|  Help  |  About  |  Contact Us

Search our database by keyword

Examples

  • Search this entire website. Enter identifiers, names or keywords for genes, diseases, strains, ontology terms, etc. (e.g. Pax6, Parkinson, ataxia)
  • Use OR to search for either of two terms (e.g. OR mus) or quotation marks to search for phrases (e.g. "dna binding").
  • Boolean search syntax is supported: e.g. Balb* for partial matches or mus AND NOT embryo to exclude a term

Search results 1 to 100 out of 818 for Tgfb3

<< First    < Previous  |  Next >    Last >>
0.042s

Categories

Hits by Pathway

Hits by Strain

Hits by Category

Type Details Score
Gene
Type: gene
Organism: human
Gene
Type: gene
Organism: chimpanzee
Gene
Type: gene
Organism: dog, domestic
Gene
Type: gene
Organism: cattle
Gene
Type: gene
Organism: chicken
Gene
Type: gene
Organism: zebrafish
Gene
Type: gene
Organism: macaque, rhesus
Gene
Type: gene
Organism: pig, domestic
Gene
Type: gene
Organism: rat
Protein Domain
Type: Family
Description: The transforming growth factors-beta (TGF-beta 1-5) constitute of a family of multi-functional cytokines that regulate cell growth and differentiation []. Many cells synthesise TGF-beta, and essentially all have specific receptors for this peptide []. TGF-beta regulates the actions of many other peptide growth factors and determines a positive or negative direction of their effects. The protein functions as a disulphide-linked homodimer. Its sequence is characterised by the presence of several C-terminal cysteine residues, which form interlocking disulphide links arranged in a knot-like topology. A similar cystine-knot arrangement has been noted in the structures of some enzyme inhibitors and neurotoxins that bind to voltage-gated Ca2+ channels, although the precise topology differs.TGF-beta genes are expressed differentially, suggesting that the various TGF- beta species may have distinct physiological roles in vivo. Examination of TGF-beta 3 mRNA levels in adult murine tissues indicated that expression is predominant in brain, heart, adipose tissue and testis []. TGF beta-3 mRNA is also observed in adult mouse lung and placenta. Research on rat foetal lung fibroblasts has shown that exposure to cortisol increases TGF-beta 3 mRNA expression in a time- and dose-dependent manner, suggesting that glucocorticoids may mediate their stimulatory effect on lung maturation by inducing TGF-beta 3 expression in foetal lung fibroblasts [].The three-dimensional structures of several members of the TGF-beta super-family have been deduced. The crystal structure of TGF-beta 3 reveals a near identical central core to that of TGF-beta 2 []. The principal differences are witnessed in the conformations of the N-terminal α-helix and in the β-sheet loops, which could account for the individual cellular responses, if these differences are recognised by the TGF-beta receptors.
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Gene
Type: gene
Organism: human
Publication
First Author: Miller DA
Year: 1989
Journal: Mol Endocrinol
Title: Complementary DNA cloning of the murine transforming growth factor-beta 3 (TGF beta 3) precursor and the comparative expression of TGF beta 3 and TGF beta 1 messenger RNA in murine embryos and adult tissues.
Volume: 3
Issue: 12
Pages: 1926-34
Publication
First Author: Yang LT
Year: 2007
Journal: Dev Biol
Title: Tgfb1 expressed in the Tgfb3 locus partially rescues the cleft palate phenotype of Tgfb3 null mutants.
Volume: 312
Issue: 1
Pages: 384-95
Publication
First Author: Yang LT
Year: 2008
Journal: Genesis
Title: Tissue-specific expression of Cre recombinase from the Tgfb3 locus.
