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Search results 1 to 100 out of 151 for Thoc2

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Categories

Hits by Pathway

Hits by Category

Hits by Strain

Type Details Score
Gene
57187 | THOC2
Type: gene
Organism: human
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Gene
100145575 | thoc2
Type: gene
Organism: frog, western clawed
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Gene
313308 | Thoc2
Type: gene
Organism: rat
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Gene
481042 | THOC2
Type: gene
Organism: dog, domestic
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Gene
465844 | THOC2
Type: gene
Organism: chimpanzee
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Gene
507738 | THOC2
Type: gene
Organism: cattle
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Gene
422361 | THOC2
Type: gene
Organism: chicken
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Gene
368417 | thoc2
Type: gene
Organism: zebrafish
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Gene
697668 | THOC2
Type: gene
Organism: macaque, rhesus
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Protein Coding Gene
MGI:2442413 | Thoc2
Type: protein_coding_gene
Organism: mouse, laboratory
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Publication
38331934 | J:345229
First Author: Bhattacharjee R
Year: 2024
Journal: Nat Commun
Title: Compromised transcription-mRNA export factor THOC2 causes R-loop accumulation, DNA damage and adverse neurodevelopment.
Volume: 15
Issue: 1
Pages: 1210
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Protein Coding Gene
MGP_CAROLIEiJ_G0033023 | -
Type: protein_coding_gene
Organism: Mus caroli
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Protein Coding Gene
MGP_129S1SvImJ_G0035673 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AJ_G0035656 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AKRJ_G0035576 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_BALBcJ_G0035642 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C3HHeJ_G0035346 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI_C57BL6J_2442413 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C57BL6NJ_G0036171 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CASTEiJ_G0034637 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CBAJ_G0035320 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_DBA2J_G0035474 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_FVBNJ_G0035423 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_LPJ_G0035562 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NODShiLtJ_G0035461 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NZOHlLtJ_G0036189 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PWKPhJ_G0034336 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_WSBEiJ_G0034781 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PahariEiJ_G0031569 | -
Type: protein_coding_gene
Organism: Mus pahari
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Protein Coding Gene
MGP_SPRETEiJ_G0034181 | -
Type: protein_coding_gene
Organism: Mus spretus
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GXD Expression
GXD Expression
     
Probe: MGI:5632357
Assay Type: RT-PCR
Annotation Date: 2015-04-24
Strength: Present
Sex: Not Specified
Emaps: EMAPS:360411
Stage: TS01
Assay Id: MGI:5632371
Age: embryonic day 0.5
Specimen Label: 1-cell
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
     
Probe: MGI:5632357
Assay Type: RT-PCR
Annotation Date: 2015-04-24
Strength: Present
Sex: Not Specified
Emaps: EMAPS:360422
Stage: TS02
Assay Id: MGI:5632371
Age: embryonic day 1.0
Specimen Label: 2-cell
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
     
Probe: MGI:5632357
Assay Type: RT-PCR
Annotation Date: 2015-04-24
Strength: Present
Sex: Not Specified
Emaps: EMAPS:360633
Stage: TS03
Assay Id: MGI:5632371
Age: embryonic day 2.0-2.5
Specimen Label: 4/8 cell
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
     
Probe: MGI:5632357
Assay Type: RT-PCR
Annotation Date: 2015-04-24
Strength: Present
Sex: Not Specified
Emaps: EMAPS:360453
Stage: TS03
Assay Id: MGI:5632371
Age: embryonic day 3.0
Specimen Label: Morula
Detected: true
Specimen Num: 4
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GXD Expression
GXD Expression
     
Probe: MGI:5632357
Assay Type: RT-PCR
Annotation Date: 2015-04-24
Strength: Present
Sex: Not Specified
Emaps: EMAPS:360464
Stage: TS04
Assay Id: MGI:5632371
Age: embryonic day 3.5
Specimen Label: Blastocyst
Detected: true
Specimen Num: 5
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GXD Expression
GXD Expression
   
