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Search results 1 to 100 out of 1384 for Tgfb2

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Hits by Pathway

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Hits by Strain

Type Details Score
Gene
7042 | TGFB2
Type: gene
Organism: human
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Gene
100489680 | tgfb2
Type: gene
Organism: frog, western clawed
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Gene
key_28207 | TGFB2
Type: gene
Organism: pig, domestic
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Gene
81809 | Tgfb2
Type: gene
Organism: rat
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Gene
488596 | TGFB2
Type: gene
Organism: dog, domestic
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Gene
457742 | TGFB2
Type: gene
Organism: chimpanzee
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Gene
534069 | TGFB2
Type: gene
Organism: cattle
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Gene
421352 | TGFB2
Type: gene
Organism: chicken
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Gene
369194 | tgfb2
Type: gene
Organism: zebrafish
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Gene
707540 | TGFB2
Type: gene
Organism: macaque, rhesus
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Protein Domain
IPR003940 | TGFb2
Type: Family
Description: The transforming growth factors-beta constitute a family ofmulti-functional cytokines that regulate cell growth and differentiation []. Many cells synthesise TGF-beta, and essentially all have specific receptors for this peptide []. TGF-beta regulates the actions of many other peptide growth factors and determines a positive or negative direction of their effects. The protein functions as a disulphide-linked homodimer. Its sequence is characterised by the presence of several C-terminal cysteine residues, which form interlocking disulphide links arranged in a knot-like topology. A similar "cystine-knot"arrangement has been noted in the structures of some enzyme inhibitors and neurotoxins that bind to voltage-gated Ca2+ channels, although the precise topology differs.The three-dimensional structures of several members of the TGF-beta super-family have been deduced [, , ]. TGF-beta genes are expressed differentially, suggesting that the various TGF-beta species may have distinct physiological roles in vivo.The complete amino acid sequence of human beta 2 transforming growth factor(hTGF-beta 2) has been determined by automated Edman degradation []. Human TGF-beta 2 consists of 2 identical disulphide-linked subunits that share a high degree of similarity with the functionally related TGF-beta 1, and reveal lower levels of similarity to porcine inhibins and activins, the C-terminal regions of human Mullerian inhibiting substance, and the putativedecapentaplegic gene complex protein of Drosophila melanogaster.The crystal structure of the TGF-beta 2 monomer lacks a well-defined hydrophobic core and displays an unusual elongated non-globular fold []. Eight cysteine residues form 4 intra-chain disulphide bonds, creating the characteristic knotted arrangement. The dimer is stabilised by a ninth cysteine, which forms an inter-chain disulphide bond,and by 2 identical hydrophobic interfaces. Other members of the TGF-betasuperfamily, including activins, inhibins and various developmental factors,are also likely to adopt the TGF-beta fold.
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Protein Coding Gene
MGI:98726 | Tgfb2
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein
Q6ZY28
Organism: Mus musculus/domesticus
Length: 90  
Fragment?: true
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Gene
103611157 | TGFB2-OT1
Type: gene
Organism: human
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GXD Expression
GXD Expression
   
Probe: MGI:5883844
Assay Type: RT-PCR
Annotation Date: 2017-04-27
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1654617
Stage: TS17
Assay Id: MGI:5888859
Age: embryonic day 10.5
Image: S2
Specimen Label: Tgfb2
Detected: true
Specimen Num: 1
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Gene
728463 | TGFB2-AS1
Type: gene
Organism: human
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Publication
22772368 | J:188799
First Author: Lindsay ME
Year: 2012
Journal: Nat Genet
Title: Loss-of-function mutations in TGFB2 cause a syndromic presentation of thoracic aortic aneurysm.
Volume: 44
Issue: 8
Pages: 922-7
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GXD Expression
GXD Expression
   
Probe: MGI:3609780
Assay Type: RNA in situ
Annotation Date: 2006-01-16
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689422
Pattern: Not Specified
Stage: TS22
Assay Id: MGI:3610173
Age: embryonic day 14.5
Specimen Label: 1 tgfb2 E14.5
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
   
