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Search results 1 to 100 out of 2740 for Tgfb1

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Categories

Hits by Pathway

Hits by Strain

Hits by Category

Type Details Score
Gene
7040 | TGFB1
Type: gene
Organism: human
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Gene
282089 | TGFB1
Type: gene
Organism: cattle
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Gene
100873157 | TGFB1
Type: gene
Organism: chicken
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Gene
100498430 | tgfb1
Type: gene
Organism: frog, western clawed
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Gene
106992315 | TGFB1
Type: gene
Organism: macaque, rhesus
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Gene
397078 | TGFB1
Type: gene
Organism: pig, domestic
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Gene
key_34219 | TGFB1
Type: gene
Organism: rabbit, European
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Gene
key_37630 | TGFB1
Type: gene
Organism: hamster, Chinese
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Gene
59086 | Tgfb1
Type: gene
Organism: rat
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Gene
403998 | TGFB1
Type: gene
Organism: dog, domestic
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Gene
456060 | TGFB1
Type: gene
Organism: chimpanzee
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Protein Domain
IPR003939 | TGFb1
Type: Family
Description: The transforming growth factors-beta constitute a family ofmulti-functional cytokines that regulate cell growth and differentiation []. Many cells synthesise TGF-beta, and essentially all have specific receptors for this peptide []. TGF-beta regulates the actions of many other peptide growth factors and determines a positive or negative direction of their effects. The protein functions as a disulphide-linked homodimer. Its sequence is characterised by the presence of several C-terminal cysteine residues, which form interlocking disulphide links arranged in a knot-like topology. A similar "cystine-knot"arrangement has been noted in the structures of some enzyme inhibitors and neurotoxins that bind to voltage-gated Ca2+ channels, although the precise topology differs.The three-dimensional structures of several members of the TGF-beta super-family have been deduced [, , ]. TGF-beta genes are expressed differentially, suggesting that the various TGF-beta species may have distinct physiological roles in vivo.The solution structure of human TGF-beta 1 was determined using multinuclear magnetic resonance spectroscopy with hybrid distance geometry/simulated annealing []. The structure shows a high degree of similarity to that of TGF-beta 2, but with notable differences in structure and flexibility. Examination of TGF-beta 1 mRNA levels in adult murine tissues indicates that expression is predominant in spleen, lung and placenta []. TGF-beta 1 is believed to play important roles in pathologic processes.
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Protein Coding Gene
MGI:98725 | Tgfb1
Type: protein_coding_gene
Organism: mouse, laboratory
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GXD Expression
GXD Expression
Probe: MGI:7408357
Assay Type: RNA in situ
Annotation Date: 2022-12-16
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:3642215
Pattern: Not Specified
Stage: TS15
Assay Id: MGI:7408380
Age: embryonic day 9.5
Image: S4A Tgfb1 DCKO
Note: Increased expression within neuroepithelium and migrating cells compared to control neural tube.
Specimen Label: S4A Tgfb1 DCKO
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
Probe: MGI:7408357
Assay Type: RNA in situ
Annotation Date: 2022-12-16
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1607315
Pattern: Not Specified
Stage: TS15
Assay Id: MGI:7408380
Age: embryonic day 9.5
Image: S4A Tgfb1 DCKO
Note: Increased expression within neuroepithelium and migrating cells compared to control neural tube.
Specimen Label: S4A Tgfb1 DCKO
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
 
Probe: MGI:7408357
Assay Type: RNA in situ
Annotation Date: 2022-12-16
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3642215
Pattern: Not Specified
Stage: TS15
Assay Id: MGI:7408380
Age: embryonic day 9.5
Image: S4A Tgfb1 Control
Specimen Label: S4A Tgfb1 Control
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
 