Probe: MGI:5632365
Assay Type: Immunohistochemistry
Annotation Date: 2015-04-24
Strength: Present
Sex: Not Specified
Emaps: EMAPS:160414
Pattern: Not Specified
Stage: TS04
Assay Id: MGI:5632377
Age: embryonic day 3.5
Specimen Label: 6F upper
Detected: true
Specimen Num: 1
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Publication
24315442 | J:204143
First Author: Wang L
Year: 2013
Journal: Cell Stem Cell
Title: The THO complex regulates pluripotency gene mRNA export and controls embryonic stem cell self-renewal and somatic cell reprogramming.
Volume: 13
Issue: 6
Pages: 676-90
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Protein
Q3UYT9
Organism: Mus musculus/domesticus
Length: 1017  
Fragment?: true
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Publication
- | J:84900
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Journal: Database Download
Title: Integrating Computational Gene Models into the Mouse Genome Informatics (MGI) Database
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Publication
16602821 | J:162220
First Author: Magdaleno S
Year: 2006
Journal: PLoS Biol
Title: BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system.
Volume: 4
Issue: 4
Pages: e86
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Publication
- | J:85000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Title: MGI Sequence Curation Reference
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Publication
- | J:148605
     
First Author: Wellcome Trust Sanger Institute
Year: 2009
Journal: MGI Direct Data Submission
Title: Alleles produced for the KOMP project by the Wellcome Trust Sanger Institute
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Publication
16141072 | J:99680
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
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Publication
- | J:23000
       
First Author: MGD Nomenclature Committee
Year: 1995
Title: Nomenclature Committee Use
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Publication
- | J:68900
     
First Author: The Jackson Laboratory Mouse Radiation Hybrid Database
Year: 2004
Journal: Database Release
Title: Mouse T31 Radiation Hybrid Data Load
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Publication
- | J:155856
       
First Author: The Gene Ontology Consortium
Year: 2014
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-rat orthologs
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Publication
- | J:342604
       
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
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Publication
- | J:72247
       
First Author: DDB, FB, MGI, GOA, ZFIN curators
Year: 2001
Title: Gene Ontology annotation through association of InterPro records with GO terms
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Publication
12466851 | J:80000
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
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Publication
- | J:164563
       
First Author: The Gene Ontology Consortium
Year: 2010
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs
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Publication
21267068 | J:153498
First Author: Diez-Roux G
Year: 2011
Journal: PLoS Biol
Title: A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Volume: 9
Issue: 1
Pages: e1000582
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Publication
- | J:75000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
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Publication
- | J:157972
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
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Publication
- | J:57747
     
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
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Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
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Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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Publication
21677750 | J:173534
First Author: Skarnes WC
Year: 2011
Journal: Nature
Title: A conditional knockout resource for the genome-wide study of mouse gene function.
Volume: 474
Issue: 7351
Pages: 337-42
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Publication
- | J:342587
       
First Author: AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators
Year: 2011
Title: Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
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Publication
- | J:60000
       
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
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Publication
- | J:342605
       
First Author: GOA curators
Year: 2016
Title: Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
26166480 | -
First Author: Kumar R
Year: 2015
Journal: Am J Hum Genet
Title: THOC2 Mutations Implicate mRNA-Export Pathway in X-Linked Intellectual Disability.
Volume: 97
Issue: 2
Pages: 302-10
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HT Experiment
GSE245539 | Compromised THOC2, a TREX mRNA export complex scaffold protein, leads to R-loop accumulation, DNA damage and adverse neurodevelopmental outcomes in mice and men
 
