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Search results 1 to 100 out of 603 for Tfeb

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0.036s
Type Details Score
Gene
Type: gene
Organism: human
Gene
Type: gene
Organism: cattle
Gene
Type: gene
Organism: chicken
Gene
Type: gene
Organism: zebrafish
Gene
Type: gene
Organism: macaque, rhesus
Gene
Type: gene
Organism: frog, western clawed
Gene
Type: gene
Organism: chimpanzee
Gene
Type: gene
Organism: rat
Gene
Type: gene
Organism: dog, domestic
Protein Domain
Type: Family
Description: The MiT/TFE family of basic helix-loop-helix leucine zipper transcription factors includes MITF (microphthalmia-associated transcription factor) and related family members TFE3, TFEB and TFEC []. The transcription factors heterodimerize with each other and recognise the same DNA sequences []. They recognise and bind E-box sequences (3'-CANNTG-5').In association with TFE3, TFEB activates the expression of CD40L in T-cells, thereby playing a role in T-cell-dependent antibody responses in activated CD4+ T-cells and thymus-dependent humoral immunity []. It also plays a role in the signal transduction processes required for normal vascularisation of the placenta [].
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Publication
First Author: Steingrímsson E
Year: 1998
Journal: Development
Title: The bHLH-Zip transcription factor Tfeb is essential for placental vascularization.
Volume: 125
Issue: 23
Pages: 4607-16
Publication
First Author: Huan C
Year: 2006
Journal: Nat Immunol
Title: Transcription factors TFE3 and TFEB are critical for CD40 ligand expression and thymus-dependent humoral immunity.
Volume: 7
Issue: 10
Pages: 1082-91
Protein
Organism: Mus musculus/domesticus
Length: 150  
Fragment?: true
Publication
First Author: Settembre C
Year: 2011
Journal: Science
Title: TFEB links autophagy to lysosomal biogenesis.
Volume: 332
Issue: 6036
Pages: 1429-33
Publication
First Author: Peña-Llopis S
Year: 2011
Journal: EMBO J
Title: Regulation of TFEB and V-ATPases by mTORC1.
Volume: 30
Issue: 16
Pages: 3242-58
Publication
First Author: Di Malta C
Year: 2023
Journal: EMBO Mol Med
Title: TFEB and TFE3 drive kidney cystogenesis and tumorigenesis.
Volume: 15
Issue: 5
Pages: e16877
Publication  
First Author: Lu H
Year: 2017
Journal: Sci Signal
Title: TFEB inhibits endothelial cell inflammation and reduces atherosclerosis.
Volume: 10
Issue: 464
Publication
First Author: Curnock R
Year: 2019
Journal: J Cell Biol
Title: TFEB controls retromer expression in response to nutrient availability.
Volume: 218
Issue: 12
Pages: 3954-3966
Publication
First Author: Fan Y
Year: 2018
Journal: Circ Res
Title: Endothelial TFEB (Transcription Factor EB) Positively Regulates Postischemic Angiogenesis.
Volume: 122
Issue: 7
Pages: 945-957
Publication
First Author: Settembre C
Year: 2013
Journal: Nat Cell Biol
Title: TFEB controls cellular lipid metabolism through a starvation-induced autoregulatory loop.
Volume: 15
Issue: 6
Pages: 647-58
Publication
First Author: Pastore N
Year: 2020
Journal: Nat Commun
Title: TFEB regulates murine liver cell fate during development and regeneration.
Volume: 11
Issue: 1
Pages: 2461
Protein
Organism: Mus musculus/domesticus
Length: 77  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 76  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 103  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 105  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 78  
Fragment?: true
Publication
First Author: Miller AJ
Year: 2005
Journal: J Biol Chem
Title: Sumoylation of MITF and its related family members TFE3 and TFEB.
Volume: 280
Issue: 1
Pages: 146-55
Publication
First Author: Fisher DE
Year: 1991
Journal: Genes Dev
Title: TFEB has DNA-binding and oligomerization properties of a unique helix-loop-helix/leucine-zipper family.
Volume: 5
Issue: 12A
Pages: 2342-52
Publication
First Author: Cortes CJ
Year: 2014
Journal: Nat Neurosci
Title: Polyglutamine-expanded androgen receptor interferes with TFEB to elicit autophagy defects in SBMA.
