Type |
Details |
Score |
Gene |
Type: |
gene |
Organism: |
human |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
cattle |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
chicken |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
frog, western clawed |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
macaque, rhesus |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
pig, domestic |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
rabbit, European |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
hamster, Chinese |
|
•
•
•
•
•
|
Gene |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
dog, domestic |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
chimpanzee |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Family |
Description: |
The transforming growth factors-beta constitute a family ofmulti-functional cytokines that regulate cell growth and differentiation []. Many cells synthesise TGF-beta, and essentially all have specific receptors for this peptide []. TGF-beta regulates the actions of many other peptide growth factors and determines a positive or negative direction of their effects. The protein functions as a disulphide-linked homodimer. Its sequence is characterised by the presence of several C-terminal cysteine residues, which form interlocking disulphide links arranged in a knot-like topology. A similar "cystine-knot"arrangement has been noted in the structures of some enzyme inhibitors and neurotoxins that bind to voltage-gated Ca2+ channels, although the precise topology differs.The three-dimensional structures of several members of the TGF-beta super-family have been deduced [, , ]. TGF-beta genes are expressed differentially, suggesting that the various TGF-beta species may have distinct physiological roles in vivo.The solution structure of human TGF-beta 1 was determined using multinuclear magnetic resonance spectroscopy with hybrid distance geometry/simulated annealing []. The structure shows a high degree of similarity to that of TGF-beta 2, but with notable differences in structure and flexibility. Examination of TGF-beta 1 mRNA levels in adult murine tissues indicates that expression is predominant in spleen, lung and placenta []. TGF-beta 1 is believed to play important roles in pathologic processes. |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:7408357 |
Assay Type: |
RNA in situ |
Annotation Date: |
2022-12-16 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:3642215 |
Pattern: |
Not Specified |
Stage: |
TS15 |
Assay Id: |
MGI:7408380 |
Age: |
embryonic day 9.5 |
Image: |
S4A Tgfb1 Control |
|
Specimen Label: |
S4A Tgfb1 Control |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:7408357 |
Assay Type: |
RNA in situ |
Annotation Date: |
2022-12-16 |
Strength: |
Strong |
Sex: |
Not Specified |
Emaps: |
EMAPS:3642215 |
Pattern: |
Not Specified |
Stage: |
TS15 |
Assay Id: |
MGI:7408380 |
Age: |
embryonic day 9.5 |
Image: |
S4A Tgfb1 DCKO |
Note: |
Increased expression within neuroepithelium and migrating cells compared to control neural tube. |
Specimen Label: |
S4A Tgfb1 DCKO |
Detected: |
true |
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:7408357 |
Assay Type: |
RNA in situ |
Annotation Date: |
2022-12-16 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1607315 |
Pattern: |
Not Specified |
Stage: |
TS15 |
Assay Id: |
MGI:7408380 |
Age: |
embryonic day 9.5 |
Image: |
S4A Tgfb1 Control |
|
Specimen Label: |
S4A Tgfb1 Control |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:7408357 |
Assay Type: |
RNA in situ |
Annotation Date: |
2022-12-16 |
Strength: |
Strong |
Sex: |