Probe: MGI:3609780
Assay Type: RNA in situ
Annotation Date: 2006-01-16
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689424
Pattern: Not Specified
Stage: TS24
Assay Id: MGI:3610173
Age: embryonic day 16.5
Specimen Label: 1 tgfb2 E16.5
Detected: true
Specimen Num: 2
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Protein
P27090
Organism: Mus musculus/domesticus
Length: 414  
Fragment?: false
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Protein
Q921T1
Organism: Mus musculus/domesticus
Length: 255  
Fragment?: false
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Protein
Q3TWH5
Organism: Mus musculus/domesticus
Length: 341  
Fragment?: true
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Protein
A0A0A6YXU9
Organism: Mus musculus/domesticus
Length: 442  
Fragment?: false
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Protein
Q8CDZ9
Organism: Mus musculus/domesticus
Length: 224  
Fragment?: true
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Publication
1631557 | -
First Author: Daopin S
Year: 1992
Journal: Science
Title: Crystal structure of transforming growth factor-beta 2: an unusual fold for the superfamily.
Volume: 257
Issue: 5068
Pages: 369-73
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Publication
8679613 | -
First Author: Hinck AP
Year: 1996
Journal: Biochemistry
Title: Transforming growth factor beta 1: three-dimensional structure in solution and comparison with the X-ray structure of transforming growth factor beta 2.
Volume: 35
Issue: 26
Pages: 8517-34
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Publication
8424942 | -
First Author: Archer SJ
Year: 1993
Journal: Biochemistry
Title: Transforming growth factor beta 1: NMR signal assignments of the recombinant protein expressed and isotopically enriched using Chinese hamster ovary cells.
Volume: 32
Issue: 4
Pages: 1152-63
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Publication
2879635 | -
First Author: Cheifetz S
Year: 1987
Journal: Cell
Title: The transforming growth factor-beta system, a complex pattern of cross-reactive ligands and receptors.
Volume: 48
Issue: 3
Pages: 409-15
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Publication
8819159 | -
First Author: Mittl PR
Year: 1996
Journal: Protein Sci
Title: The crystal structure of TGF-beta 3 and comparison to TGF-beta 2: implications for receptor binding.
Volume: 5
Issue: 7
Pages: 1261-71
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GXD Expression
GXD Expression
     
Probe: MGI:6185058
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1689419
Stage: TS19
Assay Id: MGI:6191464
Age: embryonic day 11.5
Specimen Label: Table S2 - E11.5 - Tgfb2
Detected: false
Specimen Num: 1
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GXD Expression
GXD Expression
     
Probe: MGI:6185058
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1689421
Stage: TS21
Assay Id: MGI:6191464
Age: embryonic day 13.5
Specimen Label: Table S2 - E13.5 - Tgfb2
Detected: false
Specimen Num: 2
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GXD Expression
GXD Expression
   
Probe: MGI:6185058
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689424
Pattern: Not Specified
Stage: TS24
Assay Id: MGI:6191464
Age: embryonic day 15.5
Specimen Label: Table S2 - E15.5 - Tgfb2
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
   
Probe: MGI:6185058
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689426
Pattern: Not Specified
Stage: TS26
Assay Id: MGI:6191464
Age: embryonic day 18.5
Specimen Label: Table S2 - E18.5 - Tgfb2
Detected: true
Specimen Num: 4
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GXD Expression
GXD Expression
   
Probe: MGI:6185058
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6191464
Age: postnatal day 4
Specimen Label: Table S2 - P4 - Tgfb2
Detected: true
Specimen Num: 5
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GXD Expression
GXD Expression
   
Probe: MGI:6185058
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6191464
Age: postnatal day 14
Specimen Label: Table S2 - P14 - Tgfb2
Detected: true
Specimen Num: 6
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GXD Expression
GXD Expression
   