Probe: MGI:7408357
Assay Type: RNA in situ
Annotation Date: 2022-12-16
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1607315
Pattern: Not Specified
Stage: TS15
Assay Id: MGI:7408380
Age: embryonic day 9.5
Image: S4A Tgfb1 Control
Specimen Label: S4A Tgfb1 Control
Detected: true
Specimen Num: 1
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Publication
2628730 | J:10366
First Author: Miller DA
Year: 1989
Journal: Mol Endocrinol
Title: Complementary DNA cloning of the murine transforming growth factor-beta 3 (TGF beta 3) precursor and the comparative expression of TGF beta 3 and TGF beta 1 messenger RNA in murine embryos and adult tissues.
Volume: 3
Issue: 12
Pages: 1926-34
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Protein
P04202
Organism: Mus musculus/domesticus
Length: 390  
Fragment?: false
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Protein
Q3UNK5
Organism: Mus musculus/domesticus
Length: 390  
Fragment?: false
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Publication
1631557 | -
First Author: Daopin S
Year: 1992
Journal: Science
Title: Crystal structure of transforming growth factor-beta 2: an unusual fold for the superfamily.
Volume: 257
Issue: 5068
Pages: 369-73
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Publication
8679613 | -
First Author: Hinck AP
Year: 1996
Journal: Biochemistry
Title: Transforming growth factor beta 1: three-dimensional structure in solution and comparison with the X-ray structure of transforming growth factor beta 2.
Volume: 35
Issue: 26
Pages: 8517-34
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Publication
8424942 | -
First Author: Archer SJ
Year: 1993
Journal: Biochemistry
Title: Transforming growth factor beta 1: NMR signal assignments of the recombinant protein expressed and isotopically enriched using Chinese hamster ovary cells.
Volume: 32
Issue: 4
Pages: 1152-63
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Publication
2879635 | -
First Author: Cheifetz S
Year: 1987
Journal: Cell
Title: The transforming growth factor-beta system, a complex pattern of cross-reactive ligands and receptors.
Volume: 48
Issue: 3
Pages: 409-15
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Publication
8819159 | -
First Author: Mittl PR
Year: 1996
Journal: Protein Sci
Title: The crystal structure of TGF-beta 3 and comparison to TGF-beta 2: implications for receptor binding.
Volume: 5
Issue: 7
Pages: 1261-71
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Publication
30397232 | J:269799
First Author: Oba S
Year: 2018
Journal: Sci Rep
Title: Aberrant DNA methylation of Tgfb1 in diabetic kidney mesangial cells.
Volume: 8
Issue: 1
Pages: 16338
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Publication
37865088 | J:342163
First Author: Chen L
Year: 2023
Journal: Cell Stem Cell
Title: TGFB1 induces fetal reprogramming and enhances intestinal regeneration.
Volume: 30
Issue: 11
Pages: 1520-1537.e8
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Publication
17967447 | J:128938
First Author: Yang LT
Year: 2007
Journal: Dev Biol
Title: Tgfb1 expressed in the Tgfb3 locus partially rescues the cleft palate phenotype of Tgfb3 null mutants.
Volume: 312
Issue: 1
Pages: 384-95
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Publication
15607422 | J:95911
First Author: Tang Y
Year: 2005
Journal: Genomics
Title: Epistatic interactions between modifier genes confer strain-specific redundancy for Tgfb1 in developmental angiogenesis.
Volume: 85
Issue: 1
Pages: 60-70
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Publication
27696149 | J:248139
First Author: Xu F
Year: 2016
Journal: Transgenic Res
Title: Generation of IL10 and TGFB1 coexpressed mice displaying resistance to ovalbumin-induced asthma.
Volume: 25
Issue: 6
Pages: 829-837
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GXD Expression
GXD Expression
 
Probe: MGI:1400744
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1684623
Pattern: Single cells
Stage: TS23
Assay Id: MGI:4828678
Age: embryonic day 14.5
Note: Expression is present in single cells in which the intercellular distance between stained cells is much larger than the cell diameter of an individual cell and in circles of cells. A thumbnail photo of the staining is contained in the table.
Specimen Label: Table S9 - Tgfb1
Detected: true
Specimen Num: 1
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Publication
8104872 | J:13548
First Author: Clamp PA
Year: 1993
Journal: Genomics
Title: Linkage relationships between ALPL, ENO1, GPI, PGD, and TGFB1 on porcine chromosome 6.
Volume: 17
Issue: 2
Pages: 324-9
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Publication
16702541 | J:110209
First Author: Mao JH
Year: 2006
Journal: Proc Natl Acad Sci U S A
Title: Genetic variants of Tgfb1 act as context-dependent modifiers of mouse skin tumor susceptibility.
Volume: 103
Issue: 21
Pages: 8125-30
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Publication
29297744 | J:310435
First Author: Nüchel J
Year: 2018
Journal: Autophagy
Title: TGFB1 is secreted through an unconventional pathway dependent on the autophagic machinery and cytoskeletal regulators.
Volume: 14
Issue: 3
Pages: 465-486
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Publication
22210480 | J:181959
First Author: Hull ML
Year: 2012
Journal: Am J Pathol
Title: Host-derived TGFB1 deficiency suppresses lesion development in a mouse model of endometriosis.
Volume: 180
Issue: 3
Pages: 880-7
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Publication
27928112 | J:253670
First Author: Ichimura S
Year: 2017
Journal: Exp Anim
Title: An ENU-induced p.C225S missense mutation in the mouse Tgfb1 gene does not cause Camurati-Engelmann disease-like skeletal phenotypes.
Volume: 66
Issue: 2
Pages: 137-144
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Publication
23064636 | J:190711
First Author: Freimuth J
Year: 2012
Journal: Proc Natl Acad Sci U S A
Title: Epistatic interactions between Tgfb1 and genetic loci, Tgfbm2 and Tgfbm3, determine susceptibility to an asthmatic stimulus.
Volume: 109
Issue: 44
Pages: 18042-7
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GXD Expression
GXD Expression
   