Not Specified |
Emaps: |
EMAPS:1607315 |
Pattern: |
Not Specified |
Stage: |
TS15 |
Assay Id: |
MGI:7408380 |
Age: |
embryonic day 9.5 |
Image: |
S4A Tgfb1 DCKO |
Note: |
Increased expression within neuroepithelium and migrating cells compared to control neural tube. |
Specimen Label: |
S4A Tgfb1 DCKO |
Detected: |
true |
Specimen Num: |
2 |
|
•
•
•
•
•
|
Publication |
First Author: |
Miller DA |
Year: |
1989 |
Journal: |
Mol Endocrinol |
Title: |
Complementary DNA cloning of the murine transforming growth factor-beta 3 (TGF beta 3) precursor and the comparative expression of TGF beta 3 and TGF beta 1 messenger RNA in murine embryos and adult tissues. |
Volume: |
3 |
Issue: |
12 |
Pages: |
1926-34 |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
390
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
390
|
Fragment?: |
false |
|
•
•
•
•
•
|
Publication |
First Author: |
Daopin S |
Year: |
1992 |
Journal: |
Science |
Title: |
Crystal structure of transforming growth factor-beta 2: an unusual fold for the superfamily. |
Volume: |
257 |
Issue: |
5068 |
Pages: |
369-73 |
|
•
•
•
•
•
|
Publication |
First Author: |
Hinck AP |
Year: |
1996 |
Journal: |
Biochemistry |
Title: |
Transforming growth factor beta 1: three-dimensional structure in solution and comparison with the X-ray structure of transforming growth factor beta 2. |
Volume: |
35 |
Issue: |
26 |
Pages: |
8517-34 |
|
•
•
•
•
•
|
Publication |
First Author: |
Archer SJ |
Year: |
1993 |
Journal: |
Biochemistry |
Title: |
Transforming growth factor beta 1: NMR signal assignments of the recombinant protein expressed and isotopically enriched using Chinese hamster ovary cells. |
Volume: |
32 |
Issue: |
4 |
Pages: |
1152-63 |
|
•
•
•
•
•
|
Publication |
First Author: |
Cheifetz S |
Year: |
1987 |
Journal: |
Cell |
Title: |
The transforming growth factor-beta system, a complex pattern of cross-reactive ligands and receptors. |
Volume: |
48 |
Issue: |
3 |
Pages: |
409-15 |
|
•
•
•
•
•
|
Publication |
First Author: |
Mittl PR |
Year: |
1996 |
Journal: |
Protein Sci |
Title: |
The crystal structure of TGF-beta 3 and comparison to TGF-beta 2: implications for receptor binding. |
Volume: |
5 |
Issue: |
7 |
Pages: |
1261-71 |
|
•
•
•
•
•
|
Publication |
First Author: |
Oba S |
Year: |
2018 |
Journal: |
Sci Rep |
Title: |
Aberrant DNA methylation of Tgfb1 in diabetic kidney mesangial cells. |
Volume: |
8 |
Issue: |
1 |
Pages: |
16338 |
|
•
•
•
•
•
|
Publication |
First Author: |
Chen L |
Year: |
2023 |
Journal: |
Cell Stem Cell |
Title: |
TGFB1 induces fetal reprogramming and enhances intestinal regeneration. |
Volume: |
30 |
Issue: |
11 |
Pages: |
1520-1537.e8 |
|
•
•
•
•
•
|
Publication |
First Author: |
Yang LT |
Year: |
2007 |
Journal: |
Dev Biol |
Title: |
Tgfb1 expressed in the Tgfb3 locus partially rescues the cleft palate phenotype of Tgfb3 null mutants. |
Volume: |
312 |
Issue: |
1 |
Pages: |
384-95 |
|
•
•
•
•
•
|
Publication |
First Author: |
Tang Y |
Year: |
2005 |
Journal: |
Genomics |
Title: |
Epistatic interactions between modifier genes confer strain-specific redundancy for Tgfb1 in developmental angiogenesis. |
Volume: |
85 |
Issue: |
1 |
Pages: |
60-70 |
|
•
•
•
•
•
|
Publication |
First Author: |
Xu F |
Year: |
2016 |
Journal: |
Transgenic Res |
Title: |
Generation of IL10 and TGFB1 coexpressed mice displaying resistance to ovalbumin-induced asthma. |
Volume: |
25 |
Issue: |
6 |
Pages: |
829-837 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:1400744 |
Assay Type: |
RNA in situ |
Annotation Date: |
2010-09-14 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1684623 |
Pattern: |
Single cells |
Stage: |