Probe: MGI:6185058
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6191464
Age: postnatal day 28
Specimen Label: Table S2 - P28 - Tgfb2
Detected: true
Specimen Num: 7
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Publication
8095486 | J:4102
First Author: Nishimura DY
Year: 1993
Journal: Genomics
Title: Linkage localization of TGFB2 and the human homeobox gene HLX1 to chromosome 1q.
Volume: 15
Issue: 2
Pages: 357-64
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Publication
25332192 | J:223576
First Author: Liu H
Year: 2015
Journal: Stem Cells
Title: Mohawk promotes the tenogenesis of mesenchymal stem cells through activation of the TGFβ signaling pathway.
Volume: 33
Issue: 2
Pages: 443-55
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Publication
18790002 | J:145458
First Author: Memon MA
Year: 2008
Journal: Mol Cell Endocrinol
Title: Transforming growth factor beta (TGFbeta1, TGFbeta2 and TGFbeta3) null-mutant phenotypes in embryonic gonadal development.
Volume: 294
Issue: 1-2
Pages: 70-80
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Publication
24895296 | J:213572
First Author: Ishtiaq Ahmed AS
Year: 2014
Journal: Genesis
Title: Generation of mice carrying a knockout-first and conditional-ready allele of transforming growth factor beta2 gene.
Volume: 52
Issue: 9
Pages: 817-26
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Publication
22186728 | J:178974
First Author: Sakabe M
Year: 2012
Journal: Development
Title: Ectopic retinoic acid signaling affects outflow tract cushion development through suppression of the myocardial Tbx2-Tgfβ2 pathway.
Volume: 139
Issue: 2
Pages: 385-95
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Publication
23193168 | J:191063
First Author: Short K
Year: 2013
Journal: Development
Title: Spatial mapping and quantification of developmental branching morphogenesis.
Volume: 140
Issue: 2
Pages: 471-8
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Publication
19304887 | J:147280
First Author: Pryce BA
Year: 2009
Journal: Development
Title: Recruitment and maintenance of tendon progenitors by TGFbeta signaling are essential for tendon formation.
Volume: 136
Issue: 8
Pages: 1351-61
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Publication
11784073 | J:73681
First Author: Saika S
Year: 2001
Journal: Dev Biol
Title: TGFbeta2 in corneal morphogenesis during mouse embryonic development.
Volume: 240
Issue: 2
Pages: 419-32
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Publication
21533152 | J:172391
First Author: Walker KA
Year: 2011
Journal: PLoS One
Title: Betaglycan is required for the establishment of nephron endowment in the mouse.
Volume: 6
Issue: 4
Pages: e18723
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Publication
36227576 | J:331058
 
