Fragment?: true
Publication
First Author: Nakagawa Y
Year: 2006
Journal: Nat Med
Title: TFE3 transcriptionally activates hepatic IRS-2, participates in insulin signaling and ameliorates diabetes.
Volume: 12
Issue: 1
Pages: 107-13
Publication
First Author: Pasquier A
Year: 2023
Journal: EMBO J
Title: TFEB and TFE3 control glucose homeostasis by regulating insulin gene expression.
Volume: 42
Issue: 21
Pages: e113928
Publication
First Author: Fujimoto Y
Year: 2013
Journal: Endocrinology
Title: TFE3 controls lipid metabolism in adipose tissue of male mice by suppressing lipolysis and thermogenesis.
Volume: 154
Issue: 10
Pages: 3577-88
Publication
First Author: Iwasaki H
Year: 2012
Journal: Am J Physiol Endocrinol Metab
Title: TFE3 regulates muscle metabolic gene expression, increases glycogen stores, and enhances insulin sensitivity in mice.
Volume: 302
Issue: 7
Pages: E896-902
Publication
First Author: Artandi SE
Year: 1995
Journal: Nucleic Acids Res
Title: TFE3 contains two activation domains, one acidic and the other proline-rich, that synergistically activate transcription.
Volume: 23
Issue: 19
Pages: 3865-71
Publication
First Author: Naka A
Year: 2013
Journal: Biochem Biophys Res Commun
Title: TFE3 inhibits myoblast differentiation in C2C12 cells via down-regulating gene expression of myogenin.
Volume: 430
Issue: 2
Pages: 664-9
Publication
First Author: Sidhar SK
Year: 1996
Journal: Hum Mol Genet
Title: The t(X;1)(p11.2;q21.2) translocation in papillary renal cell carcinoma fuses a novel gene PRCC to the TFE3 transcription factor gene.
Volume: 5
Issue: 9
Pages: 1333-8
Publication  
First Author: Pastore N
Year: 2019
Journal: EMBO J
Title: Nutrient-sensitive transcription factors TFEB and TFE3 couple autophagy and metabolism to the peripheral clock.
Volume: 38
Issue: 12
Publication
First Author: Huan C
Year: 2005
Journal: J Biol Chem
Title: Renal carcinoma-associated transcription factors TFE3 and TFEB are leukemia inhibitory factor-responsive transcription activators of E-cadherin.
Volume: 280
Issue: 34
Pages: 30225-35
Publication
First Author: Hemesath TJ
Year: 1994
Journal: Genes Dev
Title: microphthalmia, a critical factor in melanocyte development, defines a discrete transcription factor family.
Volume: 8
Issue: 22
Pages: 2770-80
Publication
First Author: Hong SB
Year: 2010
Journal: PLoS One
Title: Inactivation of the FLCN tumor suppressor gene induces TFE3 transcriptional activity by increasing its nuclear localization.
Volume: 5
Issue: 12
Pages: e15793
Protein
Organism: Mus musculus/domesticus
Length: 572  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 572  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 539  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 537  
Fragment?: false
Publication  
First Author: Salma N
Year: 2017
Journal: Mol Cell Biol
Title: Tfe3 and Tfeb Transcriptionally Regulate Peroxisome Proliferator-Activated Receptor γ2 Expression in Adipocytes and Mediate Adiponectin and Glucose Levels in Mice.
Volume: 37
Issue: 15
Publication
First Author: Baba M
Year: 2019
Journal: Mol Cancer Res
Title: TFE3 Xp11.2 Translocation Renal Cell Carcinoma Mouse Model Reveals Novel Therapeutic Targets and Identifies GPNMB as a Diagnostic Marker for Human Disease.
Volume: 17
Issue: 8
Pages: 1613-1626
Publication
First Author: Blair PJ
Year: 1994
Journal: Mamm Genome
Title: The mouse scurfy (sf) mutation is tightly linked to Gata1 and Tfe3 on the proximal X chromosome.
Volume: 5
Issue: 10
Pages: 652-4
Publication
First Author: Roman C
Year: 1992
Journal: Mol Cell Biol
Title: mTFE3, an X-linked transcriptional activator containing basic helix-loop-helix and zipper domains, utilizes the zipper to stabilize both DNA binding and multimerization.