TS23 |
Assay Id: |
MGI:4828678 |
Age: |
embryonic day 14.5 |
|
Note: |
Expression is present in single cells in which the intercellular distance between stained cells is much larger than the cell diameter of an individual cell and in circles of cells. A thumbnail photo of the staining is contained in the table. |
Specimen Label: |
Table S9 - Tgfb1 |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
Publication |
First Author: |
Clamp PA |
Year: |
1993 |
Journal: |
Genomics |
Title: |
Linkage relationships between ALPL, ENO1, GPI, PGD, and TGFB1 on porcine chromosome 6. |
Volume: |
17 |
Issue: |
2 |
Pages: |
324-9 |
|
•
•
•
•
•
|
Publication |
First Author: |
Mao JH |
Year: |
2006 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Genetic variants of Tgfb1 act as context-dependent modifiers of mouse skin tumor susceptibility. |
Volume: |
103 |
Issue: |
21 |
Pages: |
8125-30 |
|
•
•
•
•
•
|
Publication |
First Author: |
Nüchel J |
Year: |
2018 |
Journal: |
Autophagy |
Title: |
TGFB1 is secreted through an unconventional pathway dependent on the autophagic machinery and cytoskeletal regulators. |
Volume: |
14 |
Issue: |
3 |
Pages: |
465-486 |
|
•
•
•
•
•
|
Publication |
First Author: |
Hull ML |
Year: |
2012 |
Journal: |
Am J Pathol |
Title: |
Host-derived TGFB1 deficiency suppresses lesion development in a mouse model of endometriosis. |
Volume: |
180 |
Issue: |
3 |
Pages: |
880-7 |
|
•
•
•
•
•
|
Publication |
First Author: |
Ichimura S |
Year: |
2017 |
Journal: |
Exp Anim |
Title: |
An ENU-induced p.C225S missense mutation in the mouse Tgfb1 gene does not cause Camurati-Engelmann disease-like skeletal phenotypes. |
Volume: |
66 |
Issue: |
2 |
Pages: |
137-144 |
|
•
•
•
•
•
|
Publication |
First Author: |
Freimuth J |
Year: |
2012 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Epistatic interactions between Tgfb1 and genetic loci, Tgfbm2 and Tgfbm3, determine susceptibility to an asthmatic stimulus. |
Volume: |
109 |
Issue: |
44 |
Pages: |
18042-7 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6185056 |
Assay Type: |
RNA in situ |
Annotation Date: |
2018-07-25 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1689419 |
Pattern: |
Not Specified |
Stage: |
TS19 |
Assay Id: |
MGI:6191463 |
Age: |
embryonic day 11.5 |
|
|
Specimen Label: |
Table S2 - E11.5 - Tgfb1 |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6185056 |
Assay Type: |
RNA in situ |
Annotation Date: |
2018-07-25 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1689421 |
Pattern: |
Not Specified |
Stage: |
TS21 |
Assay Id: |
MGI:6191463 |
Age: |
embryonic day 13.5 |
|
|
Specimen Label: |
Table S2 - E13.5 - Tgfb1 |
Detected: |
true |
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6185056 |
Assay Type: |
RNA in situ |
Annotation Date: |
2018-07-25 |
Strength: |
Present |
Sex: |
Male |
Emaps: |
EMAPS:1689424 |
Pattern: |
Not Specified |
Stage: |
TS24 |
Assay Id: |
MGI:6191463 |
Age: |
embryonic day 15.5 |
|
|
Specimen Label: |
Table S2 - E15.5 - Tgfb1 |
Detected: |
true |
Specimen Num: |
3 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6185056 |
Assay Type: |
RNA in situ |
Annotation Date: |
2018-07-25 |
Strength: |
Present |
Sex: |
Male |
Emaps: |
EMAPS:1689426 |
Pattern: |
Not Specified |
Stage: |
TS26 |
Assay Id: |
MGI:6191463 |
Age: |
embryonic day 18.5 |
|
|
Specimen Label: |
Table S2 - E18.5 - Tgfb1 |
Detected: |
true |
Specimen Num: |
4 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6185056 |
Assay Type: |
RNA in situ |
Annotation Date: |
2018-07-25 |
Strength: |
Present |
Sex: |
Male |
Emaps: |
EMAPS:1689428 |
Pattern: |
Not Specified |
Stage: |
TS28 |
Assay Id: |
