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Search results 1 to 100 out of 104 for Themis

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Type Details Score
Gene
Type: gene
Organism: Homo sapiens
Gene
Type: gene
Organism: Rattus norvegicus
Gene
Type: gene
Organism: Danio rerio
Protein Domain
Type: Family
Description: This entry includes THEMIS1/2/3 from animals. THEMIS1 and THEMIS2 are restricted to B and myeloid cells, and the more distantly related THEMIS3 is expressed in the large and small intestine. THEMIS is involved in the early TCR (T-cell antigen receptor) signal transduction and thymocyte selection[]. It is recruited to LAT through GRB2 association and LAT phosphotyrosine GRB2 binding sites []. THEMIS contains CABIT modules that bind directly to the SHP-1 PTP (protein tyrosine phosphatase) domain and inhibit SHP-1 PTP activity by promoting or stabilizing oxidation of the catalytic cysteine [].
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Publication
First Author: Choi S
Year: 2017
Journal: Nat Immunol
Title: THEMIS enhances TCR signaling and enables positive selection by selective inhibition of the phosphatase SHP-1.
Volume: 18
Issue: 4
Pages: 433-441
Protein
Organism: Mus musculus
Length: 94  
Fragment?: false
Protein
Organism: Mus musculus
Length: 636  
Fragment?: false
Protein
Organism: Mus musculus
Length: 203  
Fragment?: true
Publication  
First Author: Gascoigne NR
Year: 2015
Journal: Curr Opin Immunol
Title: THEMIS: a critical TCR signal regulator for ligand discrimination.
Volume: 33
Pages: 86-92
Protein
Organism: Mus musculus
Length: 569  
Fragment?: false
Protein
Organism: Mus musculus
Length: 663  
Fragment?: false
Publication
First Author: Fu G
Year: 2009
Journal: Nat Immunol
Title: Themis controls thymocyte selection through regulation of T cell antigen receptor-mediated signaling.
Volume: 10
Issue: 8
Pages: 848-56
Publication
First Author: Johnson AL
Year: 2009
Journal: Nat Immunol
Title: Themis is a member of a new metazoan gene family and is required for the completion of thymocyte positive selection.
Volume: 10
Issue: 8
Pages: 831-9
Publication
First Author: Okada T
Year: 2014
Journal: PLoS One
Title: Differential function of Themis CABIT domains during T cell development.
Volume: 9
Issue: 2
Pages: e89115
Publication
First Author: Paster W
Year: 2013
Journal: J Immunol
Title: GRB2-mediated recruitment of THEMIS to LAT is essential for thymocyte development.
Volume: 190
Issue: 7
Pages: 3749-56
Publication
First Author: Fu G
Year: 2013
Journal: Nature
Title: Themis sets the signal threshold for positive and negative selection in T-cell development.
Volume: 504
Issue: 7480
Pages: 441-5
Publication
First Author: Garreau A
Year: 2017
Journal: J Immunol
Title: Grb2-Mediated Recruitment of USP9X to LAT Enhances Themis Stability following Thymic Selection.
Volume: 199
Issue: 8
Pages: 2758-2766
Publication
First Author: Torre S
Year: 2015
Journal: Infect Immun
Title: THEMIS is required for pathogenesis of cerebral malaria and protection against pulmonary tuberculosis.
Volume: 83
Issue: 2
Pages: 759-68
Publication
First Author: Themis M
Year: 2005
Journal: Mol Ther
Title: Oncogenesis following delivery of a nonprimate lentiviral gene therapy vector to fetal and neonatal mice.
Volume: 12
Issue: 4
Pages: 763-71
Publication
First Author: Kakugawa K
Year: 2009
Journal: Mol Cell Biol
Title: A novel gene essential for the development of single positive thymocytes.
Volume: 29
Issue: 18
Pages: 5128-35
Publication
First Author: Lesourne R
Year: 2009
Journal: Nat Immunol
Title: Themis, a T cell-specific protein important for late thymocyte development.