Volume: 46
Issue: 2
Pages: 112-8
Publication  
First Author: Lane J
Year: 2014
Journal: Front Physiol
Title: Control elements targeting Tgfb3 expression to the palatal epithelium are located intergenically and in introns of the upstream Ift43 gene.
Volume: 5
Pages: 258
Publication  
First Author: Saroya GA
Year: 2023
Journal: Front Physiol
Title: Canonical Wnt signaling is not required for Tgfb3 expression in the basal medial edge epithelium during palatogenesis.
Volume: 14
Pages: 704406
Protein
Organism: Mus musculus/domesticus
Length: 410  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 115  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 351  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 412  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 362  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 197  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 412  
Fragment?: false
Publication
First Author: Archer SJ
Year: 1993
Journal: Biochemistry
Title: Transforming growth factor beta 1: NMR signal assignments of the recombinant protein expressed and isotopically enriched using Chinese hamster ovary cells.
Volume: 32
Issue: 4
Pages: 1152-63
Publication
First Author: Cheifetz S
Year: 1987
Journal: Cell
Title: The transforming growth factor-beta system, a complex pattern of cross-reactive ligands and receptors.
Volume: 48
Issue: 3
Pages: 409-15
Publication
First Author: Mittl PR
Year: 1996
Journal: Protein Sci
Title: The crystal structure of TGF-beta 3 and comparison to TGF-beta 2: implications for receptor binding.
Volume: 5
Issue: 7
Pages: 1261-71
Publication
First Author: Wang J
Year: 1995
Journal: J Biol Chem
Title: Cloning and expression of glucocorticoid-induced genes in fetal rat lung fibroblasts. Transforming growth factor-beta 3.
Volume: 270
Issue: 6
Pages: 2722-8
GXD Expression    
Probe: MGI:6185059
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689419
Pattern: Not Specified
Stage: TS19
Assay Id: MGI:6191465
Age: embryonic day 11.5
Specimen Label: Table S2 - E11.5 - Tgfb3
Detected: true
Specimen Num: 1
GXD Expression    
Probe: MGI:6185059
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689421
Pattern: Not Specified
Stage: TS21
Assay Id: MGI:6191465
Age: embryonic day 13.5
Specimen Label: Table S2 - E13.5 - Tgfb3
Detected: true
Specimen Num: 2
GXD Expression    
Probe: MGI:6185059
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689424
Pattern: Not Specified
Stage: TS24
Assay Id: MGI:6191465
Age: embryonic day 15.5
Specimen Label: Table S2 - E15.5 - Tgfb3
Detected: true
Specimen Num: 3
GXD Expression    
Probe: MGI:6185059
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689426
Pattern: Not Specified
Stage: TS26
Assay Id: MGI:6191465
Age: embryonic day 18.5
Specimen Label: Table S2 - E18.5 - Tgfb3
Detected: true
Specimen Num: 4
GXD Expression    
Probe: MGI:6185059
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6191465
Age: postnatal day 4
Specimen Label: Table S2 - P4 - Tgfb3
Detected: true
Specimen Num: 5
GXD Expression    
Probe: MGI:6185059
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6191465
Age: postnatal day 14
Specimen Label: Table S2 - P14 - Tgfb3
Detected: true
Specimen Num: 6
GXD Expression    
Probe: MGI:6185059
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6191465
Age: postnatal day 28
Specimen Label: Table S2 - P28 - Tgfb3
Detected: true
Specimen Num: 7
Publication
First Author: Doetschman T
Year: 2012
Journal: Genesis
Title: Generation of mice with a conditional allele for the transforming growth factor beta3 gene.
Volume: 50
Issue: 1
Pages: 59-66
Publication
First Author: Memon MA