MGI:6191463 |
Age: |
postnatal day 4 |
|
|
Specimen Label: |
Table S2 - P4 - Tgfb1 |
Detected: |
true |
Specimen Num: |
5 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6185056 |
Assay Type: |
RNA in situ |
Annotation Date: |
2018-07-25 |
Strength: |
Present |
Sex: |
Male |
Emaps: |
EMAPS:1689428 |
Pattern: |
Not Specified |
Stage: |
TS28 |
Assay Id: |
MGI:6191463 |
Age: |
postnatal day 14 |
|
|
Specimen Label: |
Table S2 - P14 - Tgfb1 |
Detected: |
true |
Specimen Num: |
6 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6185056 |
Assay Type: |
RNA in situ |
Annotation Date: |
2018-07-25 |
Strength: |
Absent |
Sex: |
Male |
Emaps: |
EMAPS:1689428 |
|
Stage: |
TS28 |
Assay Id: |
MGI:6191463 |
Age: |
postnatal day 28 |
|
|
Specimen Label: |
Table S2 - P28 - Tgfb1 |
Detected: |
false |
Specimen Num: |
7 |
|
•
•
•
•
•
|
QTL |
Type: |
QTL |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
QTL |
Type: |
QTL |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
QTL |
Type: |
QTL |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
QTL |
Type: |
QTL |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
QTL |
Type: |
QTL |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
QTL |
Type: |
QTL |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Publication |
First Author: |
Tang YJ |
Year: |
2014 |
Journal: |
Am J Respir Cell Mol Biol |
Title: |
Latent transforming growth factor-β1 protects against bleomycin-induced lung injury in mice. |
Volume: |
51 |
Issue: |
6 |
Pages: |
761-71 |
|
•
•
•
•
•
|
Publication |
First Author: |
Fitch EL |
Year: |
2009 |
Journal: |
J Invest Dermatol |
Title: |
Inflammatory skin disease in K5.hTGF-beta1 transgenic mice is not dependent on the IL-23/Th17 inflammatory pathway. |
Volume: |
129 |
Issue: |
10 |
Pages: |
2443-50 |
|
•
•
•
•
•
|
Publication |
First Author: |
Shibahara K |
Year: |
2013 |
Journal: |
Cancer Res |
Title: |
Production of gastrointestinal tumors in mice by modulating latent TGF-β1 activation. |
Volume: |
73 |
Issue: |
1 |
Pages: |
459-68 |
|
•
•
•
•
•
|
Publication |
First Author: |
Hall BE |
Year: |
2010 |
Journal: |
Lab Invest |
Title: |
Conditional overexpression of TGF-beta1 disrupts mouse salivary gland development and function. |
Volume: |
90 |
Issue: |
4 |
Pages: |
543-55 |
|
•
•
•
•
•
|
Publication |
First Author: |
Sanderson N |
Year: |
1995 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Hepatic expression of mature transforming growth factor beta 1 in transgenic mice results in multiple tissue lesions. |
Volume: |
92 |
Issue: |
7 |
Pages: |
2572-6 |
|
•
•
•
•
•
|
Publication |
First Author: |
Mozes MM |
Year: |
1999 |
Journal: |
J Am Soc Nephrol |
Title: |
Renal expression of fibrotic matrix proteins and of transforming growth factor-beta (TGF-beta) isoforms in TGF-beta transgenic mice. |
Volume: |
10 |
Issue: |
2 |
Pages: |
271-80 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kopp JB |
Year: |
1996 |
Journal: |
Lab Invest |
Title: |
Transgenic mice with increased plasma levels of TGF-beta 1 develop progressive renal disease. |
Volume: |
74 |
Issue: |
6 |
Pages: |
991-1003 |
|
•
•
•
•
•
|
Publication |
First Author: |
Schiffer M |
Year: |
2001 |
Journal: |
J Clin Invest |
Title: |
Apoptosis in podocytes induced by TGF-beta and Smad7. |
Volume: |
108 |
Issue: |
6 |
Pages: |
807-16 |
|
•
•
•
•
•
|
Publication |
First Author: |
Turner JA |
Year: |
2020 |
Journal: |
Immunity |
Title: |
Regulatory T Cell-Derived TGF-β1 Controls Multiple Checkpoints Governing Allergy and Autoimmunity. |
Volume: |
53 |
Issue: |
6 |
Pages: |
1202-1214.e6 |
|
•
•
•
•
•
|
Publication |
First Author: |