Volume: 12
Issue: 2
Pages: 817-27
Publication
First Author: Macchi P
Year: 1995
Journal: Genomics
Title: The genomic organization of the human transcription factor 3 (TFE3) gene.
Volume: 28
Issue: 3
Pages: 491-4
Publication
First Author: Zhou K
Year: 2020
Journal: Theranostics
Title: TFE3, a potential therapeutic target for Spinal Cord Injury via augmenting autophagy flux and alleviating ER stress.
Volume: 10
Issue: 20
Pages: 9280-9302
Publication
First Author: Willett R
Year: 2017
Journal: Nat Commun
Title: TFEB regulates lysosomal positioning by modulating TMEM55B expression and JIP4 recruitment to lysosomes.
Volume: 8
Issue: 1
Pages: 1580
Publication
First Author: Endoh M
Year: 2020
Journal: Cell Rep
Title: A FLCN-TFE3 Feedback Loop Prevents Excessive Glycogenesis and Phagocyte Activation by Regulating Lysosome Activity.
Volume: 30
Issue: 6
Pages: 1823-1834.e5
Publication    
First Author: Li J
Year: 2019
Journal: JCI Insight
Title: Myeloid Folliculin balances mTOR activation to maintain innate immunity homeostasis.
Volume: 5
Publication
First Author: Betschinger J
Year: 2013
Journal: Cell
Title: Exit from pluripotency is gated by intracellular redistribution of the bHLH transcription factor Tfe3.
Volume: 153
Issue: 2
Pages: 335-47
Publication
First Author: Gosis BS
Year: 2022
Journal: Science
Title: Inhibition of nonalcoholic fatty liver disease in mice by selective inhibition of mTORC1.
Volume: 376
Issue: 6590
Pages: eabf8271
Publication
First Author: Baba M
Year: 2016
Journal: Stem Cells
Title: Loss of Folliculin Disrupts Hematopoietic Stem Cell Quiescence and Homeostasis Resulting in Bone Marrow Failure.
Volume: 34
Issue: 4
Pages: 1068-82
Publication
First Author: Wada S
Year: 2016
Journal: Genes Dev
Title: The tumor suppressor FLCN mediates an alternate mTOR pathway to regulate browning of adipose tissue.
Volume: 30
Issue: 22
Pages: 2551-2564
Publication
First Author: Wang S
Year: 2019
Journal: Autophagy
Title: Impaired TFEB-mediated lysosomal biogenesis promotes the development of pancreatitis in mice and is associated with human pancreatitis.
Volume: 15
Issue: 11
Pages: 1954-1969
Publication
First Author: RamĂ­rez JA
Year: 2019
Journal: J Immunol
Title: Folliculin Interacting Protein 1 Maintains Metabolic Homeostasis during B Cell Development by Modulating AMPK, mTORC1, and TFE3.
Volume: 203
Issue: 11
Pages: 2899-2908
Publication
First Author: Kato M
Year: 2010
Journal: J Biol Chem
Title: Post-transcriptional up-regulation of Tsc-22 by Ybx1, a target of miR-216a, mediates TGF-{beta}-induced collagen expression in kidney cells.
Volume: 285
Issue: 44
Pages: 34004-15
Publication
First Author: Zhang X
Year: 2023
Journal: Nature
Title: Reprogramming tumour-associated macrophages to outcompete cancer cells.
Volume: 619
Issue: 7970
Pages: 616-623
Publication
First Author: Chiellini C
Year: 2003
Journal: J Cell Physiol
Title: Identification of cathepsin K as a novel marker of adiposity in white adipose tissue.
Volume: 195
Issue: 2
Pages: 309-21
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus caroli
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus pahari
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus spretus
Publication
First Author: Roman C
Year: 1991
Journal: Science
Title: A dominant negative form of transcription activator mTFE3 created by differential splicing.