Volume: 10
Issue: 8
Pages: 840-7
Publication
First Author: Patrick MS
Year: 2009
Journal: Proc Natl Acad Sci U S A
Title: Gasp, a Grb2-associating protein, is critical for positive selection of thymocytes.
Volume: 106
Issue: 38
Pages: 16345-50
Publication      
First Author: Zhong X
Year: 2019
Journal: MGI Direct Data Submission
Title: Mutagenetix entry for Meteor.
Publication      
First Author: Zhong X
Year: 2019
Journal: MGI Direct Data Submission
Title: Mutagenetix entry for six_flags.
Publication
First Author: Wang D
Year: 2012
Journal: Nat Immunol
Title: Tespa1 is involved in late thymocyte development through the regulation of TCR-mediated signaling.
Volume: 13
Issue: 6
Pages: 560-8
Publication
First Author: Lyu J
Year: 2019
Journal: Cell Mol Immunol
Title: Thymic-specific regulation of TCR signaling by Tespa1.
Volume: 16
Issue: 12
Pages: 897-907
Publication
First Author: Brzostek J
Year: 2020
Journal: Nat Immunol
Title: T cell receptor and cytokine signal integration in CD8+ T cells is mediated by the protein Themis.
Volume: 21
Issue: 2
Pages: 186-198
Publication
First Author: Mehta M
Year: 2018
Journal: Proc Natl Acad Sci U S A
Title: Themis-associated phosphatase activity controls signaling in T cell development.
Volume: 115
Issue: 48
Pages: E11331-E11340
Publication
First Author: Paster W
Year: 2015
Journal: EMBO J
Title: A THEMIS:SHP1 complex promotes T-cell survival.
Volume: 34
Issue: 3
Pages: 393-409
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus caroli
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus pahari
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus spretus
Publication      
First Author: Wang KW
Year: 2014
Journal: MGI Direct Data Submission
Title: Direct data submission for currant
Publication      
First Author: Zeng M
Year: 2016
Journal: MGI Direct Data Submission
Title: Mutagenetix entry for death_valley
Publication      
First Author: Zhong X
Year: 2018
Journal: MGI Direct Data Submission
Title: Mutagenetix entry for cloudies
GXD Expression    
Probe: MGI:4366074
Assay Type: Northern blot
Annotation Date: 2009-11-03
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3552328
Stage: TS28
Assay Id: MGI:4366075
Age: postnatal
Image: 1
Detected: true
Specimen Num: 7
GXD Expression    
Probe: MGI:4366074
Assay Type: Northern blot
Annotation Date: 2009-11-03
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1672828
Stage: TS28
Assay Id: MGI:4366075
Age: postnatal
Image: 1
Detected: false
Specimen Num: 4
GXD Expression    
Probe: MGI:4366074
Assay Type: Northern blot
Annotation Date: 2009-11-03
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1876828
Stage: TS28
Assay Id: MGI:4366075
Age: postnatal
Image: 1
Detected: true
Specimen Num: 3
GXD Expression    
Probe: MGI:4366074
Assay Type: Northern blot
Annotation Date: 2009-11-03
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:4366075
Age: postnatal
Image: 1
Detected: false
Specimen Num: 2
GXD Expression    
Probe: MGI:4366074
Assay Type: Northern blot
Annotation Date: 2009-11-03
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1876728
Stage: TS28
Assay Id: MGI:4366075
Age: postnatal
Image: 1
Detected: true
Specimen Num: 6
GXD Expression    
Probe: MGI:4366074
Assay Type: Northern blot
Annotation Date: 2009-11-03
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1737328
Stage: TS28
Assay Id: MGI:4366075
Age: postnatal
Image: 1
Detected: false
Specimen Num: 9
GXD Expression    
Probe: MGI:4366074
Assay Type: Northern blot
Annotation Date: 2009-11-03
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1619828
Stage: TS28
Assay Id: MGI:4366075
Age: postnatal
Image: 1
Detected: false
Specimen Num: 1
GXD Expression    
Probe: MGI:4366074
Assay Type: Northern blot
Annotation Date: 2009-11-03
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:3276028
Stage: TS28
Assay Id: MGI:4366075
Age: postnatal
Image: 1
Detected: false
Specimen Num: 8
GXD Expression    
Probe: MGI:4366074
Assay Type: Northern blot
Annotation Date: 2009-11-03
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1684628
Stage: TS28
Assay Id: MGI:4366075
Age: postnatal
Image: 1
Detected: false
Specimen Num: 5
Publication
First Author: Lesourne R
Year: 2012
Journal: J Immunol
Title: Interchangeability of Themis1 and Themis2 in thymocyte development reveals two related proteins with conserved molecular function.