Volume: 17
Issue: 9
Pages: 1180-9
Publication
First Author: Martina JA
Year: 2016
Journal: EMBO J
Title: TFEB and TFE3 are novel components of the integrated stress response.
Volume: 35
Issue: 5
Pages: 479-95
Publication  
First Author: Sass F
Year: 2021
Journal: Mol Metab
Title: TFEB deficiency attenuates mitochondrial degradation upon brown adipose tissue whitening at thermoneutrality.
Volume: 47
Pages: 101173
Publication
First Author: Hemesath TJ
Year: 1994
Journal: Genes Dev
Title: microphthalmia, a critical factor in melanocyte development, defines a discrete transcription factor family.
Volume: 8
Issue: 22
Pages: 2770-80
Publication  
First Author: Evans TD
Year: 2019
Journal: Sci Signal
Title: TFEB drives PGC-1α expression in adipocytes to protect against diet-induced metabolic dysfunction.
Volume: 12
Issue: 606
Publication
First Author: Murano T
Year: 2017
Journal: Sci Rep
Title: Transcription factor TFEB cell-autonomously modulates susceptibility to intestinal epithelial cell injury in vivo.
Volume: 7
Issue: 1
Pages: 13938
Publication
First Author: Park K
Year: 2022
Journal: Nat Commun
Title: Lysosomal Ca2+-mediated TFEB activation modulates mitophagy and functional adaptation of pancreatic β-cells to metabolic stress.
Volume: 13
Issue: 1
Pages: 1300
Publication
First Author: Pasquier A
Year: 2023
Journal: EMBO J
Title: TFEB and TFE3 control glucose homeostasis by regulating insulin gene expression.
Volume: 42
Issue: 21
Pages: e113928
Publication  
First Author: Li Y
Year: 2020
Journal: J Immunother Cancer
Title: TFEB is a master regulator of tumor-associated macrophages in breast cancer.
Volume: 8
Issue: 1
Publication
First Author: Ugolino J
Year: 2016
Journal: PLoS Genet
Title: Loss of C9orf72 Enhances Autophagic Activity via Deregulated mTOR and TFEB Signaling.
Volume: 12
Issue: 11
Pages: e1006443
Publication
First Author: Schuster EM
Year: 2022
Journal: Nat Metab
Title: TFEB induces mitochondrial itaconate synthesis to suppress bacterial growth in macrophages.
Volume: 4
Issue: 7
Pages: 856-866
Publication  
First Author: Doronzo G
Year: 2019
Journal: EMBO J
Title: TFEB controls vascular development by regulating the proliferation of endothelial cells.
Volume: 38
Issue: 3
Publication
First Author: Willett R
Year: 2017
Journal: Nat Commun
Title: TFEB regulates lysosomal positioning by modulating TMEM55B expression and JIP4 recruitment to lysosomes.
Volume: 8
Issue: 1
Pages: 1580
Publication
First Author: Tsunemi T
Year: 2012
Journal: Sci Transl Med
Title: PGC-1α rescues Huntington's disease proteotoxicity by preventing oxidative stress and promoting TFEB function.
Volume: 4
Issue: 142
Pages: 142ra97
Publication
First Author: Kim YS
Year: 2017
Journal: J Immunol
Title: PPAR-α Activation Mediates Innate Host Defense through Induction of TFEB and Lipid Catabolism.
Volume: 198
Issue: 8
Pages: 3283-3295
Publication
First Author: Nakamura S
Year: 2020
Journal: Nat Cell Biol
Title: LC3 lipidation is essential for TFEB activation during the lysosomal damage response to kidney injury.
Volume: 22
Issue: 10
Pages: 1252-1263
Publication
First Author: Zhang H
Year: 2019
Journal: Mol Cell
Title: Polyamines Control eIF5A Hypusination, TFEB Translation, and Autophagy to Reverse B Cell Senescence.
Volume: 76
Issue: 1
Pages: 110-125.e9
Publication
First Author: Erlich AT
Year: 2018
Journal: Am J Physiol Cell Physiol
Title: Exercise induces TFEB expression and activity in skeletal muscle in a PGC-1α-dependent manner.