Volume: 254
Issue: 5028
Pages: 94-7
GXD Expression      
Probe: MGI:3653448
Assay Type: RT-PCR
Annotation Date: 2006-09-05
Strength: Present
Sex: Male
Emaps: EMAPS:1797228
Stage: TS28
Assay Id: MGI:3653466
Age: postnatal adult
Specimen Label: testis
Detected: true
Specimen Num: 1
GXD Expression      
Probe: MGI:3653448
Assay Type: RT-PCR
Annotation Date: 2006-09-05
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1684628
Stage: TS28
Assay Id: MGI:3653466
Age: postnatal adult
Specimen Label: liver
Detected: true
Specimen Num: 2
GXD Expression      
Probe: MGI:3653448
Assay Type: RT-PCR
Annotation Date: 2006-09-05
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:3653466
Age: postnatal adult
Specimen Label: brain
Detected: true
Specimen Num: 3
GXD Expression      
Probe: MGI:3653448
Assay Type: RT-PCR
Annotation Date: 2006-09-05
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1610528
Stage: TS28
Assay Id: MGI:3653466
Age: postnatal adult
Specimen Label: heart
Detected: true
Specimen Num: 4
GXD Expression      
Probe: MGI:3653448
Assay Type: RT-PCR
Annotation Date: 2006-09-05
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1672828
Stage: TS28
Assay Id: MGI:3653466
Age: postnatal adult
Specimen Label: lung
Detected: true
Specimen Num: 5
GXD Expression      
Probe: MGI:3653448
Assay Type: RT-PCR
Annotation Date: 2006-09-05
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1702128
Stage: TS28
Assay Id: MGI:3653466
Age: postnatal adult
Specimen Label: stomach
Detected: true
Specimen Num: 6
GXD Expression      
Probe: MGI:3653448
Assay Type: RT-PCR
Annotation Date: 2006-09-05
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1920928
Stage: TS28
Assay Id: MGI:3653466
Age: postnatal adult
Specimen Label: BAT
Detected: true
Specimen Num: 7
GXD Expression      
Probe: MGI:3653448
Assay Type: RT-PCR
Annotation Date: 2006-09-05
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3283428
Stage: TS28
Assay Id: MGI:3653466
Age: postnatal adult
Specimen Label: small intestine
Detected: true
Specimen Num: 8
GXD Expression      
Probe: MGI:3653448
Assay Type: RT-PCR
Annotation Date: 2006-09-05
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1737328
Stage: TS28
Assay Id: MGI:3653466
Age: postnatal adult
Specimen Label: kidney
Detected: false
Specimen Num: 9
GXD Expression      
Probe: MGI:3653448
Assay Type: RT-PCR
Annotation Date: 2006-09-05
Strength: Present
Sex: Female
Emaps: EMAPS:1796228
Stage: TS28
Assay Id: MGI:3653466
Age: postnatal adult
Specimen Label: ovary
Detected: true
Specimen Num: 10
GXD Expression      
Probe: MGI:3653448
Assay Type: RT-PCR
Annotation Date: 2006-09-05
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3557728
Stage: TS28
Assay Id: MGI:3653466
Age: postnatal adult
Specimen Label: muscle
Detected: true
Specimen Num: 11
GXD Expression      
Probe: MGI:3653448
Assay Type: RT-PCR
Annotation Date: 2006-09-05
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603918
Stage: TS18
Assay Id: MGI:3653466
Age: embryonic day 11.0
Specimen Label: 11 dpc
Detected: true
Specimen Num: 12
GXD Expression      
Probe: MGI:3653448
Assay Type: RT-PCR
Annotation Date: 2006-09-05
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3185726
Stage: TS26
Assay Id: MGI:3653466
Age: embryonic day 20.0
Specimen Label: body 20 dpc
Detected: true
Specimen Num: 13
GXD Expression      
Probe: MGI:3653448
Assay Type: RT-PCR
Annotation Date: 2006-09-05
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3185826
Stage: TS26