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
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Allele
Thoc2<em1Gecz> | MGI:7711300
Name: THO complex 2; endonuclease-mediated mutation 1, Jozef Gecz
Allele Type: Endonuclease-mediated
Attribute String: Humanized sequence, Hypomorph
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Genotype
Genotype
Symbol: Thoc2/?
Background: C57BL/6JArc-Thoc2
Zygosity: ot
Has Mutant Allele: true
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DO Term
DOID:0112056 | X-linked intellectual disability-short stature-overweight syndrome
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Publication
17095540 | -
First Author: Merz C
Year: 2007
Journal: RNA
Title: Protein composition of human mRNPs spliced in vitro and differential requirements for mRNP protein recruitment.
Volume: 13
Issue: 1
Pages: 116-28
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Protein Domain
IPR021726 | THO_THOC2_N
Type: Domain
Description: The THO/TREX complex is the transcription- and export-related complex associated with spliceosomes that preferentially deal with spliced mRNAs as opposed to unspliced mRNAs. Thoc2 plays a role in RNA polymerase II (RNA pol II)-dependent transcription and is required for the stability of DNA repeats []. In humans, the TRE complex is comprised of the exon-junction-associated proteins Aly/REF and UAP56 together with the THO proteins THOC1 (hHpr1/p84), Thoc2 (hRlr1), THOC3 (hTex1), THOC5 (fSAP79), THOC6 (fSAP35), and THOC7 (fSAP24). Although much evidence indicates that the function of the TREX complex as an adaptor between the mRNA and components of the export machinery is conserved among eukaryotes, in Drosophila the majority of mRNAs can be exported from the nucleus independently of the THO complex []. This entry represents a conserved domain found towards the N terminus of these proteins.
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Protein
B1AZI6
Organism: Mus musculus/domesticus
Length: 1594  
Fragment?: false
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Protein
E9Q5E2
Organism: Mus musculus/domesticus
Length: 1589  
Fragment?: false
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Protein
Q3US09
Organism: Mus musculus/domesticus
Length: 921  
Fragment?: true
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Protein Coding Gene
MGI:3040669 | Thoc2l
Type: protein_coding_gene
Organism: mouse, laboratory
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ncRNA Gene
MGP_CAROLIEiJ_G0006119 | -
Type: ncRNA_gene
Organism: Mus caroli
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ncRNA Gene
MGP_129S1SvImJ_G0006728 | -
Type: ncRNA_gene
Organism: mouse, laboratory
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ncRNA Gene
MGP_AJ_G0006722 | -
Type: ncRNA_gene
Organism: mouse, laboratory
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ncRNA Gene
MGP_AKRJ_G0006692 | -
Type: ncRNA_gene
Organism: mouse, laboratory
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ncRNA Gene
MGP_BALBcJ_G0006697 | -
Type: ncRNA_gene
Organism: mouse, laboratory
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ncRNA Gene
MGP_C3HHeJ_G0006643 | -
Type: ncRNA_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI_C57BL6J_3040669 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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ncRNA Gene
MGP_C57BL6NJ_G0006862 | -
Type: ncRNA_gene
Organism: mouse, laboratory
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ncRNA Gene
MGP_CASTEiJ_G0006566 | -
Type: ncRNA_gene
Organism: mouse, laboratory
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ncRNA Gene
MGP_CBAJ_G0006624 | -
Type: ncRNA_gene
Organism: mouse, laboratory
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ncRNA Gene
MGP_DBA2J_G0006645 | -
Type: ncRNA_gene
Organism: mouse, laboratory
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ncRNA Gene
MGP_FVBNJ_G0006669 | -
Type: ncRNA_gene
Organism: mouse, laboratory
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ncRNA Gene
MGP_LPJ_G0006729 | -
Type: ncRNA_gene
Organism: mouse, laboratory
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ncRNA Gene
MGP_NODShiLtJ_G0006653 | -
Type: ncRNA_gene
Organism: mouse, laboratory
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ncRNA Gene
MGP_NZOHlLtJ_G0006864 | -
Type: ncRNA_gene
Organism: mouse, laboratory
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ncRNA Gene
MGP_PWKPhJ_G0006505 | -
Type: ncRNA_gene
Organism: mouse, laboratory
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ncRNA Gene
MGP_WSBEiJ_G0006617 | -
Type: ncRNA_gene
Organism: mouse, laboratory
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ncRNA Gene
MGP_PahariEiJ_G0004559 | -
Type: ncRNA_gene
Organism: Mus pahari
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ncRNA Gene
MGP_SPRETEiJ_G0006411 | -
Type: ncRNA_gene
Organism: Mus spretus
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GXD Expression
GXD Expression
 
Probe: MGI:4883158
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1691619
Pattern: Widespread
Stage: TS19
Assay Id: MGI:4945728
Age: embryonic day 11.5
Image: g01351 E11.5
Specimen Label: g01351 E11.5
Detected: true
Specimen Num: 1
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

Copyright © 2017 by The Jackson Laboratory. All Rights Reserved

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Cambridge CB2 3EH, United Kingdom