Probe: MGI:6185056
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689419
Pattern: Not Specified
Stage: TS19
Assay Id: MGI:6191463
Age: embryonic day 11.5
Specimen Label: Table S2 - E11.5 - Tgfb1
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
   
Probe: MGI:6185056
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689421
Pattern: Not Specified
Stage: TS21
Assay Id: MGI:6191463
Age: embryonic day 13.5
Specimen Label: Table S2 - E13.5 - Tgfb1
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
   
Probe: MGI:6185056
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689424
Pattern: Not Specified
Stage: TS24
Assay Id: MGI:6191463
Age: embryonic day 15.5
Specimen Label: Table S2 - E15.5 - Tgfb1
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
   
Probe: MGI:6185056
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689426
Pattern: Not Specified
Stage: TS26
Assay Id: MGI:6191463
Age: embryonic day 18.5
Specimen Label: Table S2 - E18.5 - Tgfb1
Detected: true
Specimen Num: 4
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GXD Expression
GXD Expression
   
Probe: MGI:6185056
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6191463
Age: postnatal day 4
Specimen Label: Table S2 - P4 - Tgfb1
Detected: true
Specimen Num: 5
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GXD Expression
GXD Expression
   
Probe: MGI:6185056
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6191463
Age: postnatal day 14
Specimen Label: Table S2 - P14 - Tgfb1
Detected: true
Specimen Num: 6
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GXD Expression
GXD Expression
     