Wyss-Coray T |
Year: |
2000 |
Journal: |
Am J Pathol |
Title: |
Chronic overproduction of transforming growth factor-beta1 by astrocytes promotes Alzheimer's disease-like microvascular degeneration in transgenic mice. |
Volume: |
156 |
Issue: |
1 |
Pages: |
139-50 |
|
•
•
•
•
•
|
Publication |
First Author: |
Gaertner RF |
Year: |
2005 |
Journal: |
Neurobiol Dis |
Title: |
Reduced brain tissue perfusion in TGF-beta 1 transgenic mice showing Alzheimer's disease-like cerebrovascular abnormalities. |
Volume: |
19 |
Issue: |
1-2 |
Pages: |
38-46 |
|
•
•
•
•
•
|
Publication |
First Author: |
Longenecker G |
Year: |
2002 |
Journal: |
Cytokine |
Title: |
Endocrine expression of the active form of TGF-beta1 in the TGF-beta1 null mice fails to ameliorate lethal phenotype. |
Volume: |
18 |
Issue: |
1 |
Pages: |
43-50 |
|
•
•
•
•
•
|
Publication |
First Author: |
Ahamed J |
Year: |
2008 |
Journal: |
Blood |
Title: |
In vitro and in vivo evidence for shear-induced activation of latent transforming growth factor-beta1. |
Volume: |
112 |
Issue: |
9 |
Pages: |
3650-60 |
|
•
•
•
•
•
|
Publication |
First Author: |
Yoshinaga K |
Year: |
2008 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Perturbation of transforming growth factor (TGF)-beta1 association with latent TGF-beta binding protein yields inflammation and tumors. |
Volume: |
105 |
Issue: |
48 |
Pages: |
18758-63 |
|
•
•
•
•
•
|
Publication |
First Author: |
Azhar M |
Year: |
2009 |
Journal: |
Genesis |
Title: |
Generation of mice with a conditional allele for transforming growth factor beta 1 gene. |
Volume: |
47 |
Issue: |
6 |
Pages: |
423-31 |
|
•
•
•
•
•
|
Publication |
First Author: |
Stepien DM |
Year: |
2020 |
Journal: |
J Immunol |
Title: |
Tuning Macrophage Phenotype to Mitigate Skeletal Muscle Fibrosis. |
Volume: |
204 |
Issue: |
8 |
Pages: |
2203-2215 |
|
•
•
•
•
•
|
Publication |
First Author: |
Yang Z |
Year: |
2007 |
Journal: |
J Cell Biol |
Title: |
Absence of integrin-mediated TGFbeta1 activation in vivo recapitulates the phenotype of TGFbeta1-null mice. |
Volume: |
176 |
Issue: |
6 |
Pages: |
787-93 |
|
•
•
•
•
•
|
Publication |
First Author: |
Nataf S |
Year: |
2020 |
Journal: |
Int J Mol Sci |
Title: |
The Demonstration of an Aqp4/Tgf-beta 1 Pathway in Murine Astrocytes Holds Implications for Both Neuromyelitis Optica and Progressive Multiple Sclerosis. |
Volume: |
21 |
Issue: |
3 |
|
|
•
•
•
•
•
|
Publication |
First Author: |
Narola J |
Year: |
2013 |
Journal: |
PLoS One |
Title: |
Conditional expression of TGF-β1 in skeletal muscles causes endomysial fibrosis and myofibers atrophy. |
Volume: |
8 |
Issue: |
11 |
Pages: |
e79356 |
|
•
•
•
•
•
|
Publication |
First Author: |
Luo J |
Year: |
2007 |
Journal: |
J Clin Invest |
Title: |
Glia-dependent TGF-beta signaling, acting independently of the TH17 pathway, is critical for initiation of murine autoimmune encephalomyelitis. |
Volume: |
117 |
Issue: |
11 |
Pages: |
3306-15 |
|
•
•
•
•
•
|
Publication |
First Author: |
Ko J |
Year: |
2019 |
Journal: |
J Biol Chem |
Title: |
Transforming growth factor β1 alters the 3'-UTR of mRNA to promote lung fibrosis. |
Volume: |
294 |
Issue: |
43 |
Pages: |
15781-15794 |
|
•
•
•
•
•
|
Publication |
First Author: |
Li MO |
Year: |
2007 |
Journal: |
Immunity |
Title: |
T cell-produced transforming growth factor-beta1 controls T cell tolerance and regulates Th1- and Th17-cell differentiation. |
Volume: |
26 |
Issue: |
5 |
Pages: |
579-91 |
|
•
•
•
•
•
|
Publication |
First Author: |
Huen SC |
Year: |
2013 |
Journal: |
Am J Physiol Renal Physiol |
Title: |