Year: 2008
Journal: Mol Cell Endocrinol
Title: Transforming growth factor beta (TGFbeta1, TGFbeta2 and TGFbeta3) null-mutant phenotypes in embryonic gonadal development.
Volume: 294
Issue: 1-2
Pages: 70-80
Publication  
First Author: Escasany E
Year: 2021
Journal: Dis Model Mech
Title: Transforming growth factor β3 deficiency promotes defective lipid metabolism and fibrosis in murine kidney.
Volume: 14
Issue: 9
Publication
First Author: Yin Y
Year: 2013
Journal: Biochem J
Title: Nuclear export factor 3 is involved in regulating the expression of TGF-β3 in an mRNA export activity-independent manner in mouse Sertoli cells.
Volume: 452
Issue: 1
Pages: 67-78
Publication
First Author: Mu Z
Year: 2008
Journal: Mech Dev
Title: TGFbeta1 and TGFbeta3 are partially redundant effectors in brain vascular morphogenesis.
Volume: 125
Issue: 5-6
Pages: 508-16
Publication
First Author: Pryce BA
Year: 2009
Journal: Development
Title: Recruitment and maintenance of tendon progenitors by TGFbeta signaling are essential for tendon formation.
Volume: 136
Issue: 8
Pages: 1351-61
Publication
First Author: Sarper SE
Year: 2018
Journal: Sci Rep
Title: Runx1-Stat3-Tgfb3 signaling network regulating the anterior palatal development.
Volume: 8
Issue: 1
Pages: 11208
Publication
First Author: Lane J
Year: 2015
Journal: Dev Biol
Title: Tak1, Smad4 and Trim33 redundantly mediate TGF-β3 signaling during palate development.
Volume: 398
Issue: 2
Pages: 231-41
Publication  
First Author: Sarper SE
Year: 2019
Journal: Dis Model Mech
Title: Anterior cleft palate due to Cbfb deficiency and its rescue by folic acid.
Volume: 12
Issue: 6
Publication  
First Author: Xu J
Year: 2022
Journal: Development
Title: The transcription factors Foxf1 and Foxf2 integrate the SHH, HGF and TGFβ signaling pathways to drive tongue organogenesis.
Volume: 149
Issue: 21
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus caroli
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus pahari
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus spretus
Publication
First Author: Kaartinen V
Year: 1995
Journal: Nat Genet
Title: Abnormal lung development and cleft palate in mice lacking TGF-beta 3 indicates defects of epithelial-mesenchymal interaction.
Volume: 11
Issue: 4
Pages: 415-21
Publication
First Author: Le M
Year: 2012
Journal: PLoS One
Title: Transforming growth factor Beta 3 is required for excisional wound repair in vivo.
Volume: 7
Issue: 10
Pages: e48040
Publication
First Author: Li J
Year: 1999
Journal: J Biol Chem
Title: TGF-beta3, but not TGF-beta1, protects keratinocytes against 12-O-tetradecanoylphorbol-13-acetate-induced cell death in vitro and in vivo.
Volume: 274
Issue: 7
Pages: 4213-9
Publication
First Author: Wu C
Year: 2013
Journal: Mol Ther
Title: Intra-amniotic transient transduction of the periderm with a viral vector encoding TGFβ3 prevents cleft palate in Tgfβ3(-/-) mouse embryos.
Volume: 21
Issue: 1
Pages: 8-17
Publication
First Author: Petrus P
Year: 2018
Journal: Cell Rep
Title: Transforming Growth Factor-β3 Regulates Adipocyte Number in Subcutaneous White Adipose Tissue.
Volume: 25
Issue: 3
Pages: 551-560.e5
Publication
First Author: Kaartinen V
Year: 1997
Journal: Dev Dyn
Title: Transforming growth factor-beta3 regulates transdifferentiation of medial edge epithelium during palatal fusion and associated degradation of the basement membrane.
Volume: 209
Issue: 3
Pages: 255-60
Publication  
First Author: Yoshioka Y
Year: 2016
Journal: Bone
Title: CCN4/WISP-1 positively regulates chondrogenesis by controlling TGF-β3 function.
Volume: 83
Pages: 162-70
Publication
First Author: Shah S
Year: 2008