First Author: Xu J
Year: 2022
Journal: Development
Title: The transcription factors Foxf1 and Foxf2 integrate the SHH, HGF and TGFβ signaling pathways to drive tongue organogenesis.
Volume: 149
Issue: 21
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Publication
11830573 | J:74237
First Author: Kubalak SW
Year: 2002
Journal: Development
Title: Elevated transforming growth factor beta2 enhances apoptosis and contributes to abnormal outflow tract and aortic sac development in retinoic X receptor alpha knockout embryos.
Volume: 129
Issue: 3
Pages: 733-46
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Publication
27180663 | J:234115
First Author: Nik AM
Year: 2016
Journal: Dev Biol
Title: Foxf2 is required for secondary palate development and Tgfβ signaling in palatal shelf mesenchyme.
Volume: 415
Issue: 1
Pages: 14-23
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Publication
26952977 | J:235538
First Author: Tomann P
Year: 2016
Journal: Development
Title: Lhx2 is a direct NF-κB target gene that promotes primary hair follicle placode down-growth.
Volume: 143
Issue: 9
Pages: 1512-22
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Protein Coding Gene
MGP_CAROLIEiJ_G0015026 | -
Type: protein_coding_gene
Organism: Mus caroli
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Protein Coding Gene
MGP_129S1SvImJ_G0016919 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AJ_G0016898 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AKRJ_G0016863 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_BALBcJ_G0016856 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C3HHeJ_G0016680 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI_C57BL6J_98726 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C57BL6NJ_G0017319 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CASTEiJ_G0016263 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CBAJ_G0016654 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_DBA2J_G0016760 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_FVBNJ_G0016756 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_LPJ_G0016835 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NODShiLtJ_G0016788 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NZOHlLtJ_G0017356 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PWKPhJ_G0016050 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_WSBEiJ_G0016325 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PahariEiJ_G0028258 | -
Type: protein_coding_gene
Organism: Mus pahari
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Protein Coding Gene
MGP_SPRETEiJ_G0015826 | -
Type: protein_coding_gene
Organism: Mus spretus
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Publication
2797004 | J:24256
First Author: Miller DA
Year: 1989
Journal: Mol Endocrinol
Title: Murine transforming growth factor-beta 2 cDNA sequence and expression in adult tissues and embryos.
Volume: 3
Issue: 7
Pages: 1108-14
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Publication
9217007 | J:41682
First Author: Sanford LP
Year: 1997
Journal: Development
Title: TGFbeta2 knockout mice have multiple developmental defects that are non-overlapping with other TGFbeta knockout phenotypes.
Volume: 124
Issue: 13
Pages: 2659-70
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Publication
22573381 | J:187017
First Author: Walker KA
Year: 2012
Journal: Am J Physiol Renal Physiol
Title: High nephron endowment protects against salt-induced hypertension.
Volume: 303
Issue: 2
Pages: F253-8
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Publication
12220125 | J:78547
First Author: Dünker N
Year: 2002
Journal: J Anat
Title: Transforming growth factor-beta 2 heterozygous mutant mice exhibit Cowper's gland hyperplasia and cystic dilations of the gland ducts (Cowper's syringoceles).
Volume: 201
Issue: 2
Pages: 173-83
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Publication
18317401 | J:202663
First Author: Sims-Lucas S
Year: 2008
Journal: Pediatr Res
Title: Augmented and accelerated nephrogenesis in TGF-beta2 heterozygous mutant mice.
Volume: 63
Issue: 6
Pages: 607-12
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Publication
20200502 | J:184274
First Author: Short KM
Year: 2010
Journal: Kidney Int
Title: Tomographic quantification of branching morphogenesis and renal development.
Volume: 77
Issue: 12
Pages: 1132-9
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Publication
18941179 | J:140749
First Author: Avagyan S
Year: 2008
Journal: J Immunol
Title: A quantitative trait locus on chromosome 4 affects cycling of hematopoietic stem and progenitor cells through regulation of TGF-beta 2 responsiveness.
Volume: 181
Issue: 9
Pages: 5904-11
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Publication
11390347 | J:103391
First Author: Bartram U
Year: 2001
Journal: Circulation
Title: Double-outlet right ventricle and overriding tricuspid valve reflect disturbances of looping, myocardialization, endocardial cushion differentiation, and apoptosis in TGF-beta(2)-knockout mice.
Volume: 103
Issue: 22
Pages: 2745-52
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Publication
16282338 | J:129377
First Author: Kumar R
Year: 2006
Journal: Blood
Title: Transforming growth factor-beta2 is involved in quantitative genetic variation in thymic involution.
Volume: 107
Issue: 5
Pages: 1974-9
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Publication
14707111 | J:87437
First Author: Langer JC
Year: 2004
Journal: J Exp Med
Title: Quantitative trait analysis reveals transforming growth factor-beta2 as a positive regulator of early hematopoietic progenitor and stem cell function.
Volume: 199
Issue: 1
Pages: 5-14
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Publication
16257223 | J:108007
First Author: Andrews ZB
Year: 2006
Journal: Neurobiol Dis
Title: Transforming growth factor beta2 haploinsufficient mice develop age-related nigrostriatal dopamine deficits.
Volume: 21
Issue: 3
Pages: 568-75
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Publication
20858897 | J:244677
First Author: Fan Q
Year: 2010
Journal: J Biol Chem
Title: Requirement of TGFbeta signaling for SMO-mediated carcinogenesis.
Volume: 285
Issue: 47
Pages: 36570-6
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Publication
12114535 | J:78027
First Author: Bagot S
Year: 2002
Journal: Proc Natl Acad Sci U S A
Title: Identification of two cerebral malaria resistance loci using an inbred wild-derived mouse strain.
Volume: 99
Issue: 15
Pages: 9919-23
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Publication
9184209 | J:76993
First Author: Böttinger EP
Year: 1997
Journal: EMBO J
Title: Expression of a dominant-negative mutant TGF-beta type II receptor in transgenic mice reveals essential roles for TGF-beta in regulation of growth and differentiation in the exocrine pancreas.
Volume: 16
Issue: 10
Pages: 2621-33
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Publication
11404017 | J:70142
First Author: Wilder PJ
Year: 2001
Journal: Gene
Title: Isolation and characterization of the murine transforming growth factor-beta2 promoter.
Volume: 270
Issue: 1-2
Pages: 201-9
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Publication
11526486 | J:71110
First Author: Kanzler S
Year: 2001
Journal: Oncogene
Title: Hepatocellular expression of a dominant-negative mutant TGF-beta type II receptor accelerates chemically induced hepatocarcinogenesis.
Volume: 20
Issue: 36
Pages: 5015-24
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Publication
1638993 | J:1110
First Author: Mahmood R
Year: 1992
Journal: Development
Title: Interactions between retinoids and TGF beta s in mouse morphogenesis.
Volume: 115
Issue: 1
Pages: 67-74
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Publication
8075820 | J:18948
First Author: Constam DB
Year: 1994
Journal: Eur J Neurosci
Title: Transient production of TGF-beta 2 by postnatal cerebellar neurons and its effect on neuroblast proliferation.
Volume: 6
Issue: 5
Pages: 766-78
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Publication
7627810 | J:29308
First Author: Bleux C
Year: 1995
Journal: J Interferon Cytokine Res
Title: A mouse placental immunoregulatory factor different from transforming growth factor beta.
Volume: 15
Issue: 4
Pages: 351-7
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Publication
15294963 | J:92685
First Author: Henckaerts E
Year: 2004
Journal: J Immunol
Title: The positive regulatory effect of TGF-beta2 on primitive murine hemopoietic stem and progenitor cells is dependent on age, genetic background, and serum factors.
Volume: 173
Issue: 4
Pages: 2486-93
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Publication
15724248 | J:96617
First Author: Lalive PH
Year: 2005
Journal: Eur J Immunol
Title: TGF-beta-treated microglia induce oligodendrocyte precursor cell chemotaxis through the HGF-c-Met pathway.
Volume: 35
Issue: 3
Pages: 727-37
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Publication
17391645 | J:141734
First Author: Saeki K
Year: 2007
Journal: Arch Oral Biol
Title: Elevated TGF-beta2 signaling in dentin results in sex related enamel defects.
Volume: 52
Issue: 9
Pages: 814-21
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Publication
19109099 | J:145162
First Author: Li JY
Year: 2008
Journal: Eur J Histochem
Title: Temporal and spatial expression of TGF-beta2 in tooth crown development in mouse first lower molar.
Volume: 52
Issue: 4
Pages: 243-50
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Publication
30598510 | J:276299
First Author: Henen MA
Year: 2019
Journal: J Biol Chem
Title: TGF-β2 uses the concave surface of its extended finger region to bind betaglycan's ZP domain via three residues specific to TGF-β and inhibin-α.
Volume: 294
Issue: 9
Pages: 3065-3080
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Publication
30922407 | J:295520
First Author: Liu Y
Year: 2019
Journal: Stem Cell Res Ther
Title: MiR-378a suppresses tenogenic differentiation and tendon repair by targeting at TGF-β2.
Volume: 10
Issue: 1
Pages: 108
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GXD Expression
GXD Expression
     