Probe: MGI:6185056
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Absent
Sex: Male
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:6191463
Age: postnatal day 28
Specimen Label: Table S2 - P28 - Tgfb1
Detected: false
Specimen Num: 7
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QTL
MGI:3774599 | Tcnq4
Type: QTL
Organism: mouse, laboratory
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QTL
MGI:3774596 | Tcnq1
Type: QTL
Organism: mouse, laboratory
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QTL
MGI:3774600 | Tcnq5
Type: QTL
Organism: mouse, laboratory
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QTL
MGI:3774597 | Tcnq2
Type: QTL
Organism: mouse, laboratory
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QTL
MGI:3774595 | Tdnq1
Type: QTL
Organism: mouse, laboratory
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QTL
MGI:3774598 | Tcnq3
Type: QTL
Organism: mouse, laboratory
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Publication
24885478 | J:232229
First Author: Tang YJ
Year: 2014
Journal: Am J Respir Cell Mol Biol
Title: Latent transforming growth factor-β1 protects against bleomycin-induced lung injury in mice.
Volume: 51
Issue: 6
Pages: 761-71
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Publication
19357708 | J:157060
First Author: Fitch EL
Year: 2009
Journal: J Invest Dermatol
Title: Inflammatory skin disease in K5.hTGF-beta1 transgenic mice is not dependent on the IL-23/Th17 inflammatory pathway.
Volume: 129
Issue: 10
Pages: 2443-50
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Publication
23117884 | J:194125
First Author: Shibahara K
Year: 2013
Journal: Cancer Res
Title: Production of gastrointestinal tumors in mice by modulating latent TGF-β1 activation.
Volume: 73
Issue: 1
Pages: 459-68
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Publication
7708687 | J:24154
First Author: Sanderson N
Year: 1995
Journal: Proc Natl Acad Sci U S A
Title: Hepatic expression of mature transforming growth factor beta 1 in transgenic mice results in multiple tissue lesions.
Volume: 92
Issue: 7
Pages: 2572-6
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Publication
10215326 | J:55585
First Author: Mozes MM
Year: 1999
Journal: J Am Soc Nephrol
Title: Renal expression of fibrotic matrix proteins and of transforming growth factor-beta (TGF-beta) isoforms in TGF-beta transgenic mice.
Volume: 10
Issue: 2
Pages: 271-80
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Publication
8667617 | J:33495
First Author: Kopp JB
Year: 1996
Journal: Lab Invest
Title: Transgenic mice with increased plasma levels of TGF-beta 1 develop progressive renal disease.
Volume: 74
Issue: 6
Pages: 991-1003
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Publication
20142803 | J:158613
First Author: Hall BE
Year: 2010
Journal: Lab Invest
Title: Conditional overexpression of TGF-beta1 disrupts mouse salivary gland development and function.
Volume: 90
Issue: 4
Pages: 543-55
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Publication
11560950 | J:71654
First Author: Schiffer M
Year: 2001
Journal: J Clin Invest
Title: Apoptosis in podocytes induced by TGF-beta and Smad7.
Volume: 108
Issue: 6
Pages: 807-16
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Publication
33086036 | J:305828
First Author: Turner JA
Year: 2020
Journal: Immunity
Title: Regulatory T Cell-Derived TGF-β1 Controls Multiple Checkpoints Governing Allergy and Autoimmunity.
Volume: 53
Issue: 6
Pages: 1202-1214.e6
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Publication
12090759 | J:102720
First Author: Longenecker G
Year: 2002
Journal: Cytokine
Title: Endocrine expression of the active form of TGF-beta1 in the TGF-beta1 null mice fails to ameliorate lethal phenotype.
Volume: 18
Issue: 1
Pages: 43-50
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Publication
15837559 | J:98060
First Author: Gaertner RF
Year: 2005
Journal: Neurobiol Dis
Title: Reduced brain tissue perfusion in TGF-beta 1 transgenic mice showing Alzheimer's disease-like cerebrovascular abnormalities.
Volume: 19
Issue: 1-2
Pages: 38-46
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Publication
10623661 | J:59351
First Author: Wyss-Coray T
Year: 2000
Journal: Am J Pathol
Title: Chronic overproduction of transforming growth factor-beta1 by astrocytes promotes Alzheimer's disease-like microvascular degeneration in transgenic mice.
Volume: 156
Issue: 1
Pages: 139-50
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Publication
18544680 | J:141786
First Author: Ahamed J
Year: 2008
Journal: Blood
Title: In vitro and in vivo evidence for shear-induced activation of latent transforming growth factor-beta1.
Volume: 112
Issue: 9
Pages: 3650-60
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Publication
19022904 | J:142353
First Author: Yoshinaga K
Year: 2008
Journal: Proc Natl Acad Sci U S A
Title: Perturbation of transforming growth factor (TGF)-beta1 association with latent TGF-beta binding protein yields inflammation and tumors.
Volume: 105
Issue: 48
Pages: 18758-63
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Publication
19415629 | J:150024
First Author: Azhar M
Year: 2009
Journal: Genesis
Title: Generation of mice with a conditional allele for transforming growth factor beta 1 gene.
Volume: 47
Issue: 6
Pages: 423-31
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Publication
17353357 | J:120085
First Author: Yang Z
Year: 2007
Journal: J Cell Biol
Title: Absence of integrin-mediated TGFbeta1 activation in vivo recapitulates the phenotype of TGFbeta1-null mice.
Volume: 176
Issue: 6
Pages: 787-93
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Publication
32161098 | J:287172
First Author: Stepien DM
Year: 2020
Journal: J Immunol
Title: Tuning Macrophage Phenotype to Mitigate Skeletal Muscle Fibrosis.
Volume: 204
Issue: 8
Pages: 2203-2215
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Publication
32033173 | J:298519
 