Volume: 314
Issue: 1
Pages: C62-C72
Publication
First Author: Martini-Stoica H
Year: 2018
Journal: J Exp Med
Title: TFEB enhances astroglial uptake of extracellular tau species and reduces tau spreading.
Volume: 215
Issue: 9
Pages: 2355-2377
Publication  
First Author: Pastore N
Year: 2019
Journal: EMBO J
Title: Nutrient-sensitive transcription factors TFEB and TFE3 couple autophagy and metabolism to the peripheral clock.
Volume: 38
Issue: 12
Publication
First Author: Huan C
Year: 2005
Journal: J Biol Chem
Title: Renal carcinoma-associated transcription factors TFE3 and TFEB are leukemia inhibitory factor-responsive transcription activators of E-cadherin.
Volume: 280
Issue: 34
Pages: 30225-35
Protein
Organism: Mus musculus/domesticus
Length: 475  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 534  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 534  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 475  
Fragment?: false
Publication
First Author: Sun J
Year: 2021
Journal: Arterioscler Thromb Vasc Biol
Title: Endothelial TFEB (Transcription Factor EB) Improves Glucose Tolerance via Upregulation of IRS (Insulin Receptor Substrate) 1 and IRS2.
Volume: 41
Issue: 2
Pages: 783-795
Publication
First Author: Wang YT
Year: 2019
Journal: Cell Death Dis
Title: Activation of TFEB ameliorates dedifferentiation of arterial smooth muscle cells and neointima formation in mice with high-fat diet.
Volume: 10
Issue: 9
Pages: 676
Publication  
First Author: Wang H
Year: 2021
Journal: Neurobiol Aging
Title: TFEB protein expression is reduced in aged brains and its overexpression mitigates senescence-associated biomarkers and memory deficits in mice.
Volume: 106
Pages: 26-36
Protein
Organism: Mus musculus/domesticus
Length: 306  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 334  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 267  
Fragment?: false
Publication
First Author: Song W
Year: 2019
Journal: Arterioscler Thromb Vasc Biol
Title: Endothelial TFEB (Transcription Factor EB) Restrains IKK (IκB Kinase)-p65 Pathway to Attenuate Vascular Inflammation in Diabetic db/db Mice.
Volume: 39
Issue: 4
Pages: 719-730
Publication  
First Author: Salma N
Year: 2017
Journal: Mol Cell Biol
Title: Tfe3 and Tfeb Transcriptionally Regulate Peroxisome Proliferator-Activated Receptor γ2 Expression in Adipocytes and Mediate Adiponectin and Glucose Levels in Mice.
Volume: 37
Issue: 15
Publication
First Author: Rehli M
Year: 1999
Journal: Genomics
Title: Cloning and characterization of the murine genes for bHLH-ZIP transcription factors TFEC and TFEB reveal a common gene organization for all MiT subfamily members.
Volume: 56
Issue: 1
Pages: 111-20
Publication
First Author: Steingrimsson E
Year: 2002
Journal: Proc Natl Acad Sci U S A
Title: Mitf and Tfe3, two members of the Mitf-Tfe family of bHLH-Zip transcription factors, have important but functionally redundant roles in osteoclast development.
Volume: 99
Issue: 7
Pages: 4477-82
Publication
First Author: Kim J
Year: 2021
Journal: Nat Commun
Title: An autophagy enhancer ameliorates diabetes of human IAPP-transgenic mice through clearance of amyloidogenic oligomer.
Volume: 12
Issue: 1
Pages: 183
Publication
First Author: Zhang Z
Year: 2022
Journal: Mol Cell
Title: Itaconate is a lysosomal inducer that promotes antibacterial innate immunity.
Volume: 82
Issue: 15
Pages: 2844-2857.e10
Publication
First Author: Chao X
Year: 2022
Journal: Am J Pathol
Title: Loss of Hepatic Transcription Factor EB Attenuates Alcohol-Associated Liver Carcinogenesis.
Volume: 192
Issue: 1
Pages: 87-103
Publication
First Author: Fernandez MR
Year: 2022
Journal: Cancer Res
Title: Disrupting the MYC-TFEB Circuit Impairs Amino Acid Homeostasis and Provokes Metabolic Anergy.