Journal: Eur J Immunol
Title: Resting B cells expand a CD4+CD25+Foxp3+ Treg population via TGF-beta3.
Volume: 38
Issue: 9
Pages: 2488-98
Publication
First Author: Cox DA
Year: 1995
Journal: Cell Biol Int
Title: Transforming growth factor-beta 3.
Volume: 19
Issue: 5
Pages: 357-71
Publication
First Author: Brunet CL
Year: 1995
Journal: Int J Dev Biol
Title: Inhibition of TGF-beta 3 (but not TGF-beta 1 or TGF-beta 2) activity prevents normal mouse embryonic palate fusion.
Volume: 39
Issue: 2
Pages: 345-55
Publication
First Author: D'Cruz CM
Year: 2002
Journal: Mol Endocrinol
Title: Persistent parity-induced changes in growth factors, TGF-beta3, and differentiation in the rodent mammary gland.
Volume: 16
Issue: 9
Pages: 2034-51
Publication
First Author: Nawshad A
Year: 2004
Journal: Arch Oral Biol
Title: Transforming growth factor beta (TGFbeta) signalling in palatal growth, apoptosis and epithelial mesenchymal transformation (EMT).
Volume: 49
Issue: 9
Pages: 675-89
Publication
First Author: Muraoka N
Year: 2005
Journal: Birth Defects Res A Clin Mol Teratol
Title: Transforming growth factor-beta3 promotes mesenchymal cell proliferation and angiogenesis mediated by the enhancement of cyclin D1, Flk-1, and CD31 gene expression during CL/Fr mouse lip fusion.
Volume: 73
Issue: 12
Pages: 956-65
Publication
First Author: Ahmed S
Year: 2007
Journal: Dev Biol
Title: Mechanisms of palatal epithelial seam disintegration by transforming growth factor (TGF) beta3.
Volume: 309
Issue: 2
Pages: 193-207
Publication
First Author: Jalali A
Year: 2012
Journal: Dev Growth Differ
Title: Induction of palate epithelial mesenchymal transition by transforming growth factor β3 signaling.
Volume: 54
Issue: 6
Pages: 633-48
GXD Expression      
Probe: MGI:1329428
Assay Type: RT-PCR
Annotation Date: 1999-02-11
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1724519
Stage: TS19
Assay Id: MGI:1329435
Age: embryonic day 11.0
Specimen Label: E11
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:1329428
Assay Type: RT-PCR
Annotation Date: 1999-02-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1742820
Stage: TS20
Assay Id: MGI:1329435
Age: embryonic day 12.0
Specimen Label: E12
Detected: true
Specimen Num: 2
GXD Expression      
Probe: MGI:1329428
Assay Type: RT-PCR
Annotation Date: 1999-02-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1742821
Stage: TS21
Assay Id: MGI:1329435
Age: embryonic day 13.0
Specimen Label: E13
Detected: true
Specimen Num: 3
GXD Expression      
Probe: MGI:1329428
Assay Type: RT-PCR
Annotation Date: 1999-02-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1742822
Stage: TS22
Assay Id: MGI:1329435
Age: embryonic day 14.0
Specimen Label: E14
Detected: true
Specimen Num: 4
GXD Expression      
Probe: MGI:1329640
Assay Type: Northern blot
Annotation Date: 1999-02-16
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1764222
Stage: TS22
Assay Id: MGI:1329642
Age: embryonic day 14.0
Specimen Label: 1
Detected: true
Specimen Num: 1
GXD Expression      
Probe: MGI:1330210
Assay Type: Northern blot
Annotation Date: 1999-03-03
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1741220
Stage: TS20
Assay Id: MGI:1331136
Age: embryonic day 12.5
Specimen Label: Limb Bud
Detected: true
Specimen Num: 1
GXD Expression      
Probe: MGI:1330210
Assay Type: Northern blot
Annotation Date: 1999-03-03
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1736222
Stage: TS22
Assay Id: MGI:1331136
Age: embryonic day 14.5
Specimen Label: GD 14 palate
Detected: true
Specimen Num: 3
GXD Expression      
Probe: MGI:1330210
Assay Type: Northern blot
Annotation Date: 1999-03-03