Volume: 189
Issue: 3
Pages: 1154-61
Publication
First Author: Matson CA
Year: 2020
Journal: Proc Natl Acad Sci U S A
Title: CD5 dynamically calibrates basal NF-κB signaling in T cells during thymic development and peripheral activation.
Volume: 117
Issue: 25
Pages: 14342-14353
Publication
First Author: Zvezdova E
Year: 2016
Journal: Sci Signal
Title: Themis1 enhances T cell receptor signaling during thymocyte development by promoting Vav1 activity and Grb2 stability.
Volume: 9
Issue: 428
Pages: ra51
UniProt Feature
Begin: 1
Description: Protein THEMIS
Type: chain
End: 636
Publication
First Author: Liang Y
Year: 2013
Journal: Nat Immunol
Title: The lymphoid lineage-specific actin-uncapping protein Rltpr is essential for costimulation via CD28 and the development of regulatory T cells.
Volume: 14
Issue: 8
Pages: 858-66
Publication
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Title: Data Curation Using Mouse Genome Assembly
Publication      
First Author: Helmholtz Zentrum Muenchen GmbH
Year: 2010
Journal: MGI Direct Data Submission
Title: Alleles produced for the EUCOMM and EUCOMMTools projects by the Helmholtz Zentrum Muenchen GmbH (Hmgu)
Publication
First Author: Zambrowicz BP
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Volume: 100
Issue: 24
Pages: 14109-14
Publication
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
Publication          
First Author: MGD Nomenclature Committee
Year: 1995
Publication      
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
Publication
First Author: Diez-Roux G
Year: 2011
Journal: PLoS Biol
Title: A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Volume: 9
Issue: 1
Pages: e1000582
Publication      
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
Publication      
First Author: The Jackson Laboratory Mouse Radiation Hybrid Database
Year: 2004
Journal: Database Release
Title: Mouse T31 Radiation Hybrid Data Load
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2000
Title: Gene Ontology Annotation by electronic association of SwissProt Keywords with GO terms
Publication
First Author: Gaudet P
Year: 2011
Journal: Brief Bioinform
Title: Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.
Volume: 12
Issue: 5
Pages: 449-62
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
Publication      
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
Publication      
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
Publication      
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
Publication      
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
Publication      
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
Publication      
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
Author
Protein
Organism: Mus musculus
Length: 262  
Fragment?: false
Protein
Organism: Mus musculus
Length: 605  
Fragment?: false
Protein
Organism: Mus musculus
Length: 512  
Fragment?: false
Protein
Organism: Mus musculus
Length: 595  
Fragment?: false
Publication
First Author: Mellor N
Year: 2004
Journal: Liver Int
Title: Characteristics of murine histidinaemia and its potential for genetic manipulation.
Volume: 24
Issue: 4
Pages: 354-60
Allele
Name: thymocyte selection associated; mutation 4, Bruce Beutler
Allele Type: Chemically induced (ENU)
Attribute String: Not Specified
Publication categories: ProxyCollection
Strain
Attribute String: chemically induced mutation, coisogenic, mutant strain
Allele
Name: thymocyte selection associated; mutation 5, Bruce Beutler
Allele Type: Chemically induced (ENU)
Attribute String: Not Specified
Publication categories: ProxyCollection
Strain
Attribute String: mutant strain, coisogenic, chemically induced mutation
Genotype
Symbol: Themis/Themis
Background: C57BL/6J-Themis
Zygosity: hm
Has Mutant Allele: true