Macrophage-specific deletion of transforming growth factor-β1 does not prevent renal fibrosis after severe ischemia-reperfusion or obstructive injury. |
Volume: |
305 |
Issue: |
4 |
Pages: |
F477-84 |
|
•
•
•
•
•
|
Publication |
First Author: |
Tang Y |
Year: |
2009 |
Journal: |
Nat Med |
Title: |
TGF-beta1-induced migration of bone mesenchymal stem cells couples bone resorption with formation. |
Volume: |
15 |
Issue: |
7 |
Pages: |
757-65 |
|
•
•
•
•
•
|
Publication |
First Author: |
Factor VM |
Year: |
1997 |
Journal: |
Cancer Res |
Title: |
Constitutive expression of mature transforming growth factor beta1 in the liver accelerates hepatocarcinogenesis in transgenic mice. |
Volume: |
57 |
Issue: |
11 |
Pages: |
2089-95 |
|
•
•
•
•
•
|
Publication |
First Author: |
Mohammed J |
Year: |
2010 |
Journal: |
J Invest Dermatol |
Title: |
TGFbeta1-induced inflammation in premalignant epidermal squamous lesions requires IL-17. |
Volume: |
130 |
Issue: |
9 |
Pages: |
2295-303 |
|
•
•
•
•
•
|
Publication |
First Author: |
Memon MA |
Year: |
2008 |
Journal: |
Mol Cell Endocrinol |
Title: |
Transforming growth factor beta (TGFbeta1, TGFbeta2 and TGFbeta3) null-mutant phenotypes in embryonic gonadal development. |
Volume: |
294 |
Issue: |
1-2 |
Pages: |
70-80 |
|
•
•
•
•
•
|
Publication |
First Author: |
Ota M |
Year: |
2014 |
Journal: |
Cancer Res |
Title: |
Genetic suppression of inflammation blocks the tumor-promoting effects of TGF-β in gastric tissue. |
Volume: |
74 |
Issue: |
9 |
Pages: |
2642-51 |
|
•
•
•
•
•
|
Publication |
First Author: |
Schultz Jel J |
Year: |
2002 |
Journal: |
J Clin Invest |
Title: |
TGF-beta1 mediates the hypertrophic cardiomyocyte growth induced by angiotensin II. |
Volume: |
109 |
Issue: |
6 |
Pages: |
787-96 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kallapur S |
Year: |
1999 |
Journal: |
Mol Reprod Dev |
Title: |
Strain dependency of TGFbeta1 function during embryogenesis. |
Volume: |
52 |
Issue: |
4 |
Pages: |
341-9 |
|
•
•
•
•
•
|
Publication |
First Author: |
Tang Y |
Year: |
2003 |
Journal: |
Hum Mol Genet |
Title: |
Genetic modifiers interact with maternal determinants in vascular development of Tgfb1(-/-) mice. |
Volume: |
12 |
Issue: |
13 |
Pages: |
1579-89 |
|
•
•
•
•
•
|
Publication |
First Author: |
Grainger DJ |
Year: |
2000 |
Journal: |
J Cell Sci |
Title: |
Dietary fat and reduced levels of TGFbeta1 act synergistically to promote activation of the vascular endothelium and formation of lipid lesions. |
Volume: |
113 ( Pt 13) |
|
Pages: |
2355-61 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kakoki M |
Year: |
2013 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Primary aldosteronism and impaired natriuresis in mice underexpressing TGFβ1. |
Volume: |
110 |
Issue: |
14 |
Pages: |
5600-5 |
|
•
•
•
•
•
|
Publication |
First Author: |
Meroni M |
Year: |
2019 |
Journal: |
Neurobiol Aging |
Title: |
Transforming growth factor beta 1 signaling is altered in the spinal cord and muscle of amyotrophic lateral sclerosis mice and patients. |
Volume: |
82 |
|
Pages: |
48-59 |
|
•
•
•
•
•
|
Publication |
First Author: |
Gutcher I |
Year: |
2011 |
Journal: |
Immunity |
Title: |
Autocrine transforming growth factor-β1 promotes in vivo Th17 cell differentiation. |
Volume: |
34 |
Issue: |
3 |
Pages: |
396-408 |
|
•
•
•
•
•
|
Publication |
First Author: |
Shuttleworth VG |
Year: |
2018 |
Journal: |
J Cell Sci |
Title: |
The methyltransferase SET9 regulates TGFB1 activation of renal fibroblasts via interaction with SMAD3. |
Volume: |
131 |
Issue: |
1 |
|
|
•
•
•
•
•
|
Publication |
First Author: |
Wang Y |
Year: |
2024 |
Journal: |
Biochem Biophys Res Commun |
Title: |