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1736221
Stage: TS21
Assay Id: MGI:1331136
Age: embryonic day 13.5
Specimen Label: GD 13 palate
Detected: true
Specimen Num: 4
GXD Expression      
Probe: MGI:1330210
Assay Type: Northern blot
Annotation Date: 1999-03-03
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1736220
Stage: TS20
Assay Id: MGI:1331136
Age: embryonic day 12.5
Specimen Label: GD 12 palate
Detected: true
Specimen Num: 5
GXD Expression      
Probe: MGI:1330210
Assay Type: Northern blot
Annotation Date: 1999-03-03
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1736220
Stage: TS20
Assay Id: MGI:1331137
Age: embryonic day 12.5
Specimen Label: GD 12 C
Detected: true
Specimen Num: 2
GXD Expression      
Probe: MGI:1330210
Assay Type: Northern blot
Annotation Date: 1999-03-03
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1736219
Stage: TS19
Assay Id: MGI:1331137
Age: embryonic day 11.5
Specimen Label: GD 11 C
Detected: true
Specimen Num: 4
GXD Expression    
Probe: MGI:1934886
Assay Type: Northern blot
Annotation Date: 2001-09-21
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1638815
Stage: TS15
Assay Id: MGI:2150027
Age: embryonic day 9.5
Image: 5
Specimen Label: 9.5
Detected: true
Specimen Num: 1
GXD Expression    
Probe: MGI:1934886
Assay Type: Northern blot
Annotation Date: 2001-09-21
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1638816
Stage: TS16
Assay Id: MGI:2150027
Age: embryonic day 10.0
Image: 5
Specimen Label: 10
Detected: true
Specimen Num: 2
GXD Expression    
Probe: MGI:1934886
Assay Type: Northern blot
Annotation Date: 2001-09-21
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1638818
Stage: TS18
Assay Id: MGI:2150027
Age: embryonic day 11.0
Image: 5
Specimen Label: 11
Detected: true
Specimen Num: 3
GXD Expression    
Probe: MGI:1934886
Assay Type: Northern blot
Annotation Date: 2001-09-21
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1735920
Stage: TS20
Assay Id: MGI:2150027
Age: embryonic day 12.0
Image: 5
Specimen Label: 12
Detected: true
Specimen Num: 4
GXD Expression    
Probe: MGI:1934886
Assay Type: Northern blot
Annotation Date: 2001-09-21
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1792421
Stage: TS21
Assay Id: MGI:2150027
Age: embryonic day 13.0
Image: 5
Specimen Label: 13
Detected: true
Specimen Num: 5
GXD Expression    
Probe: MGI:1934886
Assay Type: Northern blot
Annotation Date: 2001-09-21
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1792422
Stage: TS22
Assay Id: MGI:2150027
Age: embryonic day 14.0
Image: 5
Specimen Label: 14
Detected: true
Specimen Num: 6
GXD Expression    
Probe: MGI:1934886
Assay Type: Northern blot
Annotation Date: 2001-09-21
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1792423
Stage: TS23
Assay Id: MGI:2150027
Age: embryonic day 15.0
Image: 5
Specimen Label: 15
Detected: true
Specimen Num: 7
GXD Expression      
Probe: MGI:2684681
Assay Type: Northern blot
Annotation Date: 2004-01-22
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603920
Stage: TS20
Assay Id: MGI:2684682
Age: embryonic day 12.5
Specimen Label: None
Detected: true
Specimen Num: 1
GXD Expression      
Probe: MGI:2684681
Assay Type: Northern blot
Annotation Date: 2004-01-22
Strength: Present
Sex: Female
Emaps: EMAPS:1796228
Stage: TS28
Assay Id: MGI:2684682
Age: postnatal week 3-8
Specimen Label: None
Detected: true
Specimen Num: 2
GXD Expression      
Probe: MGI:2684681
Assay Type: Northern blot
Annotation Date: 2004-01-22
Strength: Present
Sex: Male
Emaps: EMAPS:1797228
Stage: TS28
Assay Id: MGI:2684682
Age: postnatal week 3-8
Specimen Label: None
Detected: true
Specimen Num: 3