Probe: MGI:1329427
Assay Type: RT-PCR
Annotation Date: 1999-02-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1724519
Stage: TS19
Assay Id: MGI:1329434
Age: embryonic day 11.0
Specimen Label: E11
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
     
Probe: MGI:1329427
Assay Type: RT-PCR
Annotation Date: 1999-02-11
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1742820
Stage: TS20
Assay Id: MGI:1329434
Age: embryonic day 12.0
Specimen Label: E12
Detected: false
Specimen Num: 2
•
•
•
•
•
GXD Expression
GXD Expression
     
Probe: MGI:1329427
Assay Type: RT-PCR
Annotation Date: 1999-02-11
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1742821
Stage: TS21
Assay Id: MGI:1329434
Age: embryonic day 13.0
Specimen Label: E13
Detected: false
Specimen Num: 3
•
•
•
•
•
GXD Expression
GXD Expression
     
Probe: MGI:1329427
Assay Type: RT-PCR
Annotation Date: 1999-02-11
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1742822
Stage: TS22
Assay Id: MGI:1329434
Age: embryonic day 14.0
Specimen Label: E14
Detected: false
Specimen Num: 4
•
•
•
•
•
GXD Expression
GXD Expression
     
Probe: MGI:1330209
Assay Type: Northern blot
Annotation Date: 1999-03-03
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1741220
Stage: TS20
Assay Id: MGI:1331135
Age: embryonic day 12.5
Specimen Label: Limb Bud
Detected: true
Specimen Num: 2
•
•
•
•
•
GXD Expression
GXD Expression
     
Probe: MGI:1330209
Assay Type: Northern blot
Annotation Date: 1999-03-03
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1736222
Stage: TS22
Assay Id: MGI:1331135
Age: embryonic day 14.5
Specimen Label: GD 14 palate
Detected: true
Specimen Num: 3
•
•
•
•
•
GXD Expression
GXD Expression
     
Probe: MGI:1330209
Assay Type: Northern blot
Annotation Date: 1999-03-03
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1736221
Stage: TS21
Assay Id: MGI:1331135
Age: embryonic day 13.5
Specimen Label: GD 13 palate
Detected: true
Specimen Num: 4
•
•
•
•
•




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