Tgfb1 deficiency impairs the self-renewal capacity of murine hematopoietic stem/progenitor cells in vivo. |
Volume: |
703 |
|
Pages: |
149686 |
|
•
•
•
•
•
|
Publication |
First Author: |
Deng R |
Year: |
2022 |
Journal: |
Adv Sci (Weinh) |
Title: |
Periosteal CD68(+) F4/80(+) Macrophages Are Mechanosensitive for Cortical Bone Formation by Secretion and Activation of TGF-β1. |
Volume: |
9 |
Issue: |
3 |
Pages: |
e2103343 |
|
•
•
•
•
•
|
Publication |
First Author: |
Puthawala K |
Year: |
2008 |
Journal: |
Am J Respir Crit Care Med |
Title: |
Inhibition of integrin alpha(v)beta6, an activator of latent transforming growth factor-beta, prevents radiation-induced lung fibrosis. |
Volume: |
177 |
Issue: |
1 |
Pages: |
82-90 |
|
•
•
•
•
•
|
Publication |
First Author: |
Gostynska S |
Year: |
2022 |
Journal: |
Blood Adv |
Title: |
Megakaryocyte/platelet-derived TGF-β1 inhibits megakaryopoiesis in bone marrow by regulating thrombopoietin production in liver. |
Volume: |
6 |
Issue: |
11 |
Pages: |
3321-3328 |
|
•
•
•
•
•
|
Publication |
First Author: |
Matsubara T |
Year: |
2012 |
Journal: |
J Lipid Res |
Title: |
TGF-β-SMAD3 signaling mediates hepatic bile acid and phospholipid metabolism following lithocholic acid-induced liver injury. |
Volume: |
53 |
Issue: |
12 |
Pages: |
2698-707 |
|
•
•
•
•
•
|
Publication |
First Author: |
Ingman WV |
Year: |
2008 |
Journal: |
Biol Reprod |
Title: |
Mammary gland development in transforming growth factor beta1 null mutant mice: systemic and epithelial effects. |
Volume: |
79 |
Issue: |
4 |
Pages: |
711-7 |
|
•
•
•
•
•
|
Publication |
First Author: |
Crowe MJ |
Year: |
2000 |
Journal: |
J Invest Dermatol |
Title: |
Delayed wound healing in immunodeficient TGF-beta 1 knockout mice. |
Volume: |
115 |
Issue: |
1 |
Pages: |
3-11 |
|
•
•
•
•
•
|
Publication |
First Author: |
Bommireddy R |
Year: |
2009 |
Journal: |
Clin Exp Immunol |
Title: |
Calcineurin deficiency decreases inflammatory lesions in transforming growth factor beta1-deficient mice. |
Volume: |
158 |
Issue: |
3 |
Pages: |
317-24 |
|
•
•
•
•
•
|
Publication |
First Author: |
Ma D |
Year: |
2011 |
Journal: |
J Biol Chem |
Title: |
A novel role of periostin in postnatal tooth formation and mineralization. |
Volume: |
286 |
Issue: |
6 |
Pages: |
4302-9 |
|
•
•
•
•
•
|
Publication |
First Author: |
Hathaway CK |
Year: |
2015 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Low TGFβ1 expression prevents and high expression exacerbates diabetic nephropathy in mice. |
Volume: |
112 |
Issue: |
18 |
Pages: |
5815-20 |
|
•
•
•
•
•
|
Publication |
First Author: |
Martinez-Ruiz H |
Year: |
2016 |
Journal: |
Sci Signal |
Title: |
A TGFβ-miR-182-BRCA1 axis controls the mammary differentiation hierarchy. |
Volume: |
9 |
Issue: |
457 |
Pages: |
ra118 |
|
•
•
•
•
•
|
Publication |
First Author: |
Koesters R |
Year: |
2010 |
Journal: |
Am J Pathol |
Title: |
Tubular overexpression of transforming growth factor-beta1 induces autophagy and fibrosis but not mesenchymal transition of renal epithelial cells. |
Volume: |
177 |
Issue: |
2 |
Pages: |
632-43 |
|
•
•
•
•
•
|
Publication |
First Author: |
Liu X |
Year: |
2001 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Conditional epidermal expression of TGFbeta 1 blocks neonatal lethality but causes a reversible hyperplasia and alopecia. |
Volume: |
98 |
Issue: |
16 |
Pages: |
9139-44 |
|
•
•
•
•
•
|
Publication |
First Author: |
Sun X |
Year: |
2013 |
Journal: |
Cytokine |
Title: |
Regulation of epithelial cell turnover and macrophage phenotype by epithelial cell-derived transforming growth factor beta1 in the mammary gland. |
Volume: |
61 |
Issue: |
2 |
Pages: |
377-88 |
|
•
•
•
•
•
|