First Author: Nataf S
Year: 2020
Journal: Int J Mol Sci
Title: The Demonstration of an Aqp4/Tgf-beta 1 Pathway in Murine Astrocytes Holds Implications for Both Neuromyelitis Optica and Progressive Multiple Sclerosis.
Volume: 21
Issue: 3
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Publication
17965773 | J:127382
First Author: Luo J
Year: 2007
Journal: J Clin Invest
Title: Glia-dependent TGF-beta signaling, acting independently of the TH17 pathway, is critical for initiation of murine autoimmune encephalomyelitis.
Volume: 117
Issue: 11
Pages: 3306-15
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Publication
24244485 | J:209702
First Author: Narola J
Year: 2013
Journal: PLoS One
Title: Conditional expression of TGF-β1 in skeletal muscles causes endomysial fibrosis and myofibers atrophy.
Volume: 8
Issue: 11
Pages: e79356
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Publication
31488543 | J:283069
First Author: Ko J
Year: 2019
Journal: J Biol Chem
Title: Transforming growth factor β1 alters the 3'-UTR of mRNA to promote lung fibrosis.
Volume: 294
Issue: 43
Pages: 15781-15794
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Publication
17481928 | J:123547
First Author: Li MO
Year: 2007
Journal: Immunity
Title: T cell-produced transforming growth factor-beta1 controls T cell tolerance and regulates Th1- and Th17-cell differentiation.
Volume: 26
Issue: 5
Pages: 579-91
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Publication
19584867 | J:151616
First Author: Tang Y
Year: 2009
Journal: Nat Med
Title: TGF-beta1-induced migration of bone mesenchymal stem cells couples bone resorption with formation.
Volume: 15
Issue: 7
Pages: 757-65
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Publication
23761668 | J:200821
First Author: Huen SC
Year: 2013
Journal: Am J Physiol Renal Physiol
Title: Macrophage-specific deletion of transforming growth factor-β1 does not prevent renal fibrosis after severe ischemia-reperfusion or obstructive injury.
Volume: 305
Issue: 4
Pages: F477-84
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Publication
9187100 | J:40801
First Author: Factor VM
Year: 1997
Journal: Cancer Res
Title: Constitutive expression of mature transforming growth factor beta1 in the liver accelerates hepatocarcinogenesis in transgenic mice.
Volume: 57
Issue: 11
Pages: 2089-95
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Publication
20410912 | J:162672
First Author: Mohammed J
Year: 2010
Journal: J Invest Dermatol
Title: TGFbeta1-induced inflammation in premalignant epidermal squamous lesions requires IL-17.
Volume: 130
Issue: 9
Pages: 2295-303
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Publication
18790002 | J:145458
First Author: Memon MA
Year: 2008
Journal: Mol Cell Endocrinol
Title: Transforming growth factor beta (TGFbeta1, TGFbeta2 and TGFbeta3) null-mutant phenotypes in embryonic gonadal development.
Volume: 294
Issue: 1-2
Pages: 70-80
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Publication
24590056 | J:210524
First Author: Ota M
Year: 2014
Journal: Cancer Res
Title: Genetic suppression of inflammation blocks the tumor-promoting effects of TGF-β in gastric tissue.
Volume: 74
Issue: 9
Pages: 2642-51
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Publication
11901187 | J:124825
First Author: Schultz Jel J
Year: 2002
Journal: J Clin Invest
Title: TGF-beta1 mediates the hypertrophic cardiomyocyte growth induced by angiotensin II.
Volume: 109
Issue: 6
Pages: 787-96
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Publication
10092113 | J:53366
First Author: Kallapur S
Year: 1999
Journal: Mol Reprod Dev
Title: Strain dependency of TGFbeta1 function during embryogenesis.
Volume: 52
Issue: 4
Pages: 341-9
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Publication
23503843 | J:194237
First Author: Kakoki M
Year: 2013
Journal: Proc Natl Acad Sci U S A
Title: Primary aldosteronism and impaired natriuresis in mice underexpressing TGFβ1.
Volume: 110
Issue: 14
Pages: 5600-5
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Publication
10852815 | J:119853
 
First Author: Grainger DJ
Year: 2000
Journal: J Cell Sci
Title: Dietary fat and reduced levels of TGFbeta1 act synergistically to promote activation of the vascular endothelium and formation of lipid lesions.
Volume: 113 ( Pt 13)
Pages: 2355-61
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Publication
12812985 | J:84452
First Author: Tang Y
Year: 2003
Journal: Hum Mol Genet
Title: Genetic modifiers interact with maternal determinants in vascular development of Tgfb1(-/-) mice.
Volume: 12
Issue: 13
Pages: 1579-89
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Publication
31394426 | J:281625
 
First Author: Meroni M
Year: 2019
Journal: Neurobiol Aging
Title: Transforming growth factor beta 1 signaling is altered in the spinal cord and muscle of amyotrophic lateral sclerosis mice and patients.
Volume: 82
Pages: 48-59
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Publication
21435587 | J:169839
First Author: Gutcher I
Year: 2011
Journal: Immunity
Title: Autocrine transforming growth factor-β1 promotes in vivo Th17 cell differentiation.
Volume: 34
Issue: 3
Pages: 396-408
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Publication
29222115 | J:257277
 
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