Volume: 82
Issue: 7
Pages: 1234-1250
Publication
First Author: Najibi M
Year: 2016
Journal: Cell Rep
Title: An Evolutionarily Conserved PLC-PKD-TFEB Pathway for Host Defense.
Volume: 15
Issue: 8
Pages: 1728-42
Publication
First Author: Polito VA
Year: 2014
Journal: EMBO Mol Med
Title: Selective clearance of aberrant tau proteins and rescue of neurotoxicity by transcription factor EB.
Volume: 6
Issue: 9
Pages: 1142-60
Publication
First Author: Xia M
Year: 2022
Journal: Proc Natl Acad Sci U S A
Title: Transcription factor EB coordinates environmental cues to regulate T regulatory cells' mitochondrial fitness and function.
Volume: 119
Issue: 31
Pages: e2205469119
Publication
First Author: Wang Y
Year: 2020
Journal: Nat Commun
Title: An FGF15/19-TFEB regulatory loop controls hepatic cholesterol and bile acid homeostasis.
Volume: 11
Issue: 1
Pages: 3612
Publication
First Author: Wang X
Year: 2023
Journal: J Neuroinflammation
Title: Intermittent hypoxia therapy ameliorates beta-amyloid pathology via TFEB-mediated autophagy in murine Alzheimer's disease.
Volume: 20
Issue: 1
Pages: 240
Publication
First Author: Lu H
Year: 2020
Journal: Circulation
Title: Cyclodextrin Prevents Abdominal Aortic Aneurysm via Activation of Vascular Smooth Muscle Cell Transcription Factor EB.
Volume: 142
Issue: 5
Pages: 483-498
Publication
First Author: Trivedi PC
Year: 2020
Journal: Biochim Biophys Acta Mol Basis Dis
Title: Loss of function of transcription factor EB remodels lipid metabolism and cell death pathways in the cardiomyocyte.
Volume: 1866
Issue: 10
Pages: 165832
Publication
First Author: Hayama Y
Year: 2018
Journal: J Immunol
Title: Lysosomal Protein Lamtor1 Controls Innate Immune Responses via Nuclear Translocation of Transcription Factor EB.
Volume: 200
Issue: 11
Pages: 3790-3800
Publication
First Author: Alesi N
Year: 2021
Journal: Nat Commun
Title: TSC2 regulates lysosome biogenesis via a non-canonical RAGC and TFEB-dependent mechanism.
Volume: 12
Issue: 1
Pages: 4245
Publication
First Author: Mansueto G
Year: 2017
Journal: Cell Metab
Title: Transcription Factor EB Controls Metabolic Flexibility during Exercise.
Volume: 25
Issue: 1
Pages: 182-196
Publication
First Author: Alghamdi TA
Year: 2017
Journal: J Am Soc Nephrol
Title: Janus Kinase 2 Regulates Transcription Factor EB Expression and Autophagy Completion in Glomerular Podocytes.
Volume: 28
Issue: 9
Pages: 2641-2653
Publication    
First Author: Lynch MR
Year: 2019
Journal: JCI Insight
Title: TFEB-driven lysosomal biogenesis is pivotal for PGC1α-dependent renal stress resistance.
Volume: 5
Publication
First Author: Pastore N
Year: 2017
Journal: EMBO Mol Med
Title: TFE3 regulates whole-body energy metabolism in cooperation with TFEB.
Volume: 9
Issue: 5
Pages: 605-621
Publication
First Author: Spampanato C
Year: 2013
Journal: EMBO Mol Med
Title: Transcription factor EB (TFEB) is a new therapeutic target for Pompe disease.
Volume: 5
Issue: 5
Pages: 691-706
Publication
First Author: Sha Y
Year: 2017
Journal: EMBO J
Title: STUB1 regulates TFEB-induced autophagy-lysosome pathway.
Volume: 36
Issue: 17
Pages: 2544-2552
Publication
First Author: Li B
Year: 2020
Journal: Biochim Biophys Acta Mol Basis Dis
Title: Activation of α7nACh receptor protects against acute pancreatitis through enhancing TFEB-regulated autophagy.
Volume: 1866
Issue: 12
Pages: 165971
Publication
First Author: Zhang T
Year: 2023
Journal: Cell Rep
Title: Autophagy collaborates with apoptosis pathways to control oligodendrocyte number.