Assay Id: MGI:3653466
Age: embryonic day 20.0
Specimen Label: head 20 dpc
Detected: true
Specimen Num: 14
GXD Expression      
Probe: MGI:3816151
Assay Type: RT-PCR
Annotation Date: 2008-11-20
Strength: Present
Sex: Female
Emaps: EMAPS:3102528
Stage: TS28
Assay Id: MGI:3816955
Age: postnatal
Specimen Label: Metaphase II
Detected: true
Specimen Num: 1
GXD Expression      
Probe: MGI:3816151
Assay Type: RT-PCR
Annotation Date: 2008-11-20
Strength: Present
Sex: Not Specified
Emaps: EMAPS:360422
Stage: TS02
Assay Id: MGI:3816955
Age: embryonic day 1.5
Specimen Label: 2-cell embryo
Detected: true
Specimen Num: 2
GXD Expression      
Probe: MGI:3816151
Assay Type: RT-PCR
Annotation Date: 2008-11-20
Strength: Present
Sex: Not Specified
Emaps: EMAPS:360433
Stage: TS03
Assay Id: MGI:3816955
Age: embryonic day 2.0
Specimen Label: 4-cell embryo
Detected: true
Specimen Num: 3
GXD Expression      
Probe: MGI:3816151
Assay Type: RT-PCR
Annotation Date: 2008-11-20
Strength: Present
Sex: Not Specified
Emaps: EMAPS:360443
Stage: TS03
Assay Id: MGI:3816955
Age: embryonic day 2.5
Specimen Label: 8-cell embryo
Detected: true
Specimen Num: 4
GXD Expression      
Probe: MGI:3816151
Assay Type: RT-PCR
Annotation Date: 2008-11-20
Strength: Present
Sex: Not Specified
Emaps: EMAPS:360453
Stage: TS03
Assay Id: MGI:3816955
Age: embryonic day 3.0
Specimen Label: Morula
Detected: true
Specimen Num: 5
GXD Expression      
Probe: MGI:3816151
Assay Type: RT-PCR
Annotation Date: 2008-11-20
Strength: Present
Sex: Not Specified
Emaps: EMAPS:360464
Stage: TS04
Assay Id: MGI:3816955
Age: embryonic day 3.5
Specimen Label: E3.5 blastocyst
Detected: true
Specimen Num: 6
GXD Expression      
Probe: MGI:3816151
Assay Type: RT-PCR
Annotation Date: 2008-11-20
Strength: Present
Sex: Not Specified
Emaps: EMAPS:360465
Stage: TS05
Assay Id: MGI:3816955
Age: embryonic day 4.5
Specimen Label: E4.5 blastocyst
Detected: true
Specimen Num: 7
GXD Expression      
Probe: MGI:3816151
Assay Type: RT-PCR
Annotation Date: 2008-11-20
Strength: Present
Sex: Not Specified
Emaps: EMAPS:160415
Stage: TS05
Assay Id: MGI:3816955
Age: embryonic day 4.5
Specimen Label: E4.5 inner cell mass
Detected: true
Specimen Num: 8
GXD Expression      
Probe: MGI:3653467
Assay Type: Northern blot
Annotation Date: 2006-09-05
Strength: Present
Sex: Male
Emaps: EMAPS:3531628
Stage: TS28
Assay Id: MGI:3653470
Age: postnatal
Specimen Label: db/db
Detected: true
Specimen Num: 1
GXD Expression      
Probe: MGI:3653467
Assay Type: Northern blot
Annotation Date: 2006-09-05
Strength: Present
Sex: Male
Emaps: EMAPS:3592628
Stage: TS28
Assay Id: MGI:3653470
Age: postnatal
Specimen Label: db/db
Detected: true
Specimen Num: 1
GXD Expression      
Probe: MGI:3653467
Assay Type: Northern blot
Annotation Date: 2006-09-05
Strength: Present
Sex: Male
Emaps: EMAPS:3531628
Stage: TS28
Assay Id: MGI:3653470
Age: postnatal
Specimen Label: wt
Detected: true
Specimen Num: 2
GXD Expression      
Probe: MGI:3653467
Assay Type: Northern blot
Annotation Date: 2006-09-05
Strength: Present
Sex: Male
Emaps: EMAPS:3592628
Stage: TS28
Assay Id: MGI:3653470
Age: postnatal
Specimen Label: wt
Detected: true
Specimen Num: 2
GXD Expression  
Probe: MGI:4845713
Assay Type: RNA in situ
Annotation Date: 2010-12-22
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1611815
Pattern: Not Specified
Stage: TS15
Assay Id: MGI:4849176
Age: embryonic day 9.5
Note: Staining is present in the mandibular arch.
Specimen Label: Table S4 - E9.5
Detected: true
Specimen Num: 1