Volume: 42
Issue: 8
Pages: 112943
Publication
First Author: Scott I
Year: 2014
Journal: J Biol Chem
Title: GCN5-like protein 1 (GCN5L1) controls mitochondrial content through coordinated regulation of mitochondrial biogenesis and mitophagy.
Volume: 289
Issue: 5
Pages: 2864-72
Publication
First Author: Ferron M
Year: 2013
Journal: Genes Dev
Title: A RANKL-PKCβ-TFEB signaling cascade is necessary for lysosomal biogenesis in osteoclasts.
Volume: 27
Issue: 8
Pages: 955-69
Publication
First Author: Wang S
Year: 2020
Journal: Cell Mol Gastroenterol Hepatol
Title: Critical Role of TFEB-Mediated Lysosomal Biogenesis in Alcohol-Induced Pancreatitis in Mice and Humans.
Volume: 10
Issue: 1
Pages: 59-81
Publication  
First Author: Nakamura J
Year: 2023
Journal: JCI Insight
Title: TFEB-mediated lysosomal exocytosis alleviates high-fat diet-induced lipotoxicity in the kidney.
Volume: 8
Issue: 4
Publication
First Author: Napolitano G
Year: 2020
Journal: Nature
Title: A substrate-specific mTORC1 pathway underlies Birt-Hogg-Dubé syndrome.
Volume: 585
Issue: 7826
Pages: 597-602
Publication
First Author: Singh N
Year: 2018
Journal: Autophagy
Title: Antimycobacterial effect of IFNG (interferon gamma)-induced autophagy depends on HMOX1 (heme oxygenase 1)-mediated increase in intracellular calcium levels and modulation of PPP3/calcineurin-TFEB (transcription factor EB) axis.
Volume: 14
Issue: 6
Pages: 972-991
Publication
First Author: Sun LO
Year: 2018
Journal: Cell
Title: Spatiotemporal Control of CNS Myelination by Oligodendrocyte Programmed Cell Death through the TFEB-PUMA Axis.
Volume: 175
Issue: 7
Pages: 1811-1826.e21
Publication
First Author: Ma X
Year: 2019
Journal: J Am Heart Assoc
Title: Transcription Factor EB Activation Rescues Advanced αB-Crystallin Mutation-Induced Cardiomyopathy by Normalizing Desmin Localization.
Volume: 8
Issue: 4
Pages: e010866
Publication
First Author: Li R
Year: 2021
Journal: Cell Death Dis
Title: RIP3 impedes transcription factor EB to suppress autophagic degradation in septic acute kidney injury.
Volume: 12
Issue: 6
Pages: 593
Publication
First Author: Settembre C
Year: 2012
Journal: EMBO J
Title: A lysosome-to-nucleus signalling mechanism senses and regulates the lysosome via mTOR and TFEB.
Volume: 31
Issue: 5
Pages: 1095-108
Publication
First Author: Emanuel R
Year: 2014
Journal: Arterioscler Thromb Vasc Biol
Title: Induction of lysosomal biogenesis in atherosclerotic macrophages can rescue lipid-induced lysosomal dysfunction and downstream sequelae.
Volume: 34
Issue: 9
Pages: 1942-1952
Publication
First Author: Kim J
Year: 2021
Journal: Nat Metab
Title: TFEB-GDF15 axis protects against obesity and insulin resistance as a lysosomal stress response.
Volume: 3
Issue: 3
Pages: 410-427
Publication
First Author: Young NP
Year: 2016
Journal: Genes Dev
Title: AMPK governs lineage specification through Tfeb-dependent regulation of lysosomes.
Volume: 30
Issue: 5
Pages: 535-52
Publication  
First Author: Bécot A
Year: 2020
Journal: Cells
Title: The Transcription Factor EB Reduces the Intraneuronal Accumulation of the Beta-Secretase-Derived APP Fragment C99 in Cellular and Mouse Alzheimer’s Disease Models.
Volume: 9
Issue: 5
Publication
First Author: Wang S
Year: 2019
Journal: Autophagy
Title: Impaired TFEB-mediated lysosomal biogenesis promotes the development of pancreatitis in mice and is associated with human pancreatitis.
Volume: 15
Issue: 11
Pages: 1954-1969